Long-day induced flowering requires DNA hypermethylation in orchardgrass.

Flowering, a pivotal plant lifecycle event, is intricately regulated by environmental and endogenous signals via genetic and epigenetic mechanisms. Photoperiod is a crucial environmental cue that induces flowering by activating integrators through genetic and epigenetic pathways. However, the specific role of DNA methylation, a conserved epigenetic marker, in photoperiodic flowering remains unclear.

Genetic Services in Appalachia Conference Series.

This study examined the data generated as part of a seven-session webinar series that focused on genetics care provision in the medically underserved, rural Appalachian region and examined how these services have adapted to challenging practice environments. Barriers and facilitators to care in our region were considered. Data included a baseline survey of registrants, transcripts of sessions, and feedback about sessions.

Simple vs Complex Aortic Arch Repair in Acute Type A Aortic Dissection.

Background: The purpose of this study is to evaluate the clinical outcomes of patients undergoing a simpler (hemiarch) vs complex (zone 2 arch) aortic repair for acute type A aortic dissection (TAAD).

Methods: Adults (≥18 years) who underwent hemiarch or zone 2 arch repair for acute, hyperacute, or acute on chronic TAAD at a single institution between January 2018 and April 2024 were reviewed. Disabling stroke was defined as modified Rankin scale ≥4.

Concurrent Validity and Reliability of In-Person and Supervised Remote STEADI Fall Risk Assessment in Community-Dwelling Older Adults.

Background And Purpose: Physical therapists play a vital role in preventing and managing falls in older adults. With advancements in digital health and technology, community fall prevention programs need to adopt valid and reliable telehealth-based assessments. The purpose of this study was to evaluate the validity and reliability of the telehealth-based timed up and go (TUG) test, 30-second chair stand test (30s-CST), and four-stage (4-stage) balance test as functional components of the Stopping Elderly Accidents, Deaths, and Injuries (STEADI) fall risk assessment.

Fungal endophytes modulate the negative effects induced by Persistent Organic Pollutants in the antarctic plant Colobanthus quitensis.

Antarctica has one of the most sensitive ecosystems to the negative effects of Persistent Organic Pollutants (POPs) on its biodiversity. This is because of the lower temperatures and the persistence of POPs that promote their accumulation or even biomagnification. However, the impact of POPs on vascular plants is unknown.

Breaking down silos and echo chambers: Adolescence through an interdisciplinary lens.

Research on adolescence occurs across a variety of disciplines, including education, psychology, sociology, public health, biology, and medicine, among other fields, each with its own definition of the most pressing problems, levels of analysis, and proposed solutions. There is widespread recognition that human development occurs across levels simultaneously from molecular changes to broader cultural systems. Yet it remains challenging to integrate across levels and scholarly disciplines.

Postprandial time in tight range with faster insulin aspart compared with standard insulin aspart in youth with type 1 diabetes using automated insulin delivery.

Aims: The aim of this study was to assess postprandial glycaemic outcomes using automated insulin delivery with faster acting insulin aspart (FIA) or standard insulin aspart (SIA) over 4 weeks in youth (aged 10-18 years) with type 1 diabetes.

Materials And Methods: We undertook a secondary analysis of postprandial glycaemic outcomes from a double-blind, randomised, crossover study comparing FIA to SIA using an investigational version of MiniMed™ 780G. Endpoints included postprandial time in tight range (70-140 mg/dL; TITR), postprandial glucose excursions and peak glucose, and incremental area under curve (iAUC).

Congeneric Rodents Differ in Immune Gene Expression: Implications for Host Competence for Tick-Borne Pathogens.

Mice in the genus Peromyscus are abundant and geographically widespread in North America, serving as reservoirs for zoonotic pathogens, including Borrelia burgdorferi (B. burgdorferi), the causative agent of Lyme disease, transmitted by Ixodes scapularis ticks. While the white-footed mouse (Peromyscus leucopus (P.

Forensic Assessment of Kinship, Genomic Ancestry, and Natural History of an Iconic Tiger of Harlem-New York City.

In the fall of 2003, a two-year-old tiger named Ming, weighing some four hundred pounds, was discovered living in an apartment in Harlem, New York. Ming's rescue by NYPD was witnessed, recalled, and venerated by scores of neighbors. The tiger's history and ancestry stimulated considerable media interest, investigative sleuthing, and forensic genomic analyses.

An Evaluation of Self-Assessed Caregiver Readiness to Foster and Adopt After Participating in the National Training and Development Curriculum.

Purpose: The self-assessment is a component of the National Training and Development Curriculum (NTDC) used by resource (i.e. foster, adoptive, and kinship) parents to understand strengths and areas of potential growth associated with successful parenting.

Associations of Faith Community Rejection with Social Support and Health Outcomes among LGBTQ+ Older Adults.

Objectives: Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) older adults have varied experiences with faith communities, ranging from affirmation to religious trauma. We investigate how faith community rejection impacts social support and health outcomes among LGBTQ+ older adults in the Southern United States.

Methods: We analyze Wave 1 data from the LGBTQ+ Social Networks, Aging, and Policy Study (QSNAPS), collected between April 2020 and September 2021.

Secreted small RNAs of are biomarkers for diagnosis of primary amoebic meningoencephalitis.

Rapid and accurate diagnostics are needed to effectively detect and treat primary amoebic meningoencephalitis (PAM) caused by (). Delayed diagnosis and similarities to other causes of meningitis contribute to a case mortality rate of >97%. Thus, there is an unmet medical need for a non-invasive liquid biopsy diagnostic method.

Enforced E-selectin ligand installation enhances homing and efficacy of adoptively transferred T cells.

Adoptive T-cell transfer has revolutionized the treatment of hematological malignancies. However, this approach has had very limited success in treating solid tumors, largely due to inadequate infiltration of vascularly administered T cells at tumor sites. The shear-resistant interaction between endothelial E-selectin and its cognate ligand expressed on leukocytes, sialyl Lewis X (sLe), is an essential prerequisite for extravasation of circulating leukocytes.

Indigenous Maya-Mam leadership competencies: a grounded theory study.

Introduction: This study explores the leadership competencies within the Indigenous Maya-Mam community, aiming to understand the specific skills and qualities exhibited by Maya-Mam leaders. The research seeks to address the gap in literature regarding Indigenous leadership practices, particularly focusing on how cultural values influence leadership behaviors.

Methods: Qualitative methods were employed for this study, including interviews and thematic analysis.

A peptide mimic of SOCS1 modulates equine peripheral immune cells and ocular effector functions : implications for recurrent uveitis.

Introduction: Recurrent uveitis (RU), an autoimmune disease, is a leading cause of ocular detriment in humans and horses. Equine and human RU share many similarities including spontaneous disease and aberrant cytokine signaling. Reduced levels of SOCS1, a critical regulator of cytokine signaling, is associated with several autoimmune diseases.

Understanding marital stability through work-family experiences in proximal and distal contexts: Comparing United States and Japan.

Objective: Guided by Gottman's framework of marital stability and the ecological theories, the present study aims to understand the relationships between work-family spillover and marital stability within two levels of context-the relational and social cultural contexts.

Background: The relational context of marriage is manifested by spousal relationships-spousal support and strain, which would moderate the relationship between work-family spillover and marital stability. Identified relationships also unfold within sociocultural contexts.

Amphotericin B tissue penetration and pharmacokinetics in healthy and -infected rats: insights from microdialysis and population modeling.

Introduction: This study evaluated the relationship between total plasma and free kidney concentrations of amphotericin B (AmB) in healthy and -infected Wistar rats using microdialysis and has the potential to significantly impact future research in this field and promote the development of antifungal drugs. The findings of this study, which show that plasma levels are a good predictor for AmB kidney concentrations and can be used to optimize its dosing regimen, underscore the importance of this research.

Methods: Microdialysis probe recovery rates were determined by dialysis and retrodialysis , as well as by retrodialysis .

Pandemic Perceptions and Healthcare Decisions: Exploring Perceived COVID-19 Threat's Impact on Perinatal Healthcare in Florida.

The COVID-19 pandemic directly impacted well-being and healthcare delivery, but its indirect effects on health services utilization among pregnant women and new mothers remain less understood. Understanding how big events like pandemics impact health behaviors is essential for anticipating healthcare needs during future crises. This study examined how the perceived COVID-19 threat influenced health concerns and service utilization among 378 participants who were either pregnant or mothers of infants less than 12 months old, 18 years or older, and lived within a 50-mile radius of healthcare sites in the OneFlorida+ Clinical Research Consortium.

Oropharyngeal Lymphogranuloma Venereum: A Clinical Reasoning Challenge and Literature Review.

Lymphogranuloma venereum (LGV) is a sexually transmitted infection typically caused by serovars L1-L3 of . These serovars are tissue-invasive with a preponderance for lymphatic spread and can be acquired via unprotected oral, anal, or vaginal sex. We present the case of a 23-year-old with a prior history of syphilis admitted with four weeks of progressively enlarging painful right cervical lymphadenopathy.

A Rare Case Report of Extra-adrenal Pheochromocytoma Masquerading as a Pancreatic Head Malignancy.

Extra-adrenal pheochromocytomas are rare neuroendocrine tumors originating outside the adrenal glands and can pose significant diagnostic challenges due to their variable presentations. This report highlights a case of an extra-adrenal pheochromocytoma masquerading as a pancreatic head malignancy. We underscore the importance of considering extra-adrenal pheochromocytoma in the differential diagnosis of pancreatic masses, particularly when biochemical or clinical features suggest catecholamine excess.

Trauma-Associated Pseudo-Hutchinson Sign: An Autobiographical Case Report Emphasizing Conditions, Pseudo-Conditions, and Pseudo-Pseudo-Conditions.

Melanonychia describes black pigmentation of the nail plate that results from either melanocyte activation (such as infections, local inflammatory disorders, local trauma affecting the nail plate, numerous systemic conditions, and medications) or melanocyte hyperplasia (such as benign neoplasms or malignant tumors) or blood (resulting from a trauma-associated subungual hematoma). The black dyschromia may include not only the nail plate but also the proximal nailfold. The Hutchinson sign refers to black discoloration of both the proximal nailfold and adjacent nail plate when the underlying pigmented lesion is a malignant melanoma.

Gender influence on career trajectory as a shoulder and elbow surgeon.

Background: Women continue to make up a minority of orthopedic surgeons, especially shoulder and elbow surgeons. There exists no study that investigates the effect of gender on one's academic career as a shoulder and elbow orthopedic surgeon, which was the purpose of this cross-sectional study.

Methods: The American Shoulder and Elbow Surgeons website was used to identify surgeons.

Safety, reactogenicity, and immunogenicity of Ad26.COV2.S co-administered with a quadrivalent standard-dose or high-dose seasonal influenza vaccine: a non-inferiority randomised controlled trial.

Background: Vaccine co-administration can increase vaccination coverage. We assessed the safety, reactogenicity, and immunogenicity of concomitant administration of Ad26.COV2.

Multilocular thymic cysts- a diagnostic challenge on computed tomography.

A recent case report provided a patient scenario, wherein, a 39-year-old male patient presented with occasional palpitations, headache, and fever. Evaluation of tumor markers did not show any abnormal results. Subsequently, a computed tomography (CT) scan was undertaken, and its findings were affirmative of thymic cancer.

Characterizing Wellness Initiatives in Academic Radiation Oncology Departments.

Purpose: Burnout is prevalent in radiation oncology (RO), and an increased focus on promoting physician wellness and formalizing wellness-directed efforts has transpired in recent years. We aimed to characterize current wellness leadership positions and efforts within academic RO departments.

Methods And Materials: Academic RO department chairs were contacted to inquire whether they had a departmental wellness leader with a request for leader contact information, if applicable.