Self-Assessment of Psychosocial Care Proficiency among Nurses and Oncologists at the Mohammed VI University Hospital Center (Morocco).

 In Morocco, cancer is a disease with a concerning incidence to the point that patients are diagnosed at advanced stages. As a result, patient care requires a holistic approach, integrating medical treatment and appropriate psychosocial support to improve their well-being. This study aimed to evaluate the psychosocial care competencies of oncology healthcare professionals at the Mohammed VI University Hospital Center (CHU) in Marrakech.

Atriplex halimus: Phytochemical Insights, Traditional Applications, and Pharmacological Promises.

Medicinal and aromatic plants are used in traditional medicine due to their diverse bioactive chemicals, Atriplex halimus is a saltbush that has an extensive background in traditional medicine giving it a strong argument for further ethnopharmacological research. We aimed in this comprehensive review by using different databases as to illustrate the phytochemical composition, the traditional uses, and the pharmacological properties of A. halimus.

Antidiabetic potential of aqueous extract: insights into pancreatic lipase inhibition, antioxidant activity, antiglycation at multiple stages and anti-inflammatory effects.

Background: With the increasing global prevalence of type 2 diabetes (T2D) and obesity, there is a pressing need for novel therapeutic interventions. a medicinal plant traditionally used for various ailments, holds promise as a potential agent for T2D management, particularly in Morocco, where it is commonly used to treat diabetes. This study aims to evaluate the pharmacological potential of aqueous extract (AqLs) by assessing its lipase inhibition antioxidant and anti-inflammatory activities, identifying phenolic compounds, and examining its efficacy in reducing diabetic complications.

Electronic patient-reported outcome measures (ePROs) as tools for assessing health-related quality of life (HRQoL) in women with gynecologic and breast cancers: a systematic review.

Objectives: To provide a comprehensive review of the use of electronic patient-reported outcomes measures (ePROs) as digital health tools to assess health-related quality of life (HRQoL) in women with breast, ovarian, cervical, and endometrial cancers.

Methods: A systematic review was conducted to identify studies that used ePROs to evaluate HRQoL in women diagnosed with breast and gynecological cancers. The review followed the 2020 update of the PRISMA guidelines and a pre-registered protocol in PROSPERO (CRD42024516737).

Governance of healthcare quality: exploring the relationships between hospital board performance and healthcare quality outcomes.

Purpose: This paper aims to contribute to the existing literature in the field of hospital governance by exploring the relationship between the attributes and performance of hospital boards and hospital performance in terms of quality of healthcare.

Design/methodology/approach: A survey of board performance in public hospitals in Morocco was carried out, in which we surveyed all board members of the 13 hospitals in the Casablanca-Settat region. A total of 82 members responded (82% response rate) to the previously adapted and validated self-evaluation questionnaire on board self-assessment questionnaire (BSAQ) board member performance.

Immunohistochemical-Based Molecular Subtypes of Female Breast Cancer: A Retrospective Cross-Sectional Study at Cheikh Khalifa Hospital in Casablanca, Morocco.

Introduction: Breast cancer is a major public health concern worldwide and the most prevalent form of cancer in Morocco. This study aimed to describe the histological and immunohistochemical profiles of breast cancer in women admitted to Cheikh Khalifa Hospital in Casablanca, Morocco.

Methods: This is a retrospective cross-sectional study.

In vitro antimicrobial and antioxidant activities of bioactive compounds extracted from Streptomyces africanus strain E2 isolated from Moroccan soil.

This study aimed to isolate Streptomyces sp. from Moroccan terrestrial ecosystems and identify bioactive compounds through GC-MS analysis. Antimicrobial activity was assessed against various pathogenic microorganisms including Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922 and Candida albicans ATCC 60193, and multi-drug resistant strains comprising Listeria monocytogenes, Klebsiella pneumoniae 19K 929, Proteus sp.

Synthesis of New Pyrazolo[3,4-]pyrimidine Derivatives: NMR Spectroscopic Characterization, X-Ray, Hirshfeld Surface Analysis, DFT, Molecular Docking, and Antiproliferative Activity Investigations.

Four new pyrazolo[3,4-]pyrimidines (-) were successfully synthesized in good relative yields by reacting 3-methyl-1-phenyl-1H-pyrazolo[3,4-]pyrimidin-4-ol with various alkylating agents (methyl iodide, propargyl bromide, and phenacyl bromide) at room temperature in DMF solvent, employing liquid-solid phase transfer catalysis. The - structures were elucidated using NMR spectroscopy and X-ray diffraction. Intermolecular interactions in - were analyzed via Hirshfeld surface analysis and 2D fingerprint plots.

Seeing the Future of Lung Cancer Vaccination.

It has been nearly fifteen years since the Food and Drug Administration (FDA) approved the first therapeutic cancer vaccine for solid tumors, namely Sipuleucel-T (Provenge), marking a significant milestone in the treatment of metastatic castration-resistant prostate cancer [...

State of the Art and New Perspectives in Lung Cancer Therapeutics.

Cisplatin became a first-line chemotherapy regimen for lung cancer in the mid-1980s, marking a pivotal advance in lung cancer treatment [...

Carrier frequency and molecular basis of hemoglobinopathies among blood donors in eastern Morocco: Implications for blood donation and genetic diagnosis.

Background: Hemoglobinopathies represent the most commonly inherited autosomal recessive blood disorders in the world. The aim of this study was to determine the carrier frequency and molecular basis of hemoglobinopathies among blood donors in eastern Morocco. This is the first study of its kind for this country.

Intradiploic epidermoid cyst in the skull: Case report and systematic review.

Intradiploic epidermoid cysts are rare, benign tumors, accounting for less than 1% of all intracranial tumors. Due to their scarcity, we are reporting a case of an intradiploic epidermoid cyst and reviewing several similar cases in the literature to provide a better description of this tumor and analyze its clinical and radiological features. We conducted a search on the PubMed database for studies published between January 2010 and February 2023, including studies of nontraumatic and noniatrogenic calvarial cysts.

Can Primary Knee Tuberculosis Simulate the Clinical and Radiological Profile of Pigmented Villonodular Synovitis?

When faced with clinical and radiological findings suggestive of villonodular synovitis, tuberculosis is not often considered a differential diagnosis, especially when the patient is not a known tuberculosis carrier. In this paper, we present an exceptional case of a patient who had a tumefaction (measuring 17 cm in length) in the anterointernal region of her left knee, with a clinical and radiological picture in favor of villonodular synovitis. However, after tumor resection, the anatomopathological study of the surgical specimen came back in favor of a tuberculous lesion.

Granulomatous Colitis Due to Hermansky-Pudlak Syndrome.

Hermansky-Pudlak syndrome (HPS) is a rare genetic disorder characterized by oculocutaneous albinism, bleeding diathesis, and multiorgan involvement. Granulomatous enterocolitis may occur in a subset of patients. Distinguishing HPS from other diseases such as Crohn's disease can be challenging, and managing HPS-associated colitis is complex.

Evaluation of Phytochemical Content and In Vitro Antioxidant Activities of L. Leaves Extracts, a Medicinal Plant From the Beni-Snassen Forest (Eastern Region of Morocco).

A medicinal plant from the Beni-Snassen Forest in the eastern region of Morocco has been studied. This scientific research was carried out to measure the content of essential phytochemical constituents and their antioxidant capacities from the hydromethanolic extract of leaves of L. located on sites at varying levels of altitudes.

Ethical climate and turnover intention among nurses: A scoping review.

Introduction: Nursing shortages and turnover pose significant challenges for health organizations worldwide, driven by various organizational and individual factors. Ethical climate has emerged as a critical aspect influencing nurses' well-being and retention within healthcare settings, reflecting organizational practices with moral implications. Understanding the relationship between ethical climate and turnover intention among nurses is paramount for practitioners, managers, and policymakers.

Bilateral knee pigmented villonodular synovitis in a young adult: Radiologic diagnosis and surgical approach.

Pigmented villonodular synovitis is a rare proliferative disorder of the synovial joints, characterized by synovial thickening and hemosiderin deposition. It predominantly affects the knee joint, with bilateral involvement being exceedingly rare. We present a case of diffuse bilateral pigmented villonodular synovitis in a 20-year-old female, initially presenting with left knee pain and swelling, diagnosed via MRI.

Metastatic Sarcomatoid Carcinoma of the Larynx: A Case Report.

Laryngeal spindle cell carcinoma (SpCC) is a unique and very aggressive form of laryngeal cancer. This neoplasm, consisting of malignant epithelial and mesenchymal elements, presents major diagnostic challenges, and there is a lack of conventional therapeutic approaches due to its rarity. This report describes a case of a 53-year-old female who experienced persistent difficulty speaking and a dry cough after contracting coronavirus disease 2019 (COVID-19).

Toxicological assessment of the aqueous extract of Juniperus oxycedrus L. on acute and subacute toxicities in rats.

Juniperus oxycedrus L. (J. oxycedrus) has a rich historical background in herbal remedies to treating digestive system abnormalities.