3 results match your criteria: "Flinders University Bedford Park SA 5042 Australia colin.raston@flinders.edu.au.[Affiliation]"

Article Synopsis
  • Conventional channel-based microfluidic platforms are commonly used to create phospholipid nanostructures like liposomes, but they face scalability issues.
  • A vortex fluidic device (VFD) offers a solution by using a thin film microfluidic approach, enabling the production of ~110 nm diameter liposomes through a high-yield, continuous flow process.
  • The VFD can also facilitate the labeling of liposomes and study their stability and behavior under shear stress, revealing that ~110 nm liposomes are typically the most stable structures formed through self-assembly, similar to exosome sizes.
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Vortex fluidic induced mass transfer across immiscible phases.

Chem Sci

March 2022

Flinders Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University Bedford Park SA 5042 Australia

Mixing immiscible liquids typically requires the use of auxiliary substances including phase transfer catalysts, microgels, surfactants, complex polymers and nano-particles and/or micromixers. Centrifugally separated immiscible liquids of different densities in a 45° tilted rotating tube offer scope for avoiding their use. Micron to submicron size topological flow regimes in the thin films induce high inter-phase mass transfer depending on the nature of the two liquids.

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Shear stress in dynamic thin films, as in vortex fluidics, can be harnessed for generating non-equilibrium conditions, but the nature of the fluid flow is not understood. A rapidly rotating inclined tube in the vortex fluidic device (VFD) imparts shear stress (mechanical energy) into a thin film of liquid, depending on the physical characteristics of the liquid and rotational speed, , tilt angle, , and diameter of the tube. Through understanding that the fluid exhibits resonance behaviours from the confining boundaries of the glass surface and the meniscus that determines the liquid film thickness, we have established specific topological mass transport regimes.

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