160 results match your criteria: "Fogo Selvagem"
Genetic Association and Differential RNA Expression of Histone (De)Acetylation-Related Genes in Pemphigus Foliaceus-A Possible Epigenetic Effect in the Autoimmune Response.
Life (Basel)
December 2023
Laboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paraná (UFPR), Curitiba 81531-980, Brazil.
Article Synopsis
- Pemphigus foliaceus (PF) is an autoimmune skin disease caused by the production of antibodies against desmoglein-1, with a specific endemic form (EPF) prevalent in Brazil.
- A study examined the genetic relationship between histone (de)acetylation-related genes and EPF, identifying certain genetic variants that increase or decrease susceptibility to the disease.
- Additionally, RNA sequencing revealed altered expression levels of specific genes in CD4 T lymphocytes from untreated EPF patients, suggesting these genes may play a role in immune response and disease pathology.
Epidemiological and clinical study of cases of endemic pemphigus foliaceus and pemphigus vulgaris in a reference center in the state of Minas Gerais, Brazil.
An Bras Dermatol
January 2024
Service of Dermatology, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Postgraduate Programa in Science Applied to Adult Health, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Article Synopsis
- Pemphigus is a group of autoimmune skin diseases, with recent trends showing a decrease in endemic pemphigus foliaceus and an increase in pemphigus vulgaris; however, no research has focused on this issue in Minas Gerais, Brazil.
- The study aimed to investigate the epidemiological and clinical profiles of patients diagnosed with pemphigus at a university hospital over a six-month period, involving 122 patients categorized into those with pemphigus foliaceus and those with pemphigus vulgaris.
- Significant differences were found between the two groups in several factors, including age at diagnosis, occupation, living environment, and the number of medications needed for treatment, indicating changes in the disease's landscape over time.
The landscape of the immunoglobulin repertoire in endemic pemphigus foliaceus.
Front Immunol
August 2023
Programa de Pós-Graduação em Genética, Universidade Federal do Paraná, Curitiba, Brazil.
Article Synopsis
- - Pemphigus foliaceus (PF) is an unusual autoimmune skin disease primarily caused by autoreactive B cells, with notable prevalence in Brazil's endemic regions, suggesting environmental factors play a significant role in its development.
- - The study analyzed the B-cell repertoire of PF patients in various states—untreated, under treatment, and in remission—compared to healthy individuals from both endemic and non-endemic areas using advanced sequencing techniques.
- - Results showed significantly lower clonotype diversity in the endemic patients, longer CDR3 sequences, and specific IGHV segment usage linked to active disease, indicating that both environmental influences and disease status affect immune responses.
miRNA implication in the pathogenesis and the outcome of Tunisian endemic pemphigus foliaceus.
Exp Dermatol
July 2023
Autoimmunity, Cancer and Immunogenetics Research Laboratory (LR18SP12), Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.
Article Synopsis
- Pemphigus foliaceus (PF) is an autoimmune skin disease diagnosed via blood and skin tests, with severity linked to anti-Dsg1 antibody levels and unpredictable prognosis.
- A study examined the expression of specific microRNAs (miRNAs) in blood and skin samples from PF patients, finding higher miRNA levels in blood compared to skin samples.
- Key findings indicated that blood miR-21 may serve as a diagnostic marker for untreated patients, while cutaneous miR-155 may predict disease activity, suggesting both could enhance PF diagnosis and monitoring alongside traditional methods.
Patterns of Antinuclear Antibodies in a New Variant of Endemic Pemphigus in El Bagre, Colombia, Colocalizing with Antigens against MIZAP, ARVCF, p0071, and Desmoplakins I and II.
J Appl Lab Med
October 2022
Georgia Dermatopathology Associates, Atlanta, GA, USA.
Article Synopsis
- A new variant of pemphigus foliaceus, named El Bagre-EPF, exhibits a distinctive pattern of antinuclear antibodies (ANAs) that was studied in 57 patients compared to 57 control subjects.
- The research revealed that 24% of El Bagre-EPF patients showed a unique ANA pattern, characterized by specific nuclear staining, which was statistically significantly different from the control group.
- This new ANA pattern was linked with certain proteins (MIZAP, ARVCF, p0071, and desmoplakins I-II) and also showed that 14% of patients exhibited classic homogeneous ANA patterns related to other specific autoantibodies.
From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus.
Front Immunol
June 2022
Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Article Synopsis
- In endemic variants of pemphigus foliaceus (PF) seen in Brazil and Tunisia, patients produce harmful IgG4 autoantibodies targeting desmoglein 1 (Dsg1).
- These patients also have antibodies against salivary proteins from sand flies, which can react with Dsg1 and potentially trigger skin disease in predisposed individuals.
- The minireview examines recent studies on the role of these salivary proteins and discusses mechanisms such as molecular mimicry and epitope spreading in the onset and progression of endemic PF in these regions.
Genetic Associations and Differential mRNA Expression Levels of Host Genes Suggest a Viral Trigger for Endemic Pemphigus Foliaceus.
Viruses
April 2022
Laboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paraná (UFPR), Curitiba 81531-980, Brazil.
Article Synopsis
- The study investigates potential genetic factors linked to endemic pemphigus foliaceus (EPF) and their role in viral defense mechanisms, since no clear environmental trigger has been identified.
- An analysis of 3063 genetic variants across 166 candidate genes revealed 12 variants associated with increased susceptibility to EPF, suggesting these genes are involved in controlling viral infections.
- The findings, particularly with elevated mRNA levels of key genes in EPF patients, support the theory of a viral trigger for EPF, possibly leading to advancements in disease prevention and treatment research.
Unsuspected Associations of Variants within the Genes NOTCH4 and STEAP2-AS1 Uncovered by a GWAS in Endemic Pemphigus Foliaceus.
J Invest Dermatol
November 2021
Programa de Pós-Graduação em Genética, Universidade Federal do Paraná, Curitiba, Brazil. Electronic address:
Intraepithelial autoimmune blistering dermatoses: Clinical features and diagnosis.
J Am Acad Dermatol
June 2021
Department of Dermatology, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Article Synopsis
- * The article covers the background, how common these conditions are, their clinical features, and how they’re diagnosed.
- * It discusses various types of pemphigus, including pemphigus foliaceus and pemphigus vulgaris, among others, plus their unique characteristics and causes.
Identification of a primary antigenic target of epitope spreading in endemic pemphigus foliaceus.
J Autoimmun
January 2021
Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:
Article Synopsis
- Epitope spreading plays a key role in the formation of autoantibodies in autoimmune diseases, but identifying initial target epitopes in humans is challenging.
- Research focused on Brazilian pemphigus foliaceus (Fogo Selvagem) revealed that autoantibodies (Abs) against keratinocyte adhesion molecules are present even before the disease onset, indicating a complex immune response.
- The study found that antibodies targeting an environmental antigen in sand fly saliva (LJM11) share structural similarities with the main autoantigen (desmoglein 1) in this disease, suggesting that responses against LJM11 may trigger the autoimmune process in affected individuals.
RNA-sequencing of the Nyssomyia neivai sialome: a sand fly-vector from a Brazilian endemic area for tegumentary leishmaniasis and pemphigus foliaceus.
Sci Rep
October 2020
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Rockville, Maryland, USA.
Leishmaniasis encompasses a spectrum of diseases caused by a protozoan belonging to the genus Leishmania. The parasite is transmitted by the bite of sand flies, which inoculate the promastigote forms into the host's skin while acquiring a blood meal. Nyssomyia neivai is one of the main vectors of tegumentary leishmaniasis (TL) in Brazil.
View Article and Find Full Text PDFA Lutzomyia longipalpis Salivary Protein Induces Cross-Reactive Antibodies to Pemphigus Autoantigen Desmoglein 1.
J Invest Dermatol
December 2020
Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
Article Synopsis
- Fogo selvagem (FS) is a severe skin disease linked to harmful autoantibodies against desmoglein 1 and is endemic in certain Brazilian regions, where sand fly bites may trigger immune responses.
- Research showed that both healthy individuals and FS patients from endemic areas have higher levels of IgG4 antibodies against L. longipalpis salivary proteins compared to nonendemic controls, indicating a strong immune response.
- Mice studies revealed that antibodies generated from LJM17 (a salivary antigen of sand flies) cross-react with DSG1, suggesting that exposure to these antigens can lead to FS in susceptible individuals due to molecular mimicry.
Complement Receptor 1 (CR1, CD35) Polymorphisms and Soluble CR1: A Proposed Anti-inflammatory Role to Quench the Fire of "Fogo Selvagem" Pemphigus Foliaceus.
Front Immunol
November 2020
Laboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paraná, Curitiba, Brazil.
Article Synopsis
- * The study explored genetic factors related to FS susceptibility by analyzing eleven gene polymorphisms in patients and controls, revealing certain haplotypes linked to decreased risk and one haplotype associated with increased susceptibility.
- * Additionally, levels of soluble complement receptor 1 (sCR1) were measured, showing that lower levels are present during active disease while those in remission had higher levels, suggesting a potential link between s
Membrane attack complex (C5b-9 complex or Mac), is strongly present in lesional skin from patients with endemic pemphigus foliaceus in El Bagre, Colombia.
J Cutan Pathol
December 2019
Georgia Dermatopathology Associates, Atlanta, Georgia.
Article Synopsis
- El Bagre endemic pemphigus foliaceus (El Bagre-EPF) is a newly identified variant of a skin disease in Colombia, and the study focuses on the role of complement/C5b-9 in the affected skin of patients compared to healthy controls.
- The research involved a case-control study with 43 patients and 43 matched controls, using skin biopsies to analyze the presence of complement and antibody levels.
- Results showed that complement/C5b-9 was present in all patients with El Bagre-EPF but absent in controls, and higher autoantibody titers were linked to more severe skin lesions.
Pemphigus foliaceus patients (Fogo Selvagem) treated with kinesiotherapy presented lower levels of proinflammatory cytokines.
J Exerc Rehabil
June 2019
Federal University of Triângulo Mineiro, Uberaba, Brazil.
Article Synopsis
- Fogo Selvagem (FS) is an uncommon autoimmune disease causing skin inflammation and acantholysis, linked to high levels of proinflammatory cytokines that may be influenced by physical activity.
- Kinesiotherapy, which includes self-stretching and resistance training, has been shown to improve the quality of life and pain levels in FS patients.
- A study found that FS patients undergoing kinesiotherapy for 12 weeks had lower levels of specific inflammatory cytokines compared to those who did not participate in the therapy, indicating a beneficial effect on inflammation related to the disease.
Long noncoding RNA single-nucleotide polymorphisms: a new cause of genetic susceptibility to autoimmune blistering disease.
Br J Dermatol
August 2019
Department of Dermatology, University of Illinois at Chicago, 808 S Wood St, RM377, Chicago, IL, 60612, U.S.A.
Region 1p13.2 including the RSBN1, PTPN22, AP4B1 and long non-coding RNA genes does not bear risk factors for endemic pemphigus foliaceus (fogo selvagem).
Int J Immunogenet
June 2019
Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná, Curitiba, Brazil.
Article Synopsis
- Pemphigus foliaceus (PF) is an autoimmune skin disorder linked to autoantibodies against desmoglein-1, and this study aimed to explore its association with genetic variants at the 1p13.2 location in Brazil known as fogo selvagem.
- Four specific single nucleotide polymorphisms (SNPs) were analyzed in a case-control study involving patient and control groups, but no significant genetic associations were found.
- The findings regarding the PTPN22 gene align with prior research on other pemphigus forms, and the study suggests further investigation into the 1p13.2 region for links to immune-mediated diseases.
Long noncoding RNA polymorphisms influence susceptibility to endemic pemphigus foliaceus.
Br J Dermatol
August 2019
Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná, Curitiba, Brazil.
Article Synopsis
- Pemphigus foliaceus (PF) is an autoimmune skin disease primarily found in Brazil, Colombia, and Tunisia, characterized by autoantibodies targeting desmoglein 1.
- The study aimed to determine if single-nucleotide polymorphisms (SNPs) in long noncoding RNA (lncRNA) genes are linked to susceptibility to endemic PF by analyzing data from 229 patients and 6681 controls.
- The research found a significant association with SNP rs7144332 in the lncRNA gene AL110292·1, suggesting that variations in lncRNA genes may play a role in the development of autoimmune diseases like PF.
Fogo selvagem: endemic pemphigus foliaceus.
An Bras Dermatol
October 2018
Dermatology Service, Hospital Maria Aparecida Pedrossian, Universidade Federal de Mato Grosso do Sul, Campo Grande (MS), Brazil.
Article Synopsis
- Fogo selvagem is an autoimmune skin disease primarily affecting young adults in rural Brazil, characterized by the formation of superficial blisters due to the loss of adhesion in the skin's upper layers.
- The disease is linked to a mix of genetic, environmental (like insect bites), and immune factors, and can resemble other skin conditions such as seborrheic dermatitis and lupus.
- Treatment typically involves systemic corticosteroids and other immunosuppressive medications, with many patients achieving stability or remission over time.
Oxidative stress in patients with endemic pemphigus foliaceus and healthy subjects with anti-desmoglein 1 antibodies.
An Bras Dermatol
March 2018
Department of Dermatology, Oregon Health & Science University, Oregon, USA.
Article Synopsis
- The study investigates oxidative stress in patients with endemic pemphigus foliaceus in Peru, aiming to assess whether this condition has similar oxidative stress responses as other types of pemphigus.
- A total of 21 patients with chronic and remissive disease forms were compared to healthy individuals, revealing that those with chronic active disease and healthy carriers of anti-desmoglein 1 antibodies had significantly higher serum malondialdehyde levels, indicating lipid peroxidation.
- The study's small sample size limits the findings, but the increased malondialdehyde levels suggest a potential role of systemic lipid peroxidation in the development of endemic pemphigus foliaceus.
Exploring the in situ expression of vascular endothelial growth factor and endoglin in pemphigus foliaceus variants and pemphigus vulgaris.
J Eur Acad Dermatol Venereol
November 2018
Department of Dermatology, University of São Paulo Medical School, São Paulo, São Paulo, Brazil.
Article Synopsis
- - Overview of erythroderma as a serious form of pemphigus foliaceus (PF), highlighting the role of IgG autoantibodies against desmoglein 1 and the potential involvement of angiogenic factors.
- - Study aimed to assess the levels of vascular endothelial growth factor (VEGF) and endoglin in skin samples from various groups, including patients with erythrodermic PF and controls, using immunohistochemistry techniques.
- - Findings indicated higher VEGF expression in erythrodermic PF compared to non-erythrodermic PF and healthy individuals, suggesting that this could be part of a healing response, while lower endoglin levels hint at unbalanced angiogenesis; further
Autoimmunity and cardiac arrhythmias in endemic pemphigus foliaceus-Association, correlation, or causation?
Heart Rhythm
May 2018
Heart Rhythm Division, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope.
J Autoimmun
May 2018
Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:
Article Synopsis
- Fogo Selvagem (FS) is a type of skin disease caused by harmful IgG4 autoantibodies targeting a specific area of desmoglein 1 (Dsg1), a protein crucial for cell adhesion.
- Researchers found that a majority of FS patients had antibodies that recognized a particular 16-amino-acid peptide on Dsg1 and that changes in certain amino acids reduced antibody binding significantly.
- The study revealed that these antibodies disrupt the interaction between Dsg1 and another protein, desmocollin 1, which damages cell adhesion and contributes to the symptoms of the disease.
Cardiac rhythm and pacemaking abnormalities in patients affected by endemic pemphigus in Colombia may be the result of deposition of autoantibodies, complement, fibrinogen, and other molecules.
Heart Rhythm
May 2018
Department of Cardiology, Hospital General de Medellin, and Clinica CES Medellin, Antioquia, Colombia.
Article Synopsis
- A study of patients with endemic pemphigus foliaceus in El Bagre, Colombia, found that one-third exhibit heart-related autoimmune issues, leading to rhythm disturbances.
- Researchers compared 30 affected patients to 30 control subjects, using various diagnostic methods, including ECG and immunofluorescence, to analyze cardiac function.
- Findings revealed significant ECG abnormalities among patients, such as bradycardia and specific conduction block patterns, associated with the presence of autoantibodies targeting heart tissues, suggesting an autoimmune mechanism behind these heart issues.
Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF.
Clin Exp Dermatol
December 2017
Georgia Dermatopathology Associates, Atlanta, GA, USA.
Article Synopsis
- A new variant of endemic pemphigus foliaceus called El Bagre-EPF was identified in El Bagre, Colombia, with patients showing autoimmunity to arrector pili muscles (APM).
- In a study involving 30 patients and 30 healthy controls, researchers used various testing methods to analyze skin biopsies and discovered that 27 out of 30 patients had autoantibodies to APM.
- The findings suggest a significant immune response against certain cell junction proteins in El Bagre-EPF patients, indicating a complex polyclonal response involving various immune components.