350 results match your criteria: "First Hospital of Tsinghua University[Affiliation]"
To investigate the application of H to alleviate cardiac ischaemia-reperfusion (I/R) injury in a PGC-1α-dependent manner. A rat in vitro myocardial I/R injury model was used, Western blot was used to detect the expression levels of apoptosis markers (Bax, cleaved caspase-3, Bcl), inflammatory factors (IL-1β, TNF-α), mitochondrial fission (DRP1, MFF) and mitochondrial fusion (MFN1, MFN2, OPA1). HE staining was used to observe the effect of H on the myocardial tissue structure injured by I/R.
View Article and Find Full Text PDFZhonghua Er Ke Za Zhi
December 2024
Department of Pediatric Cardiology, Heart Center, First Hospital of Tsinghua University, Beijing100016, China.
J Med Case Rep
November 2024
Heart Center, The First Hospital of Tsinghua University, Address:No.6, First Street of Jiuxianqiao, Beijing, 100016, China.
Zhonghua Nei Ke Za Zhi
November 2024
Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Am J Rhinol Allergy
January 2025
Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China.
Background: Sinonasal inverted papilloma (SNIP) is a benign epithelial tumor with distinctive histopathological features. However, the role of inflammation in SNIP remains poorly characterized.
Objectives: This study aimed to compare the histopathological patterns and inflammatory characteristics of SNIP with those of chronic rhinosinusitis with nasal polyps (CRSwNPs) or normal ethmoid sinus mucosa.
Sci Rep
September 2024
Department of General Surgery, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, 300052, People's Republic of China.
Gastric adenocarcinoma (STAD) is the most prevalent malignancy of the human digestive system and the fourth leading cause of cancer-related death. Calcium pools, especially Ca2+ entry (SOCE) for storage operations, play a crucial role in maintaining intracellular and extracellular calcium balance, influencing cell activity, and facilitating tumor progression. Nevertheless, the prognostic and immunological value of SOCE in STAD has not been systematically studied.
View Article and Find Full Text PDFNeural Regen Res
September 2025
Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Contemp Clin Trials
November 2024
Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. Electronic address:
Minerva Cardiol Angiol
September 2024
The Radiology Department, The First Hospital of Tsinghua University, Beijing, China.
Artery imaging, a crucial component in the diagnosis and management of vascular disease, assumes a significant role in the field of medical research. Utilizing advanced imaging modalities such as computed tomography (CT) and magnetic resonance angiography (MRA), artery imaging provides detailed insights into blood flow, detecting conditions such as atherosclerosis, aneurysms, and other vascular abnormalities with high precision. Spectral CT is an innovative imaging technique that goes beyond traditional CT scans, capturing data at multiple energy levels to provide detailed insights into the composition of tissues and materials within the scanned region.
View Article and Find Full Text PDFPostgrad Med J
November 2024
Department of Gastroenterology, The First Hospital of Tsinghua University, No. 6 Jiuxianqiao, 1st Street, Chaoyang District, Beijing 100016, China.
Chronic constipation is a prevalent clinical condition. Its etiology and pathogenesis have not yet been fully understood. In recent years, mounting evidence suggests a close association between chronic constipation and intestinal dysbiosis, including alterations in the colony structure and metabolites, as well as the modulation of bowel movements via the brain-gut-microbiota axis.
View Article and Find Full Text PDFWorld J Cardiol
August 2024
First Hospital of Tsinghua University, School of Clinical Medicine, Tsinghua University, Beijing 100016, China.
Background: Antiphospholipid syndrome (APS) is a chronic autoimmune disease characterized by venous or arterial thrombosis, pregnancy morbidity and a variety of other autoimmune and inflammatory complications. Here, we report a case of APS associated with multiple coronary thromboses.
Case Summary: The patient, a 28-year-old male, suffered from recurrent coronary thromboses over a period of 31 months.
J Neurosurg
August 2024
3Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing.
Objective: Pipeline embolization device (PED) placement for the treatment of intracranial aneurysms is safe and effective under general anesthesia (GA). However, GA is associated with certain risks, longer procedural time, and higher hospital cost. The authors aimed to compare clinical outcomes and hospital cost between GA and local anesthesia (LA) procedures in patients who underwent PED placement for intracranial aneurysm treatment.
View Article and Find Full Text PDFClinics (Sao Paulo)
August 2024
Department of Thoracic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Currently, the incidence of esophageal cancer continues to rise around the world. Because of its good early prognosis, it is of great significance to establish an effective model for predicting the survival of EC patients. The purpose of this study was to predict survival after diagnosis in Esophageal Cancer (EC) patients by constructing a valid clinical nomogram.
View Article and Find Full Text PDFCurr Cancer Drug Targets
June 2024
Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Introduction: Hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4) is involved in the progression of hepatocellular carcinoma (HCC).
Aims: This study aimed to investigate the inhibitory effect of gamma-tocotrienol (γ-T3) on the proliferation and growth of HSD17B4-overexpressing HepG2 cells.
Methods: HepG2 cells were transfected with empty or HSD17B4-overexpressing plasmids, followed by vitamin E (VE) or γ-T3 treatment.
Front Genet
June 2024
Department of Neurology, The First Hospital of Tsinghua University, Beijing, China.
Injuries to the spinal cord nervous system often result in permanent loss of sensory, motor, and autonomic functions. Accurately identifying the cellular state of spinal cord nerves is extremely important and could facilitate the development of new therapeutic and rehabilitative strategies. Existing experimental techniques for identifying the development of spinal cord nerves are both labor-intensive and costly.
View Article and Find Full Text PDFAm J Prev Med
October 2024
Department of Sports Science and Physical Education, The Chinese University of Hong Kong, Shatin, Hong Kong, China. Electronic address:
Introduction: Physical activity (PA) is a promising way to improve mental health in children and adolescents with neurodevelopmental disorders (NDDs). However, the underlying mechanisms remain unclear. The current review aimed to explore the potential neurobiological, psychosocial, and behavioral mechanisms between PA interventions and mental health in children and adolescents with NDDs.
View Article and Find Full Text PDFExpert Opin Drug Saf
May 2024
Department of Pharmacy, Peking University First Hospital, Beijing, China.
Background: Drug-induced delirium is known risk factors associated with increased morbidity and mortality in older patients. The objective was to evaluate the risk of drug-related delirium in older patients based on the FDA Adverse Event Reporting System (FAERS).
Research Design And Methods: Delirium reports in older patients (age ≥65) extracted from the FAERS database using Open Vigil 2.
Ann Clin Microbiol Antimicrob
May 2024
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing, Dongcheng, Beijing, 100730, P.R. China.
Background: Infections caused by linezolid-resistant enterococci (LRE) are clinically difficult to treat and threaten patient health. However, there is a lack of studies on long time-span LRE strains in China. For this reason, our study comprehensively revealed the resistance mechanisms of LRE strains collected in a Chinese tertiary care hospital from 2011 to 2022.
View Article and Find Full Text PDFEpidemiol Infect
April 2024
Beijing Children's Hospital, Capital Medical University, China National Clinical Research Center of Respiratory Diseases, National Center for Children's Health, Beijing, China.
This paper retrospectively analysed the prevalence of macrolide-resistant (MRMP) in some parts of China. Between January 2013 and December 2019, we collected 4,145 respiratory samples, including pharyngeal swabs and alveolar lavage fluid. The highest PCR-positive rate of M.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
April 2024
Department of Rheumatology, The First Hospital of Tsinghua University, Beijing, China.
Aim: Both hyperuricemia and anemia are not only the manifestation of chronic kidney disease (CKD) but also related to its occurrence and development. A recent study has found that there was a synergetic effect between hyperuricemia and anemia on new-onset CKD. Herein we aimed to explore the roles of hyperuricemia and anemia in the all-cause mortality in patients with CKD.
View Article and Find Full Text PDFiScience
December 2023
Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Prostate cancer (PCa) is one of the most common malignant diseases of urinary system and has poor prognosis after progression to castration-resistant prostate cancer (CRPC), and increased cytosine methylation heterogeneity is associated with the more aggressive phenotype of PCa cell line. Activation-induced cytidine deaminase (AID) is a multifunctional enzyme and contributes to antibody diversification. However, the dysregulation of AID participates in the progression of multiple diseases and related with certain oncogenes through demethylation.
View Article and Find Full Text PDFChin Med J (Engl)
May 2024
Cardiac Center, Division of Cardiac Surgery, The First Hospital of Tsinghua University, Beijing 100016, China.
Background: Ebstein's anomaly (EA) is a rare and complex congenital heart anomaly, and the effect of surgical treatment is not ideal. This study aims to introduce our experience in management strategies, surgical techniques, and operative indications for patients with Ebstein's anomaly.
Methods: A retrospective study of 258 operations was performed in 253 patients by the same cardiac surgeon in The First Hospital of Tsinghua University between March 2004 and January 2020.
Int Heart J
December 2023
Department of Cardiovascular Medicine, First Hospital of Tsinghua University Hospital.
Genetic factors may be involved in postoperative atrial fibrillation (PoAF) development and cardiac injury. However, the associations of the apolipoprotein E (ApoE) gene polymorphisms with PoAF and cardiac injury after coronary artery bypass graft surgery (CABG) remain unclear.We recruited 150 patients with CABG, comprising 92 and 58 cases for the ApoE4 and ApoE3 groups, respectively, and analyzed PoAF incidence and the levels of cardiac biomarkers, including N-terminal prohormone of brain natriuretic peptide, cardiac troponin T (cTnT), and cardiac troponin I (cTnI).
View Article and Find Full Text PDFCardiovasc Eng Technol
December 2023
Department of Cardiac Surgery, Boston Children's Hospital, 300 Longwood Avenue, Bader, 2nd Floor, Boston, MA, 02215, USA.
Purpose: Pulmonary valve (PV) monocusp reconstruction in transannular patch (TAP) right ventricular outflow tract (RVOT) repair for Tetralogy of Fallot has variable clinical outcomes across different surgical approaches. The study purpose was to systematically evaluate how monocusp leaflet design parameters affect valve function in-vitro.
Methods: A 3D-printed, disease-specific RVOT model was tested under three infant physiological conditions.
Eur J Pharmacol
December 2023
Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address: