Gut microbes on the risk of advanced adenomas.

Background: More than 90% of colorectal cancer (CRC) arises from advanced adenomas (AA) and gut microbes are closely associated with the initiation and progression of both AA and CRC.

Objective: To analyze the characteristic microbes in AA.

Methods: Fecal samples were collected from 92 AA and 184 negative control (NC).

Bacterial imaging in tumour diagnosis.

Some bacteria, such as Escherichia coli (E. coli) and Salmonella typhimurium (S. typhimurium), have an inherent ability to locate solid tumours, making them a versatile platform that can be combined with other tools to improve the tumour diagnosis and treatment.

Third-generation PacBio sequencing to explore gut bacteria and gender in colorectal cancer.

Background: Gut bacteria have an important influence on colorectal cancer (CRC). The differences of gut bacteria between genders have been the hot spots.

Objective: To analyze the relationship between gut bacteria and gender differences in patients with CRC.

Age and aging process alter the gut microbes.

Background: Gut microbes and age are both factors that influence the development of disease. The community structure of gut microbes is affected by age.

Objective: To plot time-dependent gut microbe profiles in individuals over 45 years old and explore the correlation between age and gut microbes.

Aging Gut Microbiome in Healthy and Unhealthy Aging.

The characteristics of human aging manifest in tissue and organ function decline, heightening susceptibility to age-related ailments, thereby presenting novel challenges to fostering and sustaining healthy longevity. In recent years, an abundance of research on human aging has surfaced. Intriguingly, evidence suggests a pervasive correlation among gut microbiota, bodily functions, and chronic diseases.

Effect of transcranial direct current stimulation on postoperative sleep disturbance in older patients undergoing lower limb major arthroplasty: a prospective, double-blind, pilot, randomised controlled trial.

Background: Postoperative sleep disturbance (PSD) is a common and serious postoperative complication and is associated with poor postoperative outcomes.

Aims: This study aimed to investigate the effect of transcranial direct current stimulation (tDCS) on PSD in older patients undergoing lower limb major arthroplasty.

Methods: In this prospective, double-blind, pilot, randomised, sham-controlled trial, patients 65 years and over undergoing lower limb major arthroplasty were randomly assigned to receive active tDCS (a-tDCS) or sham tDCS (s-tDCS).

Transcriptional profile and immune infiltration in colorectal cancer reveal the significance of inducible T-cell costimulator as a crucial immune checkpoint molecule.

Background: Emergence of novel immuno-therapeutics has shown promising improvement in the clinical outcome of colorectal cancer (CRC).

Objective: To identify robust immune checkpoints based on expression and immune infiltration profiles of clinical CRC samples.

Methods: One dataset from The Cancer Genome Atlas database and two from Gene Expression Omnibus were independently employed for the analysis.

Advances in reprogramming of energy metabolism in tumor T cells.

Cancer is a leading cause of human death worldwide, and the modulation of the metabolic properties of T cells employed in cancer immunotherapy holds great promise for combating cancer. As a crucial factor, energy metabolism influences the activation, proliferation, and function of T cells, and thus metabolic reprogramming of T cells is a unique research perspective in cancer immunology. Special conditions within the tumor microenvironment and high-energy demands lead to alterations in the energy metabolism of T cells.

Classification of Colorectal Cancer Subtypes Based on Endoplasmic Reticulum Stress.

Introduction: Endoplasmic reticulum stress (ERS) is associated with the occurrence and development of colorectal cancer (CRC).

Methods: One thousand nine CRC samples and 3 ERS gene sets from GEO database were used to screen and validate genes related to stage and prognosis of CRC. Twenty thousand five hundred thirty samples from the TCGA database validated the ERS genes related to prognosis.

Colorectal cancer and gut viruses: a visualized analysis based on CiteSpace knowledge graph.

Background: Gut microbiome is a complex community of microbes present in the human gut and plays an important role in the occurrence and progression of colorectal cancer (CRC). However, the relationship between virus and CRC has not been fully understood.

Objective: To explore the hot spots and research trends in the field of CRC and virus.

Functional limitation and happiness among older adults: the multiple mediating role of intergenerational support and intergenerational relationship.

Objectives: This study aimed to investigate the relationship between the functional limitation and happiness among Chinese older people and examined the multiple mediating effects of intergenerational support (instrumental support and financial support) and intergenerational relationship.

Method: Data was drawn from the Chinese Family Panel Survey (CFPS) 2018 and 2020. Structural equation modeling was adopted to analyze the association among functional limitations, intergenerational support, intergenerational relationship, and the older adults happiness.