Patient-Reported Outcomes of Visual Disturbances with a Trifocal Intraocular Lens: A Meta-Analysis.

Introduction: Diffractive trifocal intraocular lenses (IOLs) provide good vision at distance, intermediate, and near, but can also cause positive dysphotopsias. This meta-analysis pooled published evidence on visual disturbances after bilateral implantation of the PanOptix (TFNTXX) IOL for patients undergoing cataract surgery.

Method: A systematic literature search was conducted in PubMed and congress presentations from April 2021 to December 2022 to identify studies with patient-reported outcomes on the incidence of visual disturbances (starbursts, halos, glare) post bilateral implantation of PanOptix IOL during cataract surgery.

Diet-Gut Microbiota Relations: Critical Appraisal of Evidence From Studies Using Metagenomics.

Diet may influence the gut microbiota and subsequently affect the host's health. Recent developments in methods analyzing the composition and function of the gut microbiota allow a deeper understanding of diet-gut microbiota relationships. A state-of-the-art methodology, shotgun metagenomics sequencing, offers a higher taxonomic resolution of the gut microbiota at the bacterial species and strain levels, and more accurate information regarding the functional potential of gut microbiota.

The fungicide propiconazole induces hepatic steatosis and activates PXR in a mouse model of diet-induced obesity.

Propiconazole is a triazole fungicide previously shown to induce triglyceride accumulation in human liver HepaRG cells, potentially via activation of the Pregnane X Receptor (PXR). However, whether propiconazole can disrupt hepatic and whole-body metabolism in vivo is currently unknown. Therefore, we aimed to examine the metabolic effects of propiconazole in the context of metabolic dysfunction-associated steatotic liver disease (MASLD), obesity, and insulin resistance.

Long-term outcome of pediatric acute severe colitis: A prospective 5-year follow-up of the PRASCO trial.

Objectives: The PRASCO trial reported the short-term superiority of an antibiotic cocktail plus intravenous corticosteroids (IVCS) over IVCS alone in children with acute severe colitis (ASC). Here, we report the extension of the PRASCO trial and the long-term outcomes of the antibiotic cocktail in ASC.

Methods: This prospective follow-up of the PRASCO trial documented disease outcomes and treatments annually through 5 years.

Linking Foraging Behaviour and Habitat Preferences During Moult Across Multiple Populations of Red-Throated Diver.

Understanding the habitat use of individuals can facilitate methods to measure the degree to which populations will be affected by potential stressors. Such insights can be hard to garner for marine species that are inaccessible during phases of their annual cycles. Here, we quantify the link between foraging habitat and behaviour in an aquatic bird of high conservation concern, the red-throated diver () across three breeding populations (Finland, Iceland and Scotland) during their understudied moult period.

Spinal cord stimulation for the treatment of complex regional pain syndrome: A systematic review of randomized controlled trials.

Background: Spinal Cord Stimulation (SCS) is a widely recognized treatment for Complex Regional Pain Syndrome (CRPS), particularly in cases where traditional methods are ineffective. This paper systematically reviews randomized controlled trials to analyze the efficacy of SCS, as well as Dorsal Root Ganglion (DRG) Stimulation in treating CRPS, focusing on its long-term effectiveness.

Methods: This systematic review focused exclusively on randomized controlled trials to assess a primary outcome of improvement in pain symptoms in patients diagnosed with CRPS.

Relationship between Air Pollution and Serum Vitamin D Levels: A Systematic Review and Meta-Analysis.

Background: Elevated levels of atmospheric pollutants might disrupt the metabolism of vitamin D in the skin. Studies showed inconsistent results about the impact of air pollution on the serum vitamin D level. This study aims to systematically review the influence of air pollution on vitamin D levels.

Evaluating carbon removal: Integrating technical potential with environmental, social, governance criteria, and sequestration permanence.

Climate modeling suggests that achieving international climate goals requires a reduction in current CO emissions by over 90%, with any remaining emissions to be addressed through carbon dioxide removal (CDR) solutions. Sixteen CDR strategies are evaluated by integrating technical potential, environmental, social, and governance (ESG) criteria, along with sequestration permanence. This evaluation, conducted by ENGIE's scientific council using an interdisciplinary Delphi panel methodology, proposes a "quality" measure for each technology.

Interventions to foster connections and interactions.

Background: The Special Issue articles describe six systems of parental interventions and developmental care several differences among each of the approaches. Nevertheless, on a deeper level there are profound similarities shared across the six systems. These similarities are at the heart of developmental care in general and parental interventions in particular.

The dispersion method does not affect the in vitro genotoxicity of multi-walled carbon nanotubes despite inducing surface alterations.

Multi-walled carbon nanotubes (MWCNTs) are a desirable class of high aspect ratio nanomaterials (HARNs) owing to their extensive applications. Given their demand, the growing occupational and consumer exposure to these materials has warranted an extensive investigation into potential hazards they may pose towards human health. This study utilised both the in vitro mammalian cell gene mutation and the cytokinesis-blocked micronucleus (CBMN) assays to investigate genotoxicity in human lymphoblastoid (TK6) and 16HBE14o human lung epithelial cells, following exposure to NM-400 and NM-401 MWCNTs for 24 h.

Incentives, Health, and Retirement: Evidence From a Finnish Pension Reform.

This paper examines, using exogenous variation generated by a Finnish pension reform implemented in 2005, the interplay between health and financial incentives to postpone retirement. Based on detailed administrative data on individual health and retirement behavior, we focus on whether individual reactions to incentives vary according to health status and analyze whether individuals with ill health are also able to take advantage of the potential monetary benefits of delayed retirement created by the reform. We find that on average, individuals react to the financial incentives created by the reform as expected.

Determinants of binge eating and its impact on indicators of obesity among Finnish adolescents - a cohort study.

Background: Binge eating, a type of disordered eating, is relatively common among youth and predisposes them to many adverse health outcomes. Diverse psychological and social factors may be associated with binge eating. The aim of this study was to examine child and parental psychosocial determinants of binge eating and its impact on indicators of obesity.

H-driven xylitol production in Cupriavidus necator H16.

Background: Biocatalysis offers a potentially greener alternative to chemical processes. For biocatalytic systems requiring cofactor recycling, hydrogen emerges as an attractive reducing agent. Hydrogen is attractive because all the electrons can be fully transferred to the product, and it can be efficiently produced from water using renewable electricity.

Perceived competency requirements for emergency medical services field supervisors in managing chemical and explosive incidents - qualitative interview study.

Background: Chemical, biological, radiological, nuclear, and explosive (CBRNE) incidents present rare and complex challenges for Emergency Medical Services (EMS), necessitating effective incident command to manage occupational and patient safety risks. EMS incident commanders must make quick decisions under pressure, coordinating medical responses and ensuring personnel's safety. This study examined the perceived competence requirements of Finnish EMS field supervisors in managing C and E incidents.

Restricting Periodontal Treatment Frequency: Impact on Tooth Loss in Danish Adults.

Objective: The study aimed to estimate the effect of a periodontal treatment policy that would restrict the receipt of periodontal therapy to no more than once every second year, on the 10-year risk of tooth extraction among Danish adults.

Methods: Data from linked nationwide Danish registers consisted of a random sample of 20 000 50-year-olds who were followed from the beginning of 1990 to the end of 2021. The longitudinal modified treatment policies' causal inference framework was used.

The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshunds.

Background: The relationship between radiographic disc calcification score and FGF4L2 genotype has been reported in only a small number of dachshunds.

Hypothesis: A genotype with either 0 or 1 FGF4L2 copy will be associated with a lower number of calcified discs (lower K-n) compared with a genotype with 2 FGF4L2 copies.

Animals: Dachshunds registered with the Norwegian or Finnish Kennel Clubs for which both K-n and FGF4L2 genotype are known (n = 407).

Geocultural differences in pre-schooler sleep profiles and family practices: an analysis of pooled data from 37 countries.

Study Objectives: To examine 1) multidimensional sleep profiles in pre-schoolers (3-6 years) across geocultural regions and 2) differences in sleep characteristics and family practices between Majority World regions (Pacific Islands, Sub-Saharan Africa, Eastern Europe, Northeast Asia, Southeast Asia, South Asia, the Middle East and North Africa, Latin America) and the Minority World (the Western world).

Methods: Participants were 3507 pre-schoolers from 37 countries. Nighttime sleep characteristics and nap duration (accelerometer: n=1950) and family practices (parental questionnaire) were measured.

Comparative analysis of patient-reported outcomes in joint arthroplasty surgeries.

Background: This study aims to report and analyze disease-specific patient-reported outcome measure (PROM) effect size (ES) variations, in patients undergoing major arthroplasty surgery.

Material And Methods: All institution-based data of primary knee, hip, or shoulder arthroplasty patients at Turku University hospital (Finland) between January 2020 -December 2022 were collected, and treatment outcome assessed as a PROM difference between baseline and one-year follow-up. PROM ES were calculated for each patient and patient group separately, and patients with ES >0.

Fabrication of 2D/2D BiMoO/S@g-CN type-II heterojunction photocatalyst for enhanced visible-light-mediated degradation of tetracycline in wastewater.

Aquatic biota and human health are seriously threatened by the dramatic rise in antibiotics in environmental matrices. In this regard, the present study aims to improve knowledge of the combined effects of heterojunction design and defect engineering on the photocatalytic degradation of pharmaceuticals in aqueous matrices. Advantageously, the positioning of the valence band (VB) and conduction band (CB) levels of S@g-CN, being higher than those of BiMoO, demonstrates the feasibility of forming a type-II heterojunction between these materials.

Genome concentration limits cell growth and modulates proteome composition in .

Defining the cellular factors that drive growth rate and proteome composition is essential for understanding and manipulating cellular systems. In bacteria, ribosome concentration is known to be a constraining factor of cell growth rate, while gene concentration is usually assumed not to be limiting. Here, using single-molecule tracking, quantitative single-cell microscopy, and modeling, we show that genome dilution in cells arrested for DNA replication limits total RNA polymerase activity within physiological cell sizes across tested nutrient conditions.

Fertility and Sexual Function in Males with Hirschsprung's Disease: A Nordic Cross-Sectional Study.

Objective: The aim was to assess fertility, sexual function and sexual quality of life in males with Hirschsprung's disease (HSCR) in the Nordic countries with a cross-sectional study using self-reported validated questionnaires.

Summary Background Data: Data on fertility and sexual function in males with HSCR are limited.

Methods: This multi-center study targeted all males born between 1970-2003 who underwent pull-through surgery at a pediatric surgery center in Sweden, Denmark, Norway, or Finland.

Comparison of original and new South African formulae for age estimation in African Black and white children and adolescents using dental and hand-wrist methods.

Background: Methods for age estimation in children involve measurements of: (1) the projections of open apices and tooth heights (T), (2) the total area of the carpal bones and the epiphyses of the ulna and radius (HW), and (3) a combination of these parameters (THW). This study aimed to compare the accuracy of the original formulae for T, HW, and THW in Black South African (BSA) and White South African (WSA) samples of children and adolescents.

Materials And Methods: The sample comprised 556 subjects, 164 BSA (71 males and 93 females) and 392 WSA (171 males and 221 females) aged 6 to 16 years.

Emergence of Exotic Spin Texture in Supramolecular Metal Complexes on a 2D Superconductor.

Designer heterostructures have offered a very powerful strategy to create exotic superconducting states by combining magnetism and superconductivity. In this Letter, we use a heterostructure platform combining supramolecular metal complexes (SMCs) with a quasi-2D van der Waals superconductor NbSe_{2}. Our scanning tunneling microscopy measurements demonstrate the emergence of Yu-Shiba-Rusinov bands arising from the interaction between the SMC magnetism and the NbSe_{2} superconductivity.

Constraints for Rare Electron-Capture Decays Mimicking Detection of Dark-Matter Particles in Nuclear Transitions.

We give for the first time theoretical estimates of unknown rare electron-capture (EC) decay branchings of ^{44}Ti, ^{57}Co, and ^{139}Ce, relevant for searches of (exotic) dark-matter particles. The nuclear-structure calculations have been done exploiting the nuclear shell model with well-established Hamiltonians and an advanced theory of β decay. In the absence of experimental measurements of these rare branches, these estimates are of utmost importance for terrestrial searches of dark-matter particles, such as axionic dark matter in the form of axionlike particles, anapole dark matter, and dark photons in nuclear transitions.