Initial Efficacy after Lateral Lumbar Interbody Fusion in Degenerative Lumbar Spinal Stenosis Classified as Schizas Grade A to D.

Objective: This study was to evaluate the initial efficacy of lateral lumbar interbody fusion (LLIF) in treating degenerative lumbar spinal stenosis (DLSS), encompassing a spectrum of stenosis severity from minor to extreme cases.

Methods: This retrospective study analyzed the outcomes of 43 patients with DLSS, involving 55 surgical segments, who underwent LLIF. Clinical efficacy and radiographic parameters were recorded during the perioperative period and at the final follow-up.

Alterations in white matter microstructure in bipolar disorder patients with and without psychosis.

Objective: The overlap of affective disturbance and psychosis considerably makes it complex to determine the etiology of bipolar disorder (BD) and develop targeted interventions. The present study aimed to determine the white matter microstructural alterations that distinguish between BD with psychosis (BDP) and BD with no psychosis (BDNP) to identify patients who may specifically benefit from appropriately effective treatments.

Methods: Diffusion-weighted magnetic resonance images were acquired from 38 participants with BDP, 52 participants with BDNP and 70 healthy controls (HCs).

Coupling of state space modules and attention mechanisms: An input-aware multi-contrast MRI synthesis method.

Background: Medical imaging plays a pivotal role in the real-time monitoring of patients during the diagnostic and therapeutic processes. However, in clinical scenarios, the acquisition of multi-modal imaging protocols is often impeded by a number of factors, including time and economic costs, the cooperation willingness of patients, imaging quality, and even safety concerns.

Purpose: We proposed a learning-based medical image synthesis method to simplify the acquisition of multi-contrast MRI.

[Modified endoscopic mucosal resection for the treatment of early gastrointestinal lesions].

To evaluate the clinical efficacy of modified endoscopic mucosal resection (EMR) in the management of early gastrointestinal lesions. Upon endoscopic identification of the lesion, normal saline is injected into the submucosa to establish a fluid cushion, which elevates the lesion's mucosa. Methylene blue may also be applied to improve visualization of the relationship between the submucosa and muscular layer.

Crucial rhythms and subnetworks for emotion processing extracted by an interpretable deep learning framework from EEG networks.

Electroencephalogram (EEG) brain networks describe the driving and synchronous relationships among multiple brain regions and can be used to identify different emotional states. However, methods for extracting interpretable structural features from brain networks are still lacking. In the current study, a novel deep learning structure comprising both an attention mechanism and a domain adversarial strategy is proposed to extract discriminant and interpretable features from brain networks.

Efficacy of docetaxel addition to next-generation androgen receptor-axis-targeted therapies and androgen deprivation therapy in metastatic hormone-sensitive prostate cancer: A tumor volume-specific analysis.

Background: The effectiveness of docetaxel in addition to next-generation androgen receptor-axis-targeted therapies and androgen deprivation therapy (ADT) for metastatic hormone-sensitive prostate cancer (mHSPC) remains unclear. We evaluated the efficacy of this combination through tumor volume-specific analysis.

Methods: Individual patient data were reconstructed from seven clinical trials focusing mHSPC (ARASENS, PEACE-1, TITAN, ENZAMET, ARCHES, STAMPEDE, and LATITUDE) through the Shiny method.

Targeted thermosensitive liposomes loaded with gold nanoparticles and temozolomide hexadecanoate for the synergistic photothermal-chemotherapy treatment of glioblastoma.

Glioblastoma (GBM) is a highly aggressive malignant brain tumour which presents a significant challenge due to the limited effectiveness of current surgical and chemotherapeutic approaches. In this study, we have developed TMZ16e and gold nanoparticles coencapsulated thermosensitive liposomes modified with anti-EphA3 (anti-EphA3-TMZ16e-GNPs-TSL) delivered via the intranasal route to achieve photothermal chemotherapy (PCT) for improving the therapeutic effects of GBM. The prepared anti-EphA3-TMZ16e-GNPs-TSL were spherical with a particle size of 173.

Comparing ADA and IDF diagnostic criteria for intermediate hyperglycaemia and diabetes in the SHiDS study.

Aims: This study aimed to assess the prevalence of IH and diabetes, as well as insulin secretion, insulin sensitivity, and related curve patterns in subjects with different glucose tolerance categories according to the diagnostic criteria established by the American Diabetes Association (ADA) and the more recently published International Diabetes Federation (IDF) guidelines.

Methods: We used data of 5,387 adult participants from the Shanghai High-risk Diabetic Screen (SHiDS) study. All participants underwent a five-point 75 g oral glucose tolerance test (OGTT).

Effects of pyrazosulfuron-ethyl on caudal fin regeneration in zebrafish larvae.

With the widespread application of pesticides, water pollution problems are becoming more and more serious, which is very likely to cause harm to fish. Lower vertebrates, including fish, have the ability to repair damaged tissues. The spread of pesticides in the water may affect their regeneration process after injury, leading to their death, thereby affecting the survival rate of the population.

A Differentiated HIV Pre-Exposure Prophylaxis Delivery Model for High-Risk Groups in Nanning City, South China: Findings from a Pilot Program.

In China, pre-exposure prophylaxis (PrEP) uptake among men who have sex with men (MSM) and HIV-serodiscordant couples is low. We offered differentiated PrEP options tailored to MSM in a community-based organization (CBO) setting, and to HIV-serodiscordant couples attempting conception in a specialized HIV care clinic. The CBO facilitated PrEP by linkage with a telemedicine platform for virtual consultation; additional online follow-up on social media was conducted by peers.

Changes in Cardiovascular Health, Genetic Risk, and Cardiometabolic Diseases: Evidence From a Large-Scale Cohort Study.

Background: Evidence has firmly established the association between superior cardiovascular health (CVH) and reduced susceptibility to cardiometabolic diseases (CMDs). In reality, CVH experiences dynamic fluctuations throughout individuals' lifespans. However, the association between changes in CVH and the impact on CMDs among individuals with different genetic risks remains unclear.

Molecular epidemiology and distribution of in human immunodeficiency-positive patients in China.

Objective: This study aims to inform the prevention and treatment of infections in China by analyzing the molecular epidemiology and distribution patterns of the pathogen.

Methods: A cross-sectional study was conducted involving a retrospective analysis of 64 clinical strains of isolated from January 2018 to April 2023 across various domestic regions. Patient information was collected from human immunodeficiency virus-positive individuals in multiple hospitals located in 19 cities within China's southeastern coastal and southwestern regions.

regulates the proliferation and differentiation of neural stem/progenitor cells.

Background: MicroRNAs (miRNAs) have emerged as an essential regulator of the cell fate commitment of neural stem/progenitor cells (NPCs), although the impacts of certain miRNAs on NPCs remain vague. The aim of this study is to investigate the regulatory effects of on the cell fate commitment of NPCs.

Methods: We investigated the impact of on the proliferation and differentiation capacities of primary NPCs by manipulating the expression of using specific mimics and inhibitors.

Ginsenoside Rd-Loaded Antioxidant Polymersomes to Regulate Mitochondrial Homeostasis for Bone Defect Healing in Periodontitis.

Periodontitis is the leading cause of tooth loss in adults. Initially triggered by bacterial infection, it is characterized by subsequent dysregulation of mitochondrial homeostasis, leading to ongoing loss of periodontal tissue. Mitophagic flux, a critical physiological mechanism for maintaining mitochondrial homeostasis, is compromised in periodontitis.

Roles of gut microbiome-associated metabolites in pulmonary fibrosis by integrated analysis.

Lung diseases often coincide with imbalances in gut microbiota, but the role of gut microbiota in pulmonary fibrosis (PF) remains unclear. This study investigates the impact of gut microbiota and their metabolites on PF. Serum and lung tissues of normal, bleomycin (BLM)- and silica-induced mice showed significant differences in gut microbiota.

Increased GDF-15 in chronic male patients with schizophrenia: correlation with body mass index and cognitive impairment.

Growth Differentiation Factor-15 (GDF-15) is a pleiotropic cytokine that plays a significant role in metabolism and inflammation. Elevated serum levels of GDF-15 have been associated with mood disorders. We propose that GDF-15 may potentially influence cognitive impairment and metabolism in male patients with chronic schizophrenia (CS), although there is limited research on this topic.

Association between composite dietary antioxidant index and metabolic dysfunction-associated fatty liver disease: a cross-sectional study from NHANES.

Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a typical hepatic steatosis with metabolic dysfunction. The composite dietary antioxidant index (CDAI) measures individual antioxidant capacity, and the relationship with MAFLD has received little attention. Our goal is to explore the association of CDAI with MAFLD.

Biodegradable Nanobowls with Controlled Dents.

Nanobowls show promising potential in biomedical applications, such as bioimaging, cargo delivery, and disease theranostics, due to their unique concave structure and interior cavities. However, the lack of biodegradable nanobowls with manipulable size (especially the dent size) still exists as an obstacle for their in-depth exploration and application in biomedical fields. Herein, polypeptide-based nanobowls are successfully obtained by the self-assembly of a graft polypeptide [named TPE-P(GAAzo--GA)] via a solvent-switch method.

Identification of key necroptosis-related genes and immune landscape in patients with immunoglobulin A nephropathy.

Background: Immunoglobulin A nephropathy (IgAN) is a major cause of chronic kidney disease (CKD) and kidney failure. Necroptosis is a novel type of programmed cell death that has been proved to be associated with the pathogenesis of infectious disease, cardiovascular disease, neurological disorders and so on. However, the role of necroptosis in IgAN remains unclear.

Exosome-based therapies for inflammatory disorders: a review of recent advances.

Exosomes, small extracellular vesicles secreted by cells, have emerged as focal mediators in intercellular communication and therapeutic interventions across diverse biomedical fields. Inflammatory disorders, including inflammatory bowel disease, acute liver injury, lung injury, neuroinflammation, and myocardial infarction, are complex conditions that require innovative therapeutic approaches. This review summarizes recent advances in exosome-based therapies for inflammatory disorders, highlighting their potential as diagnostic biomarkers and therapeutic agents.

Proteomics analysis revealed the therapeutic role of adipose-derived mesenchymal stem cells on radiation-induced colorectal fibrosis in rats.

Background: Radiation-induced colorectal fibrosis (RICF) is a chronic condition that can develop after pelvic radiation therapy for colorectal cancer. Adipose-derived mesenchymal stem cells (ADSCs) have emerged as promising candidate for fibrosis treatment, yet the mode of action of ADSC upon RICF remains obscure. This study aimed to investigate the optimal delivery route, treatment timing, anti-fibrotic effects, and underlying mechanisms of ADSCs upon RICF.

Negative pressure wound therapy for the management of deep brain stimulation-related surgical site infections: A retrospective case series.

The management of deep brain stimulation (DBS)-related surgical site infection (SSI) is challenging. This article aimed to report the efficacy of negative pressure wound therapy (NPWT) in treating DBS-related SSI while preserving all DBS devices. As a retrospective case series in a single center, localized DBS-related SSI was treated with complete debridement and NPWT, with preserving all DBS devices.

Telehealth approaches for improving depression and anxiety among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis.

Objective: This study aimed to systematically review the efficacy of telehealth approaches in alleviating depressive and anxiety symptoms in patients with chronic obstructive pulmonary disease (COPD) using evidence from randomized controlled trials (RCTs).

Methods: This systematic review and meta-analysis was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) checklist. Databases including PubMed, Embase, Web of Science, and the Cochrane Library were searched for RCTs from database inception to June 2024.

A Polypeptosome Spray To Heal Antibiotic-Resistant Bacteria-Infected Wound by Photocatalysis-Induced Metabolism-Interference.

With the booming antimicrobial drug resistance worldwide, traditional antibacterial agents (e.g., antibiotics) are usually powerless against superbug.