3 results match your criteria: "Forensic Sciences Institute of the French Gendarmerie[Affiliation]"

Unlabelled: Air crashes or explosions with numerous victims may result in thousands of fragmented human remains that present a massive challenge for disaster victim identification teams. Genetic identification may present important financial and technical limits, and the physical re-association of fractured bones by forensic anthropologists may require a time-consuming phase of cleaning and drying. A virtual re-association (VRA) of fragmented human remains using postmortem computed tomography (CT)-scan images could enhance the identification process and reduce the number of genetic analyses required.

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Determination of buprenorphine, naloxone and phase I and phase II metabolites in rat whole blood by LC-MS/MS.

J Pharm Biomed Anal

February 2020

Inserm, U1144, Paris, France; Paris-Descartes University, UMR-S 1144, Paris, France; Paris-Diderot University, UMR-S 1144, Paris, France; Forensic Toxicology Unit, Forensic Sciences Institute of the French Gendarmerie, Pontoise, France.

Article Synopsis
  • Buprenorphine and the combination with naloxone are common global maintenance treatments, but misuse can lead to severe toxic effects and fatalities, prompting research to understand these risks.
  • Researchers developed a sensitive LC-MS/MS method to simultaneously measure buprenorphine, naloxone, and their metabolites in rat blood, utilizing a small sample volume and validating it according to bioanalytical standards.
  • The validated method showed adequate accuracy and precision, successfully quantifying compounds from a rat's blood 24 hours after administering buprenorphine/naloxone.
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Illicit Drugs in Oral Fluid: Evaluation of Two Collection Devices.

J Anal Toxicol

January 2017

Inserm "Variabilité de la Réponse aux Psychotropes", 4 Avenue de l'Observatoire, 75006 U1144, Paris, France

Driving after illicit drug use is a worldwide growing concern requiring rapid and sensitive screening at the roadside. It is noteworthy that the sampling method used to collect oral fluid (OF) may significantly influence drug concentrations in the collected sample and thus alter the accuracy of the measurement. We evaluated two OF collection devices, Quantisal and Certus collectors, for their suitability for collecting samples to allow laboratory confirmation of driving after illicit drug use.

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