Efficacy of 100-U Onabotulinumtoxin A Treatment in Female Idiopathic Overactive Bladder-A Prospective Follow-Up Study.

Introduction And Hypothesis: Overactive bladder (OAB) affects 11-17% of the female population. First-line treatment with lifestyle modifications and second-line therapy with medications are often limited by inadequate efficacy or pharmacological side effects. This study was aimed at assessing the effect of 100 U onabotulinumtoxin A treatment on idiopathic OAB (iOAB) as a second-line treatment.

Metaproteomics Beyond Databases: Addressing the Challenges and Potentials of De Novo Sequencing.

Metaproteomics enables the large-scale characterization of microbial community proteins, offering crucial insights into their taxonomic composition, functional activities, and interactions within their environments. By directly analyzing proteins, metaproteomics offers insights into community phenotypes and the roles individual members play in diverse ecosystems. Although database-dependent search engines are commonly used for peptide identification, they rely on pre-existing protein databases, which can be limiting for complex, poorly characterized microbiomes.

Phosphorescent Isocyanide-Metal-Carboranyl complexes of Copper(I) and Gold(I): Synthesis and Radioluminescence.

A series of (L)MX (L = isocyanide; M = Cu(I) or Au(I); X = chloride or carboranyl) complexes have been prepared. The first examples of isocyanide Cu(I) chloride complexes with 1:1 stoichiometry between isocyanide and CuCl are reported and structurally characterised. The photophysical properties of (RNC)AuCl and (RNC)Au(η1-carboranyl) complexes have been investigated.

Ultrafast Infrared Plasmonics.

Ultrafast plasmonics represents a cutting-edge frontier in light-matter interactions, providing a unique platform to study electronic interactions and collective motions across femtosecond to picosecond timescales. In the infrared regime, where energy aligns with the rearrangements of low-energy electrons, molecular vibrations, and thermal fluctuations, ultrafast plasmonics can be a powerful tool for revealing ultrafast electronic phase transitions, controlling molecular reactions, and driving subwavelength thermal processes. Here, the evolution of ultrafast infrared plasmonics, discussing the recent progress in their manipulation, detection, and applications is reviewed.

Predictors of revision endoscopic sinus surgery in Finnish patients with chronic rhinosinusitis with nasal polyps.

Background: Although patients with chronic rhinosinusitis with nasal polyps (CRSwNP) may benefit from endoscopic sinus surgery (ESS), some patients will experience polyp recurrence, adding to the overall disease burden of CRSwNP. We aimed to investigate predictors of revision ESS in patients with CRSwNP.

Methods: A nationwide population-based study including all adults diagnosed with CRSwNP who had surgical procedure codes for ESS (N = 3506), followed up between January 2012 and December 2019.

Nature AND nurture: enabling formate-dependent growth in Methanosarcina acetivorans.

Methanosarcinales are versatile methanogens, capable of regulating most types of methanogenic pathways. Despite the versatile metabolic flexibility of Methanosarcinales, no member of this order has been shown to use formate for methanogenesis. In the present study, we identified a cytosolic formate dehydrogenase (FdhAB) present in several Methanosarcinales, likely acquired by independent horizontal gene transfers after an early evolutionary loss, encouraging re-evaluation of our understanding of formate utilization in Methanosarcinales.

Issues Related to Patient Participation in Psychiatric Hospital Care-An Integrative Literature Review of Patient Safety Research.

Aim: Explore how previous patient safety research has described issues related to patient participation in psychiatric hospital care.

Design: Integrated literature review.

Methods: The literature review was conducted according to Cooper's framework with the following five-step protocol: problem identification, a literature search, data evaluation, data analysis, and the presentation of results.

Broadening the Phenotype Spectrum of MECP2 Variants in Men.

Background: MECP2 variants cause X-chromosome-linked rare developmental syndromes. Typically, the mutation is sporadic, occurs in females and is fatal in men. Accurate genetic and clinical diagnostics are considered essential for the management of symptoms and the development of new treatments.

A Long-Term Ecological Research Data Set From the Marine Genetic Monitoring Program ARMS-MBON 2018-2020.

Molecular methods such as DNA/eDNA metabarcoding have emerged as useful tools to document the biodiversity of complex communities over large spatio-temporal scales. We established an international Marine Biodiversity Observation Network (ARMS-MBON) combining standardised sampling using autonomous reef monitoring structures (ARMS) with metabarcoding for genetic monitoring of marine hard-bottom benthic communities. Here, we present the data of our first sampling campaign comprising 56 ARMS units deployed in 2018-2019 and retrieved in 2018-2020 across 15 observatories along the coasts of Europe and adjacent regions.

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti-CD73/anti-PD-L1 immunotherapy in arm A of the NSGO-OV-UMB1/ENGOT-OV30 trial.

Immune checkpoint inhibitors have demonstrated limited efficacy in overcoming immunosuppression in patients with epithelial ovarian cancer (EOC). Although certain patients experience long-term treatment benefit, reliable biomarkers for responder pre-selection and the distinction of dominant immunosuppressive mechanisms have yet to be identified. Here, we used a 40-marker suspension mass cytometry panel to comprehensively phenotype peripheral blood leukocytes sampled over time from patients with relapsed EOC who underwent combination oleclumab (anti-CD73) and durvalumab (anti-PD-L1) immunotherapy in the NSGO-OV-UMB1/ENGOT-OV30 trial.

Toward a Comprehensive Understanding of Nurses' Compassion Fatigue: A Meta-Integrative Qualitative Synthesis.

Aims: The study aims to conduct a thematic synthesis approach of existing qualitative research to synthesise the real experiences of nurses dealing with compassion fatigue. This integration seeks to provide a comprehensive overview, identify common themes, and offer theoretical support for developing effective intervention strategies to mitigate compassion fatigue in healthcare settings.

Design: A thematic synthesis approach was utilised, synthesising qualitative studies on nurses' experiences of compassion fatigue.

Deletion of Flv3A facilitates long-term H photoproduction in diazotrophic Anabaena sp. PCC 7120.

Molecular hydrogen (H) is a promising energy carrier, and its production by photosynthetic microorganisms holds substantial potential for advancing renewable energy generation. The nitrogenase-mediated H production using heterocyst-forming cyanobacteria represents a promising approach, as the process utilizes light energy and photosynthetic reductants while being naturally protected from O-rich environments by its restriction to microoxic heterocyst cells. We investigated the impact of deleting the vegetative cell-specific flavodiiron protein, Flv3A, on the long-term H photoproduction of the model heterocyst-forming cyanobacterium Anabaena sp.

Association between T2 relaxation time and biomechanical loading of the anterior cruciate ligament in healthy individuals.

Anterior cruciate ligament (ACL) injury is common in sports that include 'change in direction' tasks. The aim of the current study was to determine the association between T2 relaxation time (an indicator of ACL integrity) of the distal portion of the ACL sub-region, biomechanical loading factors of the ACL, sex, and sport status of the participants. Participants between 18 to 35 years performed unanticipated 'change in direction' trials at their maximal self-preferred speed.

Accelerated Design of Dual-Metal-Site Catalysts via Machine-Learning Prediction.

Dual-metal site catalysts (DMSCs) supported on nitrogen-doped graphene have shown great potential in heterogeneous catalysis due to their unique properties and enhanced efficiency. However, the precise control and stabilization of metal dimers, particularly in oxygen activation reactions, present significant challenges in practical applications. In this study, we integrate high-throughput density functional theory calculations with machine learning techniques to predict and optimize the catalytic properties of DMSCs.

Coagulation Profile of Convalescent Plasma Donors and Recipients.

Convalescent plasma (CP) therapy for COVID-19 infection may have favorable safety but varying efficacy, with concerns about its procoagulant impact. We investigated whether administration of CP to hospitalized patients affects their coagulation profile. Fifty-four patients randomized in a double-blinded fashion received either placebo, low-titer CP (LCP) or high-titer CP (HCP).

Effectiveness and adverse effects of immersive technologies used for rehabilitation of patients with non-specific neck pain: a systematic review.

Objective: The aim of this study is to evaluate the effectiveness of immersive technologies in the rehabilitation of patients with non-specific neck pain and identify any potential side effects associated with their use.

Design: Systematic review.

Subjects/patients: Individuals with non-specific neck pain.

Validation of the PANAMA-Score for Survival and Benefit of Adjuvant Therapy in Patients with Resected Pancreatic Cancer After Neoadjuvant FOLFIRINOX.

Aim: To validate the prognostic value of the PAncreatic NeoAdjuvant MAssachusetts (PANAMA)-score and to determine its predictive ability for survival benefit derived from adjuvant treatment in patients after resection of pancreatic ductal adenocarcinoma (PDAC) following neoadjuvant FOLFIRINOX.

Background: The PANAMA-score was developed to guide prognostication in patients after neoadjuvant therapy and resection for PDAC. As this score focuses on the risk for residual disease after resection, it might also be able to select patients who benefit from adjuvant after neoadjuvant therapy.

Long-term outcomes of LDR-brachytherapy for localized prostate cancer.

Introduction: This retrospective study aims to evaluate the long-term efficacy and urinary toxicity of LDR-brachytherapy for localized prostate cancer.

Materials And Methods: 235 primary prostate cancer patients treated with LDR-brachytherapy and subsequently followed up in our center were included in this study. Biochemical relapse free survival (bRFS), overall survival (OS), and cancer-specific survival (CSS) were evaluated.

Pollinator species richness and abundance across diverse habitat-types on Terceira Island (Azores, Portugal).

Background: Azorean biodiversity is relatively well-known following important scientific contributions during the last three decades. These have set a comprehensive species checklist for the Archipelago, improved significantly the knowledge on species abundance, ecology and distribution and have contributed to define priorities for conservation management and scientific research. Nevertheless, despite these efforts, a key functional group - the pollinators - remains poorly known in Azores, including their occurrence in different habitat-types and islands.

Efficient extraction of carboxylated nanocellulose from ionoSolv pulps with alkaline HO assisted oxidation.

Unlabelled: We report a simple procedure to produce carboxylated cellulose nanocrystals (CNCs) from grassy biomass () using a two-step approach consisting of biomass fractionation with a protic ionic liquid followed by oxidation of the resulting cellulose-rich pulps with HO. The impact of the fractionation severity on the composition, structure, size, thermal stability, crystallinity, and degree of polymerization of the CNCs was evaluated. It was found that fractionation severity had a large impact on the pulp purity and its reactivity during the oxidation stage.

The Association Between Occupational Smoke Exposures and the Prevalence of Eye and Respiratory Health Conditions Among Commercial Fish Smokers in Abuesi, Ghana: A Cross-Sectional Self-Reported Study.

Biomass smoke exposure represents a critical health concern, especially for those in occupational settings such as fish smoking. While substantial research has addressed indoor air pollution from domestic cooking, the specific risks faced by fish smokers have received insufficient attention. This study sheds light on the alarming relationship between smoke exposure and health issues among commercial fish smokers in Abuesi, Ghana.

A deep learning approach for classifying and predicting children's nutritional status in Ethiopia using LSTM-FC neural networks.

Background: This study employs a LSTM-FC neural networks to address the critical public health issue of child undernutrition in Ethiopia. By employing this method, the study aims classify children's nutritional status and predict transitions between different undernutrition states over time. This analysis is based on longitudinal data extracted from the Young Lives cohort study, which tracked 1,997 Ethiopian children across five survey rounds conducted from 2002 to 2016.

Degeneracy-breaking and long-lived multimode microwave electromechanical systems enabled by cubic silicon-carbide membrane crystals.

Cubic silicon-carbide crystals (3C-SiC), known for their high thermal conductivity and in-plane stress, hold significant promise for the development of high-quality (Q) mechanical oscillators. We reveal degeneracy-breaking phenomena in 3C-phase crystalline silicon-carbide membrane and present high-Q mechanical modes in pairs or clusters. The 3C-SiC material demonstrates excellent microwave compatibility with superconducting circuits.