397 results match your criteria: "First People's Hospital of Kunshan[Affiliation]"
Front Med (Lausanne)
December 2024
Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Jiangsu, China.
Background: The relationship between diabetes mellitus (DM) and bone mineral density (BMD) in patients with osteoporotic fractures (OPFs) remains complex and heterogeneous, specifically between the genders. This study aimed to explore the association between diabetes status and trochanteric BMD in a cohort of patients with OPFs and elucidate the differences between male and female patients.
Methods: This retrospective analysis was performed on 710 admitted patients aged 50 years or older with OPFs.
Front Immunol
December 2024
Department of Clinical Laboratory, The First People's Hospital of Kunshan, Kunshan, Jiangsu, China.
Outer membrane vesicles (OMVs) and exosomes are essential mediators of host-pathogen interactions. Elucidating their mechanisms of action offers valuable insights into diagnosing and treating infectious diseases and cancers. However, the specific interactions of () with host cells via OMVs and exosomes in modulating host immune responses have not been thoroughly investigated.
View Article and Find Full Text PDFAnn Med
December 2025
Department of Emergency, Changzhou No.2 People's Hospital, Changzhou City, Jiangsu Province, China.
Objective: This study aimed to investigate the prognostic impact of completing 30 mL/kg fluid resuscitation within 1 h in elderly septic shock patients.
Methods: This was a multicenter prospective observational cohort study. We applied logistic regression to assess the impact of completing 30 mL/kg fluid resuscitation within 1 h on respiratory support escalation including new-onset mechanical ventilation, bilevel positive airway pressure (BiPAP), and high-flow nasal cannula (HFNC) as well as heart failure (HF).
Front Med (Lausanne)
December 2024
Department of Emergency Medicine, The First People's Hospital of Kunshan, Kunshan, China.
Traumatic Renal Artery Thrombosis (TRAT) is an uncommon condition characterized by a low clinical incidence and a lack of specific symptoms, making it highly susceptible to being overlooked or misdiagnosed. This retrospective analysis aims to review the diagnostic and therapeutic approaches applied to a TRAT patient who received successful treatment in the Emergency Medicine Department of the First People's Hospital of Kunshan. The objective is to enhance clinicians' comprehension of TRAT, promote early diagnosis and intervention, and ultimately improve patient outcomes.
View Article and Find Full Text PDFBMC Geriatr
December 2024
Global Health Research Center, Duke Kunshan University, No. 8 Duke Avenue, Kunshan, Jiangsu Province, 215316, China.
Background: Understanding and promoting healthy aging are increasingly important as China transitions into an aging society. Our study examines the challenges and opportunities faced by the older adults in urban areas regarding social engagement, potentially informing the development of effective, context-sensitive interventions and policies.
Methods: The study is based on in-depth interviews with 30 participants from a Northern city in Mainland China regarding their daily lives, attitudes towards and subjective experiences of aging, and involvement in social activities.
Medicine (Baltimore)
December 2024
Department of Cardiology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, China.
Research suggests that cathepsins, due to their extensive mechanisms of action, may play a crucial role in cardiomyopathies. However, further studies are necessary to establish causality. This study aims to investigate the causal relationship between cathepsins and various types of cardiomyopathies.
View Article and Find Full Text PDFDiagn Microbiol Infect Dis
December 2024
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215000, China. Electronic address:
This study aims to investigate the predictive value of platelet distribution width (PDW) in patients with influenza A virus (IAV) infection. The clinical data of 105 IAV-infected patients was collected and analyzed. We found that creatine kinase (CK), Acute Physiology and Chronic Health Evaluation (APACHE) II score, PDW, and red blood cell distribution width (RDW) were independent risk factors for acute respiratory distress syndrome (ARDS) development.
View Article and Find Full Text PDFClin Transl Gastroenterol
December 2024
Department of Gastroenterology, The First People's Hospital of Kunshan, Kunshan 215300, China.
Introduction: Helicobacter pylori (HP) infection is prevalent worldwide and contributes to various gastrointestinal diseases. Eradication therapy is crucial in managing HP infection, but antibiotic resistance has led to refractory cases, complicating treatment outcomes and increasing the risk of adverse events.
Objectives: This study aimed to evaluate the effectiveness of a multidisciplinary approach, termed HP Multidisciplinary Team (MDT) Clinic, in improving eradication rates and safety in patients with refractory HP infection.
Cancer Sci
December 2024
Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Cancer-associated fibroblasts (CAFs) are essential players in the tumor microenvironment (TME) due to their roles in facilitating tumor progression and metastasis. It is worth noting that the high-metastatic hepatocellular carcinoma (HCC) cell-derived exosomes have exhibited the ability to transform normal fibroblasts into CAFs, which further fosters the lung metastasis of low-metastatic HCC cells. Yet, the mechanisms underlying this tumor exosome-induced metastatic niche formation are poorly explored.
View Article and Find Full Text PDFZhonghua Zhong Liu Za Zhi
November 2024
Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing210008, China.
To observe and evaluate the clinical efficacy and safety of albumin-bound paclitaxel as first-line treatment for patients with advanced pancreatic cancer in China, and to explore the prognosis-related molecules in pancreatic cancer based on next-generation sequencing (NGS) of tumor tissues. From December 2018 to December 2020, patients with locally advanced or metastatic pancreatic cancer were recruited to accept albumin-bound paclitaxel as first-line treatment in the oncology departments of 24 hospitals in East China. The primary endpoints were overall survival (OS) and treatment related adverse events, and the secondary endpoint was progression-free survival (PFS).
View Article and Find Full Text PDFSci Rep
November 2024
Department of Orthopedics, Gusu School, Nanjing Medical University, The First People's Hospital of Kunshan, Suzhou, Jiangsu, China.
Zhonghua Er Ke Za Zhi
December 2024
Department of Neonatology, the First People's Hospital of Kunshan, Kunshan215300, China.
To analyze the ultrasonographic measurements of inferior vena cava (IVC) and abdominal aorta in healthy full-term neonates throughout the early postnatal period. Prospective observational study was conducted. A total of 132 healthy full-term neonates, who were born at the Kunshan First People's Hospital between May 1 and August 30, 2023, were enrolled as the study subjects.
View Article and Find Full Text PDFHematology
December 2024
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Introduction: rearrangement () is a common genomic alteration in acute leukemia that can be effectively targeted by menin inhibitors. While FISH is the standard laboratory test for , false positives can occur.
Case Report: We present a case of AML in which both and were identified by karyotype analysis and FISH.
J Diabetes Res
November 2024
Department of Clinical Nutrition, The First People's Hospital of Kunshan, Kunshan, Jiangsu 215300, China.
Our goal was to examine the causal link between blood metabolites, their ratios, and the risk of developing proliferative diabetic retinopathy (PDR) from a genetic insight. Summary-level data about 1400 blood metabolites and their ratios, as well as PDR, were sourced from prior genome-wide association studies (GWAS). A two-sample univariate and multivariate Mendelian randomization (MR) approach was utilized.
View Article and Find Full Text PDFJ Med Chem
November 2024
School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu 211198, P.R. China.
Bioorthogonal cleavage reactions have been developed as an intriguing strategy to enhance the safety of chemotherapeutics. Aiming to reduce the toxicity and improve the targeted release properties of the colchicine binding site inhibitors (CBSIs) based on previous work, a series of biologically inert prodrugs were further designed and synthesized through a bioorthogonal prodrug strategy. The therapeutic effects of prodrugs could be "turned-on" once combined with palladium resins.
View Article and Find Full Text PDFEur J Heart Fail
October 2024
Department of Pharmacy, The First People's Hospital of Kunshan, Kunshan, China.
Front Med (Lausanne)
October 2024
Department of Anesthesiology, The First People's Hospital of Kunshan Affiliated with Jiangsu University, Kunshan, China.
Objective: To investigate the potential correlation between body mass index (BMI) and the 28-day mortality rate among sepsis patients and the gender difference in this association.
Design: The current research was a retrospective cohort study.
Participants: A total of 14,883 male and female cohorts of sepsis patients were included in the Medical Information Mart for Intensive Care IV (MIMIC-IV V2.
Chem Biodivers
October 2024
College of Pharmacy, Nantong University, Nantong, 226001, P.R. China.
Mangrove-derived actinomycetes are prolific chemical sources of complex and novel natural products, providing an excellent chance for new drug discovery. The chemical investigation of the mangrove-derived Streptomyces sundarbansensis 06037, led to the discovery of two previously undescribed enone fatty acids (1-2), one new phenylpropionate derivate (3), along with the isolation of the ten known components (4-13). Those chemical structures of isolates were elucidated on the basis of the analysis of diverse spectroscopic data.
View Article and Find Full Text PDFSci Rep
October 2024
Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Jiangsu, China.
The association between inflammatory markers (IMs) and bone turnover markers (BTMs) in osteoporotic fracture patients has not been comprehensively studied. Therefore, this study examined the correlation between the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), or Monocyte-to-lymphocyte ratio (MLR) and BTMs in osteoporosis (OP) fracture patients. This retrospective cross-sectional study analyzed 740 OP fracture patients admitted to the hospital from January 2017 to July 2022.
View Article and Find Full Text PDFFront Pharmacol
October 2024
The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
[This corrects the article DOI: 10.3389/fphar.2024.
View Article and Find Full Text PDFFront Med (Lausanne)
September 2024
Department of Anesthesiology, The First People's Hospital of Kunshan Affiliated with Jiangsu University, Kunshan, China.
Background: This study aims to explore the association between sleep duration and the prevalence of chronic musculoskeletal pain (CMP).
Methods: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2009-2010, which involved multiple centers across the United States. The study included 3,904 adults selected based on age and complete data availability.
Zhonghua Nei Ke Za Zhi
October 2024
Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Front Endocrinol (Lausanne)
October 2024
Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Jiangsu, China.
Objective: To evaluate the correlation between the triglyceride-glucose (TyG) index and bone turnover markers (BTMs) in osteoporotic fractures (OPFs) patients hospitalized for surgical intervention.
Methods: A retrospective cross-sectional study was conducted on 3558 OPFs patients hospitalized for surgical intervention between January 2017 and July 2022. The study obtained baseline values for various biomarkers and covariates, including fasting blood glucose, β-C-terminal telopeptide of type I collagen (β-CTX), procollagen type 1 N-terminal propeptide (P1NP), triglycerides, age, sex, body mass index, smoking, drinking, low-density lipoprotein, high-density lipoprotein, aspartate aminotransferase, uric acid, the score of American society of anesthesiologists, homocysteine, parathyroid hormone, apolipoprotein B, apolipoprotein A, magnesium, phosphorus and calcium.
Nutr Metab Cardiovasc Dis
December 2024
Department of Endocrinology, Affiliated Kunshan Hospital of Jiangsu University, Jiangsu, 215300, China; Department of Clinical Nutrition, Affiliated Kunshan Hospital of Jiangsu University, Jiangsu, 215300, China. Electronic address:
Expert Opin Drug Saf
October 2024
Department of Critical Care Medicine, The First People's Hospital of Kunshan, Kunshan, China.
Background: Ivabradine is primarily indicated for patients with sinus rhythm and a heart rate ≥ 75 beats/min, who have NYHA class II-IV chronic heart failure with systolic dysfunction. There is currently a lack of large-scale, real-world studies concerning its drug adverse reactions.
Research Design & Methods: This research assesses the side effects of ivabradine by analyzing reports of adverse events (AEs) from the FDA's Adverse Event Reporting System (FAERS) database.