8 results match your criteria: "First People's Hospital of Shanghai Affiliated to Shanghai Jiaotong University[Affiliation]"
Exendin-4 protects retinal cells from early diabetes in Goto-Kakizaki rats by increasing the Bcl-2/Bax and Bcl-xL/Bax ratios and reducing reactive gliosis.
Mol Vis
June 2015
Department of Ophthalmology, Huashan Hospital Affiliated to Fudan University, Shanghai, China.
Purpose: Exendin-4 (E4), a long-acting agonist of the hormone glucagon-like peptide 1 receptor (GLP-1R), is administered to treat type II diabetes in the clinical setting and also shows a neuroprotective effect. Our previous studies demonstrated its protective effect in early experimental diabetic retinopathy (DR), but the molecular and cellular mechanisms are largely unknown. This study aimed to investigate the protective mechanism of a GLP-1R agonist E4 against early DR in Goto-Kakizaki (GK) rats.
View Article and Find Full Text PDFDendritic cells pulsed with leukemia cell-derived exosomes more efficiently induce antileukemic immunities.
PLoS One
May 2015
Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Dendritic cells (DCs) and tumor cell-derived exosomes have been used to develop antitumor vaccines. However, the biological properties and antileukemic effects of leukemia cell-derived exosomes (LEXs) are not well described. In this study, the biological properties and induction of antileukemic immunity of LEXs were investigated using transmission electron microscopy, western blot analysis, cytotoxicity assays, and animal studies.
View Article and Find Full Text PDFMacular pigment optical density and its relationship with refractive status and foveal thickness in Chinese school-aged children.
Curr Eye Res
January 2013
Department of Ophthalmology, First People's Hospital of Shanghai Affiliated to Shanghai Jiaotong University, Shanghai, China.
Purpose: To investigate macular pigment optical density (MPOD) and its relationship with refractive status and foveal thickness in Chinese school-aged children.
Methods: Ninety-four healthy Chinese children, 6 to 12 years old, were recruited to the study. MPOD was measured with a heterochromatic flicker photometer (HFP), and foveal thickness, including both minimum and central foveal thicknesses (MFT and CFT, respectively), were measured by optical coherence tomography (OCT) with fast macular map scan.
Time course of Q value after myopic laser-assisted in situ keratomileusis.
Chin Med Sci J
September 2011
Department of Ophthalmology, First People's Hospital of Shanghai Affiliated to Shanghai Jiaotong University, Shanghai 200080, China.
Objective: To assess the time course of Q value after myopic laser-assisted in situ keratomileusis (LASIK) and preliminarily evaluate the determinants of the difference of Q value between before and after LASIK.
Methods: We performed a retrospective, longitudinal investigation on patients undergoing wavefront optimized LASIK therapy for emmetropization. A total of 418 eyes from 222 cases were examined preoperatively, and partly followed up at one week (172 eyes), one month (134 eyes) and three months (51 eyes) after surgery.
Macular measurements using optical coherence tomography in healthy Chinese school age children.
Invest Ophthalmol Vis Sci
August 2011
Department of Ophthalmology, First People's Hospital of Shanghai Affiliated to Shanghai Jiaotong University, Shanghai, China.
Article Synopsis
- The study evaluated macular thickness and volume in a sample of Chinese primary school children using optical coherence tomography (OCT) and examined associations with age, sex, spherical equivalent refraction, body mass index, and intraocular pressure.
- A total of 806 healthy children were examined, and results indicated that average foveal minimum thickness was 140.0 μm, with significant differences in macular measurements between boys and girls.
- The findings suggest that macular thickness and volume vary based on sex and refraction but are not influenced by age and intraocular pressure, highlighting the importance of these parameters for diagnosing macular diseases in children.
U83836E inhibits retinal neurodegeneration in early-stage streptozotocin-induced diabetic rats.
Ophthalmic Res
October 2011
Department of Ophthalmology, First People's Hospital of Shanghai Affiliated to Shanghai Jiaotong University, Shanghai, China.
Oxidative stress plays a role in the pathogenesis of neurodegeneration in diabetic retinopathy (DR). However, whether an excellent reactive oxygen species scavenger, U83836E, inhibits the neurodegeneration in DR remains uncertain. This study is aimed at clarifying the effects of U83836E on DR.
View Article and Find Full Text PDFImprovement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha.
Diabetes
September 2010
Department of Ophthalmology, First People’s Hospital of Shanghai Affiliated to Shanghai Jiaotong University, Shanghai, China.
Article Synopsis
- Mitochondrial reactive oxygen species (ROS) contribute to the progression of diabetic retinopathy (DR), and the study investigates whether simvastatin can reduce ROS production linked to diabetes-induced retinal damage.
- Diabetic rats were given simvastatin for 24 weeks, and experiments were conducted on retinal cells to measure various biological markers and effects, including ROS levels and mitochondrial function.
- Results showed that simvastatin improved mitochondrial health, lowered ROS production, and diminished harmful factors like VEGF and p38 MAPK activity, suggesting a protective role against retinal damage in diabetes through a mechanism involving PGC-1alpha.
[Polyaxial locking plate for the treatment of tibial plateau fractures].
Zhongguo Gu Shang
March 2009
Department of Orthopaedics, Baoshan Branch of the First People's Hospital of Shanghai Affiliated to Shanghai Jiaotong University, Shanghai 200940, China.