Pelvic packing - status 2024.

Patients with unstable hemodynamics and unstable pelvic ring injuries are still demanding patients regarding initial treatment and survival. Several concepts were reported during the last 30 years. Mechanical stabilization of the pelvis together with hemorrhage control offer the best treatment option in these patients.

PACKMOL-GUI: An All-In-One VMD Interface for Efficient Molecular Packing.

PACKMOL is a widely utilized molecular modeling tool within the computational chemistry community. However, its tremendous advantages have been impeded by the longstanding lack of a robust open-source graphical user interface (GUI) that integrates parameter settings with the visualization of molecular and geometric constraints. To address this limitation, we have developed PACKMOL-GUI, a VMD plugin that leverages the dynamic extensibility of the Tcl/Tk toolkit.

Incidence of adult tonsillectomy for hypertrophic indications in Southwest Finland.

Background: Large palatine tonsils cause a variety of symptoms including obstructive sleep apnea and snoring. In adults, the prevalence of tonsillar hypertrophy remains uncertain.

Aims: We estimated the incidence of tonsillectomy for adult palatine tonsillar hypertrophy using population data and retrospective patient charts.

goChem: A Composable Library for Multi-Scale Computational Chemistry Data Analysis.

Data analysis is a major task for Computational Chemists. The diversity of modeling tools currently available in Computational Chemistry requires the development of flexible analysis tools that can adapt to different systems and output formats. As a contribution to this need, we report the implementation of goChem, a versatile open-source library for multiscale analysis of computational chemistry data.

Reconstruction of Optical Coherence Tomography Images from Wavelength Space Using Deep Learning.

Conventional Fourier domain Optical Coherence Tomography (FD-OCT) systems depend on resampling into a wavenumber () domain to extract the depth profile. This either necessitates additional hardware resources or amplifies the existing computational complexity. Moreover, the OCT images also suffer from speckle noise, due to systemic reliance on low-coherence interferometry.

Correction: Häyrinen et al. The Transcription Factor Twist1 Has a Significant Role in Mycosis Fungoides (MF) Cell Biology: An RNA Sequencing Study of 40 MF Cases. 2023, , 1527.

In the original publication [...

Effects of Betaine and Polydextrose on Intestinal Microbiota and Liver Ergothioneine in a High-Fat Diet-Fed Mouse Model and a Human Colonic Simulation Model.

Background/objectives: Ergothioneine (EGT) is an effective antioxidant that animals cannot produce and has an important anti-inflammatory role in cell protection, which can help lower the risk of various diseases. In this study, we investigated the potential role of gut microbiota in the production of EGT, which was found to increase in the mouse liver after dietary supplementation with betaine (BET) or polydextrose (PDX).

Methods: The effects of BET and PDX on the gut microbiota and tissue EGT content were investigated using a diet-induced obese mouse model and simulated fermentation in the human colon.

Sustainable Materials and Structures Used in Pavement Engineering.

Sustainable materials and structures have become widely used in asphalt pavements to mitigate the resource crisis and achieve carbon neutrality [...

Correction: Huhtanen et al. Discrepancies between Radiology Specialists and Residents in Fracture Detection from Musculoskeletal Radiographs. Diagnostics 2023, , 3207.

Regarding our publication, entitled "Discrepancies between Radiology Specialists and Residents in Fracture Detection from Musculoskeletal Radiographs" [...

Epilepsy Diagnosis from EEG Signals Using Continuous Wavelet Transform-Based Depthwise Convolutional Neural Network Model.

Epilepsy is a prevalent neurological disorder characterized by seizures that significantly impact individuals and their social environments. Given the unpredictable nature of epileptic seizures, developing automated epilepsy diagnosis systems is increasingly important. Epilepsy diagnosis traditionally relies on analyzing EEG signals, with recent deep learning methods gaining prominence due to their ability to bypass manual feature extraction.

Cationized Cellulose Materials: Enhancing Surface Adsorption Properties Towards Synthetic and Natural Dyes.

Cellulose is a homopolymer composed of β-glucose units linked by 1,4-beta linkages in a linear arrangement, providing its structure with intermolecular H-bonding networking and crystallinity. The participation of hydroxy groups in the H-bonding network results in a low-to-average nucleophilicity of cellulose, which is insufficient for executing a nucleophilic reaction. Importantly, as a polyhydroxy biopolymer, cellulose has a high proportion of hydroxy groups in secondary and primary forms, providing it with limited aqueous solubility, highly dependent on its form, size, and other materialistic properties.

Structure- and Ligand-Based Virtual Screening for Identification of Novel TRPV4 Antagonists.

Transient receptor potential vanilloid (TRPV) 4 is involved in signaling pathways specifically mediating pain and inflammation, making it a promising target for the treatment of various painful and inflammatory conditions. However, only one drug candidate targeting TRPV4 has entered the clinical trials. To identify potential TRPV4 inhibitors for drug development, we screened a library of ion channel-modulating compounds using both structure- and ligand-based virtual screening approaches.

Heptamethine Cyanine Dye-Doped Single-Walled Carbon Nanotube Electrodes for Improving Performance of HTL-Free Perovskite Solar Cells.

Perovskite solar cell (PSC) technology holds great promise with continuously improving power conversion efficiency; however, the use of metal electrodes hinders its commercialization and the development of tandem designs. Although single-walled carbon nanotubes (SWCNTs), as one-dimensional materials, have the potential to replace metal electrodes in PSCs, their poor conductivity still limits their application. In this study, the near-infrared (NIR)-absorbing anionic heptamethine cyanine dye-doped SWCNTs functioned in a dual role as an efficient charge-selective layer and electrode in PSCs.

Exploring the Physical Activity Counselling for Patients With Rheumatoid Arthritis-Perceptions of Nurses and Physiotherapists.

Background: Physical activity is beneficial for patients with rheumatoid arthritis (RA). However, little is known about how healthcare professionals counsel and support patients with RA to be physically active.

Aim: This study aims to explore nurses' and physiotherapists' perceptions of delivering physical activity counselling for patients with RA during routine follow-up appointments.

Effectiveness of Cold Smoking on Inactivating Murine Norovirus in Salami-Like Pork Sausages (Mettwurst), and Hepatitis E Virus and Murine Norovirus in Solution.

Hepatitis E virus (HEV) is a zoonotic virus that infects humans when virus-containing pork products are consumed. This study aimed to explore MNV (murine norovirus) and HEV inactivation during cold smoking and ripening/fermentation treatments used for salami-like sausages (mettwurst). MNV inactivation was monitored in culture medium solution and in sausage while being subjected to a salami-like sausage manufacturing process.

Epigenetic drug screening identifies enzyme inhibitors A-196 and TMP-269 as novel regulators of sprouting angiogenesis.

Epigenetic therapy has gained interest in treating cardiovascular diseases, but preclinical studies often encounter challenges with cell-type-specific effects or batch-to-batch variation, which have limited identification of novel drug candidates targeting angiogenesis. To address these limitations and improve the reproducibility of epigenetic drug screening, we redesigned a 3D in vitro fibrin bead assay to utilize immortalized human aortic endothelial cells (TeloHAECs) and screened a focused compound library with 105 agents. Compared to the established model using primary human umbilical vein endothelial cells, TeloHAECs needed a higher-density fibrin gel for optimal sprouting, successfully forming sprouts under both normoxic and hypoxic cell culture conditions.

Low-carbon indoor humidity regulation via 3D-printed superhygroscopic building components.

Indoor humidity can significantly impact our comfort and well-being, often leading to the use of mechanical systems for its management. However, these systems can result in substantial carbon emissions and energy precarity. This study offers an alternative: using low-carbon materials that naturally buffer moisture to passively regulate the indoor humidity.

The International System for Serous Fluid Cytopathology (TIS) survey in preparation for TIS 2.0.

Introduction: The International System for Serous Fluid Cytopathology (TIS) has gained acceptance and has led to literature validating original concepts and suggesting refinements. In preparation for the second edition of TIS, editors generated a survey to solicit experience with and opinions about TIS.

Materials And Methods: An online survey available from March 8 to June 15, 2024, included 56 questions, offered in 7 languages, related to the practice of serous fluid cytopathology.

Childhood family income and medication use in youth.

Background: Low family socioeconomic position is a well-established determinant of poor health in youth. Much less is known about the social patterning of youth medication use, and the current evidence is mixed. Furthermore, previous studies have not assessed important confounders of the associations.

Soldier performance management: insights from boots on ground research and recommendations for practitioners.

Theoretically, the serial measurement of biomarkers to monitor physiological responses to military training could be used to mitigate musculoskeletal injury risk and better understand the recovery status of personnel. To date, the cost and scalability of these initiatives have impeded their uptake by defence organisations. However, advances in technology are increasing the accessibility of a range of health and performance biomarkers.

Impact of algicidal fungus Aspergillus welwitschiae GF6 on harmful bloom-forming cyanobacterium Microcystis aeruginosa: Growth and physiological responses.

Harmful cyanobacterial blooms (HCB) have become a common issue in freshwater worldwide. Biological methods for controlling HCB are relatively cost effective and environmentally friendly. The strain of ascomycete GF6 was isolated from a water sample collected from the estuarine zone of the eastern part of the Gulf of Finland.

Maternal pre- and postnatal stress and maternal and infant gut microbiota features.

Background: Maternal stress can have short and long term adverse (mental) health effects for the mother and her child. Previous evidence suggests that the gut microbiota may be a potential mediator and moderator for the effects of stress via various pathways. This study explored the maternal microbiota trajectory during pregnancy as well as the association between pre- and postnatal maternal stress and features of the maternal and infant gut microbiota during and after pregnancy.

A reproducibility study on invasion in small pulmonary adenocarcinoma according to the WHO and a modified classification, supported by biomarkers.

Objectives: Evaluating invasion in non-mucinous adenocarcinoma (NMA) of the lung is crucial for accurate pT-staging. This study compares the World Health Organization (WHO) with a recently modified NMA classification.

Materials And Methods: A retrospective case-control study was conducted on small NMA pT1N0M0 cases with a 5-year follow-up.

Celiac disease, non-celiac wheat sensitivity, wheat allergy - clinical and diagnostic aspects.

In recent years, wheat- and gluten-free diets have increased in demand due to reported increases in various conditions reported to be driven by ingredients of these food products. Celiac disease, wheat allergy and non-celiac wheat sensitivity constitute the three main categories of wheat-related disorders. Celiac disease is a well-characterized immune-mediated disease caused by immune reaction against specific gliadin epitopes, the main protein in wheat.

A lightweight generative model for interpretable subject-level prediction.

Recent years have seen a growing interest in methods for predicting an unknown variable of interest, such as a subject's diagnosis, from medical images depicting its anatomical-functional effects. Methods based on discriminative modeling excel at making accurate predictions, but are challenged in their ability to explain their decisions in anatomically meaningful terms. In this paper, we propose a simple technique for single-subject prediction that is inherently interpretable.