2,429 results match your criteria: "Focal Status Epilepticus"
Ther Adv Infect Dis
December 2024
Department of Pediatrics, All India Institute of Medical Sciences, Bathinda 151001, India.
Tuberculosis can present myriad manifestations, affecting multiple organ systems. Common central nervous system (CNS) manifestations include vomiting, headache, blurred vision, neck stiffness, altered sensorium, seizures, and focal neurological deficits. Epilepsia partialis continua (EPC) is a rare manifestation of CNS tuberculosis.
View Article and Find Full Text PDFBMC Neurol
December 2024
Laboratory for Epilepsy Research, KU Leuven, Belgium.
Background: Neuronal hyperexcitability has been proposed to play a key role in Alzheimer's disease (AD). Understanding the relation between this enhanced excitability and AD pathology could provide a window for therapeutic interventions. However epileptiform activity is often subclinical, hidden on scalp EEG and very challenging to assess with current diagnostic modalities.
View Article and Find Full Text PDFRinsho Shinkeigaku
December 2024
Department of Neurology, Nakamura Memorial Hospital.
The patient was a 69-year-old right-handed woman. She had sensory aphasia, and the brain MRI revealed a subacute phase hemorrhage in the left subcortical temporal lobe. We speculated that the patient had post-ictal aphasia due to symptomatic epileptic seizures associated with cerebral hemorrhage.
View Article and Find Full Text PDFWorld J Biol Psychiatry
December 2024
Division of Human Genetics, Department of Pathology, University of Cape Town, South Africa.
Objective: The aetiology of epilepsy is known to have genetic contributions, yet results from genome-wide association studies (GWAS) have not always been consistent. We undertook a systematic review in order to identify risk variants for epilepsy.
Methods: This systematic review was conducted in accordance with the PRISMA protocol.
Neurol Sci
December 2024
Department of Neurology, General Hospital of Thessaloniki "Papageorgiou", 56403, Thessaloniki, Greece.
Ophthalmic Plast Reconstr Surg
December 2024
Department of Ophthalmology and Visual Science, The University of Texas Health Science Center at Houston, Houston, Texas, U.S.A.
The authors report a rare case of a 58-year-old female with mild right-sided hemifacial spasms and eyelid myokymia and a concomitant high-grade glial mass. This report outlines the clinical presentation, diagnostic approach, and management of right hemifacial spasms and eyelid myokymia. The patient had a 5-month history of gradually worsening right hemifacial spams accompanied by mild right lower eyelid twitching.
View Article and Find Full Text PDFChilds Nerv Syst
December 2024
Department of Pediatric Neurosurgery, The Pediatric Brain Center, affiliated to the Faculty of Medical and Health Sciences, Tel Aviv University, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Purpose: To describe the immediate postoperative PICU course and short-term outcomes of children undergoing various epilepsy surgeries.
Methods: Single-center, retrospective observational study. All patients younger than 20 years of age who had been admitted to the PICU between 2018 and 2022 following epilepsy surgery were eligible for study entry.
Epilepsy Behav
January 2025
Neuropediatric Clinic and Clinic for Neurorehabilitation, Epilepsy Center for Children and Adolescents, Schoen-Klinik Vogtareuth, Vogtareuth, Germany.
Neurol Sci
November 2024
Department of Neurology, General Hospital of Thessaloniki "Papageorgiou", Thessaloniki, 56403, Greece.
Medicina (Kaunas)
November 2024
Neurology Department, Cooper University Hospital, Camden, NJ 08103, USA.
Rasmussen encephalitis (RE) is a rare and progressive form of chronic encephalitis that typically affects one hemisphere of the brain and primarily occurs in pediatric individuals. The current study aims to narratively review the literature about RE, including historical information, pathophysiology, and management of this condition. RE often occurs in individuals with normal development, and it is estimated that only a few new cases are identified each year in epilepsy centers.
View Article and Find Full Text PDFTher Drug Monit
November 2024
Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen; and.
Background: This report presents the case of a patient with drug-resistant epilepsy. Despite treatment with 4 antiepileptic drugs, the patient experienced an increasing frequency of focal seizures, necessitating hospitalization, and continuous intravenous midazolam infusion.
Methods: Cobicistat was introduced as a pharmacokinetic booster to decrease the metabolic clearance of midazolam, leading to increased exposure and an extended half-life.
J Stroke Cerebrovasc Dis
November 2024
Department of Neurology, Providence Mission Medical Center, Mission Viejo, CA, USA; Department of Neurology, Keck School of Medicine at USC, Los Angeles, CA, USA. Electronic address:
Neurol Clin
February 2025
Department of Neurology, University of Lausanne, Lausanne, Switzerland. Electronic address:
In patients with status epilepticus (SE), the underlying biologic background represents the main prognostic variable. A swift application of a treatment protocol is recommended, including adequate doses of a benzodiazepine followed by an intravenous anti-seizure medicine. If refractory SE arises, general anesthetics should be used in generalized convulsive and non-convulsive SE in coma, while further non-sedating anti-seizure medications attempts are warranted in patients with focal forms.
View Article and Find Full Text PDFAnn Clin Transl Neurol
December 2024
Department of Neurology, Massachusetts General Hospital (MGH), Boston, Massachusetts, 02114, USA.
Focal status epilepticus, particularly the motor variant of epilepsia partialis continua (EPC), is a rare condition characterized by near-continuous, chronic focal motor seizures, and associated with poor outcomes. Medications, including anesthetics, are often unsuccessful. Surgical resection can result in motor deficits.
View Article and Find Full Text PDFSeizure
December 2024
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, London, United Kingdom; Department of Clinical Neurophysiology, King's College Hospital, London, United Kingdom; Department of Clinical Neurophysiology, Alder Hey Children's Hospital, London, United Kingdom.
Introduction: Epilepsia Partialis Continua (EPC) is a challenging condition in which repetitive transcranial magnetic stimulation (rTMS) can induce a neuromodulation effect of potential diagnostic and therapeutic value.
Methods: A comprehensive literature search was conducted using Pubmed and Web of Science databases to identify cases of EPC who underwent rTMS, including children and adults. Additionally, we present two patients from our centre who underwent rTMS at a low frequency (0.
Epilepsy Behav
December 2024
Department of Neurology, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Member of the European Reference Network EpiCARE, Paracelsus Medical University of Salzburg, Austria; Neuroscience Institute, Christian Doppler University Hospital, Salzburg, Austria. Electronic address:
Background: Status epilepticus (SE) is a severe neurological condition that might lead to long-term consequences such as neuronal death. This study investigated whether SE leads to brain volume loss by characterizing the dynamic of peri-ictal MRI abnormalities (PMA) through follow-up MRIs and assessing whether SE duration and specific outcome characteristics are associated with brain atrophy.
Methods: A prospective single-center cohort study enrolled 590 adult patients with definitive or possible SE.
Clin Neurophysiol
December 2024
Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA; Epilepsy Center, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA. Electronic address:
Objective: CT hyper-perfusion has been reported in non-convulsive status epilepticus (NCSE), while its occurrence and relevance after single seizures or with rhythmic and periodic patterns (RPPs) that lie along the ictal-interictal continuum (IIC), remain unclear. The goal of the study is to assess the role of CT perfusion (CTP) in diagnosing patients with clinical seizures, subclinical seizures, or RPPs that lie along the IIC, to help in the clinical assessment of these entities.
Methods: We retrospectively reviewed inpatients who underwent a CTP and an EEG within 6 h of each other.
Neurol Sci
October 2024
Neurology Dpt., Neurology & Neurophysiology Center, Vienna, Austria.
Acta Neurochir (Wien)
October 2024
Department of Neurosurgery, Bordeaux University Hospital Center, Bordeaux, Cedex, France.
Objectives: Resective surgery is a potential therapeutic option for select patients with intractable focal epilepsy. However, the presence of ictal onset zones within or surrounding highly functional brain areas presents a surgical challenge, leading to poor seizure and functional outcomes. This report describes our experiences with awake mapping-tailored resection of epileptogenic areas involving eloquent cortices and evaluates their feasibility, tolerance, limitations, and significance.
View Article and Find Full Text PDFBrain Sci
October 2024
Department of Neurochemistry, Instituto Nacional de Neurología y Neurocirugía, Av. Insurgentes Sur 3877, Mexico City 14269, Mexico.
Neurology
November 2024
From the Departments of Neurology (H.Z., J.C., G.N.) and Nuclear Medicine (Y.Z.), The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ann Afr Med
October 2024
Department of Neurology, College of Medicine and Neurology, University of Alberta, Edmonton, Alberta, Canada.
Objectives: To highlight the significance of various clinical and radiological parameters in association with specific electroencephalographic (EEG) patterns in order to prioritize EEG referrals.
Method: This retrospective, cross-sectional study was conducted in the neurology department of King Fahad University Hospital, Alkhobar, and involved a review and analysis of EEG and medical records pertaining to 604 patients referred for routine EEG. The data were analyzed using SPSS version 22.
BMC Neurol
October 2024
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Background: Focal epilepsy is common in children and adults with mitochondrial disease. Seizures are often refractory to pharmacological treatment and, in this patient group, frequently evolve to refractory focal status epilepticus (also known as epilepsia partialis continua). Where this occurs, the long-term prognosis is poor.
View Article and Find Full Text PDFZhonghua Er Ke Za Zhi
November 2024
Children's Medical Center, Peking University First Hospital, Beijing 102699, China.
To summarize the clinical features of epilepsy and (or) developmental delay associated with KCNB1 gene variants in children. A case series study was conducted on 24 children with KCNB1 gene variants associated with epilepsy and (or) developmental delay who were treated at the Children's Medical Center of Peking University First Hospital and the Department of Neurology of Shenzhen Children's Hospital from July 2015 to June 2024. The manifestations of seizures, electroencephalogram (EEG) and genetic test results of those children were analyzed.
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