Exhaled Nitric Oxide and Sputum Eosinophils Are Complementary Tools for Diagnosing Occupational Asthma.

Background: Exposure-related changes in exhaled nitric oxide (FeNO) and sputum eosinophils have not been thoroughly compared in the investigation of occupational asthma.

Objective: This study aimed at comparing the accuracies of the changes in FeNO concentrations and sputum eosinophil counts in identifying asthmatic reactions induced by occupational agents during specific inhalation challenges (SICs).

Methods: This retrospective multicenter study included 321 subjects who completed an assessment of FeNO and sputum eosinophils before and 24 h after SICs with various occupational agents, of whom 156 showed a positive result.

Vibronic Interactions in the Photoelectron Spectra of CAlGe: A Theoretical Study.

This study probes the vibronic interactions in the photoelectron spectra of CAlGe, exploring its six excited electronic states through an approach that combines the electronic structure calculations and the quantum nuclear dynamics. Central to this investigation is utilizing a model diabatic Hamiltonian, which allows for the exact evaluation of Hamiltonian parameters and fitting potential energy cuts (PECs). Notably, the analysis of these PECs uncovers pronounced nonadiabatic effects within the photoelectron spectra, emphasized by the presence of multiple conical intersections.

Differences in the palliative care phase between patients with nonmalignant pulmonary disease and lung cancer: a retrospective study.

Background: Patients with chronic nonmalignant pulmonary disease and lung cancer both need palliative care, but palliative care services may be better adjusted to serve cancer patients. We compared the timing and clinical practice of palliative care and acute hospital usage during the last year of life in patients with nonmalignant pulmonary disease or lung cancer.

Methods: This was a retrospective study of all patients in a palliative care phase (palliative goal of care) with nonmalignant pulmonary disease or lung cancer who were treated at Tampere University Hospital, Finland, during the years 2018-2020.

Association of maxillofacial injuries with traumatic brain injuries in paediatric patients: a case-control study.

Background: Traumatic brain injuries (TBIs) are among the most challenging conditions to accurately diagnose in children, and many TBIs are underdiagnosed. Patients with maxillofacial injury may be at risk for TBI. The objective of this study was to analyse the association between maxillofacial injuries and TBI among paediatric patients.

Conceiving during the first postoperative year after bariatric surgery: a retrospective study of pregnancy outcomes.

Background: An increasing number of childbearing-aged women have undergone bariatric surgery (BS). Although pregnancy outcomes generally improve after BS, concern remains over the impact of rapid weight loss and the catabolic state that occurs soon after BS. At least a 12-month surgery-to-conception time (SCT) is recommended, though the reasoning behind this has been questioned.

Bioavailability of rumen-protected histidine, lysine, and methionine assessed using different in vivo methods.

The objective of this experiment was to estimate the bioavailability (BA) of rumen-protected (RP) His, RPLys, and 2 RPMet products using 3 in vivo methods: area under the curve (AUC), plasma dose-response (PDR), and fecal free AA (FFAA) methods. We used 8 rumen-cannulated cows in a replicated 4 × 4 Latin square experiment with 16-d periods. Treatments were (1) abomasal infusion of water (control), (2) abomasal infusion of free His, Lys, and Met (FAA), (3) administration of RPHis + RPLys + RPMet1 (rumen-protected methionine protected with ethyl cellulose; RPAA1), and (4) administration of RPHis + RPLys + RPMet2 (rumen-protected methionine protected with a pH-sensitive polymer; RPAA2).

Tertiary lymphoid structures in nasopharyngeal carcinoma: A multi-institutional study.

Background: Tertiary lymphoid structures (TLSs) associate with prognosis of many malignancies. However, the clinical significance of TLSs is not well-elucidated in nasopharyngeal carcinoma (NPC) patients.

Material And Methods: In this whole population-based multicenter study, a total of 115 patients treated for NPC were included.

The Effect of Implementation of Skin Care Guidelines on Nurses' Knowledge Regarding Skin Care and Incidence of Skin Injuries Among Neonates at a Private Tertiary Care Hospital.

Background: Skin care of sick newborns is important because skin acts as a barrier to prevent neonates from infections which may lead to neonatal morbidity and mortality. The highly technological environment of the neonatal intensive care unit (NICU) makes them vulnerable to loss of skin integrity. In acute care setting maintenance of skin integrity is considered as an established quality indicator representing nursing care.

Short- and long-term costs of sinus balloon sinuplasty and middle meatal antrostomy.

Purpose: To evaluate and compare hospital related costs, postoperative costs, and the long-term costs of maxillary balloon sinuplasty (BSP) and middle meatal antrostomy (MMA) in patients with chronic rhinosinusitis.

Methods: Data were collected from patient registers on 88 patients treated with BSP and 240 patients treated with MMA between 2011 and 2017. Information was also gathered on the related costs of surgery, material, postoperative ward care, and any extra patient visits that took place within one year following the operation.

Development of Highly Stretchable Ag-MWCNT Composite for Screen-Printed Textile Electronics with Improved Mechanical and Electrical Properties.

Introduction: The rapid growth of flexible and wearable electronics has created a need for materials that offer both mechanical durability and high conductivity. Textile electronics, which integrate electronic pathways into fabrics, are pivotal in this field but face challenges in maintaining stable electrical performance under mechanical strain. This study develops highly stretchable silver multi-walled carbon nanotube (Ag-MWCNT) composites, tailored for screen printing and heat-transfer methods, to address these challenges.

Excellent Nursing Leadership Towards Magnet Culture Among Nurse Leaders: An Interview Study.

Aims: This study describes nurse leaders' experiences of nursing leadership in Finland towards Magnet hospital culture.

Design: This is a qualitative descriptive study.

Methods: The data from nurse leaders (n = 9) were collected in face-to-face or online interviews in June and August 2023 in Finland and analysed using an inductive content analysis approach.

Patterns in coarse root decomposition of woody plants: effects of climate, root quality, mycorrhizal associations and phylogeny.

Coarse roots represent a globally important belowground carbon pool, but the factors controlling coarse root decomposition rates remain poorly understood relative to other plant biomass components. We compiled the most comprehensive dataset of coarse root decomposition data including 148 observations from 60 woody species, and linked coarse root decomposition rates to plant traits, phylogeny and climate to address questions of the dominant controls on coarse root decomposition. We found that decomposition rates increased with mean annual temperature, root nitrogen and phosphorus concentrations.

Prescribing beyond borders: Navigating challenges and opportunities in cross-border ePrescriptions for enhanced medication access and safety.

Background: The European cross-border electronic prescription (CBeP) was first introduced in Estonia and Finland. The CBeP service is gradually being implemented across Europe, prompting a need for practical studies to assess its benefits and potential shortcomings.

Objective: This study aimed to investigate Estonian and Finnish pharmacists' experiences with patient identification, personal data protection and safe use of medications with CBeP, as well as main advantages and areas of development of CBeP.

DLBCL cells with ferroptosis morphology can be detected with a deep convolutional neural network.

It has been demonstrated that diffuse large B-cell lymphoma (DLBCL) is especially sensitive to ferroptosis. Currently, confirming the presence of ferroptosis requires flow cytometry, which is a time consuming and labor-intensive task. Blistering of the cell membrane has been shown to be a ferroptosis-specific morphological change.

Dynamics of thermal tolerance plasticity across fish species and life stages.

Climate warming with associated heat waves presents a concerning challenge for ectotherms such as fishes. During heatwaves, the ability to rapidly acclimate can be crucial for survival. However, surprisingly little is known about how different species and life stages vary in their acclimation dynamics, including the magnitude of change in thermal tolerance through acclimation (i.

Stress and distress in healthcare students: protective roles of social support, student community and meaningfulness of studying.

Objectives: To explore association between perceived stress and psychological distress (depressive symptoms and anxiety), and the stress-buffering effects of social support (parents, partners, friends, peers, teachers, social media), sense of community belonging and meaningfulness of studying.

Methods: A cross-sectional study was conducted in 2018 using a convenience sample of 800 healthcare students from the University of Helsinki, Finland. Participants completed an online survey.

Interventions Intended to Improve the Well-Being at Work of Nurses Working in Care Settings for Older People-A Systematic Review.

Introduction: Nurses' well-being at work (WAW) is important for overall health care outcomes. Nurses often navigate complex roles, contending with time constraints, ethical challenges and societal undervaluation, underscoring the necessity of addressing their WAW.

Methods: The aim of this systematic review was to analyse the interventions that potentially improve nurses' WAW in care settings for older people.

Propagation of Orientation Across Lengthscales in Sheared Self-Assembling Hierarchical Suspensions via Rheo-PLI-SAXS.

Simultaneous rheological, polarized light imaging, and small-angle X-ray scattering experiments (Rheo-PLI-SAXS) are developed, thereby providing unprecedented level of insight into the multiscale orientation of hierarchical systems in simple shear. Notably, it is observed that mesoscale alignment in the flow direction does not develop simultaneously across nano-micro lengthscales in sheared suspensions of rod-like chiral-nematic (meso) phase forming cellulose nanocrystals. Rather, with increasing shear rate, orientation is observed first at mesoscale and then extends to the nanoscale, with influencing factors being the aggregation state of the hierarchy and concentration.

Cancer vaccines: an update on recent achievements and prospects for cancer therapy.

Decades of basic and translational research have led to a momentum shift in dissecting the relationship between immune cells and cancer. This culminated in the emergence of breakthrough immunotherapies that paved the way for oncologists to manage certain hard-to-treat cancers. The application of high-throughput techniques of genomics, transcriptomics, and proteomics was conclusive in making and expediting the manufacturing process of cancer vaccines.

A deep fusion-based vision transformer for breast cancer classification.

Breast cancer is one of the most common causes of death in women in the modern world. Cancerous tissue detection in histopathological images relies on complex features related to tissue structure and staining properties. Convolutional neural network (CNN) models like ResNet50, Inception-V1, and VGG-16, while useful in many applications, cannot capture the patterns of cell layers and staining properties.

A secure blockchain framework for healthcare records management systems.

Electronic health records are one of the essential components of health organizations. In recent years, there have been increased concerns about privacy and reputation regarding the storage and use of patient information. In this regard, the information provided as a part of medical and health insurance, for instance, can be viewed as proof of social insurance and governance.

Predicting recovery in patients with mild traumatic brain injury and a normal CT using serum biomarkers and diffusion tensor imaging (CENTER-TBI): an observational cohort study.

Background: Even patients with normal computed tomography (CT) head imaging may experience persistent symptoms for months to years after mild traumatic brain injury (mTBI). There is currently no good way to predict recovery and triage patients who may benefit from early follow-up and targeted intervention. We aimed to assess if existing prognostic models can be improved by serum biomarkers or diffusion tensor imaging metrics (DTI) from MRI, and if serum biomarkers can identify patients for DTI.

Worldwide patterns and trends in ovarian cancer incidence by histological subtype: a population-based analysis from 1988 to 2017.

Background: Ovarian cancer (OC) is a heterogeneous malignancy with multiple histological subtypes, showing global variability in incidence. Temporal changes in diagnostic criteria and risk factors might influence the incidence and distribution of OC and its subtypes.

Methods: This study analyzed incidence patterns (2013-2017) and trends (1988-1992 to 2013-2017) of OC and its subtypes across 65 and 40 countries, respectively.

Risk for Flexor Pollicis Longus Rupture after Volar Lock Plating for Distal Radius Fracture Lasts Over a Decade.

Objectives: Volar locking plate (VLP) fixation is a very common procedure due to the high incidence of distal radius fractures (DRFs). Attritional flexor tendon rupture is a rare, but recognized complication after VLP fixation. There is no current consensus to prevent the condition.