Body roundness index as a predictor of all-cause and cardiovascular mortality in patients with diabetes and prediabetes.

Background: There are limited population-based studies examining the correlation between body roundness index (BRI) and mortality in diabetes and prediabetes patients.

Method: Our final analysis encompassed 15,848 patients with diabetes and prediabetes sourced from the National Health and Nutrition Examination Survey(NHANES) spanning from 2003 to 2018. Cox proportional hazards model and restricted cubic splines (RCS) were utilized to assess the correlation between BRI and both all-cause mortality and cardiovascular mortality.

Development and application of a comprehensive hospital pharmacy service assessment model using principal component analysis.

Background: The management of pharmacy services within healthcare institutions presents significant challenges, particularly in ensuring the rational use of medications. These challenges include managing complex medication regimens and ensuring patient safety amidst a growing number of drug interactions.

Objective: This study aimed to construct a hospital pharmacy service competence assessment model focused on the promoting the rational use of medications so as to enable hospitals to assess their pharmacy services more accurately and efficiently.

The receptor binding mechanism of mouse sPLA2 group IIE.

Secreted phospholipase A2s (sPLA2s) participate in physiological function by their enzyme and receptor binding activity. Muscle-type phospholipase A2 receptor (M-type PLA2R) is the sPLA2 binding protein with the highest affinity so far, and also inhibits the enzyme activity of sPLA2. There is species specificity and pH dependence for the binding of M-type PLA2R to sPLA2.

Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation (2024 edition).

Background: Minimally invasive surgeries are increasingly central to modern medicine, particularly in liver transplantation. These techniques, which offer reduced trauma, precise operations, minimal bleeding, and swift recovery, are, however, unevenly adopted across China. Only a limited number of centers routinely perform minimally invasive donor hepatectomies, indicating a significant imbalance in the development and application of these advanced procedures.

Bibliometric analysis of youth myocardial infarction research (1980-2023).

Introduction: Cardiovascular diseases include myocardial infarction, a high mortality disease. Myocardial infarction patients are becoming younger, typically defined as patients under 45 years of age. This study analyzes the relevant papers on myocardial infarction in youth in the Web of Science Core Collection (WoSCC) between 1980 and 2023.

Realizing real-time optical molecular imaging in peripheral nerve tissue via Rhodamine B.

Background: Iatrogenic nerve injury is a consequential complication during surgery. Thus, real-time imaging of peripheral nerve (PN) possesses significant clinical implications. In recent years, the rapid advancements in optical molecular imaging (OMI) technology have provided essential technical foundations for the implementation of PN fluorescence imaging.

Advances in MRI Research for First-Episode Schizophrenia: A Selective Review and NSFC-Funded Analysis.

Background And Hypotheses: The causes of schizophrenia remain unclear, and research has been hindered by the lack of quantifiable standards. However, magnetic resonance imaging (MRI) is addressing these challenges, revealing critical neurobiological details and emphasizing its importance in both evaluation and treatment.

Study Design: First, we reviewed the progress of research on structural MRI (sMRI), functional MRI (fMRI), multimodal/multiomics analysis, artificial intelligence, and neuromodulation in first-episode schizophrenia (FES) over the past 5 years.

[Research progress of long-term right ventricular dysfunction after acute pulmonary embolism].

Acute pulmonary thromboembolism (PTE) is a disease with a high mortality rate. Although most patients can recover after timely treatment and intervention during the acute phase, some patients may still have long-term right ventricular dysfunction (RVD), which affects the quality of life and long-term prognosis. A comprehensive understanding of the factors, diagnosis and treatment and management of persistent RVD after acute PTE is crucial for optimizing long-term management for PTE patients and improving their prognosis.

DUPAN-2 in pancreatic cancer: Systematic review and meta-analysis.

Objective: Pancreatic cancer (PC) is a highly aggressive malignancy with poor prognosis and high mortality rate. Identifying reliable biomarkers for the early diagnosis and treatment is urgently needed. This study aims to comprehensively evaluate the diagnostic and prognostic value of DUPAN-2 in PC through a meta-analysis.

Single-cell transcriptome profiling of mA regulator-mediated methylation modification patterns in elderly acute myeloid leukemia patients.

Millions of people worldwide die of acute myeloid leukaemia (AML) each year. Although N6-methyladenosine (mA) modification has been reported to regulate the pathogenicity of AML, the mechanisms by which mA induces dysfunctional hematopoietic differentiation in elderly AML patients remain elusive. This study elucidates the mechanisms of the mA landscape and the specific roles of mA regulators in hematopoietic cells of elderly AML patients.

Effects of polyphenol-rich seed foods on lipid and inflammatory markers in patients with coronary heart disease: a systematic review.

Background: Coronary heart disease (CHD) is a prevalent cardiovascular condition, with its incidence and mortality rates steadily rising over time, posing a significant threat to human health. Studies have indicated that polyphenols exhibit a certain degree of protective effect against coronary heart disease. However, the findings regarding the impact of polyphenol-rich seed foods on patients with CHD have yielded inconsistent results.

Predictive nomogram for ischemic stroke risk in clear cell renal cell carcinoma patients.

Clear cell renal cell carcinoma (ccRCC) and ischemic stroke are critical global health challenges with a notable association. This study explores the correlation between tumor-related factors and ischemic stroke risk, aiming to construct a predictive nomogram model for ischemic stroke in ccRCC patients. We retrospectively analyzed data from ccRCC patients who underwent nephrectomy at the First Hospital of Shanxi Medical University between January 1, 2013, and May 31, 2022.

miRNAs in HCC, pathogenesis, and targets.

Liver cancer is the third leading cause of cancer-related mortality worldwide. HCC, the most common type of primary liver cancer, is driven by complex genetic, epigenetic, and environmental factors. MicroRNAs, a class of naturally occurring small noncoding RNAs, play crucial roles in HCC by simultaneously modulating the expression of multiple genes in a fine-tuning manner.

Application of machine learning in acute upper gastrointestinal bleeding: bibliometric analysis.

Background: In the past decade, the application of machine learning (ML) in the clinical management of acute upper gastrointestinal bleeding (AUGIB) has received much attention and has become a hot research topic. However, no scientometric report has systematically summarized and outlined the research progress in this field.

Objective: This study aims to utilize bibliometric analysis methods to delve into the applications of machine learning in AUGIB and the collaborative network behind it over the past decade.

The Predictive Value of Absolute Lymphocyte Count and T Cell Subpopulations for Sepsis Prognosis.

Background: Sepsis causes substantial morbidity and mortality and constitutes a major public health problem. In patients with sepsis, immunosuppression is associated with poor prognosis, and immune monitoring during the early stages has prognostic value. This study aims to explore immunologic parameters associated with sepsis prognosis, potentially identifying patients who may benefit from immunotherapy, improving intensive care survival.

Lentivirus-Mediated Missense Mutation in HtrA1 Leads to Activation of the TGF-β/Smads Pathway and Increased Apoptosis of Mouse Brain Microvascular Endothelial Cells via the Oxidative Stress Pathway.

Background: The aim of this study was to investigate the possible molecular mechanisms underlying cerebral small vessel disease caused by a missense mutation in the high-temperature serine peptidase A1 gene, (NM_002775.4, Exon4, c.905G>A, p.

Impact of cognitive impairment on heart failure prognosis: insights into central nervous system mechanism.

Background: Epidemiological studies have indicated that patients with heart failure (HF) who experience cognitive impairment (CI) have a poor prognosis. While poor self-management and compliance are suggested as contributing factors, they do not fully explain the underlying mechanisms of high risk of cardiac events in HF patients with CI. Given the interconnectedness of CI and the autonomic nervous system (ANS), both regulated by the central nervous system, this study investigated the relationship among cognitive function, metabolism in ANS-related brain regions, and major arrhythmic events (MAEs) in patients with HF with reduced ejection fraction (HFrEF).