Fusing Artificial Intelligence and Machine Learning for Anti-Cancer Drug Discovery.

The integration of artificial intelligence (AI) and machine learning (ML) in modern oncology is rapidly transforming cancer drug discovery and development [...

Influence of Harvesting Stage on Phytochemical Composition, Antioxidant, and Antidiabetic Activity of Immature L. Pulp from Béni Mellal-Khénifra Region, Morocco: In Silico, In Vitro, and In Vivo Approaches.

L. is a medicinal plant that has long been used in traditional Moroccan medicine to treat many diseases. This study aimed to assess the impact of the stages of the immature phase of carob pulp (M1, M2, M3, M4, and M5) on phytochemical composition, antioxidant activity, and antidiabetic activity of L.

The Promise of Artificial Intelligence in Reshaping Anticancer Drug Development.

While the concept of artificial intelligence (AI) has deep historical roots, its development as a formal scientific field was initiated in the 1950s by Newell and Simon, who invented a "thinking machine" called the Logic Theorist [...

Primary Anorectal Mucosal Melanoma: A Unique Presentation of Mucosal Melanomas.

Anorectal mucosal melanoma (AMM) is a rare and highly aggressive malignancy. It frequently presents with nonspecific symptoms, often resulting in delayed diagnosis and poor prognosis. This report describes the case of a 60-year-old male who presented with a painful para-anal papule that progressed to a fistula.

The Oncologic Value of Transoral Resection in Early-Stage Laryngeal Squamous Cell Carcinoma of the Glottis: A Retrospective Study.

Background and objective The treatment of early-stage laryngeal glottic cancer involves surgery or radiotherapy, and both have similar survival rates. However, discrepancies between systematic reviews in the literature point towards the continuous need for more data. In this study, we aimed to investigate the oncologic value of surgery at an ENT university department of a tertiary hospital in Greece.

In vitro and computational investigation of antioxidant and anticancer properties of Streptomyces coeruleofuscus SCJ extract on MDA-MB-468 triple-negative breast cancer cells.

This study aimed to explore the antioxidant potential of the ethyl acetate extract of Streptomyces coeruleofuscus SCJ strain, along with its inhibitory effects on the triple-negative human breast carcinoma cell line (MDA-MB-468). The ethyl acetate extract's total phenolic and flavonoid contents were quantified, and its antioxidant activity was investigated using DPPH (1,1-Diphenyl-2-picrylhydrazyl), ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid), and FRAP (Ferric Reducing Antioxidant Power) assays. Furthermore, the cytotoxic effect of the organic extract from Streptomyces coeruleofuscus SCJ on MDA-MB-468 cancer cells was assessed via the crystal violet assay.

Noise filter using a periodic system of dual Helmholtz resonators.

This study investigates noise reduction using a periodic arrangement of dual Helmholtz resonators and explores the introduction of defects within this periodic structure. The transfer matrix method was employed to carry out theoretical research. The computations of the interface response function approach results are verified, and consistent outcomes are demonstrated.

Smart conducting polymer innovations for sustainable and safe food packaging technologies.

Biofilm formation on food packaging surfaces is a major issue in the industry, as it leads to contamination, reduces shelf life, and poses risks to human health. To mitigate these effects, developing smart coatings that can actively sense and combat microbial growth has become a critical research focus. This study is motivated by the need for intelligent packaging solutions that integrate antimicrobial agents and sensors for real-time contamination detection.

Isolated right atriopathy and microreentry atrial tachycardia in a young male.

Atrial tachycardias in young patients may portend ominous prognosis. We present the case of a 17-year-old male with atrial tachycardia and extensive low-voltage areas in the right atrium, its treatment, and discuss potential diagnoses.

Mesonephric carcinoma of the cervix associated with ovarian serous carcinoma: a case report.

Malignant mesonephric tumor of the uterine cervix is an extremely uncommon subtype of cervical adenocarcinoma with rare, documented cases in the literature. In this report, we present a case of 58 yo, with abdominal pain and ascites that was found to have a synchronous presence of a mesonephric adenocarcinoma of the cervix and advanced serous ovarian carcinoma on the surgical specimen. The histological study identified a tumor showing a mix of tubular and ductal growth patterns.

Management of Proximal Humerus Fracture With Concurrent Axillary Artery Injury Using a Saphenous Vein Graft and Reverse Shoulder Prosthesis: A Case Report.

This case report details the management of a 60-year-old male who sustained a complex proximal humerus fracture with an axillary artery injury following a fall. Initial assessment revealed a fractured humeral head and complete occlusion of the axillary artery, which was repaired using a saphenous vein graft. Subsequently, the patient underwent reverse shoulder arthroplasty (RTSA) after the limb stabilized.

Isolated Transitory Radial Nerve Palsy as a Complication After Luxatio Erecta Humeri: A Case Report.

Shoulder dislocations are common, with luxatio erecta humeri (LEH) being a rare variant. This report discusses a case of isolated transitory radial nerve palsy following LEH, which occurred after a high-energy motorcycle accident. Neurological examination revealed radial nerve involvement.

N-alkylation of amines for the synthesis of potential antiviral agents: A structural modification approach.

The threat of emerging viral outbreaks has increased the need for fast and effective development of therapeutics against emerging pathogens. One approach is to modify the structure of existing therapeutic agents to achieve the desired antiviral properties. Here, we attempted to synthesize a new antiviral compound by modifying the structure of chloroquine using the of the primary amine (N1,N1-diethylpentane-1,4-diamine) that is used in chloroquine synthesis.

Nutritional Composition and Effect of Loquat Fruit ( L. var. ) on Lipid Metabolism and Liver Steatosis in High-Fat High-Sucrose Diet-Fed Mice.

Loquat ( L.) is a popular fruit known for its sweet and slightly tangy flavor, which is widely consumed both fresh and in various processed forms. This study aimed to analyze the biochemical composition of loquat juice and investigate its metabolic benefits in mice fed a high-fat/high-sucrose diet (HFSD).

Opportunistic Infections in HIV-Infected Children on Treatment in Southern Morocco: A 12-Years Retrospective Follow-up Study.

Background: Human immunodeficiency virus (HIV) infection in children is a significant public health concern, increasing the risk of infant mortality. Immunodeficiency caused by HIV favors the development of opportunistic infections (OIs), which are responsible for over 90% of HIV-related deaths. This study seeks to determine the primary OIs in children with HIV followed at the Hassan II Regional Hospital Center in Sous Massa, during the period from 2012 to 2023.

Lung cancer masquerading as COVID-19 in a young non-smoking woman: case report.

Introduction And Importance: The clinical and radiological similarities between COVID-19 and lung cancer pose diagnostic challenges, particularly in young, non-smoking individuals. Ground glass opacities (GGO) on imaging, often associated with COVID-19, can also indicate lung cancer. Distinguishing between these conditions is crucial but complex, requiring a systematic approach.

Antioxidant Effects of Cactus Seed Oil against Iron-Induced Oxidative Stress in Mouse Liver, Brain and Kidney.

In recent times, exploring the protective potential of medicinal plants has attracted increasing attention. To fight reactive oxygen species (ROS), which are key players in hepatic, cerebral and renal diseases, scientists have directed their efforts towards identifying novel compounds with antioxidant effects. Due to its unique composition, significant attention has been given to Cactus Seed Oil (CSO).

Synthesis and Antiproliferative Effect of 3,4,5-Trimethoxylated Chalcones on Colorectal and Prostatic Cancer Cells.

In the context of designing innovative anticancer agents, the synthesis of a series of chalcones bearing a 3,4,5-trimethoxylated A ring and a variety of B rings, including phenols and original heterocycles such as chromones, was conducted. For this end, Claisen-Schmidt condensation was performed in basic or acidic conditions between the common starting material 3,4,5-trimethoxyacetophenone and appropriate aldehydes; this allowed the recovery of fifteen chalcones in moderate-good yields. The synthesized compounds were screened for their antiproliferative activity against colorectal and prostatic cancer cells, using a colorimetric MTT assay.

YAP/TAZ Signaling in the Pathobiology of Pulmonary Fibrosis.

Pulmonary fibrosis (PF) is a severe, irreversible lung disease characterized by progressive scarring, with idiopathic pulmonary fibrosis (IPF) being the most prevalent form. IPF's pathogenesis involves repetitive lung epithelial injury leading to fibroblast activation and excessive extracellular matrix (ECM) deposition. The prognosis for IPF is poor, with limited therapeutic options like nintedanib and pirfenidone offering only modest benefits.

Ethnobotanical survey and scientific validation of liver-healing plants in northeastern Morocco.

Introduction: Liver diseases represent a significant global health challenge, with primary causes including excessive alcohol consumption, infections, chemotherapy, and autoimmune disorders. Medicinal plants, due to their natural bioactive compounds, hold promise for developing effective treatments and preventive measures against liver ailments. This study aimed to document the use of herbal remedies in northeastern Morocco for liver diseases and correlate these uses with scientific evidence through a bibliometric analysis.

Assessment of mental well-being and psychological distress in Moroccan breast cancer patients.

Unlabelled: The quality of life of breast cancer patients is strongly affected by physical pain, psychological distress, and uncertainty about vital prognosis.

Objective: To assess breast cancer patients' mental well-being and level of psychological distress at the Mohammed VI University Hospital in Marrakech.

Methods: Cross-sectional study carried out from April to December 2023 at the Mohammed VI University Hospital of Marrakech.

Digital health for cancer symptom management in palliative medicine: systematic review.

Background: Digital health technologies (DHTs) play a crucial role in symptom management, particularly in palliative care, by providing patients with accessible tools to monitor and manage their symptoms effectively. The aim of this systematic review was to examine and synthesise the scientific literature on DHTs for symptom management in palliative oncology care.

Methods: A systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for systematic reviews and meta-analyses from 2 June to 20 June 2024.