398 results match your criteria: "First Medical Center of PLA General Hospital.[Affiliation]"

Preliminary exploration of the association of CXCR6T lymphocytes in T2D.

Int Immunopharmacol

January 2025

State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases Research, Beijing, China; National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China; Department of Gastroenterology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China. Electronic address:

Type 2 diabetes (T2D) is a metabolic disease, in which inflammation is a key factor. It has been well established that T cells play important role in antigen-driven immune disorders or immune defense, but were less discussed in inflammatory metabolic diseases. However, accumulating evidences suggest that CD186 (also known as CXCR6)-positive tissue infiltrating T cells might play a key role in inflammatory metabolic diseases.

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Effects of synbiotics surpass probiotics alone in improving type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial.

Clin Nutr

January 2025

Department of Nutrition and Health, Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing 100193, China. Electronic address:

Background And Aims: Combining probiotics and prebiotics in synbiotics may present a synergistic approach to improve type 2 diabetes mellitus (T2DM); however, further evidence is required to establish the comparative efficacy of synbiotics versus probiotics. This study aimed to evaluate the effects of Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup) and a synbiotic mixture of MN-Gup and galactooligosaccharide (MN-Gup-GOS) on glycemic control in T2DM patients and explore possible mechanisms.

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A prospective cohort study of cochlear implantation as a treatment for tinnitus in post-lingually deafened individuals.

Commun Med (Lond)

December 2024

Senior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.

Background: Cochlear implants have helped over one million individuals restore functional hearing globally, but their clinical utility in suppressing tinnitus has not been firmly established.

Methods: In a decade-long study, we examined longitudinal effects of cochlear implants on tinnitus in 323 post-lingually deafened individuals including 211 with pre-existing tinnitus and 112 without tinnitus. The primary endpoints were tinnitus loudness and tinnitus handicap inventory.

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Purpose: Previous studies have indicated mixed short-term outcomes between drug-coated balloon (DCB) angioplasty and percutaneous transluminal angioplasty (PTA) in the treatment of infrapopliteal lesions. However, the long-term durability of DCB angioplasty remains uncertain. The objective of this study is to present the long-term outcomes of DCB angioplasty for infrapopliteal lesions in patients with critical limb ischemia (CLI).

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The optical attenuation coefficient (AC), a crucial tissue parameter indicating the rate of light attenuation within a medium, enables quantitative analysis of tissue properties and facilitates tissue differentiation. Despite its growing clinical significance, accurate quantification of AC from optical coherence tomography (OCT) signals remains a pressing concern. This study comprehensively investigates the factors influencing the accuracy of quantitative AC extraction among existing OCT-based AC extraction algorithms.

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Monitoring of microvascular calcification by time-resolved photoacoustic microscopy.

Photoacoustics

February 2025

Smart Computational Imaging Laboratory (SCILab), School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China.

Article Synopsis
  • The study focuses on monitoring microvascular calcification (MC) to better understand health conditions like drug abuse and chronic diseases.* -
  • A new technique called time-resolved photoacoustic microscopy (TR-PAM) is developed, which effectively observes changes in blood vessel elasticity due to calcium build-up.* -
  • Validation through experiments on both phantoms and animal models shows TR-PAM's potential as an advanced method for assessing microvascular health, aiding in disease prediction and monitoring.*
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Article Synopsis
  • Visual impairment from pneumosinus dilatans (PSD) in adolescents is rare and can lead to blindness due to its subtle symptoms and lack of effective treatment options.
  • MRI and CT imaging are valuable tools for diagnosing PSD, and the endoscopic transnasal optic nerve decompression (ETOND) procedure can significantly enhance vision in affected patients.
  • This case series not only improves awareness among clinicians to prevent misdiagnoses but also proposes new ideas for investigating the causes of PSD and emphasizes the importance of accurate terminology in discussing its various forms.
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A high-quality fluorescence elimination dual-wavelength Raman method for biological detection and its application in cancer diagnosis.

Spectrochim Acta A Mol Biomol Spectrosc

November 2024

Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China. Electronic address:

Article Synopsis
  • Raman-based methods are promising for in vivo biological detection but face challenges due to fluorescence interference in measurement accuracy.
  • This study introduces a dual-wavelength Raman method using two different lasers to improve Raman signal quality by eliminating fluorescence effects.
  • The method was successfully applied to early cancer diagnosis, identifying significant biomolecules in esophageal tissue that indicate different malignancy levels.
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Restoring sweat gland function in mice using regenerative sweat gland cells derived from chemically reprogrammed human epidermal keratinocytes.

Sci Bull (Beijing)

December 2024

Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, State Key Laboratory of Trauma and Chemical Poisoning, PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051, Beijing 100048, China. Electronic address:

The regeneration of sweat glands (SwGs) plays a pivotal role in the functional recovery of extensive skin wounds. Recent research has illuminated the possibility of reprogramming human epidermal keratinocytes (HEKs) into induced SwG cells through the ectopic expression of ectodysplasin A. However, the clinical application of this genetic manipulation approach is inherently limited.

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In the field of medical imaging, microwave tomography (MWT) is based on the scattering and absorption characteristics of different tissues to microwaves and can reconstruct the electromagnetic property distribution of biological tissues non-invasively and without ionizing radiation. However, due to the inherently nonlinear and ill-posed characteristics of MWT calculations, actual imaging is prone to overfitting or artifacts. To address this, this paper proposes a two-step iterative imaging approach for rapid medical microwave tomography.

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Evolution of treatment strategies for solid tumors with RET rearrangement in China and real-world treatment status of Non-small Cell Lung Cancer (NSCLC).

BMC Pulm Med

November 2024

Department of Oncology, the First Medical Center of PLA General Hospital, (Chinese PLA Key Laboratory of Oncology, Key Laboratory for Tumor Targeting Therapy and Antibody Drugs (Ministry of Education, China)), Beijing, 100853, China.

Article Synopsis
  • - The study reviews advancements in research on RET rearrangements in solid tumors, specifically focusing on therapeutic strategies and outcomes in advanced non-small cell lung cancer (NSCLC) within China.
  • - It analyzes the incidence of RET rearrangements, treatment approaches, and evaluates the effectiveness of targeted RET inhibitors, particularly assessing real-world patient outcomes.
  • - A retrospective analysis of 64 patients shows that the KIF5B-RET fusion is the most common, with Pralsetinib achieving a median progression-free survival of 16.03 months, significantly better than chemotherapy.
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[The retrospective clinical study of asymptomatic primary hyperparathyroidism].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi

October 2024

Sennior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing 100048, China.

To summarize and analyze the diagnostic and therapeutic characteristics of asymptomatic primary hyperparathyroidism (aPHPT). A retrospective analysis was conducted on the clinical data of 103 patients with aPHPT admitted to the Chinese PLA General Hospital from January 2012 to September 2023. The clinical characteristics, treatment modes, and prognoses of the patients were analyzed.

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Article Synopsis
  • Researchers created a modified acellular bovine bone matrix (ABBM-Mg) that releases Magnesium ions to promote bone healing and growth in defective areas, specifically in the jawbone.
  • The study used various methods to analyze the microstructure, mechanical properties, and cell interactions of both the standard ABBM and the modified ABBM-Mg, showing that the latter performed better in enhancing cell growth and bone formation.
  • In a rat model with mandibular defects, the ABBM-Mg scaffold not only supported better bone repair but also maintained its structural integrity, indicating its potential for clinical use in bone regeneration therapies.
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Article Synopsis
  • Spinal cord injury (SCI) is a serious condition that typically has a poor recovery outlook; researchers developed a scaffold, called LOCAS, loaded with stem cells to improve treatment outcomes in a rat model of SCI.
  • The LOCAS scaffold exhibited excellent properties, such as high porosity and water absorption, and significantly improved motor function and neural recovery in rats compared to control groups.
  • This study suggests that combining LOCAS with stem cells can enhance tissue repair and recovery in SCI, pointing to new and promising methods for treating similar injuries in humans.
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Assessing IgG4-related autoimmune pancreatitis with contrast-enhanced ultrasonography based on time-intensity curve: a single-centre prospective study.

Clin Exp Rheumatol

October 2024

Chinese PLA Medical School, PLA General Hospital, Beijing; Department of Rheumatology and Immunology, The First Medical Center of PLA General Hospital, Beijing; and State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, China.

Objectives: The aim of this study was to investigate the changes in various parameters of contrast-enhanced ultrasound (CEUS) before and after treatment in patients with IgG4-related autoimmune pancreatitis (IgG4-AIP), and to identify potential indicators that can assist in evaluating disease activity.

Methods: In this prospective study, we enrolled patients diagnosed with IgG4-AIP from June 2021 to November 2022. Demographic characteristics, clinical features, laboratory tests were recorded.

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Objective: To investigate the pharmacological mechanisms and clinical effects of Traditional Chinese Medicine (TCM) wet compresses on pain, inflammation, and quality of life in patients with soft tissue injuries.

Methods: First, the network pharmacology of the active ingredients from TCM wet compresses were identified using the TCMSP (Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform) database (Common monkshood mother root, Two-toothed achyranthes root, Sour orange, Garden balsam stem, Safflower, Ground beetle, Zingiber, Haichow elsholtzia herb). Relevant targets for soft tissue injuries were obtained from GeneCards, revealing 20 key therapeutic targets.

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Influence of hip prosthesis position on postoperative gait in symptomatic hip osteoarthritis secondary to hip dysplasia patients after primary total hip arthroplasty: a short-term follow-up study.

BMC Musculoskelet Disord

October 2024

Department of Orthopedics, the First Medical Center of PLA General Hospital, Hospital, 28 Fuxing Road, Haidian District, Beijing, 100039, China.

Article Synopsis
  • The study aimed to investigate how the alignment of hip replacement components affects walking patterns in patients with hip osteoarthritis due to hip dysplasia.
  • Researchers measured the acetabular anteversion (AA) and femoral anteversion (FA) angles using CT scans and analyzed gait data with a specialized system before and after surgery.
  • Results indicated that while THA significantly improved various gait parameters post-surgery, a lower AA angle was associated with increased walking cadence, suggesting that optimizing AA could enhance recovery.
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Background And Objectives: Autologous skin graft (ASG) transplantation is a challenging approach but a promising option for patients to prevent postoperative esophageal stricture. Nonetheless, the current strategies require improvement. We aimed to investigate the effectiveness of the injection of platelet-rich plasma (PRP) before skin graft transplantation for extensive esophageal defects after endoscopic resection.

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Article Synopsis
  • The study explores how the traditional Chinese medicine HuangQiSiJunZi Decoction (HQSJZD) may treat triple-negative breast cancer (TNBC) by examining its chemical components and their action targets using advanced bioinformatics tools.
  • Key findings identified 256 potential targets for HQSJZD and 16 significant hub genes affecting TNBC, including FOS, which also plays a role in patient survival predictions.
  • The research highlights the involvement of immune cells in TNBC while validating these findings through various analyses, supporting the potential effectiveness of HQSJZD in cancer treatment.
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Introduction: The causality between personality and psychiatric traits and lung cancer (LC) remains unclear. Therefore, we aimed to elucidate the causality between these traits and LC.

Methods: Bidirectional two-sample Mendelian randomization (MR) and bibliometric approaches were conducted to estimate the causality between personality (neuroticism, extraversion, agreeableness, conscientiousness, and openness) and psychiatric (schizophrenia, attention-deficit/hyperactivity disorder [ADHD], major depressive disorder, autism spectrum disorder, bipolar disorder, insomnia, and anxiety) traits and LC and its subtypes (lung squamous cell carcinoma, lung adenocarcinoma, and small cell LC).

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De novo lipogenesis (DNL), a hallmark of cancer, facilitates tumor growth and metastasis. Therapeutic drugs targeting DNL are being developed. However, how DNL is directly regulated in cancer remains largely unknown.

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Lung cancer ranks as the second most diagnosed cancer and the leading cause of cancer-related deaths worldwide. Novel chemotherapeutic strategies are crucial to efficiently target tumor cells while minimizing toxicity to normal cells. In this study, we proposed a combination strategy using energy blocker lonidamine (LND) and cytotoxic drug nimustine (ACNU, 1-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea) to enhance the killing of a human lung cancer cell line and investigated the potential chemo-sensitizing mechanism of LND.

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