10,894 results match your criteria: "Flinders Medical Centre; School of Medicine[Affiliation]"

Background: In the digital age, search engines and social media platforms are primary sources for health information, yet their commercial interests-focused algorithms often prioritize irrelevant content. Web-based health applications by reputable sources offer a solution to circumvent these biased algorithms. Despite this advantage, there remains a significant gap in research on the effective integration of content-ranking algorithms within these specialized health applications to ensure the delivery of personalized and relevant health information.

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Background: Among the Pentraxins, the long Pentraxin-3 (PTX-3) is associated with several processes, particularly in the earliest phases of the innate humoral response. Increased blood PTX-3 concentrations have been observed in a wide range of conditions, from infectious to cardiovascular disorders. Since its increase is more rapid than C-reactive protein (CRP), PTX-3 can be useful to detect and monitor early inflammation.

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Near-death experiences after cardiac arrest: a scoping review.

Discov Ment Health

May 2024

Health and Information, Adelaide, South Australia, Australia.

Background: This scoping review aimed to characterise near-death experiences in the setting of cardiac arrest, a phenomenon that is poorly understood and may have clinical consequences.

Method: PubMed/MEDLINE was searched to 23 July 2023 for prospective studies describing near-death experiences in cardiac arrest. PRISMA-ScR guidelines were adhered to.

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Sources and determinants of free sugars intake by 5-year-old Australian children in the SMILE cohort.

Matern Child Nutr

October 2024

Adelaide Dental School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.

Reducing free sugars intake is important for the prevention of dental caries and obesity in children. The study aimed to determine the amount and sources of free sugars known to contribute to dental caries, and identify sociodemographic determinants of intake by children aged 5 years in Australia. Cross-sectional analysis of dietary data from a cohort study, collected using a customized food frequency questionnaire were used to calculate free sugars intake as grams/day and percentage contribution to Estimated Energy Requirement (EER).

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Article Synopsis
  • The study aimed to investigate how changes in multiple biological measurements (like blood pressure and cholesterol) over time affect cognitive performance and cardiovascular disease risk.
  • Data from the ORIGIN trial were analyzed, focusing on how the variability in these measurements relates to cognitive tests (MMSE score) and cardiovascular events.
  • Results showed that higher variability in certain biological measures is linked to worse cognitive performance and a greater risk of cardiovascular issues, with a stronger impact observed in individuals with high variability in four or more measurements.
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Serum carbohydrate antigen 19-9 (CA19-9) is used for recurrence surveillance in patients with resected pancreatic ductal adenocarcinoma (PDAC). This report describes the association of increasing CA19-9 in a male PDAC survivor with presence of prostatic hyperplasia. Unexplained elevation of CA19-9 in male PDAC survivors might be attributable to benign prostatic conditions.

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Introduction: The identification of new, easily measurable biomarkers might assist clinicians in diagnosing and managing systemic sclerosis (SSc). Although the full blood count is routinely assessed in the evaluation of SSc, the diagnostic utility of specific cell-derived inflammatory indices, i.e.

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Impact of comorbidities on prostate cancer-specific mortality: A population-based cohort study.

Prostate

September 2024

Cancer Epidemiology and Population Health Research Group, Allied Health and Human Performance, University of South Australia, Adelaide, Australia.

Aim: To assess the impact of comorbidities on prostate cancer mortality.

Methods: We studied 15,695 South Australian men diagnosed with prostate cancer between 2003 and 2019 from state-wide administrative linked data sets. Comorbidity was measured 1-year before prostate cancer diagnosis using Rx-Risk, a medication-based comorbidity index.

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Frailty evidence-practice gaps in acute care hospitals.

Australas J Ageing

June 2024

Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.

Objectives: Frailty is common in hospitalised older people. Clinical practice guidelines for the management of frailty provide recommendations for identification and management; however, adoption into practice in hospitals is limited. This study identified and quantified the evidence-practice gap between frailty guidelines and clinical practice in two hospitals using an audit tool.

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Objective: To describe the types of hospital and out-of-hospital services provided by public geriatric medicine departments in Australia and New Zealand, and to explore head of department (HOD) views on issues in current and future service provision.

Methods: An electronic survey was sent to HODs of public geriatric medicine departments.

Results: Seventy-six (89%) of 85 identified HODs completed the survey.

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Enhancing safety culture in radiology: Key practices and recommendations for sustainable excellence.

Radiography (Lond)

June 2024

Faculty of Science and Health, Charles Sturt University, Level 5, 250 Boorooma St, NSW 2678, Australia; South Australia Medical Imaging, Flinders Medical Centre, 1 Flinders Drive, Bedford Park, SA 5042, Australia. Electronic address:

Objectives: This review aims to explore and thematically synthesize the existing literature on safety culture within the context of radiology. The primary objective is to identify key practices that effectively strengthen safety culture, highlighting the pivotal roles of leadership, effective teamwork, and interprofessional collaboration in these efforts. The review intends to showcase actionable recommendations that are particularly relevant to the radiology setting.

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Single and dual integrated screw femoral nails are both commonly used to treat intertrochanteric fractures. This study investigated if using single or dual integrated screw femoral nails result in different post-operative hip joint loading. In the presence of differences, we investigated potential contributing factors.

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 Clinical reasoning is essential to physicians' competence, yet assessment of clinical reasoning remains a significant challenge. Clinical reasoning is a complex, evolving, non-linear, context-driven, and content-specific construct which arguably cannot be assessed at one point in time or with a single method. This has posed challenges for educators for many decades, despite significant development of individual assessment methods.

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: Community-acquired pneumonia (CAP) is a common emergency presentation in Australia, with the choice of admitting specialty unit often influenced by pneumonia severity and comorbidities. However, it remains unclear whether there are between-specialty differences in patient characteristics and outcomes. We sought to address this issue by investigating the characteristics and outcomes of CAP patients admitted to General Medicine (GM) versus Respiratory units.

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Evolving Adult ADHD Care: Preparatory Evaluation of a Prototype Digital Service Model Innovation for ADHD Care.

Int J Environ Res Public Health

May 2024

Digital Health Research Lab, College of Medicine and Public Health, Flinders University, Adelaide 5042, Australia.

Background: Given the prevalence of ADHD and the gaps in ADHD care in Australia, this study investigates the critical barriers and driving forces for innovation. It does so by conducting a preparatory evaluation of an ADHD prototype digital service innovation designed to help streamline ADHD care and empower individual self-management.

Methods: Semi-structured interviews with ADHD care consumers/participants and practitioners explored their experiences and provided feedback on a mobile self-monitoring app and related service innovations.

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Social Support Postpartum: Bengali Women from India on Their Coping Experiences following Childbirth.

Int J Environ Res Public Health

April 2024

College of Education, Psychology and Social Work, Flinders University, Adelaide, SA 5042, Australia.

Undertaken in Kolkata, India, our study aimed to explore the experiences of Bengali middle-class women on perceived stressful events, social support, and coping experiences following childbirth. Becoming a mother following childbirth is a shared phenomenon irrespective of culture, social strata, or country, while stress during the postpartum period or depression is not. Discrete medical intervention does not sufficiently address the complexities of postpartum experiences since influencing factors also include economic, political, cultural, and social backgrounds.

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The significance of BAP1 and MTAP/CDKN2A expression in well-differentiated papillary mesothelial tumour: a series of 21 cases and a review of the literature.

Pathology

August 2024

Department of Surgical Pathology, SA Pathology at Flinders Medical Centre, Bedford Park, SA, Australia; Department of Anatomical Pathology, Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Bedford Park, SA, Australia. Electronic address:

The nomenclature and diagnostic criteria of well-differentiated papillary mesothelial tumour (WDPMT) have been changed in the 2021 World Health Organization (WHO) classification of thoracic tumours, and a new entity, mesothelioma in situ (MIS), introduced. Histologically these two entities may be similar. However, MIS is regarded as a precursor to invasive mesothelioma and requires demonstration of loss of BAP1 and/or MTAP/CDKN2A for diagnosis, whereas performance of these ancillary tests is desirable but not essential for a diagnosis of WDPMT, in which the significance of BAP1 and/or MTAP/CDKN2A loss is not well understood or well defined.

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Article Synopsis
  • Randomized controlled trials (RCTs) indicate that using sodium glucose cotransporter-2 inhibitors reduces rates of acute kidney injury and renal failure, but observational studies show mixed results, especially for at-risk populations.
  • The research specifically focused on three high-risk groups: older adults over 65, individuals with heart failure, and those with impaired kidney function.
  • Of the 922 studies reviewed, eight met the criteria, revealing that older adults, people with heart failure, and those with reduced kidney function experience a higher absolute risk of acute kidney issues when using these medications, but more evidence is needed to compare the risks across these different groups.
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Community-acquired pneumonia (CAP) poses a significant global health challenge, prompting exploration of innovative treatments. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of vitamin C supplementation in adults undergoing treatment for CAP. A comprehensive search of the MEDLINE, Embase, CINAHL, the Cochrane Central Register of Controlled Trials, and Clinical Trials.

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Chronic pain is a substantial health problem with a high prevalence of comorbid depression. To understand the link between chronic pain and depression, cognitive factors including pain catastrophising and pain self-efficacy have been theorised as significant contributing variables. There is relatively strong evidence that pain catastrophising mediates the relationship between pain severity and depression symptoms.

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The distribution of motion between the radiocarpal and midcarpal joints in scapholunate instability is poorly understood. This has potential implications in predicting degenerative changes and in selecting salvage procedures. We studied 19 healthy wrists and 19 wrists with scapholunate instability using dynamic computed tomography during wrist extension to flexion and ulnar to radial deviation.

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Maternal and perinatal outcomes in nulliparous women with a booking body mass index exceeding 50 kg/m.

Aust N Z J Obstet Gynaecol

December 2024

Department of Obstetrics and Gynaecology, Flinders Medical Centre, Adelaide, South Australia, Australia.

Article Synopsis
  • Women with a BMI over 50 kg/m have increased obstetric risks, with a study focusing on their maternal and perinatal outcomes revealing significant complications.
  • The study examined 48 nulliparous women, finding a high rate of interventions like inductions (68.8%) and emergency cesarean sections, especially as BMI increased.
  • Results indicate a mean BMI of 53.7 kg/m, with risks such as diabetes and hypertension prevalent, highlighting that a higher BMI is linked to poorer health outcomes during pregnancy.
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Background: Elder abuse often goes unreported and undetected. Older people may be ashamed, fearful, or otherwise reticent to disclose abuse, and many health providers are not confident in asking about it. In the No More Shame study, we will evaluate a co-designed, multi-component intervention that aims to improve health providers' recognition, response, and referral of elder abuse.

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Environmental conditions associated with initial northern expansion of anatomically modern humans.

Nat Commun

May 2024

Global Ecology | Partuyarta Ngadluku Wardli Kuu, College of Science and Engineering, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia.

Article Synopsis
  • Our ancestors’ ability to adapt their diets and migrate to better environments facilitated their rapid spread from Africa over 120,000 years ago.
  • The influence of environmental factors versus cultural aspects on this migration process remains uncertain.
  • A statistical analysis of archaeological and genetic data reveals that migration routes were primarily shaped by regional environmental conditions, despite the potential role of cultural influences on a smaller scale.
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