Macular Atrophy in Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis.

Topic: Macular atrophy incidence in neovascular age-related macular degeneration (AMD) patients undergoing anti-vascular endothelial growth factor (VEGF) treatment.

Clinical Relevance: Macular atrophy is a significant event that may occur in eyes with neovascular AMD treated with anti-VEGF therapy.

Methods: We conducted a systematic review and meta-analysis following PRISMA guidelines (PROSPERO, CRD42024474924).

Acromioclavicular Joint Injuries: Multi-center Expert Consensus Study using the Delphi Method.

Introduction: Acromioclavicular (AC) joint injuries pose significant challenges in clinical management, necessitating consensus guidelines for optimal treatment. There is a lack of consensus in several areas, including imaging protocols, surgical techniques, and rehabilitation timelines. This study aims to develop a consensus regarding the diagnosis, treatment, and rehabilitation of AC joint separations.

Structural Determinants of School Discipline: Examining State-Level Racial Bias and Neighborhood Opportunity.

Objective: Addressing the disproportionate use of school detentions and suspensions among Black youth is crucial for reducing educational and health disparities across the lifespan. Yet, few studies have explored external factors beyond school or individual characteristics as potential contributors to school discipline disparities, such as state-level racial bias and neighborhood opportunity.

Method: A subsample from the larger Adolescent Brain Cognitive Development (ABCD) Study® was used (M age at baseline = 9.

Efficient removal of cationic malachite green using co-pyrolyzed corn straw biochar-montmorillonite composites.

New efficient and sustainable methods for the removal of malachite green (MG) from environmental media are needed. In this study, corn straw was co-pyrolyzed with montmorillonite under a variety of conditions (400, 500, 600, and 700 °C and 10-40 wt% montmorillonite), without any use of toxic chemicals, to produce a series of biochar-clay composites. Characteristics of the composites that make them promising contaminant sorbents include a uniform lamellar-particle micromorphology, enhanced mesoporous structure and surface area (53.

Ethnicity and race as modifiers of the association between patient sex and stage at diagnosis of bladder cancer.

Background: With over 80,000 projected new diagnoses in 2024, bladder cancer remains a significant public health concern. Given the absence of routine screening protocols, identifying high-risk populations becomes crucial for early detection and intervention. This study aimed to investigate whether race and ethnicity modify the association between sex and stage at diagnosis in adults with primary bladder cancer.

The U.S.A. eligible retinopathy of prematurity screening population 2003-2022: WONDER-ROP Study.

Purpose: To delineate the trends of the United States population eligible for retinopathy of prematurity (ROP) screening as defined by the Joint Statement Screening Guidelines of the American Academies of Pediatrics and Ophthalmology from the Centers for Disease Control using the Wide-ranging Online Data for Epidemiologic Research (WONDER) Database.

Design: National, retrospective study.

Subjects: Infants with ROP in the United States between 2003 and 2022.

Disparities in Rehabilitation Services for Victims of Violence.

Introduction: Access to rehabilitation services after a traumatic injury improves functional outcomes. No study has examined the association between injury intent, violent versus nonviolent, and receipt of rehabilitation services after injury.

Materials And Methods: We conducted a retrospective cohort study of injured adult patients admitted to our level I trauma center from January 1, 2014 to December 31, 2021.

Drusen Regression Following Macular Hole Surgery: A Case Report.

Purpose: To report a case of drusen regression following pars plana vitrectomy with internal limiting membrane peel (ILMP) in a patient with a full-thickness macular hole and dry age-related macular degeneration (AMD).

Methods: A 67-year-old gentleman presented in April 2024 with a full-thickness macular hole in OS and intermediate dry AMD OU. The patient underwent pars plana vitrectomy, ILMP, and an injection of sulfur hexafluoride gas for macular hole repair in OS.

Prefrontal 5α-reductase 2 mediates male-specific acute stress response.

A key response to acute stress is the increased brain synthesis of the neurosteroid allopregnanolone (AP). Although the rate-limiting step of this reaction is catalyzed by 5α-reductase (5αR), the role of its two primary isoenzymes, 5αR1 and 5αR2, in stress reactivity remains unclear. Here, we found that acute stress led to increased levels of 5αR2, but not 5αR1, in the medial prefrontal cortex (mPFC) of male, but not female, rats.

Expanding the Genetic Etiology of Multiple Morphological Abnormalities of the Sperm Flagella: A Case Report of Two Novel DNAH1 Variants.

Background: The following case report details the genetic evaluation and treatment of a 30-year-old male with a history of asthenoteratospermia and notable abnormalities of the sperm flagella.

Methods: Genetic evaluation was performed via a multi-gene panel of genes associated with primary ciliary dyskinesia and multiple morphological abnormalities of the sperm flagella (MMAF) prior to the couple's in vitro fertilization (IVF) cycle.

Results: Genetic evaluation was performed via a multi-gene panel of genes associated with primary ciliary dyskinesia and multiple morphological abnormalities of the sperm flagella (MMAF) prior to the couple's in vitro fertilization (IVF) cycle.

Geographical patterns of intraspecific genetic diversity reflect the adaptive potential of the coral Pocillopora damicornis species complex.

Marine heatwaves are increasing in intensity and frequency however, responses and survival of reef corals vary geographically. Geographical differences in thermal tolerance may be in part a consequence of intraspecific diversity, where high-diversity localities are more likely to support heat-tolerant alleles that promote survival through thermal stress. Here, we assessed geographical patterns of intraspecific genetic diversity in the ubiquitous coral Pocillopora damicornis species complex using 428 sequences of the Internal Transcribed Spacer 2 (ITS2) region across 44 sites in the Pacific and Indian Oceans.

Inorganic nitrogen and organic matter jointly regulate ectomycorrhizal fungi-mediated iron acquisition.

Ectomycorrhizal fungi (EMF) play a crucial role in facilitating plant nutrient uptake from the soil although inorganic nitrogen (N) can potentially diminish this role. However, the effect of inorganic N availability and organic matter on shaping EMF-mediated plant iron (Fe) uptake remains unclear. To explore this, we performed a microcosm study on Pinus taeda roots inoculated with Suillus cothurnatus treated with +/-Fe-coated sand, +/-organic matter, and a gradient of NHNO concentrations.

A brief review of methods for determining time-activity patterns in California.

In this review paper, we provide a comprehensive overview of approaches for collecting time-activity pattern (TAP) data from individuals, a crucial component in understanding human behavior and its implications across various fields such as urban planning, environmental science, and, particularly, public health in relation to air pollution exposures.Furthermore, our paper introduces and critically evaluates several emerging methods for TAP data collection. These novel approaches, including but not limited to Google Location History, iPhone Significant Locations, and crowdsourced smartphone location data, offer unprecedented granularity in tracking human activities.

Demographic Characteristics and Relational Coordination in ICU Teams: Implications for Building Diverse and Effective Healthcare Collaboration.

Objective: To determine if professional roles and demographic characteristics predict relational coordination (RC) among healthcare professionals in the ICU.

Background: Race, age, and sex diversity are increasing in the medical and nursing workforce, raising questions regarding how well healthcare professionals are collaborating. RC is a validated model for coordinating interdependent work among healthcare professionals.

Talking About Religion? Differences in Religious Socialization Among Recently Arrived Refugees Between Quebec and Other Provinces in Canada.

How does context shapes religious practices and religious expression of immigrants? Existing work has focussed on changes over the long term and across generations. We argue that context can shape religious practice shortly after arrival. Using a nationally representative survey of Syrian refugees with children who arrived between late 2015 and 2018, we examine how often parents talk to their children about religion, a central mechanism in religious socialization.

Translational Outcomes Project in Neurotrauma (TOP-NT) Pre-Clinical Consortium Study: A Synopsis.

Traumatic brain injury (TBI) has long been a leading cause of death and disability, yet research has failed to successfully translate findings from the pre-clinical, animal setting into the clinic. One factor that contributes significantly to this struggle is the heterogeneity observed in the clinical setting where patients present with injuries of varying types, severities, and comorbidities. Modeling this highly varied population in the laboratory remains challenging.

The Kinesin Kar3 is Required for Endoplasmic Reticulum-Associated Degradation.

Degradation of aberrant, excess, and regulatory proteins at the endoplasmic reticulum (ER) is a conserved feature of eukaryotic cells, disruption of which contributes to disease. While remarkable progress has been made in recent years, mechanisms and genetic requirements for ER-Associated Degradation (ERAD) remain incompletely understood. We recently conducted a screen for genes required for turnover of a model ER translocon-associated substrate of the Hrd1 ubiquitin ligase in .

Psychiatric, Neurological, and Somatic Comorbidities in Intermittent Explosive Disorder.

Importance: Intermittent explosive disorder (IED) is an understudied psychiatric condition marked by impulsive aggression and poorly regulated emotional control, often resulting in interpersonal and societal consequences. Better understanding of comorbidities can improve screening, diagnosis, and treatment.

Objective: To investigate the prevalence of IED and its associations with psychiatric, neurological, and somatic disorders.

Oral vs Intravenous Antibiotics for Fracture-Related Infections: The POvIV Randomized Clinical Trial.

Importance: Fracture-related infection (FRI) is a serious complication following fracture fixation surgery. Current treatment of FRIs entails debridement and 6 weeks of intravenous (IV) antibiotics. Lab data and retrospective clinical studies support use of oral antibiotics, which are less expensive and may have fewer complications than IV antibiotics.

Depressive Symptoms and Amyloid Pathology.

Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology.

Future Directions in the Treatment of Low-Grade Gliomas.

There is major interest in deintensifying therapy for isocitrate dehydrogenase-mutant low-grade gliomas, including with single-agent cytostatic isocitrate dehydrogenase inhibitors. These efforts need head-to-head comparisons with proven modalities, such as chemoradiotherapy. Ongoing clinical trials now group tumors by intrinsic molecular subtype, rather than classic clinical risk factors.