2 results match your criteria: "First Maternity and Infant Hospital affiliated Tongji University[Affiliation]"
An Update on Circumventing Multidrug Resistance in Cancer by Targeting P-Glycoprotein.
Curr Cancer Drug Targets
October 2019
Department of Gynecology and Obstetrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Background: The ultimate emergence of multidrug resistance remains a severe limitation of chemotherapy treatment for patients with cancer. The best-characterized cause of drug resistance involves the overexpression of P-glycoprotein (Pgp), which decreases the intracellular accumulation of chemotherapeutic agents in drug-resistant cancer cells. Thus, Pgp has become an attractive potential target for treating chemotherapy-resistant cancer, but the outcomes of using chemotherapy in combination with Pgp inhibitors in clinical trials to date have been disappointing.
View Article and Find Full Text PDFDetection of common deafness mutation by maternal plasma cell-free DNA.
Eur Rev Med Pharmacol Sci
April 2015
Department of Obstetrics, First Maternity and Infant Hospital affiliated Tongji University, Shanghai, China.
Objectives: The aim is to investigate the use of the ligase detection reaction (LDR) microarray to examine the difference of the single nucleotide between the pregnant woman and the fetus by cell-free DNA in the maternal plasma in congenital deafness.
Materials And Methods: The proband and the couples' venous blood samples and the amniotic fluid/ chorionic villi collected from seven deafness families for prenatal diagnosis were analyzed. The cell-free DNA from maternal plasma was examined to determine if they carried the mutations of GJB2 235delC.