2 results match your criteria: "Fischell Dept. of Bioengineering University of Maryland College Park MD.[Affiliation]"
For therapies targeting diseases of the gastrointestinal tract, we and others envision probiotic bacteria that synthesize and excrete biotherapeutics at disease sites. Toward this goal, we have engineered commensal E. coli that selectively synthesize and secrete a model biotherapeutic in the presence of nitric oxide (NO), an intestinal biomarker for Crohn's disease (CD).
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- MSC-derived extracellular vesicles (EVs) show promise as therapeutic agents, offering advantages like improved safety and stability compared to traditional cell therapies.
- Key findings reveal that as mesenchymal stem cells (MSCs) are passaged in culture, their production of EVs decreases, especially after the fourth passage, impacting their bioactivity.
- Adjustments in cell culture techniques, such as increasing the frequency of EV collection and lowering seeding density, can enhance EV production, highlighting the importance of optimizing these parameters for effective EV biomanufacturing.