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Microbial exposure in infancy and subsequent appearance of type 1 diabetes mellitus-associated autoantibodies: a cohort study.

JAMA Pediatr

August 2014

Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland7Children's Hospital, University of Helsinki, and University Central Hospital, Helsinki, Finland8University of Helsinki, Diabetes and Obesity Research.

Importance: The role of microbial exposure during early life in the development of type 1 diabetes mellitus is unclear.

Objective: To investigate whether animal contact and other microbial exposures during infancy are associated with the development of preclinical and clinical type 1 diabetes.

Design, Setting, And Participants: A birth cohort of children with HLA antigen-DQB1-conferred susceptibility to type 1 diabetes was examined.

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