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Diagnostic pathology of lymphoproliferative disorders.
Pathology
December 2005
Anatomical Pathology, Flinders Medical Centre and Gribbles Pathology, Adelaide, South Australia.
Article Synopsis
- The classification and diagnosis of lymphoma have evolved significantly over the last 20 years, moving from a simplistic system reliant on H&E sections to a more complex multidisciplinary approach that includes immunophenotyping and molecular studies.
- The transition began with early classifications like Kiel and REAL, ultimately leading to the current WHO classifications that incorporate various clinical features, morphological data, and genetic information.
- This modern process demands cooperation among multiple specialized laboratories and integration of diverse diagnostic findings into a comprehensive report for accurate diagnosis of lymphoproliferative disorders.