7 results match your criteria: "First Faculty of Medicine of Charles University and Military University Hospital[Affiliation]"

Diagnostic challenges in complicated case of glioblastoma.

Pathol Oncol Res

November 2024

Center of Oncocytogenomics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine of Charles University in Prague, Prague, Czechia.

Article Synopsis
  • Glioblastoma is the most common and aggressive primary brain tumor, making diagnosis difficult due to its genetic variability and poor prognosis.
  • A complex case study utilized multiple cytogenomic methods to identify key genetic markers, revealing classical glioblastoma characteristics and distinct pathological clones.
  • The study suggests an integrated approach for diagnosis, focusing on detecting genetic alterations to potentially improve patient outcomes in terms of diagnosis, prognosis, and treatment predictions.
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Where Did the Midline Catheter Disappear?

Clin Med Insights Case Rep

December 2021

Department of Anesthesiology, Resuscitation and Intensive Care, First Faculty of Medicine of Charles University and Military University Hospital in Prague, Praha, Czech Republic.

Intravascular catheter break off is a rare complication during insertion or nursing care. We report the intravascular break off of a midline catheter after wound dressing change and its migration into the pulmonary artery. The broken piece of catheter was removed percutaneously using a snare kit.

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Objectives: This paper sought to evaluate the occurrence of decompression sickness (DCS) after the application of a patent foramen ovale (PFO) screening and risk stratification strategy.

Background: PFO is associated with an increased risk of DCS. Recently, transcatheter closure was reported to reduce DCS occurrence in divers with a high-grade shunt.

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The relationship between tDCS (transcranial direct current stimulation) and its influence on glycemia has been the aim of limited research efforts. Usually, the focus has been set on lowering the blood sugar level or interference with insulin resistance, but also the treatment of diabetic polyneuropathy and pain management. In this case report, we outline the development of hyperglycemia and the following onset of type I diabetes during a series of tDCS in a 24-year old Caucasian female patient treated with our research protocol (10 sessions; 2 mA; 30 min; the anode over F3; the cathode over Fp2) for anorexia nervosa.

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Background: A pineal cyst is a relatively common benign condition of the pineal gland. The clinical management of patients with a pineal cyst remains controversial, especially when patients present with nonspecific symptoms.

Methods: We performed a prospective study between 2000 and 2016.

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Increased tissue and circulating levels of dipeptidyl peptidase-IV enzymatic activity in patients with pancreatic ductal adenocarcinoma.

Pancreatology

March 2017

Laboratory of Cancer Cell Biology, Institute of Biochemistry & Experimental Oncology, First Faculty of Medicine, Charles University in Prague, Czech Republic. Electronic address:

Background/objectives: Pancreatic ductal adenocarcinoma (PDAC) is frequently heralded by an impairment of glucose homeostasis. Dipeptidyl peptidase-IV (DPP-IV) and fibroblast activation protein alpha (FAP) are aminopeptidases that regulate several bioactive peptides involved in glucoregulation, and are frequently dysregulated in cancer. The present study analyzes blood plasma levels and the quantity and localization of DPP-IV and FAP in PDAC tissues.

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