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10 results match your criteria: "Foundation of Learning Health Society Institute[Affiliation]"
Background: Prolonged symptoms have been reported following both COVID-19 infection and vaccination, with some cases leading to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Of 80 patients presenting to our hospital with postvaccination syndrome, 28 met the diagnostic criteria for ME/CFS. We conducted a retrospective study on these 28 patients.
View Article and Find Full Text PDFJAMA Netw Open
December 2023
Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
Importance: Recent evidence indicates the efficacy of β-amyloid immunotherapy for the treatment of Alzheimer disease, highlighting the need to promote β-amyloid removal from the brain. Cilostazol, a selective type 3 phosphodiesterase inhibitor, promotes such clearance by facilitating intramural periarterial drainage.
Objective: To determine the safety and efficacy of cilostazol in mild cognitive impairment.
Curr Alzheimer Res
November 2023
Institute of Neurology, Huashan Hospital Fudan University, Shanghai, China.
Autoimmunity
December 2023
Cardiology, Truth for Health Foundation, Tucson, AZ, USA.
Neurotherapeutics
September 2023
Department of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-Dori, Chuoku, Niigata, 951-8585, Japan.
Stroke is the leading cause of severe long-term disability. Cell therapy has recently emerged as an approach to facilitate functional recovery in stroke. Although administration of peripheral blood mononuclear cells preconditioned by oxygen-glucose deprivation (OGD-PBMCs) has been shown to be a therapeutic strategy for ischemic stroke, the recovery mechanisms remain largely unknown.
View Article and Find Full Text PDFDement Geriatr Cogn Disord
July 2023
Clinical Trial Center (CTC), China Medical University Hospital, Taichung, Taiwan.
Introduction: Vascular factors have been shown to be associated with increased risk of dementia. However, clinical trials have so far been unsuccessful, suggesting new approaches are needed. The aim of this study was to use population-based real-world data to investigate risk factors and preventive factors for dementia, including the effects of traditional Chinese medicine (TCM).
View Article and Find Full Text PDFAsia Pac J Sports Med Arthrosc Rehabil Technol
April 2022
Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Background/objective: The purpose of this study was to report the outcomes of a clinical trial conducted in Japan to assess the safety and effectiveness of third-generation autologous chondrocyte implantation (ACI) using IK-01 (CaReS™), which does not require flap coverage, in the treatment of patients with focal cartilage injury of the knee.
Methods: This was an open label, exploratory clinical trial. Patients were enrolled between June 2012 and September 2016.
Front Med (Lausanne)
March 2022
Department of Regenerative Medicine Research, Foundation for Biomedical Research and Innovation at Kobe, Hyogo, Japan.
This study was conducted to evaluate the safety and efficacy of human peripheral blood CD34 positive (CD34) cells transplanted into a murine chronic stroke model to obtain pre-clinical proof of concept, prior to clinical testing. Granulocyte colony stimulating factor (G-CSF) mobilized human CD34 cells [1 × 10 cells in 50 μl phosphate-buffered saline (PBS)] were intravenously (iv) or intra-carotid arterially (ia) transplanted 4 weeks after the induction of stroke (chronic stage), and neurological function was evaluated. In this study, severe combined immune deficiency (SCID) mice were used to prevent excessive immune response after cell therapy.
View Article and Find Full Text PDFPLoS One
February 2022
Department of Biostatistics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
This study aimed to clarify the etiologic factors predicting acute ocular progression in SJS/TEN, and identify patients who require immediate and intensive ophthalmological treatment. We previously conducted two Japanese Surveys of SJS/TEN (i.e.
View Article and Find Full Text PDFObjective: Titanium bridges are used to separate the thyroid ala during type 2 thyroplasty for adductor spasmodic dysphonia. Revision surgeries have adventitiously indicated that bridge wing failure occurs in the area of the medial hole in some cases. This study investigated the rate and cause of device malfunctions and developed an improved device.
View Article and Find Full Text PDF