4 results match your criteria: "Fourth Military Medical UniversityXi'an 710032[Affiliation]"
Melatonin represses oral squamous cell carcinoma metastasis by inhibiting tumor-associated neutrophils.
Am J Transl Res
December 2017
State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical UniversityXi'an 710032, Shannxi, China.
Tumor-associated neutrophils (TANs) promote metastasis of multiple cancers, including oral squamous cell carcinoma (OSCC). Melatonin (Mel) reportedly exerts anti-metastatic effects on OSCC. However, little is known about the anti-OSCC effects of Mel involved in TANs.
View Article and Find Full Text PDFCombined administration of a sedative dose sevoflurane and 60% oxygen reduces inflammatory responses to sepsis in animals and in human PMBCs.
Am J Transl Res
June 2017
Department of Anesthesiology and Critical Care Medicine, Xijing Hospital, The Fourth Military Medical UniversityXi'an 710032, Shaanxi Province, P. R. China.
Our study aims to investigate the effects of the inhalation of subanesthestic doses of sevoflurane combined with oxygen on sepsis. Male Sprague-Dawley rats or Male ICR/Km mice underwent caecal ligation and puncture (CLP) or intraperitoneal injection of lipopolysccharide (LPS) to induce sepsis, while sham rats were used as control. Then, rats were treated with the inhalation of sevoflurane in oxygen; and air or 100% oxygen was used as control.
View Article and Find Full Text PDFA prostate-specific antigen-dependent fusion polypeptide inhibits growth of prostate cancer cells in vitro and in vivo.
Am J Cancer Res
June 2016
Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth Military Medical University Xi'an 710032, China.
Polypeptide APP8 is a prostate-specific antigen (PSA)-activated prodrug that was designed to synergize the effects of the Bcl-2 homology domain 3 (BH3) peptide, K237 and the DG2 peptide. The aim of this study is to evaluate its biodistribution and anticancer effect in vitro and in vivo. In this study, APP8 and each component peptide were synthesized.
View Article and Find Full Text PDFKyoT2 downregulates airway remodeling in asthma.
Int J Clin Exp Pathol
October 2016
Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University Xi'an 710032, China.
Article Synopsis
- The study investigates KyoT2's role in asthma, focusing on airway remodeling and hyperresponsiveness.
- KyoT2, which inhibits Notch signaling, was tested on asthmatic mice to assess its effects on airway structure and resistance.
- Results showed that KyoT2 reduces Hes1 expression, lessens airway remodeling, and improves hyperresponsiveness, suggesting it could be a viable treatment for asthma.