One hundred thirty-four germ line PU.1 variants and the agammaglobulinemic patients carrying them.

Leukopoiesis is lethally arrested in mice lacking the master transcriptional regulator PU.1. Depending on the animal model, subtotal PU.

Significant Impact of a Daytime Halogen Oxidant on Coastal Air Quality.

Chlorine radicals (Cl) are highly reactive and affect the fate of air pollutants. Several field studies in China have revealed elevated levels of daytime molecular chlorine (Cl), which, upon photolysis, release substantial amounts of Cl but are poorly represented in current chemical transport models. Here, we implemented a parametrization for the formation of daytime Cl through the photodissociation of particulate nitrate in acidic environments into a regional model and assessed its impact on coastal air quality during autumn in South China.

Investigating the moments of "aha" and "hmm" through acoustic analysis of voice and speech in pre-service physics teacher education-A novel method for identifying significant learning moments.

The aim of the study was to find whether certain meaningful moments in the learning process are noticeable through features of voice and how acoustic voice analyses can be utilized in learning research. The material consisted of recordings of nine university students as they were completing tasks concerning direct electric circuits as part of their course of teacher education in physics. Prosodic features of voice-fundamental frequency (F0), sound pressure level (SPL), acoustic voice quality measured by LTAS, and pausing-were investigated.

Associations between dialysis modality and adherence to immunosuppression after kidney transplantation-A single-center study.

Background: Patients with end-stage kidney disease often prefer home-based dialysis due to higher self-efficacy, which relates to improved medical treatment adherence. Kidney transplantation (KT) success depends on adhering to immunosuppressive medication post-transplant.

Objectives: To investigate whether adherence post-kidney transplantation (KT) and patients' attitudes toward immunosuppression were influenced by their prior dialysis type modality.

Effect of bar jump height on kinetics and kinematics of take-off in agility dogs.

Sport-related injuries have been reported to occur in around one-third of agility dogs. Higher bar height in competitions has been shown to increase odds of an injury. This study evaluated the effect of bar height on the kinetics and kinematics at take-off to a bar jump.

Dental Caries, Erosive Tooth Wear, and Periodontal Status of Military Student Pilots in Finland: A Comparative Cross-Sectional Study.

Introduction: Oral health is a crucial factor for service safety among military pilots, but studies specifically on pilots are still very few in Finland. The aim of this study was to assess the oral health status of military student pilots compared to other conscripts of the same age group.

Materials And Methods: The data were collected during the oral health examinations of the annual class of the Pilot Reserve Officer Course students at the beginning of their duty at the Air Force Academy (N = 38).

Maternal Emotional Availability Supports Child Communicative Development Regardless of Child Temperament-Findings From the FinnBrain Birth Cohort Study.

The interplay of emotional availability (EA) and child temperament in association with early language development is understudied. We explored associations between maternal EA and infant communicative development and possible moderations by child temperament. Participants were 151 mother-child dyads from the FinnBrain Birth Cohort Study.

Social support and online interaction and their links to psychosocial well-being among Nordic adolescents: Integrating variable-centered and person-centered approaches.

The Nordic countries are among the most digitally advanced societies in the world. Past research suggests that both social support offline and interaction online are linked to adolescent psychological adjustment. However, less is known regarding the complex implications of distinctive sources of social support offline and online interaction for a broader range of indices of adolescent psychosocial well-being, including its contemporary forms such as social media addiction.

Communicating scientific evidence: drugs for Alzheimer's disease as a case study.

This paper reviews the scientific evidence on new anti-amyloid monoclonal antibodies for treating Alzheimer's disease as a case study for improving scientific evidence communication. We introduce five guidelines condensed from the biomedical evidence literature but adapted to the short format of science communication in e.g.

Combining Transversus Abdominis Plane and Rectus Sheath Blocks in Open Inguinal Hernia Surgery Anesthesia: A Retrospective Cohort Analysis.

Background: Lichtenstein hernia repair is a common surgical procedure. Previously, combined rectus sheath (RS) and transversus abdominis plane (TAP) blocks have been shown to be beneficial in laparoscopic inguinal hernia surgery. Our hypothesis is that combining the two blocks will also be beneficial in open Lichtenstein hernioplasty day-case procedures.

Unraveling the immunomodulatory and metabolic effects of bioactive glass S53P4 on macrophages in vitro.

Macrophage metabolism is closely linked to their phenotype and function, which is why there is growing interest in studying the metabolic reprogramming of macrophages. Bioactive glass (BG) S53P4 is a bioactive material used especially in bone applications. Additionally, BG S53P4 has been shown to affect macrophages, but the mechanisms through which the possible immunomodulatory effects are conveyed remain unclear.

Primary surgery of subcondylar mandibular fracture using patient-specific implant: the Helsinki protocol.

Purpose: Preoperative virtual planning and osteosynthesis with patient-specific implants (PSIs) have become a quotidian approach to many maxillofacial elective surgery setups. When a process is well-organized, a similar approach can be harnessed to serve the needs of exact primary reconstructions, especially in midfacial trauma cases. PSI osteosynthesis of the mandible is, however, more challenging because a mirror technique of the facial sides is often unreliable due to inherent lack of symmetry, and movement of the mandible increases the risk of loosening of the osteosynthesis.

Association Between Symptoms of Body Dysmorphia and Social Media Usage: A Cross-Generational Comparison.

The rise of social media parallels a mental health epidemic. The effect of social media usage on rates and severity of body dysmorphic disorder is not well-understood. To determine if an association exists between social media engagement, body dysmorphia symptoms, and/or interest in cosmetic surgery in a demographically diverse cross-section of the U.

Skin Grafting.

Although skin grafting is a basic surgical procedure, there are many sophisticated innovations that are used only by experienced surgeons. In-depth knowledge of new and old methods gives the opportunity to select the most appropriate technique in each case. Most methods have been invented long ago, but some of them have been rediscovered and further refined.

Predictors of Perceived Positive and Negative Consequences of Sexual Compliance.

Sexual compliance (i.e., consenting to sex without initial sexual desire) can have both positive and negative consequences for well-being.

Factors Associated With Social-Pragmatic Understanding in Deaf and Hard of Hearing and Typically Hearing 6-Year-Old Children.

Purpose: Children develop social-pragmatic understanding with the help of sensory, cognitive, and linguistic functions by interacting with other people. This study aimed to explore (a) associations between auditory, demographic, cognitive, and linguistic factors and social-pragmatic understanding in children who use bilateral hearing aids (BiHAs) or bilateral cochlear implants (BiCIs) and in typically hearing (TH) children and (b) the effect of the group (BiHA, BiCI, TH) on social-pragmatic understanding when the effects of demographic, cognitive, and linguistic factors are controlled for.

Method: The Pragma test was used to assess social-pragmatic understanding in 119 six-year-old children: 25 children who use BiHAs, 29 who use BiCIs, and 65 TH children.

Causal Effects of Air Pollution, Noise, and Shift Work on Unstable Angina and Myocardial Infarction: A Mendelian Randomization Study.

Cardiovascular disease continues to be a major contributor to global morbidity and mortality, with environmental and occupational factors such as air pollution, noise, and shift work increasingly recognized as potential contributors. Using a two-sample Mendelian randomization (MR) approach, this study investigates the causal relationships of these risk factors with the risks of unstable angina (UA) and myocardial infarction (MI). Leveraging single nucleotide polymorphisms (SNPs) as genetic instruments, a comprehensive MR study was used to assess the causal influence of four major air pollutants (PM, PM, NO, and NO), noise, and shift work on unstable angina and myocardial infarction.

Kienböck's Disease - Incidence and operations in Finland: a nationwide register study.

This study assessed the nationwide incidence of Kienböck's Disease, and operations performed for Kienböck's Disease from the Care Register for Health Care in Finland 1996-2022. The mean annual total standardized incidence rate per million person-years was 9.60 (95% CI: 9.

Fitting Geometric Shapes to Fuzzy Point Cloud Data.

This article describes procedures and thoughts regarding the reconstruction of geometry-given data and its uncertainty. The data are considered as a continuous fuzzy point cloud, instead of a discrete point cloud. Shape fitting is commonly performed by minimizing the discrete Euclidean distance; however, we propose the novel approach of using the expected Mahalanobis distance.

The Representational Challenge of Integration and Interoperability in Transformed Health Ecosystems.

: Health and social care systems around the globe are currently undergoing a transformation towards personalized, preventive, predictive, participative precision medicine (5PM), considering the individual health status, conditions, genetic and genomic dispositions, etc., in personal, social, occupational, environmental, and behavioral contexts. This transformation is strongly supported by technologies such as micro- and nanotechnologies, advanced computing, artificial intelligence, edge computing, etc.

Detection of Cancer Stem Cells from Patient Samples.

The existence of cancer stem cells (CSCs) in various tumors has become increasingly clear in addition to their prominent role in therapy resistance, metastasis, and recurrence. For early diagnosis, disease progression monitoring, and targeting, there is a high demand for clinical-grade methods for quantitative measurement of CSCs from patient samples. Despite years of active research, standard measurement of CSCs has not yet reached clinical settings, especially in the case of solid tumors.

Playing a serious game to increase fertility awareness: perceptions of adolescents, parents and teachers.

Infertility is increasing globally, affecting one in six adults due to factors like delayed childbearing and lifestyle changes. Despite the recognition of the importance of increasing fertility awareness, levels remain low. This study evaluated the perceptions of 'FActs!', a serious game aimed at improving adolescents' fertility awareness.

Local adaptation and phenotypic plasticity in two forest understorey herbs in response to forest management intensity.

Local adaptation is a common phenomenon that helps plant populations to adjust to broad-scale environmental heterogeneity. Given the strong effect of forest management on the understorey microenvironment and often long-term effects of forest management actions, it seems likely that understorey herbs may have locally adapted to the practiced management regime and induced environmental variation. We investigated the response of and to forest management using a transplant experiment along a silvicultural management intensity gradient.

Towards high atom economy in whole-cell redox biocatalysis: up-scaling light-driven cyanobacterial ene-reductions in a flat panel photobioreactor.

Light-driven biotransformations in recombinant cyanobacteria benefit from the atom-efficient regeneration of reaction equivalents like NADPH from water and light by oxygenic photosynthesis. The self-shading of photosynthetic cells throughout the reaction volume, along with the need for extended light paths, limits adequate light supply and significantly restricts the potential for upscaling. Here, we present a flat panel photobioreactor (1 cm optical path length) as a scalable system to provide efficient illumination at high cell densities.

Mechanically regulated microcarriers with stem cell loading for skin photoaging therapy.

Long-term exposure to ultraviolet radiation compromises skin structural integrity and results in disruption of normal physiological functions. Stem cells have gained attention in anti-photoaging, while controlling the tissue mechanical microenvironment of cell delivery sites is crucial for regulating cell fate and achieving optimal therapeutic performances. Here, we introduce a mechanically regulated human recombinant collagen (RHC) microcarrier generated through microfluidics, which is capable of modulating stem cell differentiation to treat photoaged skin.