203,368 results match your criteria: "Finland; The Baker IDI Heart and Diabetes Institute[Affiliation]"

Background: Children's eating behaviors, including a tendency towards overeating, are strongly influenced by the family. Children prone to overeating are at a high risk of excessive weight gain, which can lead to further adverse health outcomes. Therefore, identifying factors that contribute to overeating is crucial for promoting healthy weight development.

View Article and Find Full Text PDF

Structural insights into mechanisms of zinc scavenging by the zincophore Pra1.

bioRxiv

January 2025

Faculty of Health and Life Sciences, Medical Research Council Centre for Medical Mycology, Geoffrey Pope Building, University of Exeter, Exeter, EX4 4QD, UK.

causes more than 400,000 life-threatening, and half a billion mucosal infections annually. In response to infection, the host limits availability of essential micronutrients, including zinc, to restrict growth of the invading pathogen. As assimilation of zinc is essential for pathogenicity, its limitation induces the secretion of the zincophore protein Pra1 to scavenge zinc from the host.

View Article and Find Full Text PDF

Enhancement of Thermal, Mechanical, and Oxidative Properties of Polypropylene Composites with Exfoliated Hexagonal Boron Nitride Nanosheets.

ACS Omega

January 2025

Department of Materials Science and Engineering, Gachon University, 1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do 13120, South Korea.

This study investigates the enhancement of polypropylene (PP) composites through the incorporation of exfoliated hexagonal boron nitride (h-BN) nanosheets. The preparation process involved exfoliating h-BN in a liquid phase using a high-pressure homogenizer, followed by the coating of PP pellets with the exfoliated nanosheets using an acoustic mixer. Melt extrusion was then employed to fabricate h-BN-reinforced PP composite films.

View Article and Find Full Text PDF

Characterization of Photo-Cross-Linked Polyethylene Pipes for Geothermal Energy Storage.

ACS Omega

January 2025

Swedish Centre for Resource Recovery, Faculty of Textiles, Engineering and Business, University of Borås, 501 90 Boras, Sweden.

This study investigates the morphology and thermo-mechanical properties of cross-linked polyethylene (PEX) pipes for potential use in high-temperature borehole thermal energy storage systems. Particular attention is given to a novel type of PEX pipe produced through photoinitiated cross-linking (PEX-e). Two formulations, PEX-e1 and PEX-e2, were analyzed and compared to peroxide-cross-linked polyethylene (PEX-a) and non-cross-linked bimodal polyethylene (PE100) pipes.

View Article and Find Full Text PDF

Steric and Electronic Effects of Zirconocenealkyl-Borate Ion Pairs on Catalyst Activation: A Theoretical Study.

ACS Omega

January 2025

Unit of Excellence in Computational Molecular Science and Catalysis, and Division of Chemistry, School of Science, University of Phayao, Phayao 56000, Thailand.

The effectiveness of metallocene catalysts in the cationic ring-opening polymerization (cationic ROP) of ε-caprolactone (CL) is influenced by the choice of metallocene/borate systems, particularly their bulkiness. Recent research examines this effect on the initiation and propagation stages of cationic ROP. We conducted a density functional theory study on the precatalyst activation of cationic CL ROP by zirconocene/borate catalysts, where four models of zirconocene precatalysts (CpZrMe (), (MeCp)CpZrMe (), (MeCp)ZrMe (), and IndZrMe ()) were combined with boron cocatalysts B(CF) and [X][B(CF) ] (X = PhC or PhMeNH).

View Article and Find Full Text PDF

Afforestation is increasingly recognized as a critical strategy to restore ecosystems and enhance biodiversity on post-agricultural landscapes. However, agricultural legacies, such as altered soil structure, nutrient imbalances, and depleted microbial diversity, can slow down forest establishment or cause ecosystems to deviate from expected successional trajectories. In this opinion paper, we explore the potential of soil inoculations as a tool to overcome these challenges by introducing beneficial microbial communities that can accelerate ecosystem recovery and forest development.

View Article and Find Full Text PDF

Trees First Inhibit Then Promote Litter Decomposition in the Subarctic.

Ecol Lett

January 2025

Biological and Environmental Sciences, School of Natural Sciences, University of Stirling, Stirling, UK.

Trees affect organic matter decomposition through allocation of recently fixed carbon belowground, but the magnitude and direction of this effect may depend on substrate type and decomposition stage. Here, we followed mass loss, chemical composition and fungal colonisation of leaf and root litters incubated in mountain birch forests over 4 years, in plots where belowground carbon allocation was severed by tree girdling or in control plots. Initially, girdling stimulated leaf and root litter mass loss by 12% and 22%, respectively, suggesting competitive release of saprotrophic decomposition when tree-mediated competition by ectomycorrhizal fungi was eliminated (Gadgil effect).

View Article and Find Full Text PDF

Introduction: This study describes epidemiology of attention deficit hyperactivity disorder (ADHD) and use of ADHD medication across all age groups in Finland.

Methods: This retrospective study is based on nationwide registers in Finland. The study population included individuals with ADHD diagnosis and/or an ADHD medication record at least once during 2015-2020.

View Article and Find Full Text PDF

Aim: The aim of the study was to survey the observed incidence of adverse effects (AEs) related to electroconvulsive therapy (ECT) in Finnish neuromodulation units, as well as to explore what medical interventions are used to prevent and treat them in those units.

Methods: An electronic survey was conducted among Finnish neuromodulation units at the end of 2022. The survey included 35 questions related to AEs and their prevention and/or treatment in the responding units' ECT patient populations.

View Article and Find Full Text PDF

The reaction of three equivalents of LiCH(SiMe) with TiCl(NMe) afforded the rare homoleptic Ti(III) alkyl Ti{CH(SiMe)} (1) which crystallized as blue needles in 32 % yield. Single crystal X-Ray data for 1 showed a trigonal pyramidal coordination geometry around titanium, which could be ascribed to weak interactions between the C-H bonds and the Ti(III) atom based on computational results. X-band EPR spectroscopy gives spectral parameters consistent with the proposed Ti(III) formulation.

View Article and Find Full Text PDF

Background: To align with climate goals, greenhouse gas (GHG) emissions from agriculture must be reduced significantly. Cultivated peatlands are an important source of such emissions. One proposed measure is to convert arable fields on peatlands to grassland, as the Intergovernmental Panel on Climate Change (IPCC) default emission factors (EF) for organic soils are lower from grasslands.

View Article and Find Full Text PDF

Aims/purpose: This study aims to assess whether changes in intraocular pressure (IOP) occur after a blood draw and quantify these changes' magnitude in a group of patients over 60 years old.

Methods: We analysed data from the right eye of 54 subjects, with a mean ( SD) age of 68 4 years. The measurements were conducted in the morning while fasting.

View Article and Find Full Text PDF

The traditional model of protein structure determined by the amino acid sequence is today seriously challenged by the fact that approximately half of the human proteome is made up of proteins that do not have a stable 3D structure, either partially or in totality. These proteins, called intrinsically disordered proteins (IDPs), are involved in numerous physiological functions and are associated with severe pathologies, e.g.

View Article and Find Full Text PDF

Objective: Neurosurgical care is difficult to access in many scenarios. Aeromedical evacuation of acutely unwell neurosurgical patients from remote, isolated or poorly equipped locations can be considered. This article aims to provide a framework of logistical factors which deserve special consideration in the preparation of these patients for transfer.

View Article and Find Full Text PDF

Antibiotic treatment versus appendicectomy for acute appendicitis in adults: an individual patient data meta-analysis.

Lancet Gastroenterol Hepatol

January 2025

Department of Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands. Electronic address:

Background: Randomised controlled trials (RCTs) have found antibiotics to be a feasible and safe alternative to appendicectomy in adults with imaging-confirmed acute appendicitis. However, patient inclusion criteria and outcome definitions vary greatly between RCTs. We aimed to compare antibiotics with appendicectomy for the treatment of acute appendicitis using individual patient data and uniform outcome definitions.

View Article and Find Full Text PDF

The contribution of shipping to the emission of water and air pollutants in the northern Adriatic Sea - current and future scenarios.

Mar Pollut Bull

January 2025

Department of Environmental Sciences, Informatics and Statistics, University Ca' Foscari of Venice, Via Torino 155, 30172 Venice, Mestre, Italy. Electronic address:

Marine pollution management requires identifying all sources of contaminants, yet shipping's role in marine contamination remains unexplored. To address this gap, we investigated shipping contribution to water and air pollutant loads in the Northern Adriatic Sea in 2018 and under two future scenarios. The approach integrated (i) modelled data of shipping-related emissions, (ii) load from tributaries, and (iii) land-based emissions to the atmosphere.

View Article and Find Full Text PDF

Muscle mass has been traditionally assessed by measuring paraspinal muscle areas at the level of the third lumbar vertebra on computed tomography (CT). Neurological or neurosurgical patients seldom undergo CT scans of the lumbar region. Instead, temporal muscle thickness (TMT), cross-sectional area (TMA) and radiodensity measured from head CT scans are readily available measures of muscle mass and quality in these patient cohorts.

View Article and Find Full Text PDF

Mitochondrial ribosomes (mitoribosomes) are essential, and their function of synthesising mitochondrial proteins is universal. The core of almost all mitoribosomes is formed from a small number of long and self-folding rRNA molecules. In contrast, the mitoribosome of the apicomplexan parasite Toxoplasma gondii assembles from over 50 extremely short rRNA molecules.

View Article and Find Full Text PDF

Abdominal obesity and cardiometabolic risk markers: A comparative analysis of waist circumference, dual-energy X-ray absorptiometry, and magnetic resonance imaging techniques.

Nutr Metab Cardiovasc Dis

November 2024

Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil; Turku PET Centre, University of Turku, Turku, Finland. Electronic address:

Background And Aims: This study compares three methods to determine central adiposity (waist circumference -WC - and visceral adipose tissue - VAT - estimated by dual-energy x-ray absorptiometry - DXA, and by magnetic resonance imaging - MRI) in their ability to predict increases in cardiometabolic risk (CMR) markers in young individuals. We examined their associations with CMR in 47 men and women aged 25-40.

Methods And Results: VAT mass was assessed using DXA and MRI.

View Article and Find Full Text PDF

Background: Support for the treatment of uncomplicated appendicitis with non-operative management rather than surgery has been increasing in the literature. We aimed to investigate whether treatment of uncomplicated appendicitis with antibiotics in children is inferior to appendicectomy by comparing failure rates for the two treatments.

Methods: In this pragmatic, multicentre, parallel-group, unmasked, randomised, non-inferiority trial, children aged 5-16 years with suspected non-perforated appendicitis (based on clinical diagnosis with or without radiological diagnosis) were recruited from 11 children's hospitals in Canada, the USA, Finland, Sweden, and Singapore.

View Article and Find Full Text PDF

Physical Color Calibration of Digital Pathology Scanners for Robust Artificial Intelligence Assisted Cancer Diagnosis.

Mod Pathol

January 2025

Department of Medical Epidemiology and Biostatistics, SciLifeLab, Karolinska Institutet, Stockholm, Sweden. Electronic address:

The potential of artificial intelligence (AI) in digital pathology is limited by technical inconsistencies in the production of whole slide images (WSIs). This causes degraded AI performance and poses a challenge for widespread clinical application, as fine-tuning algorithms for each site is impractical. Changes in the imaging workflow can also compromise diagnostic accuracy and patient safety.

View Article and Find Full Text PDF

ICT acceptance in social and healthcare context - A scoping review of theories and models.

Int J Med Inform

January 2025

Faculty of Social Sciences and Business Studies, University of Eastern Finland, Kuopio, Finland; Research Centre for Nursing Science and Social and Health Management, Kuopio University Hospital, Wellbeing Services County of North Savo, Kuopio, Finland; Finnish Centre for Evidence-Based Health Care: A JBI Centre of Excellence, Helsinki, Finland.

Background: Although Information and Communication Technology (ICT) acceptance processes have been studied widely in the social and healthcare context, the theoretical background of these studies is widely based on Technology Acceptance Models (TAM, TAM2, UTAUT) and their extensions. These theoretical models have been criticized for being overly simplistic and focusing narrowly on individual adopters' beliefs, perceptions, and usage intentions without considering multidimensional approaches to capture the complexity of certain phenomena. Thus, there is a need for identifying other approaches to study ICT acceptance in the complex and digitalizing social and health care context.

View Article and Find Full Text PDF

Relax: Analytic and automatic NMR relaxation theory.

J Magn Reson

January 2025

NMR Research Unit, University of Oulu, P.O. Box 3000, FI-90014, Finland. Electronic address:

Spin relaxation is modelled using the so-called relaxation superoperator Γˆˆ. Analytic forms of Γˆˆ have been derived in the literature in the simplest cases of one- or two-spin systems, with S=12 nuclei and no more than two different simultaneous relaxation mechanisms involved. Beyond that, for systems of more than two spins, with S>12 and/or multiple relaxation mechanisms at play, the derivations become notoriously complicated, which is why analytic relaxation theory has mostly been considered a dead end.

View Article and Find Full Text PDF