Hyaluronan Synthase 1: A Novel Candidate Gene Associated With Late-Onset Non-syndromic Hereditary Hearing Loss.

Objectives: Hyaluronan synthase 1 (HAS1) is a membrane-bound protein that is abundant in the epidermis and dermis, and it is important for skin function. However, its association with hearing loss has not yet been studied. Herein, we sought to evaluate the potential contribution of HAS1: c.

Protective effects of vitamins E, B and C and L-carnitine in the prevention of cisplatin-induced ototoxicity in rats.

Objective: This experimental study aimed to investigate the effects of vitamins E, B and C and L-carnitine in preventing cisplatin-induced ototoxicity.

Methods: Twenty-five adult, male, Wistar albino rats were randomly allocated to receive intraperitoneal cisplatin either alone or preceded by vitamins B, E or C or L-carnitine. Auditory brainstem response (i.

Congenital bilateral parotid gland agenesis in Klinefelter syndrome.

Bilateral parotid gland agenesis is a rare clinical entity and it's an etiopathogenesis remains obscure. The literature contains no reports of the co-existence of bilateral parotid gland agenesis and Klinefelter syndrome. The condition is usually asymptomatic and causes asymmetry in the head and neck areas.

Atypical lipomatous tumor in the submental region.

A 54-year-old male patient presented to our outpatient clinic complaining of a mass under his chin, which appeared nearly 1 year earlier. Pathologic diagnosis was atypical lipomatous tumor. To the best of our knowledge, this is the first reported case to localize subcutaneously in the head and neck region.

The effects of merocel and glove finger tampon applications on the nasal septum mucosa of rabbits.

Objective: The use of tampons after nasal septum surgery is important for both prevention of postoperative bleeding and stabilization of the nasal flaps and the septum. One of the most important factors in achieving rapid postoperative recovery is the choice of the nasal tampon material, among many, to produce minimal damage on the nasal mucosa. In this study, the histopathological effects of the glove finger and merocel tampons, which are commonly used in clinical applications, have been investigated on the nasal mucosa of rabbits.

Meningoencephalocele as a rare cause of cerebrospinal fluid fistula during dacryocystorhinostomy.

A meningoencephalocele is a herniation of meninges and brain out of the cranial fossa through a bony defect. Cerebrospinal fluid leakage may occur due to a defect in the wall of the meningoencephalocele. The defect may be traumatic, iatrogenic, or may appear spontaneously.

An unrecognized foreign body in the parotid gland after trauma.

Objective: Foreign bodies within the parotid gland retained after trauma are rarely observed, due in part to ease of detection. Few, however, particularly wooden foreign bodies, may not be identified clinically and radiologically.

Case: A 44-year-old male was admitted complaining of recurrent swelling and pain in the left parotid gland with recent history of penetrating parotid trauma and foreign body removal.

An unusual foreign body in the floor of the mouth presenting as a gradually growing mass.

Foreign bodies in the upper aerodigestive tract represent one of the most common ENT emergencies, but patients with foreign bodies in the floor of the mouth rarely present to the otolaryngologist. Only a very small number of these foreign bodies are embedded under normal mucosa and can result in lethal complications. In this article, we report the case of a 3-year-old girl with a gradually enlarging mass in the floor of the mouth.

A multivariate analysis of otological, surgical and patient-related factors in determining success in myringoplasty.

Objectives: The aim of this study was to evaluate the effects of smoking and other prognostic factors on long-term surgical outcome and hearing results in myringoplasty.

Design: Retrospective cohort.

Setting: Tertiary medical centre.

Surgical exposure in translabyrinthine approaches--an anatomical study.

Objective: Translabyrinthine approach (TLA) is a procedure of choice for the removal of vestibular schwannomas in cases of profound hearing loss. There is a lack of anatomic studies reviewing the surgical anatomy of the cerebellopontine angle (CPA) as seen in the classical and enlarged TLAs.

Methods: Seven formalin-preserved cadavers were dissected.

Sucralfate for posttonsillectomy analgesia.

Pain is one of the most troublesome complications of tonsillectomy. The pain appears as throat pain, otalgia, or both, and continues until mucosal recovery on the tonsillar fossae is complete. Some surgical and hemostasis techniques may increase pain.

Facial nerve paralysis in chronic suppurative otitis media: Ankara Numune Hospital experience.

Although the incidence of facial nerve paralysis (FNP) decreased with the use of contemporary diagnostic tools and the advent of antibiotics, it is still a challenging problem. In this retrospective study, the charts of 1188 patients with chronic suppurative otitis media (CSOM), treated between 1988 and 1996 in the First ENT Clinic of Ankara Numune Hospital, Turkey, were analysed to establish the pre-operative incidence of FNP in CSOM. There were 20 (1.

Anatomic relationships between surgical landmarks in type b and type c infratemporal fossa approaches.

Anatomic relationships of the structures exposed in type B and C infratemporal fossa approaches were studied in 20 temporal bones. The intrapetrous carotid artery (ICA), cochlea (CH), eustachian tube (ET), foramen spinosum (FS), foramen ovale (FO) and anterior foramen lacerum (AFL) were exposed by drilling of the glenoid fossa and base of middle cranial fossa. The relationships of the ICA with the cochleariform process (CP), CH, ET, FS, FO and AFL were noted along with associated measurements.

The cochlear aqueduct: an important landmark in lateral skull base surgery.

The cochlear aqueduct (CA) is used as a landmark in lateral skull base surgery. In this study anatomic relationships between the CA and adjacent neurovascular structures were examined by dissecting 32 temporal bones. Observations of the relationship of the external opening (EO) of the CA with the ninth, tenth, and eleventh cranial nerves, inferior petrosal sinus (IPS), and intrapetrous carotid artery (ICA) were noted.

Susceptibility of microorganisms isolated from chronic suppurative otitis media to ciprofloxacin.

In order to evaluate the susceptibility of the microorganisms isolated from chronic suppurative otitis media to ciprofloxacin, cultures of specimens from 127 patients with chronic suppurative otitis media and their antibiotic sensitivity results were examined. The most common aerobic isolates were Pseudomonas sp., Proteus sp.

Saccular afferents to second-order cochlear neurons. An horseradish peroxidase and immunocytochemical study.

Previous studies have described a primary afferent vestibular projection to second-order cochlear neurons originating from the saccular maculae. As could be shown in the guinea pig by means of anterograde transport of horseradish peroxidase and immuno-cytochemistry, these saccular afferents terminated at cells immunoreactive to glutamate and aspartate but not to gamma-aminobutyric acid (GABA). These were intermingled among the fibers of the acoustic striae and situated between the dorsal cochlear nucleus and the octopus cell area.

Optimizing of electroneuronography of the facial nerve.

The amplitude ratio between the paretic and the normal side as determined by electroneuronography is used as a basis for estimating the prognosis of facial palsy. Several methods have been described of placing the surface electrodes and of finding the supramaximal impulse strength. We investigated 16 normal test persons with the aim (1) of optimizing the procedure of neuronography with regard to the possible variations of electrode placement and stimulus intensity and (2) of finding out the right/left difference in normal test subjects.