6 results match your criteria: "Fifth Clinical College of Harbin Medical University[Affiliation]"
Inhibition of lncRNA Gm15834 Attenuates Autophagy-Mediated Myocardial Hypertrophy via the miR-30b-3p/ULK1 Axis in Mice.
Mol Ther
March 2021
Department of Pharmacology, Harbin Medical University-Daqing, Daqing, Heilongjiang 163319, China. Electronic address:
Emerging evidence reveals that autophagy plays crucial roles in cardiac hypertrophy. Long noncoding RNAs (lncRNAs) are novel transcripts that function as gene regulators. However, it is unclear whether lncRNAs regulate autophagy in cardiac hypertrophy.
View Article and Find Full Text PDFAllicin attenuates pathological cardiac hypertrophy by inhibiting autophagy via activation of PI3K/Akt/mTOR and MAPK/ERK/mTOR signaling pathways.
Phytomedicine
May 2019
Department of Pharmacology, Harbin Medical University-Daqing, Daqing, Heilongjiang 163319, China. Electronic address:
Background: Cardiac hypertrophy is an adaptive response of the myocardium to pressure or volume overload. Recent evidences indicate that allicin can prevent cardiac hypertrophy. However, it is not clear whether allicin alleviates cardiac hypertrophy by inhibiting autophagy.
View Article and Find Full Text PDFActivation of AMPK Attenuated Cardiac Fibrosis by Inhibiting CDK2 via p21/p27 and miR-29 Family Pathways in Rats.
Mol Ther Nucleic Acids
September 2017
Department of Pharmacology, Harbin Medical University-Daqing, Daqing, Heilongjiang 163319, China. Electronic address:
Cardiac fibrosis is pathological damage associated with nearly all forms of heart disease. AMP-activated protein kinase (AMPK) is an evolutionary conserved energy-sensing enzyme. Emerging evidences indicate that AMPK plays an important role in cardiac fibrosis and cell proliferation.
View Article and Find Full Text PDFCarvacrol inhibits proliferation and induces apoptosis in human colon cancer cells.
Anticancer Drugs
September 2015
Departments of aPathophysiology bPathology and cPharmacology, Harbin Medical University-Daqing dDepartment of Surgery, Fifth Clinical College of Harbin Medical University, Daqing, Heilongjiang, China.
Colon cancer is one of the most common malignancies worldwide and has a high mortality rate. Carvacrol is a major component of oregano and thyme essential oils and shows antitumor properties. Here, we investigated the effects of carvacrol on the proliferation and apoptosis of two human colon cancer cell lines, HCT116 and LoVo, and studied the molecular mechanisms of its antitumor properties.
View Article and Find Full Text PDFRole of calcium-sensing receptor in cardiac injury of hereditary epileptic rats.
Pharmacology
October 2015
Department of Surgery, Fifth Clinical College of Harbin Medical University, Daqing, China.
Article Synopsis
- - The study investigates how the calcium-sensing receptor (CaSR) contributes to cardiac injury in rats with epilepsy, focusing on factors like apoptosis and fibrosis in heart tissue.
- - Results showed elevated levels of CaSR in the hearts of epileptic rats, leading to increased cardiac cell death (apoptosis) and fibrosis, confirmed through various staining and biochemical assays.
- - The findings suggest that CaSR worsens cardiac complications in epilepsy through specific pathways that involve mitochondrial dysfunction and various signaling proteins, indicating its potential role as a therapeutic target.
The mechanism of neurogenic pulmonary edema in epilepsy.
J Physiol Sci
January 2014
Department of Respiratory Medicine, The Fifth Clinical College of Harbin Medical University, Daqing, 163316, Heilongjiang, China.
Neurogenic pulmonary edema (NPE) is found in many epilepsy patients at autopsy. It is a life-threatening complication, known for almost 100 years, but its etiopathogenesis is still not completely understood. In this study, we used the tremor rat (TRM: tm/tm) as an animal model of epilepsy to investigate the potential mechanisms of NPE under epileptic conditions.
View Article and Find Full Text PDF