397 results match your criteria: "First People's Hospital of Kunshan[Affiliation]"

Background: The relationship between diabetes mellitus (DM) and bone mineral density (BMD) in patients with osteoporotic fractures (OPFs) remains complex and heterogeneous, specifically between the genders. This study aimed to explore the association between diabetes status and trochanteric BMD in a cohort of patients with OPFs and elucidate the differences between male and female patients.

Methods: This retrospective analysis was performed on 710 admitted patients aged 50 years or older with OPFs.

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Outer membrane vesicles (OMVs) and exosomes are essential mediators of host-pathogen interactions. Elucidating their mechanisms of action offers valuable insights into diagnosing and treating infectious diseases and cancers. However, the specific interactions of () with host cells via OMVs and exosomes in modulating host immune responses have not been thoroughly investigated.

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Objective: This study aimed to investigate the prognostic impact of completing 30 mL/kg fluid resuscitation within 1 h in elderly septic shock patients.

Methods: This was a multicenter prospective observational cohort study. We applied logistic regression to assess the impact of completing 30 mL/kg fluid resuscitation within 1 h on respiratory support escalation including new-onset mechanical ventilation, bilevel positive airway pressure (BiPAP), and high-flow nasal cannula (HFNC) as well as heart failure (HF).

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Traumatic Renal Artery Thrombosis (TRAT) is an uncommon condition characterized by a low clinical incidence and a lack of specific symptoms, making it highly susceptible to being overlooked or misdiagnosed. This retrospective analysis aims to review the diagnostic and therapeutic approaches applied to a TRAT patient who received successful treatment in the Emergency Medicine Department of the First People's Hospital of Kunshan. The objective is to enhance clinicians' comprehension of TRAT, promote early diagnosis and intervention, and ultimately improve patient outcomes.

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Perceptions, opportunities and barriers of social engagement among the Chinese older adults: a qualitative study.

BMC Geriatr

December 2024

Global Health Research Center, Duke Kunshan University, No. 8 Duke Avenue, Kunshan, Jiangsu Province, 215316, China.

Background: Understanding and promoting healthy aging are increasingly important as China transitions into an aging society. Our study examines the challenges and opportunities faced by the older adults in urban areas regarding social engagement, potentially informing the development of effective, context-sensitive interventions and policies.

Methods: The study is based on in-depth interviews with 30 participants from a Northern city in Mainland China regarding their daily lives, attitudes towards and subjective experiences of aging, and involvement in social activities.

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Research suggests that cathepsins, due to their extensive mechanisms of action, may play a crucial role in cardiomyopathies. However, further studies are necessary to establish causality. This study aims to investigate the causal relationship between cathepsins and various types of cardiomyopathies.

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This study aims to investigate the predictive value of platelet distribution width (PDW) in patients with influenza A virus (IAV) infection. The clinical data of 105 IAV-infected patients was collected and analyzed. We found that creatine kinase (CK), Acute Physiology and Chronic Health Evaluation (APACHE) II score, PDW, and red blood cell distribution width (RDW) were independent risk factors for acute respiratory distress syndrome (ARDS) development.

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Introduction: Helicobacter pylori (HP) infection is prevalent worldwide and contributes to various gastrointestinal diseases. Eradication therapy is crucial in managing HP infection, but antibiotic resistance has led to refractory cases, complicating treatment outcomes and increasing the risk of adverse events.

Objectives: This study aimed to evaluate the effectiveness of a multidisciplinary approach, termed HP Multidisciplinary Team (MDT) Clinic, in improving eradication rates and safety in patients with refractory HP infection.

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Cancer-associated fibroblasts (CAFs) are essential players in the tumor microenvironment (TME) due to their roles in facilitating tumor progression and metastasis. It is worth noting that the high-metastatic hepatocellular carcinoma (HCC) cell-derived exosomes have exhibited the ability to transform normal fibroblasts into CAFs, which further fosters the lung metastasis of low-metastatic HCC cells. Yet, the mechanisms underlying this tumor exosome-induced metastatic niche formation are poorly explored.

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[A real-world study of first-line albumin-bound paclitaxel in the treatment of advanced pancreatic cancer in China].

Zhonghua Zhong Liu Za Zhi

November 2024

Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing210008, China.

To observe and evaluate the clinical efficacy and safety of albumin-bound paclitaxel as first-line treatment for patients with advanced pancreatic cancer in China, and to explore the prognosis-related molecules in pancreatic cancer based on next-generation sequencing (NGS) of tumor tissues. From December 2018 to December 2020, patients with locally advanced or metastatic pancreatic cancer were recruited to accept albumin-bound paclitaxel as first-line treatment in the oncology departments of 24 hospitals in East China. The primary endpoints were overall survival (OS) and treatment related adverse events, and the secondary endpoint was progression-free survival (PFS).

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Article Synopsis
  • The research explored the relationship between triglyceride (TG) levels and lumbar bone mineral density (BMD) in patients over 50 with osteoporotic fractures who had surgery.
  • A total of 3,558 patients were analyzed, showing a positive correlation between TG levels and lumbar BMD, particularly until TG levels reached a threshold of 1.26 mmol/L.
  • Beyond this threshold, while higher TG levels were noted, no significant difference in lumbar BMD was observed, suggesting that maintaining TG levels below this threshold is important for OPF patients.
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To analyze the ultrasonographic measurements of inferior vena cava (IVC) and abdominal aorta in healthy full-term neonates throughout the early postnatal period. Prospective observational study was conducted. A total of 132 healthy full-term neonates, who were born at the Kunshan First People's Hospital between May 1 and August 30, 2023, were enrolled as the study subjects.

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Introduction: rearrangement () is a common genomic alteration in acute leukemia that can be effectively targeted by menin inhibitors. While FISH is the standard laboratory test for , false positives can occur.

Case Report: We present a case of AML in which both and were identified by karyotype analysis and FISH.

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Our goal was to examine the causal link between blood metabolites, their ratios, and the risk of developing proliferative diabetic retinopathy (PDR) from a genetic insight. Summary-level data about 1400 blood metabolites and their ratios, as well as PDR, were sourced from prior genome-wide association studies (GWAS). A two-sample univariate and multivariate Mendelian randomization (MR) approach was utilized.

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Bioorthogonal cleavage reactions have been developed as an intriguing strategy to enhance the safety of chemotherapeutics. Aiming to reduce the toxicity and improve the targeted release properties of the colchicine binding site inhibitors (CBSIs) based on previous work, a series of biologically inert prodrugs were further designed and synthesized through a bioorthogonal prodrug strategy. The therapeutic effects of prodrugs could be "turned-on" once combined with palladium resins.

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Objective: To investigate the potential correlation between body mass index (BMI) and the 28-day mortality rate among sepsis patients and the gender difference in this association.

Design: The current research was a retrospective cohort study.

Participants: A total of 14,883 male and female cohorts of sepsis patients were included in the Medical Information Mart for Intensive Care IV (MIMIC-IV V2.

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Mangrove-derived actinomycetes are prolific chemical sources of complex and novel natural products, providing an excellent chance for new drug discovery. The chemical investigation of the mangrove-derived Streptomyces sundarbansensis 06037, led to the discovery of two previously undescribed enone fatty acids (1-2), one new phenylpropionate derivate (3), along with the isolation of the ten known components (4-13). Those chemical structures of isolates were elucidated on the basis of the analysis of diverse spectroscopic data.

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The association between inflammatory markers (IMs) and bone turnover markers (BTMs) in osteoporotic fracture patients has not been comprehensively studied. Therefore, this study examined the correlation between the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), or Monocyte-to-lymphocyte ratio (MLR) and BTMs in osteoporosis (OP) fracture patients. This retrospective cross-sectional study analyzed 740 OP fracture patients admitted to the hospital from January 2017 to July 2022.

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Background: This study aims to explore the association between sleep duration and the prevalence of chronic musculoskeletal pain (CMP).

Methods: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2009-2010, which involved multiple centers across the United States. The study included 3,904 adults selected based on age and complete data availability.

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[Report of six cases with mast cell leukemia and a literature review].

Zhonghua Nei Ke Za Zhi

October 2024

Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Article Synopsis
  • A retrospective analysis of six patients with acute mast cell leukemia (MCL) at Soochow University revealed a median age of 54, with various clinical presentations such as hypoalbuminemia, fatigue, and fever, highlighting the complexity of this rare disease.
  • Most patients displayed significant abnormalities in specific proteins (CD117, CD30, CD25, CD2) and gene mutations, indicating aggressive disease characteristics and a need for better diagnostic criteria.
  • Treatment outcomes were poor, with some patients receiving various therapies like venetoclax and cladribine, but only one achieved partial remission; this emphasizes the urgent need for improved understanding and treatment approaches for MCL.
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Objective: To evaluate the correlation between the triglyceride-glucose (TyG) index and bone turnover markers (BTMs) in osteoporotic fractures (OPFs) patients hospitalized for surgical intervention.

Methods: A retrospective cross-sectional study was conducted on 3558 OPFs patients hospitalized for surgical intervention between January 2017 and July 2022. The study obtained baseline values for various biomarkers and covariates, including fasting blood glucose, β-C-terminal telopeptide of type I collagen (β-CTX), procollagen type 1 N-terminal propeptide (P1NP), triglycerides, age, sex, body mass index, smoking, drinking, low-density lipoprotein, high-density lipoprotein, aspartate aminotransferase, uric acid, the score of American society of anesthesiologists, homocysteine, parathyroid hormone, apolipoprotein B, apolipoprotein A, magnesium, phosphorus and calcium.

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Article Synopsis
  • - Elevated serum uric acid (SUA) levels have been linked to metabolic disorders and can be influenced by how well the kidneys function, leading researchers to study the SUA to serum creatinine (SCr) ratio and its association with type 2 diabetes in elderly individuals.
  • - In a study of non-diabetic elderly from Kunshan, China, researchers found that a higher SUA/SCr ratio was associated with an increased risk of developing type 2 diabetes over an average follow-up of nearly 4 years, particularly in women.
  • - The findings suggest that regular monitoring of the SUA/SCr ratio in this population could be useful for predicting and evaluating the risk of type 2 diabetes.
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Background: Ivabradine is primarily indicated for patients with sinus rhythm and a heart rate ≥ 75 beats/min, who have NYHA class II-IV chronic heart failure with systolic dysfunction. There is currently a lack of large-scale, real-world studies concerning its drug adverse reactions.

Research Design & Methods: This research assesses the side effects of ivabradine by analyzing reports of adverse events (AEs) from the FDA's Adverse Event Reporting System (FAERS) database.

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