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A randomized, controlled multicenter feasibility pilot trial on imaging confirmed uncomplicated acute appendicitis: Appendectomy vs. symptomatic treatment in pediatric patients (the APPSYPP) trial study protocol.
Contemp Clin Trials
December 2022
Department of Pediatric Surgery, Helsinki University Central Hospital, Helsinki, Finland and Karolinska University, Stockholm, Sweden.
Article Synopsis
- Study Overview
- : The APPSYPP trial is a multicenter study investigating the effectiveness of appendectomy versus symptomatic treatment for children aged 7-16 with uncomplicated acute appendicitis confirmed by imaging.
- Inclusion Criteria
- : Participants must meet specific criteria including imaging-confirmed appendicitis, CRP levels ≤ 65 mg/l, and consent to either surgery or symptomatic management involving an initial hospital stay.
- Primary Outcome
- : The main goal is to assess treatment success within 30 days, defined by the absence of treatment failure, which varies for both surgical and symptomatic treatments.