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Background: Melorheostosis is a rare chronic bone disease of unknown etiology that often affects a single limb.

Aim: Report a new case of melorheostosis of the ribs improved by pamidronate infusions

Case: A 36-year-old man without any medical history was admitted for a history of one month painful tumefaction on the 7th left rib. The diagnosis of melorheostosis of the rib and the tibia was made.

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