226 results match your criteria: "Floppy Eyelid Syndrome"
A novel variant associated with NEDDFSA and new ocular features: case report and review of literature.
Ophthalmic Genet
December 2024
Department of Ophthalmology, Université de Montréal, Montreal, Québec, Canada.
Introduction: Neurodevelopmental disorder with dysmorphic facies and distal skeletal anomalies (NEDDFSA) is a recently described syndromic disease linked to genetic variants. We present a novel variant associated with a phenotype of NEDDFSA in a pediatric patient presenting with multiple anomalies including bilateral congenital ptosis and blepharophimosis, floppy eyelids, telecanthus, downward palpebral slants, myopia, cryptorchidism, hallux valgus and developmental delay.
Methods: Genetic testing performed on a large panel revealed a likely pathogenic variant in the gene (heterozygous, c.
Comparison of manual versus automated thermal lid therapy with expression for meibomian gland dysfunction in patients with dry eye disease.
Sci Rep
September 2024
From UCSD School of Medicine Department of Ophthalmology, Shiley Eye Institute, La Jolla, CA, USA.
Article Synopsis
- A study was conducted to compare manual thermoelectric lipid expression (MiBoFlo) and automated lipid expression (Lipiflow) for treating dry eye disease, using standardized methods for evaluation.
- Both treatments showed improvements in dry eye questionnaire scores and objective measures, with MiBoFlo performing better than Lipiflow in several areas.
- Factors like blepharitis and autoimmune disease negatively impacted the likelihood of symptom improvement, highlighting that MiBoFlo manual therapy was more effective than Lipiflow for alleviating dry eye symptoms.
Is Floppy Eyelid Syndrome predictive of Intraoperative Floppy Iris Syndrome? A prospective and translational study.
J Fr Ophtalmol
November 2024
Ophthalmology department, University Hospital of Nice, 30 Voie Romaine, 06000 Nice, France. Electronic address:
Article Synopsis
- Intraoperative floppy iris syndrome (IFIS) is a condition during cataract surgery where the iris excessively billows, and this study investigates its potential link to floppy eyelid syndrome (FES).
- Conducted at the University Hospital of Nice, the study analyzed data from cataract surgeries and examined tissue samples to assess the relationship between FES and IFIS.
- Results showed that FES significantly predicts the occurrence of IFIS in patients, highlighting the need for surgeons to recognize this association to avoid complications during surgery.
The Overlooked Floppy Eyelid Syndrome: From Diagnosis to Medical and Surgical Management.
Diagnostics (Basel)
August 2024
Department of Ophthalmology, Campus Bio-Medico University Hospital, 00128 Rome, Italy.
Article Synopsis
- - Floppy Eyelid Syndrome (FES) is a common but often overlooked eye condition that causes loose upper eyelids, resulting in eye irritation and redness.
- - The review explores the causes of FES, including genetic factors and links to other health issues like obesity and sleep apnea, as well as detailing diagnostic methods necessary for effective treatment.
- - Treatment options for FES vary from basic medical care to surgical procedures, requiring a team-based approach to improve the quality of life for those affected by this condition.
Article Synopsis
- A 60-year-old man had serious eye problems caused by conditions like diabetes and arthritis, which made it hard for him to take care of his health.
- Doctors found he had multiple eye issues, including a rare infection, and struggled to treat it properly at first.
- Using a dry patch of amniotic membrane helped his eye heal much faster, and after 11 weeks, his cornea was completely healed.
Congenital eyelid imbrication syndrome: A rare occurrence in Pakistan.
J Pak Med Assoc
June 2024
Isra Postgraduate Institute of Ophthalmology, Karachi, Pakistan.
Article Synopsis
- * This overlapping results in the upper eyelid spontaneously turning outward (eversion) over time.
- * In the case studied, the patient showed normal eye structures, and no treatment was necessary as the condition resolved itself within two weeks.
Looking beyond in Sleep Medicine Practice: Effect of OSA Management in Floppy Eyelid Syndrome - A Case Report.
Sleep Sci
June 2024
Department of Neurology, The Iranian Center of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- - Obstructive Sleep Apnea Syndrome (OSA) leads to upper airway blockage during sleep, while Floppy Eye Syndrome (FES) causes eyelids to evert easily and results in uncomfortable eye symptoms.
- - A 49-year-old man with a history of snoring, sleep issues, and eye discomfort was seen in a sleep clinic, where he was diagnosed with OSA and experienced persistent eye symptoms for five years.
- - After starting continuous positive airway pressure (CPAP) therapy for OSA, the man's FES symptoms improved, highlighting the need for further investigation of ocular symptoms in sleep disorder patients for better overall treatment.
Effects of full-thickness wedge resection on ocular surface and in vivo confocal microscopy findings in floppy eyelid syndrome patients.
Eur J Ophthalmol
November 2024
Department of Ophthalmology, Yuksek Ihtisas University, Liv Hospital, Ankara, Turkey.
Article Synopsis
- The study aimed to assess the impact of full-thickness wedge resection (FTWR) surgery on the ocular surface and IVCM findings in patients with floppy eyelid syndrome (FES).
- Two groups were analyzed: one receiving FTWR surgery and the other undergoing conservative treatment, with various ocular metrics recorded and compared over six months.
- Results indicated significant improvements in tear break-up time, corneal fluorescein staining, and nerve density in the surgical group, highlighting FTWR as an effective treatment for moderate to severe FES not responsive to conservative methods.
Tarsal Buckling and Entropion after Levator Aponeurosis Advancement in Patients with Floppy Eyelid Syndrome.
Ophthalmic Plast Reconstr Surg
January 2024
Department of Ophthalmology and Visual Sciences, The Ohio State University Wexner Medical Center and The Ohio State University Comprehensive Cancer Center-James Cancer Hospital and Solove Research Institute, Columbus, Ohio, U.S.A.
Article Synopsis
- Two patients with floppy eyelid syndrome experienced intense eye pain and a feeling of something in their eyes following surgery to advance their eyelid muscles.
- During their exams, doctors found that both patients had inward-turning upper eyelids (entropion), and eversion of the eyelid revealed abnormal tarsus (the tissue that gives structure to the eyelid).
- Surgical revision involving a specific procedure to remove the abnormal tarsus successfully corrected the issue, and the authors suggest a new surgical approach to prevent similar complications in the future.
Congenital Eyelid Imbrication and Floppy Eyelid Syndromes Complicated by Eversion due to Prostaglandin E Infusion in a Patient With Trisomy 21 and Tetralogy of Fallot.
Ophthalmic Plast Reconstr Surg
May 2024
Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado, U.S.A.
Article Synopsis
- Congenital eyelid imbrication syndrome is a rare condition where the upper eyelid overlaps the lower eyelid when the eyes are shut, with very few documented cases in medical literature.
- The case presented involves a patient with both trisomy 21 and tetralogy of Fallot who was receiving a prostaglandin E1 infusion to keep a heart duct open before surgery.
- The patient experienced eyelid swelling and related symptoms, which improved after stopping the prostaglandin E1 treatment, highlighting a potential link between the medication and the eyelid condition.
Severe Upper Lid Fornix Prolapse After a Ptosis Repair in Floppy Eyelid Syndrome: A Case Report.
Ann Plast Surg
November 2023
From the Elson S. Floyd College of Medicine, Washington State University.
Article Synopsis
- A 43-year-old woman with floppy eyelid syndrome (FES) presented with severe ptosis, causing difficulty in driving and chronic eye issues like tearing and crusting.
- She underwent surgical procedures, including a wedge excision and ptosis repair, which initially led to complications that obstructed her vision.
- After a fornix reconstruction, her symptoms improved, and this case highlights the need for further research on complications in younger patients with FES.
Response to "Observations on the association between obstructive sleep apnea and floppy eyelid syndrome: A systematic review and meta-analysis".
Surv Ophthalmol
August 2024
Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore; Department of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore, Singapore; SingHealth Duke-NUS Sleep Centre, Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore; Surgery Academic Clinical Program, SingHealth, Singapore, Singapore. Electronic address:
Observations on the association between obstructive sleep apnea and floppy eyelid syndrome: A systematic review and meta-analysis.
Surv Ophthalmol
August 2024
Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia; Department of Ophthalmology, Prince of Wales Hospital, Sydney, New South Wales, Australia. Electronic address:
Tape-splint tarsorrhaphy technique to manage exposure keratopathy in a patient refusing surgical intervention.
Clin Case Rep
August 2023
Professional Eye Associates Dalton Georgia USA.
Article Synopsis
- The case report discusses a unique tape-splinting technique used as a nonsurgical remedy for exposure keratopathy.
- This method was applied to a patient who opted against surgical treatment for their condition.
- The tape-splinting technique is highlighted for its effectiveness in managing symptoms associated with exposure keratopathy without needing surgery.
Iris color as a predictive factor for intraoperative floppy iris syndrome.
Graefes Arch Clin Exp Ophthalmol
December 2023
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Article Synopsis
- The study aimed to examine how iris color influences the risk of intraoperative floppy iris syndrome (IFIS) during cataract surgeries.
- It involved reviewing medical records of patients who had surgery, excluding those with specific ocular conditions, and assessing their iris colors through follow-up calls.
- Findings showed that patients with blue and green irises had a significantly higher risk for IFIS compared to those with brown irises, with light-colored irises also linked to more severe cases and higher chances of affecting both eyes.
Ocular manifestations of obstructive sleep apnea: a systematic review and meta-analysis.
Graefes Arch Clin Exp Ophthalmol
January 2024
Department of Ophthalmology and Surgery, Centre for Eye Research Australia, Victoria, 3002, Australia.
Article Synopsis
- This systematic review and meta-analysis investigates the link between obstructive sleep apnea (OSA) and various eye disorders, examining literature from multiple databases up to July 2022.
- The analysis revealed a significant association between OSA and conditions such as non-arteritic anterior ischemic optic neuropathy (NAION), floppy eyelid syndrome (FES), and retinal vein occlusion (RVO), with NAION showing the highest odds ratio (3.98).
- The study emphasizes the importance of awareness among clinicians and ophthalmologists regarding these associations to enable early diagnosis and treatment of eye conditions in patients at risk for OSA, ultimately aiming to prevent vision-related issues.
Comparison of ocular surface assessment outcomes between healthy controls and patients with obstructive sleep apnea-hypopnea syndrome: a meta-analysis of the literature.
Front Physiol
May 2023
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Article Synopsis
- * Patients with OSAHS showed significant ocular issues: 40% had floppy eyelid syndrome, 48% had dry eye syndrome, and they experienced lower tear production and stability compared to healthy controls.
- * The study found correlations indicating that increased disease severity in OSAHS patients is associated with worse ocular health, as those with severe disease had higher scores on ocular disease assessments and significant loss of meibomian glands.
Evaluation of Eyelid, Angle, and Anterior Segment Parameters Using Scheimpflug Camera and Topography System in Obstructive Sleep Apnea Syndrome.
Beyoglu Eye J
March 2023
Department of Ophthalmology, Afyon Kocatepe University, Faculty of Medicine, Afyon, Türkiye.
Article Synopsis
- The study aimed to examine eyelid hyperlaxity and various corneal parameters in patients with obstructive sleep apnea syndrome (OSAS) using advanced imaging techniques.
- A total of 32 patients with OSAS and 32 healthy individuals were evaluated, measuring parameters like corneal thickness and anterior chamber characteristics.
- Results showed that while most parameters were similar between groups, significant increases in certain eye measurements and a higher prevalence of upper eyelid hyperlaxity were found in the OSAS group, suggesting a link to glaucoma risk in these patients.
Prevalence of Obstructive Sleep Apnea With Floppy Eyelid Syndrome: A Systematic Review and Meta-analysis.
Ophthalmic Plast Reconstr Surg
May 2023
Department of Ophthalmology, Royal Victorian Eye and Ear Hospital; Centre for Eye Research Australia, Melbourne, Victoria, Australia.
Article Synopsis
- The study examined the prevalence of obstructive sleep apnea (OSA) in patients with floppy eyelid syndrome (FES) and assessed how severe OSA is among these patients.
- A total of 12 studies involving 511 patients were analyzed, revealing that 57.1% of FES patients also had OSA, with a significant majority being male (98%).
- The findings suggest that since ophthalmologists frequently see FES patients, they should screen for sleep apnea symptoms, and more extensive research is needed to confirm these results and understand the causes of FES better.*
Floppy Eyelid Syndrome: an Overlooked Comorbidity Among Bariatric Patients.
Obes Surg
February 2023
Department of Surgery, New Jersey Medical School, Rutgers, The State University of New Jersey, 185 South Orange Avenue, Newark, NJ, 07103, USA.
Article Synopsis
- Floppy eyelid syndrome (FES) is characterized by overly lax eyelids, leading to irritation, dryness, and potential serious eye complications, notably among patients with obstructive sleep apnea syndrome (OSAS).
- A study involving 88 patients showed that 44% reported chronic eye symptoms prior to bariatric surgery, with some experiencing improvement in these symptoms post-surgery.
- The findings suggest that bariatric surgery may positively influence FES symptoms and OSAS severity, highlighting the need for bariatric surgeons to pay attention to FES in patients with obesity and chronic eye issues.
Association between obstructive sleep apnea and floppy eyelid syndrome: A systematic review and metaanalysis.
Surv Ophthalmol
February 2023
Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore; Department of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore, Singapore; SingHealth Duke-NUS Sleep Centre, Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore; Surgery Academic Clinical Program, SingHealth, Singapore, Singapore. Electronic address:
Article Synopsis
- Obstructive sleep apnoea (OSA) is suspected to be linked to floppy eyelid syndrome (FES), but previous research has produced inconclusive results regarding this association.
- This study systematically reviewed data from four medical databases and conducted a meta-analysis on observational studies to determine the relationship between OSA and FES, finding that more severe OSA significantly increases the risk of developing FES.
- The analysis concluded that severe OSA correlates with the highest risk of FES, and further longitudinal studies are necessary for a more definitive understanding of this relationship.
Congenital eyelid imbrication syndrome in a Hispanic newborn: case report and review of the literature.
J AAPOS
February 2023
Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Mexico. Electronic address:
Article Synopsis
- - A 6-hour-old newborn boy was diagnosed with congenital eyelid imbrication syndrome (CEIS), characterized by the upper eyelids overriding the lower eyelids and spontaneous eversion.
- - After a physical examination revealed canthal tendon laxity and eye irritation, the newborn was treated conservatively with lubricant ointment, leading to a complete resolution of symptoms by day 4.
- - This case marks the first report of CEIS in a Hispanic infant, adding to the existing literature that primarily documents cases in Asian patients, often resolving without intervention.
Lax eyelid condition (LEC) and floppy eyelid syndrome (FES) prevalence in obstructive sleep apnea syndrome (OSA) patients: a systematic review and meta-analysis.
Graefes Arch Clin Exp Ophthalmol
June 2023
Ophthalmology Unit, Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Article Synopsis
- - The study focuses on understanding how common lax eyelid condition (LEC) and floppy eyelid syndrome (FES) are among patients with obstructive sleep apnea (OSA), finding that these conditions have a significant presence in such patients.
- - Researchers analyzed 11 studies involving 1,225 OSA patients and estimated that around 40.2% had LEC and 22.4% had FES, suggesting a large number of affected individuals globally.
- - The findings indicate that OSA patients are at a higher risk for developing LEC and FES compared to healthy individuals, and further research is needed to explore the underlying causes and potential screening methods.
The Importance of Identifying Meibomian Gland Inversion in Patients With Floppy Eyelid Syndrome.
Ophthalmic Plast Reconstr Surg
March 2023
Corneoplastic Unit, Queen Victoria Hospital NHS Trust, East Grinstead, Sussex, United Kingdom.
Article Synopsis
- Floppy Eyelid Syndrome (FES) is a condition known for eyelid hyperlaxity and associated irritation, often linked with meibomian gland dysfunction (MGD) and upper eyelid issues like meibomian gland inversion (MGI).
- The study aimed to investigate MGI's role in FES patients and analyze outcomes from surgeries correcting MGI, with or without eyelid tightening, over a 5-year period.
- Results from 9 patients showed significant improvement in symptoms (88.9% success rate) after surgery, highlighting the importance of recognizing MGI in FES management.