Association between nucleotide-binding oligomerization domain protein 2 () gene polymorphisms and Parkinson's disease (PD) susceptibility.

This study aimed to explore the association between single nucleotide polymorphisms (SNPs) of nucleotide-binding oligomerization domain protein 2 () gene and Parkinson's disease susceptibility, including IVS4 + 10A > C (rs72796353) and a missense mutation at exon 9 (c.2857A > G p.K953E).

Impairment of amyloid precursor protein alpha-processing in cerebral microvessels of type 1 diabetic mice.

The mechanisms underlying dysfunction of cerebral microvasculature induced by type 1 diabetes (T1D) are not fully understood. We hypothesized that in cerebral microvascular endothelium, α-processing of amyloid precursor protein (APP) is impaired by T1D. In cerebral microvessels derived from streptozotocin (STZ)-induced T1D mice protein levels of APP and its α-processing enzyme, a disintegrin and metalloprotease 10 (ADAM10) were significantly decreased, along with down-regulation of adenylate cyclase 3 (AC3) and enhanced production of thromboxane A (TXA).

Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats.

Aims: In this study, we investigated the effects of Bax-inhibiting peptide (Bip)-V5, an anti-apoptosis membrane-permeable peptide, on the 6-hydroxydopamine (6-OHDA) induced Parkinson's disease (PD) model rats.

Materials And Methods: Rats were randomly divided into five groups: Control, 6-OHDA only, Vehicle+6-OHDA, zVAD+6-OHDA, and V5+6-OHDA, that rats were preadministrated with different reagents before 6-OHDA administration.

Key Findings: The result showed that intrastriatal preadministration of Bip-V5 significantly decreased the amphetamine-induced rotation of the 6-OHDA model rats and the loss of the nigral dopaminergic (DA) neurons.