Associations of temperament, family functioning with loneliness trajectories in patients with breast cancer: a longitudinal observational study.

Purpose: Loneliness is a prevalent affective issue among patients with breast cancer, with its developmental trajectory being a contentious subject. Therefore, the aim of this study was to explore trends in loneliness in patients with breast cancer and identify predictors of different trajectory categories.

Methods: Using convenience sampling, 176 patients planning to undergo breast cancer surgery in a university hospital in Shaanxi Province, China, were followed up six times over 12 months following surgery, and data from 144 patients were analyzed.

Targeting enteric glial CRF-R1/Cx43 attenuates stress-induced accelerated colonic motility.

Stress triggers disorders in accelerated peristalsis, with corticotropin releasing factor receptor 1 (CRF-R1) playing a pivotal role. Enteric glia cells (EGCs) and glial Cx43 are known to influence gastrointestinal motility, yet their involvement in colonic motor responses to stress remains unclear. Using immunofluorescence and single-cell RNA sequencing data, we identified CRF-R1 expression in EGCs.

Neonatal sevoflurane exposures inhibits DHHC5-mediated palmitoylation of TfR1 in oligodendrocytes, leading to hypomyelination and neurological impairments.

Introduction: Neonatal anesthesia-related neurological impairments are of significant concern, closely linked to oligodendrocyte dysfunction. However, there is a notable temporal discrepancy between the sustained development of oligodendrocytes (myelination) and the short-term vulnerability to anesthesia exposures.

Objectives: Given the significant rise in iron demand by oligodendrocytes during neonatal period, our objective was to clarify the potential roles and underlying mechanisms of iron homeostasis, particularly focusing on transferrin receptor 1 (TfR1), in governing the transient susceptibility to anesthesia.

Presence of nonimpacted third molars affect the response of neighboring teeth to nonsurgical periodontal therapy.

Background: This study focused on whether the effectiveness of nonsurgical periodontal therapy (NSPT) on second molars (M2s) varies with the status of adjacent nonimpacted third molars (N-M3s).

Methods: In this retrospective cohort study, 776 regions from 268 patients were evaluated. Based on the adjacent N-M3 status, quadrants with M2s were categorized into three groups: N-M3 group (present N-M3), A-M3 group (absent M3), and R-M3 group (removed N-M3).

METTL3-mediated NFAT5 Upregulation Promotes Cervical Cancer Progression Through Enhancing the Mitochondrial Function by Transcriptional Regulation of PRDX1.

Nuclear factor of activated T-cells 5 (NFAT5) is recognized as an oncogene in a variety of tumors. However, the role of NFAT5 in cervical cancer (CC) cell phenotypic alterations remains to be elucidated. Here, we demonstrated that NFAT5 expression was elevated in CC samples and cells using quantitative real-time reverse transcription PCR, Western blot analysis, and immunohistochemistry assays, and high NFAT5 expression showed a poor prognosis.

Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis.

Background/aims: The molecular mechanisms driving nonalcoholic steatohepatitis (NASH) progression are poorly understood. This research examines the involvement of chaperone-mediated autophagy (CMA) in NASH progression.

Methods: Hepatic CMA activity was analysed in NASH mice and patients.

Correlation between plasma epidermal growth factor and follow-up cognitive decline in Parkinson's disease.

Background: Epidermal growth factor (EGF) has been shown to have neuroprotective effects in Parkinson's disease (PD). However, there is a lack of research on the association between plasma EGF levels and cognitive impairments in PD patients.

Methods: The study included 135 PD patients.

Standardization, validation, and comparative evaluation of a convenient surrogate recombinant vesicular stomatitis virus plaque reduction test for quantification of Hantaan orthohantavirus (HTNV) neutralizing antibodies.

Hantaan orthohantavirus (HTNV) is responsible for severe hemorrhagic fever with renal syndrome (HFRS), which has a case fatality rate of 1% to 10%. Currently, the inactive vaccine licensed in endemic areas elicit low levels of neutralizing antibodies (NAbs). Early NAbs administration is helpful for patients recovery from HFRS.

Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration.

Healthy aging is a common goal for humanity and society, and one key to achieving it is the rejuvenation of senescent resident stem cells and empowerment of aging organ regeneration. However, the mechanistic understandings of stem cell senescence and the potential strategies to counteract it remain elusive. Here, we reveal that the aging bone microenvironment impairs the Golgi apparatus thus diminishing mesenchymal stem cell (MSC) function and regeneration.

The role of left anterior temporal lobe in basic linguistic composition: Evidence from stereo-electroencephalography.

Determining the neural bases of basic linguistic composition is central to research on the cognitive neuroscience of language. The left anterior temporal lobe (LATL) is widely reported during linguistic composition of visual stimuli in magnetoencephalography (MEG) studies. However, this effect is less reported during the linguistic composition of auditory stimuli in intracranial electroencephalography (iEEG) studies.

Sini decoction alleviates LPS-induced sepsis partly via restoration of metabolic impairments in the hypothalamic-pituitary-adrenal microenvironment.

Ethnopharmacological Relevance: The hypothalamic-pituitary-adrenal (HPA) axis plays a vital role in the protection against sepsis. Sini decoction (SND) could improve HPA axis function.

Aim Of The Study: This work aimed to explore the effective mechanism of SND against lipopolysaccharide (LPS)-induced sepsis in rats from the metabolic regulation of the HPA axis microenvironment.

Entity-level multiple instance learning for mesoscopic histopathology images classification with Bayesian collaborative learning and pathological prior transfer.

Background: Entity-level pathologic structures with independent structures and functions are at a mesoscopic scale between the cell-level and slide-level, containing limited structures thus providing fewer instances for multiple instance learning. This restricts the perception of local pathologic features and their relationships, causing semantic ambiguity and inefficiency of entity embedding.

Method: This study proposes a novel entity-level multiple instance learning.

Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2.

Microglial canonical transient receptor potential channel 1 (TRPC1) has been proposed to influence neuroinflammation after cerebral ischemia and reperfusion injury (CIRI), however, the underlying mechanism remains poorly understood. This study demonstrates that TRPC1 is modified by small ubiquitin-related modifier (SUMO)ylation. Our findings suggest a notable increase in microglial TRPC1 SUMOylation within both the middle cerebral artery occlusion reperfusion (MCAO/R) model and the in vitro oxygen-glucose deprivation/regeneration model.

Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade.

Glioblastoma (GBM) is a primary brain tumor known for its high levels of aggressiveness and resistance to current treatments such as radiotherapy and chemotherapy. As a result, there is a pressing need for innovative therapeutic approaches to combat GBM. Thus, we have developed an engineered multifunctional extracellular vesicle (EV) delivery system that offers an "all-in-one" strategy for GBM therapy.

Diagnostic Values of Magnetic Resonance Imaging and Computed Tomography for Predicting Macrotrabecular-Massive Hepatocellular Carcinoma Subtype: A Meta-analysis.

Background: The diagnostic accuracy of magnetic resonance imaging (MRI) vs. computed tomography (CT) for predicting macrotrabecular-massive hepatocellular carcinoma (MTM-HCC) is yet to be ascertained. Therefore, this meta-analysis aimed to summarise the diagnostic accuracies of MRI and CT for MTM-HCC.

Correlation of Occlusion Asymmetry and Temporomandibular Disorders: A Cross-Sectional Study.

Background: The association between occlusion and temporomandibular disorders (TMD) remains obscure. The present purpose was to explore the asymmetrical occlusion feature(s) potentially linked to TMDs.

Methods: This study enrolled 148 patients with a chief complaint of malocclusion.

Ivarmacitinib, a selective Janus kinase 1 inhibitor, in patients with moderate-to-severe active rheumatoid arthritis and inadequate response to conventional synthetic DMARDs: results from a phase III randomised clinical trial.

Objective: To assess the efficacy/safety of ivarmacitinib, a selective Janus kinase (JAK) 1 inhibitor, in patients with moderate-to-severe active rheumatoid arthritis (RA) who had an inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs).

Methods: Patients were randomised (1:1:1) to receive either placebo (n=188), ivarmacitinib 4 mg (n=189) or ivarmacitinib 8 mg (n=189) once daily, with background csDMARDs allowed. After 24 weeks, patients on placebo switched to ivarmacitinib 4 mg for an additional 28 weeks, while those on ivarmacitinib continued their initial dosage.

Assessing the ecological resilience of Ebola virus in Africa and potential influencing factors based on a synthesized model.

Background: The Ebola epidemic has persisted in Africa since it was firstly identified in 1976. However, few studies have focused on spatiotemporally assessing the ecological adaptability of this virus and the influence of multiple factors on outbreaks. This study quantitatively explores the ecological adaptability of Ebola virus and its response to different potential natural and anthropogenic factors from a spatiotemporal perspective.

Oxidative stress in asthma pathogenesis: mechanistic insights and implications for airway smooth muscle dysfunction.

Airway smooth muscle (ASM) dysfunction is a key factor in the narrowing of airways in asthma patients, characterized by excessive secretion of inflammatory factors, increased mass, and amplified contractile responses. These pathological features are instrumental in the propagation of airway inflammation, structural remodeling, and the escalation of airway hyperresponsiveness (AHR), which are also principal factors underlying the limitations of current therapeutic strategies. In asthmatic ASM, an imbalance between oxidant production and antioxidant defenses culminates in oxidative stress, which is involved in the excessive secretion of inflammatory factors, increased mass, and amplified contractile responses of ASM, and is a critical etiological factor implicated in the dysregulation of ASM function.

Clinical biomarkers of perioperative neurocognitive disorder: initiation and recommendation.

Perioperative neurocognitive disorder (PND) is a significant neurological complication in aging perioperative patients that impacts post-operative cognition. PND is currently diagnosed through cognitive function testing, which is limited by its subjectivity and time requirements. Thus, the identification of biomarkers to assess PND onset is a priority to identify at-risk individuals and enable interventions and treatments to patient outcomes.

Heart rate variability, a potential assessment tool for identifying anxiety, depression, and sleep disorders in elderly individuals.

Introduction: This study investigates how anxiety, depression, and sleep disorders impact heart rate variability (HRV) in the elderly, exploring the clinical implications of HRV changes.

Methods: We examined 355 patients (163 men, 192 women) at Xijing Hospital from July 2021 to December 2022 during health check-ups. Demographics were recorded, and emotional status was assessed using the Hamilton Anxiety Scale (HAMA) and the Hamilton Depression Scale (HAMD).

Tac1-expressing neurons in the central amygdala predominantly mediate histamine-induced itch by receiving inputs from parabrachial Tac1-expressing neurons.

Itch is a distinct and bothersome sensation closely associated with a strong urge to scratch. Both the parabrachial nucleus (PBN) and the central amygdala (CeA) are responsive to itch stimuli and contain neurons that express tachykinin 1 (Tac1), which are known for their significant involvement in itch-induced scratching at both spinal and supraspinal levels. Significantly, the PBN neurons project their axons to form close connections with the CeA neurons.

Dietary self-management behavior and associated factors among breast cancer patients receiving chemotherapy: A latent profile analysis.

Purpose: Breast cancer patients experience more gastrointestinal symptoms during chemotherapy than during the survival period post-treatment. This can interfere with daily dietary intake and increase the risk of malnutrition. This study aimed to evaluate the level and classification of dietary self-management behavior and the influence of self-care self-efficacy, outcome expectations, treatment self-regulation and perceived social support guided by "Integrated theory of Health Behavior Change".

Value of [Ga]Ga-PSMA-11 PET/CT in Reflecting the Intra- and Intertumor Heterogeneity of Neovascularization in Clear Cell Renal Cell Carcinoma.

Prostate-specific membrane antigen (PSMA) is a potential target for the diagnosis and treatment of angiogenesis in clear cell renal cell carcinoma (ccRCC). We aimed to investigate the degree of PSMA signal variability in ccRCC and assess its correlation with neovascularization in the tumor microenvironment. We included 120 patients with suspected renal tumors who underwent [Ga]Ga-PSMA-11 positron emission tomography/computed tomography (PET/CT) scan before surgery in this retrospective study, including 98 ccRCC, 17 non-ccRCC, and 5 benign diseases.