2 results match your criteria: "Fourth Hospital and Clinical College of Harbin Medical University[Affiliation]"
Tumor necrosis factor α-induced protein 3 mediates inflammation and neuronal autophagy in Parkinson's disease via the NFκB and mTOR pathways.
Neurosci Lett
May 2023
Department of Neurology, Fourth Hospital and Clinical College of Harbin Medical University, Harbin 150001, Heilongjiang, PR China. Electronic address:
This study aimed to probe the function of tumor necrosis factor α-induced protein 3 (TNFAIP3) in the pathogenesis of Parkinson disease (PD) with its association with autophagy and inflammatory response. TNFAIP3 was reduced in the SN of PD patients (the GSE54282 dataset) and mice and in the MPP-treated SK-N-SH cells. TNFAIP3 inhibited inflammatory response and enhanced autophagy, thereby alleviating PD in mice.
View Article and Find Full Text PDFPre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats.
Life Sci
January 2016
Department of Neurology, First Hospital and Clinical College of Harbin Medical University, Harbin, Heilongjiang Province 150001, China.
Aims: In this study, we investigated the effects of Bax-inhibiting peptide (Bip)-V5, an anti-apoptosis membrane-permeable peptide, on the 6-hydroxydopamine (6-OHDA) induced Parkinson's disease (PD) model rats.
Materials And Methods: Rats were randomly divided into five groups: Control, 6-OHDA only, Vehicle+6-OHDA, zVAD+6-OHDA, and V5+6-OHDA, that rats were preadministrated with different reagents before 6-OHDA administration.
Key Findings: The result showed that intrastriatal preadministration of Bip-V5 significantly decreased the amphetamine-induced rotation of the 6-OHDA model rats and the loss of the nigral dopaminergic (DA) neurons.