32 results match your criteria: "Focal EEG Waveform Abnormalities"

Connectivity of high-frequency bursts as SOZ localization biomarker.

Front Netw Physiol

September 2024

Biomedical Engineering Department, University of California, Irvine, Irvine, CA, United States.

Article Synopsis
  • The study focuses on improving the identification of seizure onset zones (SOZ) in patients with refractory epilepsy using a new metric called channel-level connectivity dispersion (CLCD) to analyze brain activity.
  • CLCD measures the variability in synchronization between individual electrodes and aims to identify connections associated with abnormal brain activity linked to SOZ.
  • The method was tested on two datasets of intracranial electroencephalography signals, showing promising results in differentiating SOZ channels from non-SOZ channels based on lower CLCD values.
View Article and Find Full Text PDF
Article Synopsis
  • Epileptiform abnormalities can mimic normal sleep patterns, particularly when they arise from the midline, complicating their identification during sleep.
  • A case study of a 24-year-old man with drug-resistant epilepsy highlights how his seizures started with leg posturing and progressed to more severe symptoms, with distinct interictal patterns visible on EEG while awake and asleep.
  • To differentiate epileptiform transients from normal sleep activity, it’s important to analyze their shape, how they disrupt the EEG background, and their behavior during different states of consciousness.
View Article and Find Full Text PDF

Electroclinical Features of Infantile Epileptic Spasms Syndrome.

Ann Indian Acad Neurol

May 2024

Pediatric Epilepsy Section, Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Article Synopsis
  • Epileptic spasms are a type of seizure found in infants and young children, often linked to a syndrome that can cause developmental delays and declines due to abnormal brain activities seen in EEGs.
  • Early detection and treatment of these spasms are crucial to improving children's outcomes, with hypsarrhythmia patterns playing a key role in diagnosis.
  • Some patients may have treatable causes for their spasms that can be identified with brain imaging, though surgical decisions may not always require invasive EEG monitoring.
View Article and Find Full Text PDF

Development of spontaneous recurrent seizures accompanied with increased rates of interictal spikes and decreased hippocampal delta and theta activities following extended kindling in mice.

Exp Neurol

September 2024

Krembil Research Institute, University Health Network, Canada; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Article Synopsis
  • Interictal epileptiform discharges are abnormal brain signals occurring between seizures that can help in diagnosing epilepsy through EEG tests.
  • In a mouse study of kindling-induced seizures, researchers found an increase in interictal spikes rates prior to the onset of spontaneous recurrent seizures, while other brain patterns remained unchanged.
  • The findings suggest that higher rates of interictal spikes and lower delta and theta rhythms in the hippocampus are linked to the development of spontaneous recurrent seizures in this model.
View Article and Find Full Text PDF

Source Localization of Normal Variants Seen on EEG.

J Clin Neurophysiol

February 2024

Departments of Neurology and Pediatrics, Duke University Hospital, Durham, North Carolina, USA.

Purpose: The EEG is an essential neurological diagnostic tool. EEG abnormalities can guide diagnosis and management of epilepsy. There are also distinctive EEG waveforms that are seen in healthy individuals.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates interoception, or the awareness of internal body signals, in individuals with Anorexia Nervosa (AN) and its relationship to hunger, body image, and emotional awareness.
  • Researchers used high-density electroencephalography (hdEEG) to analyze heartbeat-related brain activity in people with AN compared to healthy controls, focusing on specific timeframes after heartbeats.
  • Findings indicated that individuals with AN show decreased brain activity in key areas responsible for processing interoceptive signals, suggesting that enhancing interoception may aid in recovery for those with AN.
View Article and Find Full Text PDF

Wired for sound: The effect of sound on the epileptic brain.

Seizure

November 2022

Consultant Neurologist & Honorary Clinical Associate Professor of Neurology, Department of Neurology, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK. Electronic address:

Sound waves are all around us resonating at audible and inaudible frequencies. Our ability to hear is crucial in providing information and enabling interaction with our environment. The human brain generates neural oscillations or brainwaves through synchronised electrical impulses.

View Article and Find Full Text PDF

Background Epilepsy is a neurological disorder that presents with recurrent seizures associated with erratic brain activity which can be measured through EEG in addition to other neurological investigations. However, EEG may show abnormal patterns and waveforms while the patient is having a seizure which is crucial for making an accurate diagnosis. Objective This study aims to evaluate the spectrum of EEG findings in newly diagnosed epileptic patients as part of a neurological investigation.

View Article and Find Full Text PDF
Article Synopsis
  • Obsessive-Compulsive Disorder (OCD) is connected to abnormal activity in the frontostriatal circuit, but the specific electrical disruptions haven't been fully explored.
  • The study aimed to examine neuronal synchronization in OCD patients, predicting that abnormal brain wave activity in frontal areas would improve with deep brain stimulation (DBS) of the nucleus accumbens (NAc).
  • Results showed that when DBS was off, OCD patients exhibited significantly increased coupling of brain wave phases and amplitudes compared to healthy controls, and this abnormal activity decreased when DBS was activated, suggesting a potential biomarker for OCD.
View Article and Find Full Text PDF

Adult EEG.

Handb Clin Neurol

December 2019

Department of Neurology, Mayo Clinic College of Medicine and Health Sciences, Jacksonville, FL, United States.

Article Synopsis
  • - **EEG has been a trusted diagnostic tool for over 85 years, thanks to its reliability, low cost, and ability to analyze brain activity, especially with advancements in digital technology expanding its applications.**
  • - **Despite new discoveries, fundamental neurophysiology remains vital in using EEG for diagnosing neurological events, classifying seizures, and assessing conditions even when other imaging methods appear normal.**
  • - **Innovations like high-density EEG and quantitative EEG are enhancing the precision of epilepsy surgeries and deepening our understanding of brain functions.**
View Article and Find Full Text PDF

Periodic focal epileptiform discharges.

Clin Neurophysiol

August 2019

Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA.

Objective: To report intraoperative periodic focal epileptiform discharges (PFEDs) during awake craniotomy using high-density electrocorticography (HD-ECoG).

Methods: We retrospectively analyzed 81 patients undergoing awake craniotomy between 9/29/2016 and 7/5/2018. Intraoperative HD-ECoG was performed with direct electrocortical stimulation (DECS) for functional brain mapping.

View Article and Find Full Text PDF
Article Synopsis
  • * Two experiments were conducted; the first focused on the ending chords of phrases, while the second looked at half cadences, both manipulating syntactic regularity.
  • * Results showed that while control participants reacted to irregularities in the music (indicating they processed syntax), those with amusia did not exhibit similar responses, highlighting their difficulties with both local and long-distance syntactic structures in music.
View Article and Find Full Text PDF

Motivated attention and family risk for depression: Neuronal generator patterns at scalp elicited by lateralized aversive pictures reveal blunted emotional responsivity.

Neuroimage Clin

November 2017

Department of Psychiatry, Columbia University College of Physicians & Surgeons, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA; Mailman School of Public Health, Columbia University, New York, NY, USA.

Article Synopsis
  • A study found that major depression (MDD) is linked to dysfunction in the right parietotemporal region of the brain, which is important for processing arousing emotional stimuli.
  • The research examined how family risk for MDD and previous experiences with depression or anxiety influenced different stages of emotional processing in individuals at high risk for MDD.
  • Results showed that high-risk individuals had altered emotional responses to negative stimuli and reduced brain activity differences between the left and right sides of the brain compared to low-risk individuals, suggesting potential impairments in emotional processing.
View Article and Find Full Text PDF
Article Synopsis
  • Sepsis negatively affects capillary function and oxygen delivery, potentially worsening patient outcomes.
  • Lower levels of immunoglobulin G2 do not contribute to severe flu complications, suggesting other factors may play a role in flu severity.
  • New research indicates that intravenous immunoglobulin may provide brain protection during sepsis by blocking harmful immune responses such as complement activation and apoptosis. *
View Article and Find Full Text PDF

Periodic Discharges: Insight From Magnetoencephalography.

J Clin Neurophysiol

May 2017

*Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, U.S.A.; †Department of Neurology, Nathan Littauer Hospital, Gloversville, New York, U.S.A.; ‡Department of Neurology, Henry Ford Health System, Detroit, Michigan, U.S.A.; §Department of Neurology, Wayne State University, Detroit, Michigan, U.S.A.; ‖Department of Physics, Oakland University, Rochester, Michigan, U.S.A.; and ¶Department of Neurology, Spectrum Health, Grand Rapids, Michigan, U.S.A.

Purpose: This study used magnetoencephalography (MEG) dipole localization and coherence measurement to evaluate the magnetic fields associated with periodic discharges. The primary goal of the study was to evaluate whether MEG could consistently localize quasiperiodic discharges that were observed on the EEG portion of the recording. The secondary objective was to evaluate whether coherence measurements would correlate with topographic maxima of epileptiform activity.

View Article and Find Full Text PDF

The Texting Rhythm: A Novel EEG Waveform Using Smartphones.

J Clin Neurophysiol

August 2016

*Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic in Florida, Jacksonville, Florida, U.S.A.; †University of Florida, Gainesville, Florida, U.S.A.; and ‡Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, U.S.A.

Introduction: We report a unique EEG phenomenon in patients with paroxysmal neurological events undergoing video EEG monitoring.

Methods: Two epilepsy centers analyzed the interictal scalp EEG in patients using personal electronic devices during epilepsy monitoring. The texting rhythm (TR) was defined as a reproducible, stimulus-evoked, generalized frontocentral monomorphic burst of 5-6 Hz theta consistently induced by active text messaging.

View Article and Find Full Text PDF

Assessment of EEG as a Diagnostic and Prognostic Indicator Tool in the Febrile Seizures.

Indian J Physiol Pharmacol

December 2024

Department of Physiology, AIIMS, Rishikesh - 249 201.

Objective: To assess the sensitivity, specificity, and predictive value of EEG as a diagnostic and prognostic tool in the febrile seizures.

Method: This study was conducted on 50 consecutive children with febrile seizures attending the pediatric OPD of a tertiary care hospital. The children were prospectively identified and EEG was carried out on two occasions.

View Article and Find Full Text PDF

Source localization of an event-related potential marker of executive attention following mild traumatic brain injury.

Neuroreport

October 2015

aSchool of Psychology, Australian Catholic University, Sydney bSchool of Health and Human Sciences, Southern Cross University, Coffs Harbour, New South Wales cSchool of Psychology, Australian Catholic University, Melbourne, Victoria, Australia.

Recent research suggests that intact performance on an executive attention task after mild traumatic brain injury (mTBI) reflects functional adaptation within neural networks, rather than recovery of premorbid modes of information processing. However, it is unclear whether this compensation includes the recruitment of alternative neural processing resources. The current study used source localization analysis to determine the location and timing of activated brain areas involved in the generation of an event-related potential (ERP) component marker of executive attention in 10 adults with mTBI and in 10 matched healthy controls.

View Article and Find Full Text PDF

Purpose: This study focused on the characteristic needle-like epileptic spikes of short duration and steep shape seen on magnetoencephalography (MEG) in patients diagnosed with focal cortical dysplasia (FCD) morphologically. We aimed to validate the analysis of MEG spike morphology as a noninvasive method of identifying the presence and location of FCD.

Methods: MEG was collected by 204-channel helmet-shaped gradiometers.

View Article and Find Full Text PDF

Real-life signals such as biomedical signals are non-stationary and random in their pattern, and cannot be characterized by any specific waveform or spectral content. Processing of these natural signals involves consideration of certain significant attributes such as their non-stationary behavior over time, scaling behavior, translation invariance. Due to their random behavior, the existing discriminative methods often fail to provide a reasonable quantification performance, thereby resulting in poor classification rates.

View Article and Find Full Text PDF

The risk of dose-dependent seizures is a safety issue with bupropion hydrochloride. To evaluate the presence of specific electroencephalographic (EEG) waveforms, 210 adult subjects taking stable doses of bupropion hydrochloride were recruited to undergo 2 EEGs in a prospective, single-center cohort study. The occurrence of spike waves, sharp waves, and focal slowing was recorded and assessed with a continuation ratio logit model for polytomous responses.

View Article and Find Full Text PDF

Unlabelled: Collating the findings regarding the role of focal interictal epileptiform discharges (IEDs) on CNS functions raises the possibility that IEDs might have negative impact that outlasts the duration of the spike-and-wave complexes. The aim of this study was the electrophysiological demonstration of the "delayed effect" of the IEDs. 19-channel, linked-ears referenced, digital waking EEG records of 11 children (aged 6-14 years, eight with idiopathic, three with cryptogenic focal epilepsy, showing a single spike focus) were retrospectively selected from our database.

View Article and Find Full Text PDF

A review of electroencephalograms done at the Kenyatta National Hospital, Nairobi.

East Afr Med J

February 2008

Department of Medicine, Aga Khan University Hospital, Nairobi, P. O. Box 19624-00202, Nairobi, Kenya.

Background: Electroencephalogram based studies done elsewhere suggest that epileptiform activity originates predominantly from the left cortical hemisphere. There is evidence that partial epilepsies (focal spike and wave epileptiform discharges on tracings) connotes focal; secondary structural cortical dysfunction. Studies seeking similar findings have not been done locally.

View Article and Find Full Text PDF