Characterization of molecular interactions between HDAC7 and MEF2A.

Interactions of transcriptional corepressors such as histone deacetylase 7 (HDAC7), a class IIa HDAC, with myocyte enhancer factor-2 (MEF2) regulate MEF2 activity. Despite previous investigations exploring interactions between HDAC7 and MEF2, a detailed characterization of the HDAC7-MEF2 functional complex is still lacking. Herein, we first modeled the structure of the HDAC7-MEF2A complex and investigated the inter-protein interactions using all-atom molecular dynamics (MD) simulations.

Landscape and meteorological variables associated with and mosquito infestation in two southeastern U.S.A. coastal cities.

Human cases of arboviral disease transmitted by mosquitoes are increasing worldwide and spreading to new areas of the United States. These diseases continue to re-emerge, likely due to changes in vector ecology, urbanization, human migration, and larger range of climatic suitability. Recent shifts in landscape and weather variables are predicted to impact the habitat patterns of urban mosquitoes such as and .

Predictors of Retention in the 1Florida Alzheimer's Disease Research Center (ADRC) Over Two Waves.

Attrition is a significant methodological concern in longitudinal studies. Sample loss can limit generalizability and compromise internal validity. Wave one ( = 346) and wave two follow-ups ( = 196) of the 1Florida ADRC clinical core were examined using a 24-month visit window.

Leptomeningeal metastatic disease: new frontiers and future directions.

Leptomeningeal metastatic disease (LMD), encompassing entities of 'meningeal carcinomatosis', neoplastic meningitis' and 'leukaemic/lymphomatous meningitis', arises secondary to the metastatic dissemination of cancer cells from extracranial and certain intracranial malignancies into the leptomeninges and cerebrospinal fluid. The clinical burden of LMD has been increasing secondary to more sensitive diagnostics, aggressive local therapies for discrete brain metastases, and improved management of extracranial disease with targeted and immunotherapeutic agents, resulting in improved survival. However, owing to drug delivery challenges and the unique microenvironment of LMD, novel therapies against systemic disease have not yet translated into improved outcomes for these patients.

Culture and Patient-Provider Trust Among People with HIV: Psychometric Properties of the HCR Trust Scale-Revised in Haitian Creole and Spanish.

Patient-provider trust is associated with optimal HIV care engagement and ART adherence. However, cross-cultural examination of trust in providers in this diverse population is limited. The current study examines data from 1272 Miami-Dade County Ryan White Program clients.

Review of Nychia marshalli in the Western Palaearctic, with new records and distributional notes (Hemiptera: Heteroptera: Notonectidae).

The backswimmer Nychia marshalli (Scott, 1872) (Hemiptera: Heteroptera: Notonectidae) is reported for the first time from Italy on the island of Sardinia. A new record of N. marshalli from Corsica (the first from the eastern coast) is provided and the distribution of the species in the Western Palearctic region is summarized.

Reliable peak detection and feature extraction for wireless electrocardiograms.

The electrocardiogram (ECG) is a vital device to examine the electrical activities of the heart. It is useful for diagnosing cardiovascular diseases, which often manifest themselves through alterations in the ECG signals' characteristics. These alterations are primarily observed in the signals' key components: the Q, R, S, T, and P peaks.

The Effect of Intervention Preference Matching on Outcomes and Engagement in a Post-cessation Weight Management Trial.

Purpose: This study examined the effect of intervention treatment preference in a post-smoking cessation weight management trial.

Design & Setting: Participants were randomized to a weight management intervention (Stability, Loss, or Bibliotherapy); all participants received a standard smoking cessation program. Adults aged 18+ were recruited from Memphis, TN, and nationally.

Parenting Challenges Among Families Experiencing Homelessness with Children with and without Externalizing Behavior Problems.

Objective: To examine differences in parenting factors among caregivers with children with and without externalizing behavior problems (EBP) in a community homeless shelter sample versus a stable housing sample.

Method: Nine hundred and fourteen children (ages = 2.01-7.

Nonreciprocal scattering and unidirectional cloaking in nonlinear nanoantennas.

Reciprocal scatterers necessarily extinguish the same amount of incoming power when excited from opposite directions. This property implies that it is not possible to realize scatterers that are transparent when excited from one direction but that scatter and absorb light for the opposite excitation, limiting opportunities in the context of asymmetric imaging and nanophotonic circuits. This reciprocity constraint may be overcome with an external bias that breaks time-reversal symmetry, posing however challenges in terms of practical implementations and integration.

The push to infuse mental health education across advanced nursing curricula.

Research indicates that knowledge gaps and unfavorable attitudes among primary care advanced practice registered nurses (APRNs) are linked to stigma surrounding psychiatric care, affecting the management of patients experiencing mental illness. Despite standards of practice and educational guidelines set forth by professional nursing organizations to increase quality of care, challenges exist when delivering care to patients with mental health disorders. Lack of integration of mental health education throughout graduate nursing courses contributes to an underestimation of its significance and applicability within advanced practice nursing in primary care.

Exploring sociodemographic moderators of the association between sleep duration and self-rated health.

Objective: This study examined the association of sleep duration with self-rated health (SRH) and if age, sex, and race/ethnicity modifies this association.

Methods: This was a cross-sectional analysis of 396,455 adults who were aged ≥ 18 years in the 2020 Behavioral Risk Factor Surveillance System. Sleep duration was categorized into three: short (< 7 h), normal (7-9 h; reference), and long (> 9 h).

Leaching profile of per- and polyfluoroalkyl substances (PFAS) from biosolids after thickening, anaerobic digestion, and dewatering processes, and significance of protein, phosphorus, and selected ions.

Batch leaching experiments were conducted to evaluate the release of forty per- and polyfluoroalkyl substances (PFAS) from sludge samples collected after thickening, anaerobic digestion, and dewatering processes at two wastewater treatment plants. The South District wastewater treatment plant (SDWWTP), which receives domestic wastewater and landfill leachate from a nearby landfill, and the Central District wastewater treatment plant (CDWWTP), which receives only domestic wastewater, were selected for this study. PFAS released into the aqueous phase were analyzed by sacrificial sampling after 1, 3, 7, 14, and 30 days.

"They Think Transgender is Like Something on the Side:" Perceptions of Transgender Women of Color of Cisgender Members of the LGBTQIA+ "Community".

Due to multiple minority statuses, transgender women of color are exposed to minority stress through distal (external) stressors from society causing proximal (internal) stress, leading to potentially negative physical and mental health outcomes. Often considered allies to the transgender community, cisgender members of the LGBTQIA+ "community" have historically presented different plights resulting in divergent rights, protections, and societal views. Guided by the minority stress framework, a secondary analysis of individual interviews and focus groups ( = 20) with transgender women of color was performed.

Emergency Department Patient Satisfaction Scores Are Lower for Patients Who Arrive During the Night Shift.

Background: Increasingly, patient satisfaction scores are being used to assess emergency physicians. We sought to determine whether the patient satisfaction scores collected by our hospital system are lower for patients who are treated in the emergency department (ED) on night shifts as compared to those treated on day shifts.

Methods: We performed a cross-sectional analysis of patient satisfaction scores from three EDs in Florida.