398 results match your criteria: "First Medical Center of PLA General Hospital.[Affiliation]"
Int Immunopharmacol
January 2025
State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases Research, Beijing, China; National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China; Department of Gastroenterology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China. Electronic address:
Type 2 diabetes (T2D) is a metabolic disease, in which inflammation is a key factor. It has been well established that T cells play important role in antigen-driven immune disorders or immune defense, but were less discussed in inflammatory metabolic diseases. However, accumulating evidences suggest that CD186 (also known as CXCR6)-positive tissue infiltrating T cells might play a key role in inflammatory metabolic diseases.
View Article and Find Full Text PDFJAMA Neurol
January 2025
Senior Department of Neurosurgery, the First Medical Center of PLA General Hospital, Hai-dian District, Beijing, China.
Clin Nutr
January 2025
Department of Nutrition and Health, Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing 100193, China. Electronic address:
Background And Aims: Combining probiotics and prebiotics in synbiotics may present a synergistic approach to improve type 2 diabetes mellitus (T2DM); however, further evidence is required to establish the comparative efficacy of synbiotics versus probiotics. This study aimed to evaluate the effects of Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup) and a synbiotic mixture of MN-Gup and galactooligosaccharide (MN-Gup-GOS) on glycemic control in T2DM patients and explore possible mechanisms.
View Article and Find Full Text PDFCommun Med (Lond)
December 2024
Senior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Background: Cochlear implants have helped over one million individuals restore functional hearing globally, but their clinical utility in suppressing tinnitus has not been firmly established.
Methods: In a decade-long study, we examined longitudinal effects of cochlear implants on tinnitus in 323 post-lingually deafened individuals including 211 with pre-existing tinnitus and 112 without tinnitus. The primary endpoints were tinnitus loudness and tinnitus handicap inventory.
J Endovasc Ther
December 2024
Department of Vascular Surgery, First Medical Center of PLA General Hospital, Beijing, China.
Purpose: Previous studies have indicated mixed short-term outcomes between drug-coated balloon (DCB) angioplasty and percutaneous transluminal angioplasty (PTA) in the treatment of infrapopliteal lesions. However, the long-term durability of DCB angioplasty remains uncertain. The objective of this study is to present the long-term outcomes of DCB angioplasty for infrapopliteal lesions in patients with critical limb ischemia (CLI).
View Article and Find Full Text PDFBiomed Opt Express
December 2024
School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
The optical attenuation coefficient (AC), a crucial tissue parameter indicating the rate of light attenuation within a medium, enables quantitative analysis of tissue properties and facilitates tissue differentiation. Despite its growing clinical significance, accurate quantification of AC from optical coherence tomography (OCT) signals remains a pressing concern. This study comprehensively investigates the factors influencing the accuracy of quantitative AC extraction among existing OCT-based AC extraction algorithms.
View Article and Find Full Text PDFPhotoacoustics
February 2025
Smart Computational Imaging Laboratory (SCILab), School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China.
Heliyon
October 2024
College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China.
Spectrochim Acta A Mol Biomol Spectrosc
November 2024
Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China. Electronic address:
Sci Bull (Beijing)
December 2024
Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, State Key Laboratory of Trauma and Chemical Poisoning, PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051, Beijing 100048, China. Electronic address:
The regeneration of sweat glands (SwGs) plays a pivotal role in the functional recovery of extensive skin wounds. Recent research has illuminated the possibility of reprogramming human epidermal keratinocytes (HEKs) into induced SwG cells through the ectopic expression of ectodysplasin A. However, the clinical application of this genetic manipulation approach is inherently limited.
View Article and Find Full Text PDFSensors (Basel)
October 2024
Department of Neurosurgery, The First Medical Center of PLA General Hospital, Beijing 100853, China.
In the field of medical imaging, microwave tomography (MWT) is based on the scattering and absorption characteristics of different tissues to microwaves and can reconstruct the electromagnetic property distribution of biological tissues non-invasively and without ionizing radiation. However, due to the inherently nonlinear and ill-posed characteristics of MWT calculations, actual imaging is prone to overfitting or artifacts. To address this, this paper proposes a two-step iterative imaging approach for rapid medical microwave tomography.
View Article and Find Full Text PDFEndoscopy
December 2024
Department of Gastroenterology, First Medical Center of PLA General Hospital, Beijing, China.
BMC Pulm Med
November 2024
Department of Oncology, the First Medical Center of PLA General Hospital, (Chinese PLA Key Laboratory of Oncology, Key Laboratory for Tumor Targeting Therapy and Antibody Drugs (Ministry of Education, China)), Beijing, 100853, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
October 2024
Sennior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing 100048, China.
To summarize and analyze the diagnostic and therapeutic characteristics of asymptomatic primary hyperparathyroidism (aPHPT). A retrospective analysis was conducted on the clinical data of 103 patients with aPHPT admitted to the Chinese PLA General Hospital from January 2012 to September 2023. The clinical characteristics, treatment modes, and prognoses of the patients were analyzed.
View Article and Find Full Text PDFJ Mater Sci Mater Med
October 2024
Department of Stomatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100071, China.
Endoscopy
December 2024
Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing, China.
Stem Cell Res Ther
October 2024
Department of Neurosurgery, The First Medical Center of PLA General Hospital, Beijing, 100853, China.
Clin Exp Rheumatol
October 2024
Chinese PLA Medical School, PLA General Hospital, Beijing; Department of Rheumatology and Immunology, The First Medical Center of PLA General Hospital, Beijing; and State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, China.
Objectives: The aim of this study was to investigate the changes in various parameters of contrast-enhanced ultrasound (CEUS) before and after treatment in patients with IgG4-related autoimmune pancreatitis (IgG4-AIP), and to identify potential indicators that can assist in evaluating disease activity.
Methods: In this prospective study, we enrolled patients diagnosed with IgG4-AIP from June 2021 to November 2022. Demographic characteristics, clinical features, laboratory tests were recorded.
Am J Transl Res
September 2024
Department of Auditory, The Sixth Medical Center of PLA General Hospital Beijing 100048, China.
Objective: To investigate the pharmacological mechanisms and clinical effects of Traditional Chinese Medicine (TCM) wet compresses on pain, inflammation, and quality of life in patients with soft tissue injuries.
Methods: First, the network pharmacology of the active ingredients from TCM wet compresses were identified using the TCMSP (Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform) database (Common monkshood mother root, Two-toothed achyranthes root, Sour orange, Garden balsam stem, Safflower, Ground beetle, Zingiber, Haichow elsholtzia herb). Relevant targets for soft tissue injuries were obtained from GeneCards, revealing 20 key therapeutic targets.
BMC Musculoskelet Disord
October 2024
Department of Orthopedics, the First Medical Center of PLA General Hospital, Hospital, 28 Fuxing Road, Haidian District, Beijing, 100039, China.
J Transl Int Med
September 2024
Senior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, Beijing, China.
Background And Objectives: Autologous skin graft (ASG) transplantation is a challenging approach but a promising option for patients to prevent postoperative esophageal stricture. Nonetheless, the current strategies require improvement. We aimed to investigate the effectiveness of the injection of platelet-rich plasma (PRP) before skin graft transplantation for extensive esophageal defects after endoscopic resection.
View Article and Find Full Text PDFBMC Cancer
September 2024
Department of Traditional Chinese Medicine, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Front Psychiatry
September 2024
Department of Medical Oncology, Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing, China.
Introduction: The causality between personality and psychiatric traits and lung cancer (LC) remains unclear. Therefore, we aimed to elucidate the causality between these traits and LC.
Methods: Bidirectional two-sample Mendelian randomization (MR) and bibliometric approaches were conducted to estimate the causality between personality (neuroticism, extraversion, agreeableness, conscientiousness, and openness) and psychiatric (schizophrenia, attention-deficit/hyperactivity disorder [ADHD], major depressive disorder, autism spectrum disorder, bipolar disorder, insomnia, and anxiety) traits and LC and its subtypes (lung squamous cell carcinoma, lung adenocarcinoma, and small cell LC).
Adv Sci (Weinh)
November 2024
Beijing Institute of Biotechnology, Beijing, 100071, China.
De novo lipogenesis (DNL), a hallmark of cancer, facilitates tumor growth and metastasis. Therapeutic drugs targeting DNL are being developed. However, how DNL is directly regulated in cancer remains largely unknown.
View Article and Find Full Text PDFACS Omega
August 2024
Beijing Key Laboratory of Environment & Viral Oncology, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.
Lung cancer ranks as the second most diagnosed cancer and the leading cause of cancer-related deaths worldwide. Novel chemotherapeutic strategies are crucial to efficiently target tumor cells while minimizing toxicity to normal cells. In this study, we proposed a combination strategy using energy blocker lonidamine (LND) and cytotoxic drug nimustine (ACNU, 1-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea) to enhance the killing of a human lung cancer cell line and investigated the potential chemo-sensitizing mechanism of LND.
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