32 results match your criteria: "Formulation Research Institute[Affiliation]"
J Control Release
November 1999
Formulation Research Institute, Otsuka Pharmaceutical Co., Ltd., 224-18 Ebisuno, Hiraishi, Kawauchi-cho, Tokushima, Japan.
The International Conference on Harmonization (ICH) provides a forum for constructive dialogues between regulatory authorities and the pharmaceutical industry on the real and perceived differences in the technical requirements for product registration in the EU, US and Japan. Achievement obtained so far is beyond expectation, having strong impacts both favorable and unfavorable on Japanese regulatory authorities and the pharmaceutical industry. The ICH guidelines are very science-oriented and little consideration seems to have been paid to the cultural and legal differences among the three regions.
View Article and Find Full Text PDFJ Colloid Interface Sci
April 1999
Formulation Research Institute, Otsuka Pharmaceutical Factory, Inc., Kuguhara 115, Tateiwa, Muya-cho, Naruto, Tokushima, Japan
To clarify the insolubilization mechanism of water-soluble dextran, the association of dextran in water was studied by dynamic light scattering measurements and a surface chemical approach. Dynamic light scattering measurements indicated that insolubilization of dextran is accompanied by a structural change in dextran. Surface tension data for dextran molecules revealed a structural change in dextran molecules at the air-liquid interface.
View Article and Find Full Text PDFBiomaterials
February 1999
Formulation Research Institute, Otsuka Pharmaceutical Factory Inc., Naruto, Tokushima, Japan.
In order to clarify the insolubilization mechanism of water-soluble dextran, comparison of water-soluble dextran and insoluble particles was carried out by detailed structural and surface chemical studies. The precipitate that form in bottled dextran solutions are composed of dextran itself, resulting from the interaction of dextran molecules (e.g.
View Article and Find Full Text PDFJ Chromatogr B Biomed Appl
November 1995
Formulation Research Institute,. Otsuka Pharmaceutical Co. Ltd., Tokushima, Japan.
A specific and sensitive gas chromatographic-high-resolution mass spectrometric method for the determination of 5-(3-tert.-butylamino-2-hydroxy)propoxy-3,4-dihydrocarbostyril (carteolol), which is a beta-blocker giving depression of intraocular pressure, was developed to elucidate the pharmacokinetics of its ophthalmic application. Carteolol has been determined by high-performance liquid chromatography but with less satisfactory sensitivity.
View Article and Find Full Text PDFHybridoma
August 1992
Formulation Research Institute, Otsuka Pharmaceutical, Tokushima, Japan.
Eight mouse monoclonal antibodies, GOM-1, GOM-2, GOM-3, GOM-5, GOM-6, GOM-7, GOM-8 and GOM-9 were established that recognized carbohydrate antigens on the human gastric cancer cell line KATO-III. Their binding specificities were studied by enzyme-linked immunosorbent assay, cellular enzyme-linked immunosorbent assay, flow cytometry analysis and thin layer chromatography immunostaining. All these monoclonal antibodies bound to peanut agglutinin receptor glycoproteins and neutral glycolipids extracted from KATO-III cells, but they could be divided into three groups, namely GOM-1, -3, -9 group, GOM-5 and GOM-2, -6, -7, -8 group.
View Article and Find Full Text PDFGlycoconj J
April 1992
Formulation Research Institute, Otsuka Pharmaceutical Company, Tokushima, Japan.
The antigen structure of a mouse monoclonal antibody, GOM-2, established by immunization with KATO-III human gastric cancer cells, was examined. GOM-2 reactive glycolipids were prepared from KATO-III cells and treated with endoglycoceramidase. Structural studies of ten GOM-2 reactive oligosaccharides by a combination of glycosidase digestions, methylation, and affinity chromatography on an Ulex europeus agglutinin I (UEA-I) column revealed that nine of them had a Y-related B-active difucosylated determinant (B-Le(y)) and one had a B-active determinant.
View Article and Find Full Text PDFJ Chromatogr
August 1990
Analytical Development, Formulation Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.
To find a series of compounds for use as internal standards in reversed-phase high-performance liquid chromatography, about 70 commercially available phenols were chromatographed under various conditions. The stationary phases used were hydrocarbon chemically bonded silica gels (phenyl, C8 and C18 columns). The mobile phases consisted of 10-60% aqueous-organic solutions (organic solvents, methanol, acetonitrile, tetrahydrofuran and mixtures thereof; aqueous phases, water, buffer solutions of pH 2 and 7, 20 mM sodium sulphate or water containing 5 mM of counter ion).
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