1,457 results match your criteria: "First Affiliated Hospital With Nanjing Medical University[Affiliation]"
The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined.
Heart Fail Rev
November 2024
Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Activation of the sympathetic nervous system has been attributed to the development of hypertension. Two established approaches for treating hypertension are pharmacotherapy and lifestyle changes. With an improved understanding of renal nerve anatomy and physiology, renal denervation has been proposed as an alternative treatment for hypertension.
View Article and Find Full Text PDFTargeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension.
Commun Biol
November 2024
Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.
The endothelium-dependent vascular injury, a primary pathological feature of angiotensin II (Ang II)-induced hypertension. This study aimed to explore the role and underlying mechanisms of G protein-coupled receptor 39 (GPR39) in the pathogenesis of Ang II-induced hypertension. For in vivo studies, GPR39 knockout (KO) mice (C57BL/6 J, male) were generated and administered Ang II for 4 weeks.
View Article and Find Full Text PDFAlterations in the transcriptome and microRNAs of adipose-derived mesenchymal stem cells from different sites in rats during aging.
Am J Physiol Cell Physiol
January 2025
Department of Cardiology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, People's Republic of China.
Aging is an intricate and gradual process characterized by tissue and cellular dysfunction. Adipose-derived mesenchymal stem cells (ADMSCs) experience a functional decline as part of systemic aging. However, the alterations in ADMSCs across various anatomical sites throughout an individual's lifespan remain unclear.
View Article and Find Full Text PDFCamrelizumab combined with gemcitabine and apatinib in treating advanced PD-L1-positive biliary tract cancers.
Cancer Sci
January 2025
Department of Oncology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Article Synopsis
- * Fourteen patients participated, achieving a 42.9% objective response rate, with six showing partial response and four having stable disease, while the disease control rate was 71.4%.
- * The median progression-free survival was 5.4 months, median overall survival was 13.5 months, and the main serious side effect noted was neutropenia in 29% of patients, indicating the treatment was both effective and tolerable.
Transarterial chemoembolization combined with molecular targeted agents plus immune checkpoint inhibitors for unresectable hepatocellular carcinoma beyond the up-to-seven criteria: a propensity score-matching analysis.
Ann Med
December 2024
Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Article Synopsis
- The study examines the effectiveness of combining transarterial chemoembolization (TACE) with molecular-targeted agents and immune checkpoint inhibitors (TACE-MTAs-ICIs) compared to TACE alone in patients with unresectable hepatocellular carcinoma (uHCC) that exceeds specific criteria.
- A total of 130 patients were involved, with results showing that those treated with TACE-MTAs-ICIs had significantly longer overall survival (27.2 months) and progression-free survival (15.4 months) compared to those receiving only TACE (15.9 months and 4.8 months, respectively).
- The TACE-MTAs-ICIs group also demonstrated a higher objective response rate
Comments on "Predictors of persistent pain after extracorporeal shockwave lithotripsy for painful chronic calcific pancreatitis".
Endoscopy
November 2024
Digestive Endoscopy Department and General Surgery Department, The First Affiliated Hospital with Nanjing Medical University and Jiangsu Province Hospital, Nanjing, China.
Discrimination Model Construction for Non-Lactational Mastitis and Breast Cancer Based on Imaging Features.
Br J Hosp Med (Lond)
October 2024
Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Article Synopsis
- The study focuses on differentiating non-lactational mastitis (NLM) from breast cancer (BC), as their symptoms can overlap, leading to misdiagnosis.
- It involves a retrospective analysis of 108 patients suspected of having NLM, where various imaging techniques (ultrasound and MRI) were analyzed to build a diagnostic model.
- The final model demonstrated a high accuracy (ROC area under the curve of 0.920) in distinguishing NLM from BC, using specific clinical and imaging features as key factors.
Efficacy of brachial plexus block in reducing radial artery spasm during interventional aneurysm surgery.
iScience
October 2024
Department of neurosurgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Article Synopsis
- * A study involved 177 patients comparing the effects of a brachial plexus block (BPB) against a control group, measuring RAS incidence during surgery.
- * Results showed RAS occurred in only 9% of the BPB group versus 62.5% in the control, indicating BPB significantly reduces RAS during transradial access for intracranial aneurysm surgeries.
Efficacy of Atezolizumab Plus Bevacizumab Combined with Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma: A Real-World Study.
J Hepatocell Carcinoma
October 2024
Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, People's Republic of China.
Article Synopsis
- The study investigated the effectiveness and safety of transarterial chemoembolization (TACE) combined with immunotherapy (atezolizumab) and antiangiogenic therapy (bevacizumab) in treating unresectable hepatocellular carcinoma (HCC) in a real-world setting.
- A total of 92 patients were analyzed, revealing an objective response rate of 54.3%, with median overall survival and progression-free survival times of 15.9 months and 9.1 months, respectively.
- The combination therapy was found to have acceptable therapeutic effects and manageable side effects, with 16.3% of patients experiencing serious treatment-related adverse events.
Identification of SLC31A1 as a prognostic biomarker and a target for therapeutics in breast cancer.
Sci Rep
October 2024
Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, 161 Shaoshan South Road, Changsha, 410000, China.
Copper-induced cell death is regulated through protein lipoylation, which is critical for gene expression and phenotypic regulation. Neverless, the role of Cuproptosis-related genes in breast cancer (BC) remains unknown. This study aimed to construct a prognostic signature based on the expression of Cuproptosis-related genes in order to guide the diagnosis and treatment for BC.
View Article and Find Full Text PDFSuccessful endoscopic management of severe low rectal stenosis caused by chemical burns.
Rev Esp Enferm Dig
October 2024
Digestive Endoscopy, he First Affiliated Hospital with Nanjing Medical, China.
Chemical burns of the rectum are so rare that there are few cases reported about this situation. In fact, chemical burns of the rectum can cause severe serious consequence, such as bleeding, perforation and necrosis, even developing to persistent rectal stricture. Here we present a case report of a 12-year-old child with rectal stenosis who imitates the use of corkage and inserts rust remover into the rectum unsupervised by family members.
View Article and Find Full Text PDFIn Silico Analysis Uncovers FOXA1 as a Potential Biomarker for Predicting Neoadjuvant Chemotherapy Response in Fine-Needle Aspiration Biopsies.
J Cancer
September 2024
Department of General surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
The preoperative identification of neoadjuvant chemotherapy (NAC) treatment responsiveness in breast cancer (BC) patients is advantageous for tailoring treatment regimens. There is a relative scarcity in the current research exploring NAC treatment responsive biomarkers using bulk sequencing data obtained from fine-needle aspiration (FNA). Limma was employed for the selection of differentially expressed genes.
View Article and Find Full Text PDFRNA-binding protein IGF2BP1 is required for spermatogenesis in an age-dependent manner.
Commun Biol
October 2024
Department of Andrology, The Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Article Synopsis
- Post-transcriptional regulation by RNA binding proteins is important for male germline development, with the protein IGF2BP1 specifically expressed in male gonads.
- A study showed that knocking out Igf2bp1 in mice led to age-dependent spermatogenic defects, including fewer undifferentiated spermatogonia and increased cell death.
- IGF2BP1 is essential for spermatogenesis, as it regulates the mRNA of Lin28a, which is crucial for the expansion of spermatogonia.
Artificial Intelligence Hybrid Survival Assessment System for Robot-Assisted Proctectomy: A Retrospective Cohort Study.
JCO Precis Oncol
October 2024
Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Article Synopsis
- Robotic-assisted proctectomy (RAP) is becoming the main surgical method for treating rectal cancer, but there is still a need for better prognostic tools to help manage patient recovery after surgery.
- This study analyzed data from 506 RAP patients to develop a new survival prediction tool called RAP-AIscore, using advanced AI techniques to identify key survival-related factors.
- The RAP-AIscore has shown strong potential for accurately predicting patient outcomes, providing valuable insights for treatment and follow-up care.
A Qualitative Thematic Analysis Exploring Chinese Young Adults' Experiences in Decision Making on the Management of Low-Risk Papillary Thyroid Cancer.
Thyroid
December 2024
School of Nursing and Midwifery, Brookfield Health Sciences Complex, University College Cork, Cork, Ireland.
Article Synopsis
- Thyroid cancer is the most common endocrine cancer in China, and this study explores the experiences of young adults in shared decision-making (SDM) for low-risk papillary thyroid cancer (PTC).
- Conducted through semistructured interviews with 24 patients aged 18-38, the study revealed four main themes about their SDM experiences: challenges in information sharing, reasons for seeking information, factors influencing decisions, and how they see their role in decision-making.
- The analysis highlighted three self-positions regarding treatment choices: dependent (paternalistic), collaborative (shared decision-making), and autonomous (personal responsibility), with significant challenges including limited treatment options, use of complex medical language, and gaps in communication with healthcare
The association between oral frailty and HbA1c among older adults with T2DM: the chain mediating effect of nutritional status and physical frailty.
Eur Geriatr Med
December 2024
School of Nursing, Nanjing Medical University, Nanjing, 211166, LA, China.
Article Synopsis
- The study examined the relationship between oral frailty and glycated hemoglobin (HbA1c) in older adults with type 2 diabetes (T2DM), focusing on how nutritional and physical frailty can mediate this relationship.
- Participants over 60 years old were assessed for oral frailty, nutritional status, and physical frailty, revealing that higher oral frailty was linked to worse HbA1c levels.
- The results indicate that improving oral health may enhance nutritional and physical status, potentially leading to better glycemic control for older adults with T2DM.*
Safety of flexible ureteroscopic lithotripsy with 365 μm fibers of Ho: YAG laser: a short-term follow-up.
Lasers Med Sci
October 2024
Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Article Synopsis
- The study evaluated the safety of FURL (fiber-enabled ureteroscopic laser lithotripsy) using 365 μm fibers and Ho: YAG laser over a 16-week period, focusing on clinical outcomes and risks.
- A total of 274 patients showed a high stone-free rate (SFR) linked to stone size and composition, with no severe complications observed post-procedure.
- Urosepsis occurred in only 1.82% of patients, and critical infection-related lab values remained stable, indicating that kidney function was preserved throughout the follow-up period.
WGS Analysis of Outbreak in a Neonatal Intensive Care Unit.
Infect Drug Resist
October 2024
NHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu Province, People's Republic of China.
Article Synopsis
- - A study was conducted on an outbreak of an opportunistic pathogen in a neonatal intensive care unit (NICU) that resulted in multiple hospital-acquired infections (HAIs) among newborns due to environmental contamination.
- - Researchers performed a detailed epidemiological investigation, including whole genome sequencing (WGS), which identified the source of the infection as the milk preparation workbench and confirmed that six clinical cases were linked to a single strain from this environmental source.
- - Following the outbreak, strict infection prevention measures, such as thorough environmental disinfection and isolation of affected neonates, were implemented, effectively stopping further infections and highlighting the need for improved disinfection practices in healthcare settings.
Postoperative Injection of a Triptolide-Preloaded Hydrogel Prevents the Recurrence of Glioblastoma by Dual-Pathway Activation of Ferroptosis.
Small
December 2024
Department of Cell Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, P. R. China.
Article Synopsis
- A new injectable hydrogel, TP@DNH, is developed to help prevent the recurrence of glioblastoma (GBM) after surgery by using triptolide to trigger a form of cell death called ferroptosis.
- This hydrogel targets a specific cellular pathway that involves deactivating GPX4, which is crucial for neutralizing harmful substances in GBM cells, leading to increased levels of reactive oxygen species (ROS).
- In tests with mice, the TP@DNH hydrogel significantly slows down the growth of recurrent GBM and improves overall survival, suggesting a promising new approach for postoperative GBM treatment.
Development and validation of a clinic-radiomics model based on intratumoral habitat imaging for progression-free survival prediction of patients with clear cell renal cell carcinoma: A multicenter study.
Urol Oncol
January 2025
Engineering Research Center of Health Emergency, From the Medical Imaging College, Nanjing Medical University, Nanjing, China; Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. Electronic address:
Article Synopsis
- The study aimed to create and validate a model using intratumoral habitat imaging to predict progression-free survival (PFS) in patients with clear cell renal cell carcinoma (ccRCC) and to examine gene expression linked to progression.
- It involved analyzing data from 691 ccRCC patients, using various Cox regression models to compare traditional radiomics features with those derived from habitat subregions, yielding a stronger predictive model when combining both types (Hybrid Cox).
- The Hybrid Cox model showed better predictive performance in terms of PFS, with significant survival differences observed among patient risk groups, and identified crucial genes associated with tumor characteristics that may influence metabolism and immune response.
Burden of gastrointestinal cancers among working-age population over past thirty years in China.
World J Gastrointest Oncol
September 2024
Department of Primary Healthcare Management, Nanjing Municipal Center for Disease Control and Prevention, Nanjing 210003, Jiangsu Province, China.
Article Synopsis
- - The study assesses the burden of gastrointestinal (GI) cancers in China's working-age population from 1990 to 2019, focusing on factors like incidence, mortality, and disability-adjusted life years (DALYs).
- - Results indicate a decline in key cancer metrics between 1999 and 2019, though there was an increase in age-standardized incidence rates for GI cancers from 2016 to 2019, with certain cancers affecting younger individuals more.
- - The findings highlight ongoing disparities in GI cancer burden based on age, sex, and specific cancer types, emphasizing the need for targeted prevention strategies to address the issue in this population.
Feasibility of using synthetic MRI to predict lymphatic vascular space invasion status in early-stage cervical cancer: added value to morphological MRI.
Clin Radiol
December 2024
Department of Radiology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210018, China. Electronic address:
Objectives: To investigate the feasibility of synthetic magnetic resonance imaging (syMRI) in predicting the lymphatic vascular space invasion (LVSI) status of early-stage cervical cancer, and its added value to morphological MRI.
Materials And Methods: A total of 72 patients with pathology-confirmed early-stage cervical cancer were enrolled, and classified into LVSI- positive (n=41) and LVSI- negative (n=31) groups. Together with morphological parameters including gross tumor volume (GTV) and maximum tumor diameter (MTD), the T1, T2, and proton density (PD) values of the tumors were also measured and compared between two groups.
Ziresovir in Hospitalized Infants with Respiratory Syncytial Virus Infection.
N Engl J Med
September 2024
From the Department of Respiratory Medicine (S.Z.), Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, National Clinical Research Center for Respiratory Diseases (S.Z., X.N.), National Center for Pediatric Cancer Surveillance, Key Laboratory of Major Diseases in Children, Ministry of Education (X.N), and the Department of Pediatric Medicine, Peking University Third Hospital (W.Z.), Beijing, the Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang (Y.S.), the Department of Pediatric Respiratory Medicine, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine (Y. Yin), the Department of Pulmonology, Shanghai Children's Hospital, and the School of Medicine, Shanghai Jiao Tong University (X.D.), and Shanghai Ark Biopharmaceutical (X.Z., T.J., Y.W., G.Z., K.R., J.Z.W.), Shanghai, the Department of Respiratory Medicine, Tianjin Children's Hospital, Machang Campus (Y. Zou), the Department of Respiratory Medicine, Tianjin Children's Hospital, Longyan Campus (Y.X.), and Tianjin University (Y. Zou, Y.X.), Tianjin, Children's Medical Center, Hunan Provincial People's Hospital, Changsha (L.Z.), the Departments of Respiratory Medicine and Pediatric Infectious Diseases, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou (Hailin Zhang, Y.C.), the Department of Pediatrics, Sanya Central Hospital, Hainan Third People's Hospital, Sanya (Hua Zhang), the Department of Pediatric Respiratory Medicine, Children's Hospital of Nanjing Medical University (D.Z.), and the Department of Pediatric Medicine, First Affiliated Hospital with Nanjing Medical University (R.D.), Nanjing, the Department of Pediatrics, Women and Children's Hospital, and the School of Medicine, Xiamen University (T.S.), and the Department of Pediatric Respiratory Medicine, First Affiliated Hospital of Xiamen University (Y. Yang), Xiamen, the Department of Pediatrics, Zhongshan Women and Children's Hospital-Zhongshan Boai Hospital, Zhongshan (D.H.), the Department of Pediatric Respiratory Medicine, Jiangxi Provincial Children's Hospital, Nanchang (Q.C.), the Department of Pediatric Respiratory Medicine, Liaocheng People's Hospital, Liaocheng (Q.Y.), the Department of Respiratory Medicine and Clinical Allergy Center, Wuxi Children's Hospital, Wuxi (L.L.), the Department of Pediatric Respiratory Medicine, Children's Hospital, Zhejiang University School of Medicine, Hangzhou (Z.C.), the Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing (E.L.), the Department of Pediatric Respiratory Medicine, Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou (L.D., W.J.), the Department of Pediatric Respiration, Children's Medical Center, First Hospital of Jilin University, Changchun (H.C.), the Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning (G.N.), the Department of Pediatric Respiratory Medicine, Third Affiliated Hospital of Zhengzhou University (X.W.), and the Respiratory Department, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, and Zhengzhou Children's Hospital (Z.S.), Zhengzhou, the Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen (Y. Zheng), the Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan (X.L.), the Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou (C.H.), and the Department of Pediatric Respiratory and Immunology Medicine, West China Second University Hospital, Sichuan University, Chengdu (H.L.) - all in China.
Background: Respiratory syncytial virus (RSV) is a leading cause of severe illness in infants, with no effective treatment. Results of a phase 2 trial suggested that ziresovir may have efficacy in the treatment of infants hospitalized with RSV infection.
Methods: In a phase 3, multicenter, double-blind, randomized, placebo-controlled trial conducted in China, we enrolled participants 1 to 24 months of age who were hospitalized with RSV infection.
CT features of gastric calcifying fibrous tumors: differentiation from gastrointestinal stromal tumors.
Abdom Radiol (NY)
September 2024
Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
A nomogram for predicting the risk of postoperative delirium in individuals undergoing cardiovascular surgery.
Eur J Neurol
December 2024
Department of Cardiac Surgery, First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Article Synopsis
- Delirium is a common issue after cardiovascular surgery, affecting 15-23% of patients, and current treatments are often ineffective.
- A study involving 729 patients developed a nomogram—a predictive tool using logistic regression—to estimate the chances of experiencing postoperative delirium, validated through various statistical analyses.
- The model identified seven key predictors of delirium including age and certain medical indicators, achieving a satisfactory accuracy (AUROC = 0.754), indicating its potential clinical usefulness in predicting delirium in surgical patients.