28 results match your criteria: "Fralin Translational Obesity Research Center[Affiliation]"
Mitochondrial alteration in type 2 diabetes and obesity: an epigenetic link.
Cell Cycle
October 2014
Department of Human Nutrition, Foods, and Exercise; Fralin Translational Obesity Research Center; Fralin Life Science Institute; College of Agriculture and Life Sciences; Virginia Tech; Blacksburg, VA USA.
The growing epidemic of type 2 diabetes mellitus (T2DM) and obesity is largely attributed to the current lifestyle of over-consumption and physical inactivity. As the primary platform controlling metabolic and energy homeostasis, mitochondria show aberrant changes in T2DM and obese subjects. While the underlying mechanism is under extensive investigation, epigenetic regulation is now emerging to play an important role in mitochondrial biogenesis, function, and dynamics.
View Article and Find Full Text PDFBeginning a patient-centered approach in the design of a diabetes prevention program.
Int J Environ Res Public Health
February 2014
Fralin Translational Obesity Research Center, Department of Human Nutrition, Foods and Exercise, Virginia Tech, 215 War Memorial Hall, Blacksburg, VA 24061, USA.
Objective: The purpose of this study was to identify patient preferences for different components of a local diabetes prevention program that would improve reach. A secondary purpose was to determine if patient characteristics were related to program preferences.
Methods: Participants were identified through electronic medical records from two family medicine clinics in Virginia.
Singular and combined effects of nebivolol and lifestyle modification on large artery stiffness in hypertensive adults.
Ther Adv Cardiovasc Dis
December 2013
Human Integrative Physiology Laboratory, Fralin Translational Obesity Research Center, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Background: We hypothesized that the combination of nebivolol and lifestyle modification would reduce large artery stiffness in middle-aged and older hypertensive adults more than either intervention alone.
Methods: To address this, 45 men and women (age 40-75 years) with stage I hypertension were randomized to receive either nebivolol (NB; forced titration to 10 mg OD; n = 15; age 57.2 ± 11.