10,894 results match your criteria: "Flinders Medical Centre; School of Medicine[Affiliation]"
High-Sensitivity Cardiac Troponin T Reporting, Clinical Outcomes, and Health Care Resource Use.
JAMA Netw Open
October 2024
Department of Emergency Medicine, The Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
Article Synopsis
- Concerns exist about the clinical effectiveness and resource use related to high-sensitivity cardiac troponin assays (hs-cTnT), despite their recommendation in guidelines.
- This study aims to evaluate how reporting hs-cTnT at the lowest limit of quantification influences clinical outcomes compared to conventional reporting.
- Involving over 40,000 patients from South Australia, the study measures outcomes such as myocardial infarction rates, hospitalization length, and discharge rates before and after changes in hs-cTnT reporting practices.
"Such a different type of tiredness": people with brain tumour, their caregivers', and healthcare professionals' qualitative perceptions of cancer-related fatigue.
J Cancer Surviv
October 2024
Psycho-Oncology Cooperative Research Group, School of Psychology, Faculty of Science, The University of Sydney, Camperdown, Sydney, NSW, Australia.
Article Synopsis
- Cancer-related fatigue (CRF) is a prevalent symptom among individuals with primary brain tumors, but previous studies have largely relied on quantitative data, missing the depth of personal experiences.
- The research involved semi-structured interviews with patients, caregivers, and healthcare professionals, uncovering four key themes: the widespread nature of CRF, its significant impacts, the support provided, and self-management practices by patients.
- Findings reveal a profound lack of targeted information and resources for managing CRF in brain tumor patients, emphasizing the urgent need for specialized support and interventions.
Healthy from the Start: Co-Designing Sleep, Nutrition and Physical Activity Resources for Young Shiftworkers-Novel Implementation and Evaluation.
Health Expect
October 2024
Appleton Institute, CQUniversity, Wayville, South Australia, Australia.
Introduction: The increasing prevalence of shiftwork among young adults poses significant health risks, primarily due to its disruptive effects on sleep, nutrition and physical activity. Addressing these risks necessitates the development of tailored, evidence-based resources to support these key health behaviours. Participatory research approaches, engaging those with relevant lived experience (i.
View Article and Find Full Text PDFUnrecognised actionability for breast cancer risk variants identified in a national-level review of Australian familial cancer centres.
Eur J Hum Genet
December 2024
Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Article Synopsis
- Breast cancer continues to be a major global health issue, with increasing VUS complicating diagnosis in Australia’s healthcare system.
- This study examined VUS data from 11 familial cancer centers, revealing that 4% of variants might be reclassified as pathogenic and 80% as benign.
- Surveys indicated that there are challenges in VUS management due to limited resources, suggesting the need for routine reviews to improve patient care and communication between laboratories and cancer centers.
Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial.
Nat Commun
October 2024
Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Article Synopsis
- A study examined the effects of providing vascular imaging results on diet and cardiovascular disease risk factors in 240 participants aged 60-80 with abdominal aortic calcification.
- Participants were randomly assigned to receive (intervention group) or not receive (control group) their calcification results while both groups received educational resources.
- The results showed no significant changes in fruit and vegetable intake, but the intervention group had lower cholesterol levels and cardiovascular disease risk scores after 12 weeks compared to the control group.
Effect of CPAP therapy on blood pressure in patients with obstructive sleep apnoea: a worldwide individual patient data meta-analysis.
Eur Respir J
January 2025
Department of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Background: Obstructive sleep apnoea (OSA) is associated with hypertension, and OSA treatment can reduce systolic blood pressure (SBP) and diastolic blood pressure (DBP), but with a modest mean effect size and vast heterogeneity among studies. The aim of this individual patient data (IPD) meta-analysis was to understand which OSA phenotypes could benefit the most in terms of BP reduction.
Methods: A systematic review of randomised controlled trials that compared continuous positive airway pressure (CPAP) with either passive or active treatment was conducted.
Article Synopsis
- - Obesity is a long-term condition that often needs various treatments and increased intervention over time.
- - There was no common definition for recurrent weight gain and lack of adequate weight loss until the recent consensus from IFSO, which aims to standardize terminology for better data comparison.
- - The IFSO position statement offers guidance on managing weight regain after bariatric surgery, highlighting the importance of using these new definitions in future research and publications.
Treatment Targets and Strategies for Eating Disorders Recovery: A Delphi Consensus With Lived Experience, Carers, Researchers, and Clinicians.
Int J Eat Disord
December 2024
School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia.
Objective: Long-term recovery rates following eating disorders (EDs) treatment remain low. This might be partly due to a lack of agreement between key stakeholder groups, including people with lived experience, carers, clinicians, and researchers, regarding optimal therapeutic targets and strategies. We aimed to reach a consensus across these diverse groups on the most valued treatment targets and strategies for fostering ED recovery.
View Article and Find Full Text PDFPlatelet interaction and performance of antibacterial bioinspired nanostructures passivated with human plasma.
Mater Today Bio
December 2024
STEM, University of South Australia, Mawson Lakes, South Australia, 5095, Australia.
Article Synopsis
- The increasing ageing population necessitates better orthopedic implants to address issues like infection and inflammation affecting implant longevity.
- Researchers explored bioinspired nanostructured materials, specifically titanium alloy and plasma-sprayed titania, to enhance antibacterial properties and blood compatibility in complex environments.
- The study found that these nanostructured surfaces exhibited strong antibacterial effects and improved platelet healing responses compared to traditional materials, suggesting their potential in orthopedic applications.
Aggregatibacter is inversely associated with inflammatory mediators in sputa of patients with chronic airway diseases and reduces inflammation in vitro.
Respir Res
October 2024
Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.
Article Synopsis
- - The study explores the role of different bacteria in chronic airway disease (CAD), focusing on how they might influence inflammation in the lungs, particularly looking for anti-inflammatory species.
- - Using microbiome samples and inflammatory data from patients with CAD, researchers found that the genus Aggregatibacter was more common in patients with lower inflammation levels, linked to reduced inflammatory markers IL-8 and IL-1β.
- - Laboratory tests indicate that Aggregatibacter species have the potential to reduce inflammation in lung cells without harming their viability, suggesting a possible therapeutic role for these bacteria in managing CAD symptoms.
Methotrexate, blood pressure and arterial function in rheumatoid arthritis: study protocol.
Future Cardiol
November 2024
College of Medicine & Public Health, Flinders Health & Medical Research Institute, Flinders University, Adelaide, Australia.
This article discusses the rationale and design of the study "Methotrexate, blood pressure, and arterial function in rheumatoid arthritis". The recognition that immune activation and excess inflammation favor atherosclerosis has stimulated a significant body of research not only to identify new drugs targeting these pathways but also to repurpose (reposition) existing immunomodulatory medications as atheroprotective agents. Observational studies in patients with rheumatoid arthritis have reported that treatment with methotrexate, a traditional disease-modifying antirheumatic drug, is associated with a significantly lower risk of cardiovascular morbidity and mortality when compared with other disease-modifying antirheumatic drugs.
View Article and Find Full Text PDFQuality-of-life evaluation in hidradenitis suppurativa in Australia: Validation and outcomes of the HiSQOL questionnaire.
Australas J Dermatol
December 2024
The Skin Hospital Darlinghurst, Sydney, New South Wales, Australia.
Background: Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory disease with significant impact upon quality of life. Generic quality-of-life measures suffer from decreased face validity and content validity, leading to the development of disease-specific quality-of-life measures such as the Hidradenitis Suppurativa Quality of Life (HiSQOL) outcome measure. The aim of this study was to validate the use of the HiSQOL in the Australian population and evaluate the quality-of-life impact in HS patients in Australia.
View Article and Find Full Text PDFSexual health after breast cancer: a clinical practice review.
Ann Palliat Med
September 2024
Sunnybrook Health Sciences Centre, Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
Article Synopsis
- Breast cancer affects not only physical health but also the mental and sexual well-being of survivors, leading to issues like pain during sex and decreased sexual satisfaction.
- The literature currently identifies varying contributing factors to sexual health challenges, including physical symptoms and psychosocial stressors, yet there is a notable gap in research regarding the intersectionality of ethnicity, age, and socioeconomic status in these experiences.
- Recommendations suggest a shift towards a more holistic, patient-centered approach in survivorship care that prioritizes sexual health and comfort, moving beyond just managing the disease itself.
Comparative efficacy of intrathecal morphine and adductor canal block in the knee arthroplasty population: a retrospective multi-centre cohort study.
BMC Anesthesiol
October 2024
Department of Anesthesiology, Flinders Medical Centre, Flinders Drive, Bedford Park Adelaide, South Australia, 5042, Australia.
Article Synopsis
- The study investigated how different pain management techniques—intrathecal morphine (ITM), adductor canal block (ACB), and their combination—affect recovery after Total Knee Arthroplasty (TKA).
- It analyzed data from 1006 patients to assess pain levels, mobility times, and hospital stay lengths based on the type of analgesia received.
- Results showed that the combination of ITM and ACB led to better pain control, reduced opioid use, and faster mobilization compared to using either method alone.
Article Synopsis
- The study delves into the various health issues that affected Frida Kahlo and how these experiences shaped her personality.
- It utilizes a historico-medical approach to examine the relationship between Kahlo and her doctor, Dr. Leo Eloesser, emphasizing the significance of their bond in her treatment.
- The findings suggest that the connection between physician and patient extends beyond medical care, highlighting the importance of trust and emotional support in healthcare.
Reply to letter to the editor.
Aust Crit Care
November 2024
Allied Health & Human Performance, University of South Australia, Adelaide, SA, Australia. Electronic address:
In-hospital mortality is associated with observation-chart modifications.
Aust Crit Care
November 2024
Lyell McEwin Hospital, Elizabeth Vale SA 5112, Australia; Flinders University, Bedford Park SA 5042, Australia.
Comparison of awake respiratory control versus sleep obstructive sleep apnea endotypes.
J Appl Physiol (1985)
December 2024
Neuroscience Research Australia (2nd arm work performed), School of Medical Sciences, University of New South Wales, Randwick, New South Wales, Australia.
Article Synopsis
- Most research on precision medicine for obstructive sleep apnea (OSA) focuses on sleep parameters, but this study highlights the importance of wakefulness physiology measures for predicting OSA therapies.
- The study investigated the relationship between awake ventilatory control and OSA endotypes, analyzing data from a trial comparing morphine and placebo effects on OSA severity.
- Findings showed that awake chemosensitivity correlates with critical airway pressures and can predict changes in OSA severity when administered morphine, suggesting awake measures could enhance understanding of OSA physiology.
Cost-effective identification of Barrett's esophagus in the community: A first step towards screening.
J Gastroenterol Hepatol
December 2024
Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Background And Aim: The first step towards developing a screening strategy for Barrett's esophagus (BE) is the identification of individuals in the community. Currently available tools include endoscopy, less-invasive non-endoscopic devices, and non-invasive risk stratification models. We evaluated the cost of potential strategies for identification of BE as a first step towards screening.
View Article and Find Full Text PDFAn Adjustable Positivity Threshold for Non-invasive Screening Tests for Colorectal Neoplasms Can Improve Screening Program Effectiveness and Feasibility.
Dig Dis Sci
October 2024
Flinders Cancer Research, Flinders University, Bedford Park, Adelaide, SA, 5042, Australia.
Article Synopsis
- Two-step screening for colorectal cancer (CRC) begins with a fecal immunochemical test (FIT) to identify individuals who may need a follow-up colonoscopy based on their fecal hemoglobin concentration (f-Hb).
- The study emphasizes the need to adjust the f-Hb positivity threshold in order to optimize detection rates for colorectal neoplasia while managing the number of follow-up colonoscopies required. This balance impacts clinical accuracy, colonoscopy workload, and overall effectiveness in reducing CRC incidence and mortality.
- As non-invasive screening methods evolve, new biomarkers from various biological samples are being developed, employing machine learning for better predictive accuracy in identifying individuals at risk for CRC.
A cross-sectional study of associations between the C-sucrose breath test, the lactulose rhamnose assay, and growth in children at high risk of environmental enteropathy.
Am J Clin Nutr
December 2024
Rutgers Global Health Institute, Department of Biostatistics and Epidemiology, School of Public Health, Rutgers, the State University of New Jersey, New Brunswick, NJ, United States. Electronic address:
Article Synopsis
- Environmental enteropathy (EE) is a condition affecting children in low-resource settings due to exposure to enteric pathogens, and a new noninvasive breath test (C-SBT) to assess carbohydrate digestion was developed and validated.
- The study aimed to link the C-SBT results to the lactulose/rhamnose ratio (LR) and identify their relationship with child growth, as well as investigate connections with socio-economic factors, dietary diversity, and other EE biomarkers.
- Results indicated variability in C-SBT and LR measurements across different sites, with some associations found between child growth and test timing, but no significant links between C-SBT and LR or overall growth metrics were established.
Strategies and tactics to reduce the impact of healthcare on climate change: systematic review.
BMJ
October 2024
Centre for Healthcare Resilience and Implementation Science, Australian Institute of Health Innovation, Macquarie University, Sydney, 2109, Australia.
Article Synopsis
- * The review analyzed 33,737 publications, ultimately including 205 studies that explored various strategies to limit emissions in healthcare, with a focus on clinical practices, governance, waste management, and decarbonization efforts.
- * Key findings highlighted nine themes for emission reduction efforts, including changes in surgical practices, policy enactment, waste management, and minimizing transportation, among others.
Step-by-step: A clinical pathway for stepped care management of fear of cancer recurrence-results of a three-round online delphi consensus process with Australian health professionals and researchers.
J Cancer Surviv
October 2024
School of Psychology, Psycho-Oncology Cooperative Research Group, The University of Sydney, Sydney, NSW, Australia.
Article Synopsis
- Many cancer survivors worry about their cancer coming back, but healthcare providers often don’t help them with this fear.
- A group of Australian health experts worked together to create a plan for doctors to better understand and manage this fear in patients who had early-stage cancer.
- They found that most items in their plan were agreed upon by the majority, suggesting that regular screenings and conversations about this fear should be part of cancer care.
Retinal Function in Young Adults Following Topical Application of Levodopa to the Eye.
Transl Vis Sci Technol
October 2024
Centre for Research into Therapeutic Solutions, Faculty of Science and Technology, University of Canberra, Canberra, Australia.
Purpose: Levodopa has been investigated as a therapeutic solution for ocular disorders involving dysregulation of the dopaminergic system, especially in the context of myopia. However, given the critical role dopamine plays in normal vision, this phase I trial examined whether levodopa/carbidopa eye drops induce any regional changes in retinal structure and function.
Methods: Twenty-nine healthy male subjects 18 to 30 years of age were randomly assigned to receive either a low (1.
Background: Robust and accurate prediction of cardiovascular disease (CVD) risk facilitates early intervention to benefit patients. The intricate relationship between mental health disorders and CVD is widely recognized. However, existing models often overlook psychological factors, relying on a limited set of clinical and lifestyle parameters, or being developed on restricted population subsets.
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