60 results match your criteria: "Foster Hospital for Small Animals[Affiliation]"

A Clinical Study on Urinary Clusterin and Cystatin B in Dogs with Spontaneous Acute Kidney Injury.

Vet Sci

May 2024

Department of Clinical Sciences, Cummings School of Veterinary Medicine, Foster Hospital for Small Animals, Tufts University, North Grafton, MA 01536, USA.

Novel biomarkers are needed in diagnosing reliably acute kidney injury (AKI) in dogs and in predicting morbidity and mortality after AKI. Our hypothesis was that two novel tubular biomarkers, urinary clusterin (uClust) and cystatin B (uCysB), are elevated in dogs with AKI of different etiologies. In a prospective, longitudinal observational study, we collected serum and urine samples from 18 dogs with AKI of different severity and of various etiology and from 10 healthy control dogs.

View Article and Find Full Text PDF

Background: Hypercoagulability has been documented in cats with cardiac disease. However, hemostatic parameters, including viscoelastic coagulation monitoring (VCM) have not been reported in cats with arterial thromboembolism (ATE).

Hypothesis/objectives: Compare VCM parameters in cats with acute cardiogenic ATE and in control cats.

View Article and Find Full Text PDF

Retrospective evaluation of 22 dogs with leptospirosis treated with extracorporeal renal replacement therapies (2018-2021).

J Vet Intern Med

March 2024

Department of Clinical Sciences, Tufts University, Cummings School of Veterinary Medicine, Foster Hospital for Small Animals, North Grafton, Massachusetts, USA.

Background: Outcomes of dogs with acute kidney injury secondary to leptospirosis (AKI-L) treated using renal replacement therapies (RRT) are poorly characterized.

Hypothesis/objectives: Describe survival to discharge, short (≤30 days) and long-term (≥6 months) outcomes of AKI-L dogs receiving RRT and determine if there is a significant difference in maximum blood urea nitrogen (maxBUN), maximum creatinine (maxCr), maximum bilirubin (maxBili) and the number of body systems affected between survivors and non-survivors.

Animals: Twenty-two client-owned dogs with AKI-L receiving RRT.

View Article and Find Full Text PDF

Objective: To determine the normal reference interval (RI) for thiamine concentrations in healthy dogs and investigate the prevalence of thiamine deficiency in critically ill dogs with and without sepsis.

Design: Prospective, observational, multicenter study, conducted between 2019 and 2021.

Setting: Two veterinary university teaching hospitals.

View Article and Find Full Text PDF

Background: Traditional management of non-steroidal anti-inflammatory drug (NSAID) intoxication includes gastrointestinal decontamination, intravenous administration of fluids (IVF), and gastroprotection. Intravenous administration of lipid emulsion (ILE) and therapeutic plasma exchange (TPE) are popular novel therapeutic strategies.

Hypothesis: Compare outcomes of dogs treated with IVF, ILE, and TPE for NSAID intoxications and evaluate outcome predictors for drug subgroups.

View Article and Find Full Text PDF

Objectives: To determine if the tidal volume (V) delivered (V) to canine patients being mechanically ventilated by a volume-controlled ventilator differed from the volume set on the ventilator (V) at three fresh gas flow (FGF) rates. To determine if V could be accurately predicted by an FGF-based mathematical model.

Study Design: Prospective proof-of-concept study.

View Article and Find Full Text PDF

Outcomes of nonsteroidal anti-inflammatory drug toxicosis treated with therapeutic plasma exchange in 62 dogs.

J Vet Intern Med

September 2022

Department of Clinical Sciences, Tufts University, Cummings School of Veterinary Medicine, Foster Hospital for Small Animals, N. Grafton, Massachusetts, USA.

Background: Therapeutic plasma exchange (TPE) is gaining popularity for the management of nonsteroidal anti-inflammatory drug (NSAID) overdose in dogs.

Hypothesis/objectives: Describe a population of dogs treated with TPE for NSAID overdose.

Animals: Sixty-two dogs with NSAID overdose treated with TPE.

View Article and Find Full Text PDF

The purpose of this multi-institutional retrospective study was to expand the available data pertaining to pre-operative clinical findings, progression-free and overall survival times, and potential prognostic factors for cats undergoing surgery for intestinal adenocarcinomas. Fifty-eight cats treated over a 12-year period were included in the study. Progression-free and overall survival times were estimated using Kaplan-Meier analyses.

View Article and Find Full Text PDF

Case Summary: A 7-year-old male neutered domestic shorthair cat was presented with a 3-month history of dyspnea when exercising and increased respiratory noise when purring. Initial radiographs identified a suspected laryngeal mass. Point-of-care ultrasound found a fluid-filled structure on the larynx, which was drained percutaneously.

View Article and Find Full Text PDF

The use of caffeine as a respiratory stimulant in a cat.

J Vet Emerg Crit Care (San Antonio)

July 2022

Foster Hospital for Small Animals, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA.

Objective: To report the use of caffeine as a respiratory stimulant in a cat with hypoventilation.

Case Summary: A cat was mechanically ventilated due to persistent hypercapnia (P co  > 75 mm Hg) following median sternotomy and thymectomy. After 3 days of mechanical ventilatory support, the cat would initiate breaths but failed weaning due to persistent hypercapnia.

View Article and Find Full Text PDF

Evaluation of bexagliflozin in cats with poorly regulated diabetes mellitus.

Can J Vet Res

January 2022

Cummings School of Veterinary Medicine (Benedict), Foster Hospital for Small Animals (Mahony), Tufts University, 200 Westboro Road, North Grafton, Massachusetts 01536, USA; VCA Clinical Studies, 12401 West Olympic Blvd, Los Angeles, California 90064, USA (McKee, Bergman).

Article Synopsis
  • - The study aimed to examine how the drug bexagliflozin affects blood sugar control in poorly managed diabetic cats over a 4-week period while monitoring for any negative side effects.
  • - Five cats on insulin therapy participated, showing a notable decrease in their insulin needs, with two cats completely stopping insulin treatment.
  • - Blood glucose levels improved significantly during the study, and while serum fructosamine levels dropped in four cats, this wasn't a statistically significant change; overall, the drug had mild side effects and positively impacted diabetic management.
View Article and Find Full Text PDF

Background: Awareness of exocrine pancreatic insufficiency (EPI) in cats has increased since the development of an assay for feline trypsin-like immunoreactivity (fTLI). Ultrasound findings in cats with EPI have only been reported rarely and described as nonspecific.

Hypothesis/objectives: To describe the ultrasonographic findings, clinical signs, and concurrent diseases in cats with EPI.

View Article and Find Full Text PDF

Cutaneous Vasculopathy and Pulmonary Thromboembolism in an Unstable Diabetic Cat.

Top Companion Anim Med

March 2021

The University of Edinburgh, Royal (Dick) School of Veterinary Studies, Hospital for Small Animals, Easter Bush Campus, Midlothian, EH25 9RG, UK.

A 6-year-old, male-neutered, domestic short-haired cat was referred for further management of a 3-month history of uncontrolled diabetes mellitus. The cat visited the hospital on 3 occasions during a 3-week time period. Hyperglycemia was documented at all visits.

View Article and Find Full Text PDF

Background: Oclacitinib is an orally bioavailable Janus Kinase (JAK) inhibitor approved for the treatment of canine atopic dermatitis. Aberrant JAK/ Signal Transducer and Activator of Transcription (STAT) signaling within hematologic and solid tumors has been implicated as a driver of tumor growth through effects on the local microenvironment, enhancing angiogenesis, immune suppression, among others. A combination of JAK/STAT inhibition with cytotoxic chemotherapy may therefore result in synergistic anti-cancer activity, however there is concern for enhanced toxicities.

View Article and Find Full Text PDF

Background: Chemotherapeutic options for the treatment of canine lymphoma have not changed in several decades necessitating the identification of new therapeutics to improve patient outcome. KPT-335 (verdinexor) is a novel orally bioavailable selective inhibitor of nuclear export (SINE) that exhibited anti-tumor activity against non-Hodgkin lymphoma in a prior phase I study. The objective of this phase II study was to expand upon the initial findings and assess the activity and safety in a larger population of dogs with lymphoma.

View Article and Find Full Text PDF

2016 AAHA Oncology Guidelines for Dogs and Cats.

J Am Anim Hosp Assoc

September 2018

From Flint Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO (B.B.); the Department of Clinical Sciences, Foster Hospital for Small Animals, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA (J.B.); College of Veterinary Medicine at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL (L.G.); Veterinary Specialty Hospital of the Carolinas, NC (D.R.); VCA Ragland & Riley Animal Hospital, Livingston, TN (R.W.); Arapahoe Animal Hospital, Boulder, CO (B.A.); College of Veterinary Medicine, North Carolina State University, Raleigh-Durham, NC (M.P.); Red Bank Veterinary Hospital, NJ (D.S.); and Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, MS, and Primary Care Veterinary Educators (C.B.).

All companion animal practices will be presented with oncology cases on a regular basis, making diagnosis and treatment of cancer an essential part of comprehensive primary care. Because each oncology case is medically unique, these guidelines recommend a patient-specific approach consisting of the following components: diagnosis, staging, therapeutic intervention, provisions for patient and personnel safety in handling chemotherapy agents, referral to an oncology specialty practice when appropriate, and a strong emphasis on client support. Determination of tumor type by histologic examination of a biopsy sample should be the basis for all subsequent steps in oncology case management.

View Article and Find Full Text PDF

Successful treatment of Solanum dulcamara intoxication in a Labrador retriever puppy.

Can Vet J

December 2015

New England Animal Medical Center, 595 West Center Street, West Bridgewater, Massachusetts, 02379, USA (Kees, Beckel); Tufts University Cummings School of Veterinary Medicine, Foster Hospital for Small Animals, 55 Willard Street, North Grafton, Massachusetts 01536, USA (Sharp).

A 10-week-old intact male Labrador retriever dog was presented for acute onset of weakness, ataxia, and generalized muscle tremors. The puppy was suffering respiratory and central nervous system (CNS) depression, was mildly pyrexic, and vomited plant material that was identified as creeping nightshade (Solanum dulcamara). He responded well to supportive care and was discharged successfully.

View Article and Find Full Text PDF

What is your diagnosis? Heart base tumors.

J Am Vet Med Assoc

May 2014

Department of Clinical Sciences, Foster Hospital for Small Animals, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.

View Article and Find Full Text PDF

Ultrasonographic evaluation of the thickness of the wall layers in the intestinal tract of dogs.

Am J Vet Res

April 2014

Foster Hospital for Small Animals, Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.

Objective: To ultrasonographically measure the thickness of the individual wall layers of the duodenum, jejunum, and colon of dogs.

Animals: 85 dogs with no clinical signs or ultrasonographic evidence of gastrointestinal tract disease.

Procedures: Total wall thickness and thickness of the mucosa, submucosa, muscularis, and serosa were measured ultrasonographically in the duodenum, jejunum, and colon of each dog.

View Article and Find Full Text PDF

What is your diagnosis? Foreign body.

J Am Vet Med Assoc

June 2013

Department of Clinical Sciences, Foster Hospital for Small Animals, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.

View Article and Find Full Text PDF

Ultrasonographic measurement of the pancreas and pancreatic duct in clinically normal dogs.

Am J Vet Res

March 2013

Foster Hospital for Small Animals, Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.

Objective: To obtain ultrasonographic reference values for the thickness of the pancreas and the diameter of the pancreatic duct in clinically normal dogs.

Animals: 242 adult dogs with no clinical signs of gastrointestinal tract disease.

Procedures: The maximum pancreatic thickness and the diameter of the pancreatic duct were recorded ultrasonographically at the level of the left lobe, body, and right lobe of the pancreas.

View Article and Find Full Text PDF

Mechanical analysis of twelve toggle suture constructs for stabilization of coxofemoral luxations.

Vet Surg

November 2012

Orthopedic Research Laboratory, Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, Foster Hospital for Small Animals, North Grafton, MA 01536, USA.

Objective: To compare the mechanical performance of 12 commonly used toggle suture constructs (TSCs).

Study Design: In vitro biomechanical study.

Sample Population: Toggle suture constructs (n = 136).

View Article and Find Full Text PDF

What is your diagnosis? Polyostotic medullary infarcts with an aggressive lesion of the distal aspect of the left radius.

J Am Vet Med Assoc

July 2012

Department of Clinical Sciences, Foster Hospital for Small Animals, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.

View Article and Find Full Text PDF

Background: Administration of epinephrine during CPR is recommended for treatment of cardiopulmonary arrest (CPA) in dogs. Administration of epinephrine during CPR might be associated with deleterious adverse effects. Vasopressin has been studied for use in CPR as an alternative.

View Article and Find Full Text PDF

Extralabel use of cabergoline in the treatment of a pituitary adenoma in a rat.

J Am Vet Med Assoc

September 2011

Department of Clinical Sciences, Foster Hospital for Small Animals, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.

Case Description: A 0.65-kg (1.43-lb) 24-month-old sexually intact male albino pet rat was examined because of a 3-week history of hypodipsia, apparent blindness, and sudden change in behavior.

View Article and Find Full Text PDF