Feasibility of occlusal plane in predicting the changes in anteroposterior mandibular position: a comprehensive analysis using deep learning-based three-dimensional models.

Background: A comprehensive analysis of the occlusal plane (OP) inclination in predicting anteroposterior mandibular position (APMP) changes is still lacking. This study aimed to analyse the relationships between inclinations of different OPs and APMP metrics and explore the feasibility of OP inclination in predicting changes in APMP.

Methods: Overall, 115 three-dimensional (3D) models were reconstructed using deep learning-based cone-beam computed tomography (CBCT) segmentation, and their accuracy in supporting cusps was compared with that of intraoral scanning models.

Diagnosis of lymph node metastasis in oral squamous cell carcinoma by an MRI-based deep learning model.

Background: Cervical lymph node metastasis (LNM) is a well-established poor prognosticator of oral squamous cell carcinoma (OSCC), in which occult metastasis is a subtype that makes prediction challenging. Here, we developed and validated a deep learning (DL) model using magnetic resonance imaging (MRI) for the identification of LNM in OSCC patients.

Methods: This retrospective diagnostic study developed a three-stage DL model by 45,664 preoperative MRI images from 723 patients in 10 Chinese hospitals between January 2015 and October 2020.

Baolier Capsule's Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis.

Purpose: The Baolier capsule (BLEC) is a proprietary Mongolian medicine administered for treating hypercholesterolemia and atherosclerosis (AS). However, the therapeutic effects, primary bioactive ingredients, and potential mechanisms underlying hypercholesterolemia and AS remain unclear. This study aimed to investigate the pharmacological effects, principal active ingredients, and mechanisms of BLEC against hypercholesterolemia and AS.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential.

Periodontal ligament fibroblasts (PDLFs) play a crucial role in the etiology of periodontitis and periodontal tissue regeneration. In healthy periodontal tissues, PDLFs maintain the homeostasis of periodontal soft and hard tissues as well as the local immune microenvironment. PDLFs also have the potential for multidirectional transdifferentiation and are involved in periodontal tissue regeneration.

Effects of Visualized Health Education Based on Health Belief Model on Self-Management of Patients Undergoing Maintenance Hemodialysis.

Background: Patients with end-stage renal disease often require maintenance hemodialysis (MHD). Effective self-management is crucial for the prognosis of patients undergoing MHD; however, their self-management practices remain suboptimal.

Objective: This study aimed to explore the effects of visualized health education based on health belief model on self-management, self-efficacy, quality of life, and quality of dialysis in patients undergoing MHD.

Berberine promotes primordial follicle activation and increases ovulated oocyte quantity in aged mice.

Background: Primordial follicle activation is vital for the reproduction of women with advanced age and premature ovarian insufficiency (POI). But there is a lack of effective and safe therapeutic options to activate their primordial follicles in vivo. Berberine (BBR) possesses multiple pharmacological properties, but its impact on primordial follicle activation remains unclear.

[Evidence mapping analysis of clinical studies in treatment of chronic kidney disease with traditional Chinese medicine in recent ten years].

Traditional Chinese medicine(TCM) has significant advantages in treatment of chronic kidney disease, but its clinical research evidence needs to be further summarized and improved. By means of evidence mapping, this paper systematically categorized the clinical research on TCM in treating chronic kidney disease in recent ten years, so as to understand the existing evidence level in this field and offer a reference for addressing current issues. The relevant literature published between January 1, 2013 and December 31, 2023 was systematically searched in both Chinese and English databases.

Small molecule inhibitors targeting PD-L1, CTLA4, VISTA, TIM-3, and LAG3 for cancer immunotherapy (2020-2024).

Cancer immunotherapy, leveraging antibodies, excels in targeting efficacy but faces hurdles in tissue penetration, oral delivery, and prolonged half-life, with costly production and risk of adverse immunogenic effects. In contrast, small molecule immuno-oncology agents provide favorable pharmacokinetic properties and benign toxicity profiles. These agents are well-positioned to address the limitations of antibody-based immunotherapies, augment existing treatment modalities, and achieve synergistic effects when combined with antibodies.

Mechanochemical activation of 2D MnPS for sub-attomolar sensing.

Molecular detection is important in biosensing, food safety, and environmental surveillance. The high biocompatibility, superior mechanical stability, and low cost make plasmon-free surface-enhanced Raman scattering (SERS) a promising sensing technique, the ultrahigh sensitivity of which is urgently pursued for realistic applications. As a proof of concept, we report a mechanochemical strategy, which combines the wrinkling and chemical functionalization, to fabricate a plasmon-free SERS platform based on 2D MnPS with a sub-attomolar detection limit.

Neutrophil-activating protein in spores inhibits casein allergy via TLR2 signaling.

Background: Milk allergy commonly occurs in children, mainly caused by bovine-derived casein (CAS) protein. Neutrophil-activating protein (NAP) of plays an immunomodulatory role with potential to suppress Th2-type immune responses. () spores are commonly used as oral vectors for drug delivery.

BMSC Derived Exosomes Attenuate Apoptosis of Temporomandibular Joint Disc Chondrocytes in TMJOA via PI3K/AKT Pathway.

Bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) are crucial means of intercellular communication and can regulate a range of biological processes by reducing inflammation, decreasing apoptosis and promoting tissue repair. We treated temporomandibular joint (TMJ) disc chondrocytes with TNF-α and performed local injection of sodium iodoacetate (MIA) in the TMJ of rats to establish in vitro and in vivo models of TMJ osteoarthritis (TMJOA). BMSC-Exos were isolated and extracted to evaluate their proliferation and trilineage differentiation abilities, and their antiapoptotic and chondroprotective effects were assessed.

Multivalent acetylated-sialic acid as recognition elements for the electrochemical sensing of viral antigens.

Electrochemical biosensors hold great promise for the rapid screening of viral infectious diseases. However, the recognition elements of these biosensors are typically limited to antibodies, aptamers, and molecularly imprinted polymers. In this study, acetylated sialic acids were explored as recognition elements because they serve as natural viral receptors expressed on host cells.

Multifaceted role of nanocomposite hydrogels in diabetic wound healing: enhanced biomedical applications and detailed molecular mechanisms.

The complex microenvironment of diabetic wounds, which is characterized by persistent hyperglycemia, excessive inflammatory responses, and hypoxic conditions, significantly impedes the efficacy of traditional hydrogels. Nanocomposite hydrogels, which combine the high-water content and biocompatibility of hydrogels with the unique functionalities of nanomaterials, offer a promising solution. These hydrogels exhibit enhanced antibacterial, antioxidant, and drug-release properties.

Dental stem cell dynamics in periodontal ligament regeneration: from mechanism to application.

Periodontitis, a globally prevalent chronic inflammatory disease is characterized by the progressive degradation of tooth-supporting structures, particularly the periodontal ligament (PDL), which can eventually result in tooth loss. Despite the various clinical interventions available, most focus on symptomatic relief and lack substantial evidence of supporting the functional regeneration of the PDL. Dental stem cells (DSCs), with their homology and mesenchymal stem cell (MSC) properties, have gained significant attention as a potential avenue for PDL regeneration.

Caerin 1.1 and 1.9 peptides halt B16 melanoma metastatic tumours via expanding cDC1 and reprogramming tumour macrophages.

Background: Cancer immunotherapy, particularly immune checkpoint inhibitors (ICBs) such as anti-PD-1 antibodies, has revolutionised cancer treatment, although response rates vary among patients. Previous studies have demonstrated that caerin 1.1 and 1.

Latent class analysis-derived classification improves the cancer-specific death stratification of lymphomas: A large retrospective cohort study.

Lymphomas have diverse etiologies, treatment approaches, and prognoses. Accurate survival estimation is challenging for lymphoma patients due to their heightened susceptibility to non-lymphoma-related mortality. To overcome this challenge, we propose a novel lymphoma classification system that utilizes latent class analysis (LCA) and incorporates demographic and clinicopathological factors as indicators.

Zirconia crowns manufactured using digital light processing: Effects of build angle and layer thickness on the accuracy.

Objectives: This study investigated the effects of build angle and layer thickness on the trueness and precision of zirconia crowns manufactured using digital light processing (DLP) technology.

Materials And Methods: Single crowns were fabricated from zirconia using DLP technology. The crowns were manufactured with three different representative build angles (0°, 45°, and 90°) and two different layer thicknesses (30 μm and 50 μm).