1 results match your criteria: "Food and EnvironmentThe Hebrew University of Jerusalem[Affiliation]"

Fasting Hormones Synergistically Induce Amino Acid Catabolism Genes to Promote Gluconeogenesis.

Cell Mol Gastroenterol Hepatol

March 2022

Institute of Biochemistry, Food Science and Nutrition. Robert H. Smith Faculty of Agriculture, Food and EnvironmentThe Hebrew University of Jerusalem, Rehovot, Israel. Electronic address:

Background & Aims: Gluconeogenesis from amino acids (AAs) maintains glucose homeostasis during fasting. Although glucagon is known to regulate AA catabolism, the contribution of other hormones to it and the scope of transcriptional regulation dictating AA catabolism are unknown. We explored the role of the fasting hormones glucagon and glucocorticoids in transcriptional regulation of AA catabolism genes and AA-dependent gluconeogenesis.

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