Does the interface between individual 3D acetabular implants and host bone influence the functional outcomes in patients with severe bone loss after revision surgery?

Introduction: There is a wide range of commercially produced revision implants for adequate reconstruction of acetabular large bone defects today, however, it is not always possible to achieve long-term survival of these implants. There is an increasing number of scientific publications concerning the use of custom-designed 3D components, which make it possible not only to achieve stable fixation and connect the pelvic bones but also to restore hip joint biomechanics.

Objectives: To evaluate the positioning of 3D acetabular implants after revision hip arthroplasty and its impact on clinical and functional outcomes.

Special aspects of total hip arthroplasty in patients with proximal femur pseudarthrosis.

Introduction: The rate of proximal femur fractures (PFF) in the structure of musculoskeletal system injuries among all fractures of long bones ranges from 3.9 to 18%. According to Russian Ministry of Health 2020 data, the incidence of femoral fractures in Russia was up to 61 cases per 100,000 population (90,000 per year); and femoral neck fractures incidence was 4 times higher among people over 75 years of age.

CT and MRI in the Preoperative Planning of Balloon Dilation of the Eustachian Tube: Literature Review.

Balloon dilatation of the Eustachian tube (BET) is a surgical treatment method for Eustachian tube dysfunction (ETD), which relieves the symptoms in the majority of cases. However, there are potential intraoperative risks associated with BET; the decision-making process with regard to indications for BET is not standardized up to date. The objective of this study was to review the role of computed tomography (CT) and magnetic resonance imaging (MRI) in the preoperative planning of BET.

Approaches to Sampling for Quality Control of Artificial Intelligence in Biomedical Research.

Unlabelled: is to evaluate the efficacy of approaches to sampling during periodic quality control of the artificial intelligence (AI) results in biomedical practice.

Materials And Methods: The approaches to sampling based on point statistical estimation, statistical hypothesis testing, employing ready-made statistical tables, as well as options of the approaches presented in GOST R ISO 2859-1-2007 "Statistical methods. Sampling procedures for inspection by attributes" have been analyzed.

[The modern role of the resort medicine in medical diplomacy and national humanitarian policy].

Health care in general and medicine in particular play an important role in the geopolitical landscape and the political positioning of the state in the modern world. The health of the citizens of the country is the most important resource of national security. This article, based on a SWOT-analysis, highlights the strengths and weaknesses of the foreign and national resort industry as a part of medical diplomacy, with decomposition to its individual participants.

[Analysis of compensation payments for moral damage in cases related to poorly provided dental care (2013-2022)].

The Aim Of The Study: Was an analysis of compensation payments for moral damage in cases related to poorly provided dental care in 2013-2022.

Materials And Methods: The study of judicial practice for the period 2013-2022 was conducted on 1731 cases related to poor-quality medical care in dentistry and maxillofacial surgery. The analysis of statistical data on patients' claims for compensation for moral damage caused during the provision of dental care was carried out.

Sport-Specific Rehabilitation, but Not PRP Injections, Might Reduce the Re-Injury Rate of Muscle Injuries in Professional Soccer Players: A Retrospective Cohort Study.

Platelet-rich plasma (PRP) injections are extremely popular in the management of sports injuries in elite athletes. However, data on the use of various administration protocols of PRP are contradictory. The efficacy of platelet-rich plasma in the treatment of muscle injuries in professional soccer players has to be contextualized within the sport-specific rehabilitation program.

Influence of ABCB1, CYP3A5 and CYP3A4 gene polymorphisms on prothrombin time and the residual equilibrium concentration of rivaroxaban in patients with non-valvular atrial fibrillation in real clinical practice.

Objective: The study of ABCB1 and CYP3A4/3A5 gene polymorphism genes is promising in terms of their influence on prothrombin time variability, the residual equilibrium concentration of direct oral anticoagulants (DOACs) in patients with atrial fibrillation and the development of new personalized approaches to anticoagulation therapy in these patients. The aim of the study is to evaluate the effect of ABCB1 (rs1045642) C>T; ABCB1 (rs4148738) C>T and CYP3A5 (rs776746) A>G, CYP3A4*22(rs35599367) C>T gene polymorphisms on prothrombin time level and residual equilibrium concentration of rivaroxaban in patients with atrial fibrillation.

Methods: In total 86 patients (42 men and 44 female), aged 67.

Сomparative analysis of large diameter bearing ceramic monoblock acetabular components.

Introduction: The goal of total hip arthroplasty (THA) is to provide ease to patients with persistent and exhausting pain. Durability is the main challenge associated with any tribological pair, with the aim of minimizing wear and thus avoiding problems with aseptic loosening of components and osteolysis. When polyethylene inserts are used in young patients, we should always consider their disadvantages, e.

Current Drug Targets for Gut Microbiota Biocorrection during the SARS-CoV-2 Pandemic: A Systematic Review.

Unlabelled: The gut microbiota are known to play an important role in maintaining the body's homeostasis and increasing its immunoresistance. Their role has not been well defined in the course of SARS-CoV-2 infection.

Aim: The aim of this study was to evaluate the pathogenetic relationship between gut microbiota, immunological reactivity disruption and microbiota pathologies with the new coronavirus infection's course in order to substantiate the use of current drugs correcting gut microbiota during the SARS-CoV-2 pandemic.

Nociceptors: Their Role in Body's Defenses, Tissue Specific Variations and Anatomical Update.

The human body is constantly under the influence of numerous pathological factors: both external and internal. These factors can be potentially harmful and are perceived as such with a specialized nervous system subunit: the nociceptive system. The functional unit of the nociceptive system is the nociceptor.

[Internal control of the quality and safety of medical activities in the field of information interaction between patient and medical organization].

The scope of information interaction between patients, medical organizations and regulatory authorities is regulated by a large number of legislative and regulatory documents, a number of which are discussed in this article. The quality of information interaction in the Russian Federation is assessed within the framework of internal quality control and safety of medical activities. At the same time, the analysis of court cases related to poor-quality dental care over 6 years allowed the authors to identify a large proportion of patient complaints about the quality of information interaction between patients and medical organizations.

[INFLUENCE OF PHYSIOLOGICAL AND PATHOLOGICAL SLEEP ON THE CLINICAL CHARACTERISTICS OF TYPE 2 DIABETES MELLITUS (REVIEW)].

The prevalence of sleep disorders in the general population is quite high. At the same time, changes in sleep duration, sleep apnoea syndrome, fragmentation and other changes in sleep are significant factor of risk for the development of diabetes mellitus type 2, and also have a negative impact on the ability to achieve satisfactory compensation in these patients. The article presents up-to-date information on the association between sleep disorders and diabetes mellitus type 2.

[Left ventricular global function index as a predictor of adverse cardiovascular events in patients with acute coronary syndrome].

Aim      To evaluate the prognostic significance of the left ventricular global function index (LV GFI) in patients with acute coronary syndrome (ACS) using echocardiography (EchoCG).Material and methods             The LV GFI is an index that integrates LV cavity volumes, stroke volume, and myocardial volume. This study included 2169 patients with ACS (1340 (61.

ASSESSMENT OF LEUKOCYTES FUNCTION IN PERIPHERAL BLOOD IN PATIENTS WITH MEDICINAL JAWS OSTEONEKROSIS.

The aim of the study was to assess the functional activity of peripheral blood phagocytes in patients with drug-induced osteonecrosis of the jaws to develop a new approach to treatment. A total of 35 people were examined, including: 10 healthy individuals, 8 with purulent-inflammatory diseases of the maxillofacial region (GVZ ChLO), 17 patients with medical osteonecrosis of the jaws (MRONJ). Among patients with MRONJ, there were 10 men and 7 women, aged from 54 to 73 years, with a mean age of 62 years.

Age Pathognomonic Indicators of Injury Predisposition as a Basis for Public Health Preservation during Physical Activity.

A necessary condition for public health maintenance is regular physical activity. A significant increase in the number of musculoskeletal injuries, occurring during physical education and sport activities, actualizes the development of effective measures for their prevention. Early diagnosis of injury predisposition, based on identification of connective tissue dysplasia indicators specific for different age periods, is of particular importance for the prevention of such injuries.

First main series of transition elements with atomic numbers from 22 to 29, found in air pollution and detected in the plants from Tajikistan areas.

According to several reports, the presence of transition metal elements in the atmosphere was associated with adverse health effects. The purpose of this investigation was to analyze the presence of transition metal particles with atomic numbers 22-29 on some medicinal plants (n = 22) from various regions of the Republic of Tajikistan and their content in the atmosphere. Samples (n = 43) of individual plant organs, such as seeds, flowers, leaves, trunks, and plant roots, were examined for their elemental composition using X-ray fluorescence analysis.

[Evaluation of the effectiveness of the compression method for infiltration anesthesia of the mandibular molars].

Aim: To study the depth of analgesia and the electrical excitability dynamics of the pulp of the tooth under local anesthesia without and with compression on the depot of local anesthetics.

Materials And Methods: 87 men and 93 women took part in the study, the average age of men was 36.8±5.

[Comparative study of dental and psychological status in athletes of Olympic teams and the population of Moscow].

Aim: To compare dental and psychological status in athletes of Olympic teams and the population of Moscow.

Materials And Methods: In order to study the features of the dental rehabilitation of Olympic athletes, a comparative study of the dental and psychological status of 132 athletes was carried out when they were included in the Olympic teams and 104 residents of Moscow of the same age. Clinical x-ray examination was supplemented by «Hamburg testing» of the masticatory apparatus and psychological examination using common questionnaires and scales.

[Evaluation of dentists regulatory systems stress during the provision of dental care according to pulse oximetry data].

Objective: To evaluate the status of individual hemodynamic parameters (HR) and respiratory indicators of dentists performing local anesthesia. Material and methods. In the period from April 2019 to December 2019 the determination of heart rate (Heart rate) and blood saturation at 120 doctors aged 25-55 years was performed.

Paneth cells: Maintaining dynamic microbiome-host homeostasis, protecting against inflammation and cancer.

The human intestines are constantly under the influence of numerous pathological factors: enteropathogenic microorganisms, food antigens, physico-chemical stress associated with digestion and bacterial metabolism, therefore it must be provided with a system of protection against adverse impact. Recent studies have shown that Paneth cells play a crucial role in maintaining homeostasis of the small intestines. Paneth cells perform many vital functions aimed at maintaining a homeostatic balance between normal microbiota, infectious pathogens and the human body, regulate the qualitative composition and number of intestinal microorganisms, prevent the introduction of potentially pathogenic species, and protect stem cells from damage.

Morphological signs of connective tissue dysplasia as predictors of frequent post-exercise musculoskeletal disorders.

Background: Connective tissue dysplasia (CTD) is a risk factor for musculoskeletal disorders. Changes caused by disorganization of collagen and elastin fibers lead to the inability of withstanding heavy mechanical stress. In clinical practice, diagnosis of these disorders depends on physical and anthropomorphic evaluation.

[Forensic diagnosis of sudden death of young people based on morphological analysis of the cardiac conduction system].

The aim of study was to develop a comprehensive assessment of the central and peripheral parts of the nervous system with a determination of degree of severity of alterative changes in comparison with the condition of myocardial contractile apparatus. Own observations on modern methods of morphological study of the cardiac conduction system in the sudden death of young people are presented. Particular attention is paid to the technique of isolating and coloring the nervous structures of sympathetic and parasympathetic parts of the autonomic nervous system, including the medulla oblongata, sinus-atrial and atrial-ventricular nodes, atrioventricular bundle (the His bundle), Purkinje fibers.

[Variants for conducting situational studies and expertises in forensic medical practice].

The aim of the study is to analyze the features of commissioning and conducting the forensic situational studies and expertises and to consider variants for their practical implementation. The importance of a situational analysis when conducting various types of forensic medical expertises is considered. The variants for conducting situational studies and situational expertises in practical work are proposed.

[Statistical parallels of mortality indicators and alcohol intoxications according to forensic autopsies in Moscow].

The aim of work is to study dynamics of frequency of alcohol intoxications incidence revealed at forensic examination of corpses in Moscow. Frequency of intoxications incidence was determined as index making a share part of cases where ethyl alcohol was found in blood of corpses, comparing to total number of forensic autopsies. For every calendar year of the five-year period from 2014 till 2018 the comparative analysis of frequency of incidence of alcohol intoxications at concrete types of death was carried out.