PAIP1 regulates expression of immune and inflammatory response associated genes at transcript level in liver cancer cell.

Poly(A) binding protein interacting protein 1 (PAIP1) is a translation regulator and also regulate the decay of mRNA. PAIP1 has also been reported to be a marker of increased invasive potential of liver cancer. However, the roles and underlying molecular mechanism of PAIP1 in liver cancer is still unclear.

[Corrigendum] Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer cells by inhibiting the expression of FAT‑1.

Following the publication of the above paper, the authors drew the Editor's attention to the fact that their article contained two textual errors located in the same sentence: In the '' subsection of the Materials and methods section on p. 1086 (the first sentence), the text here should have read as follows (changes highlighted in bold): 'In the present study, 85 bladder cancer tissues and 27 adjacent normal tissues were collected from patients with BC who attended the for treatment.' (i.

Effect of apparent temperature on hospitalization from a spectrum of cardiovascular diseases in rural residents in Fujian, China.

Cardiovascular disease (CVD) is a leading threat to global public health. Although associations between temperature and CVD hospitalization have been suggested for developed countries, limited evidence is available for developing countries or rural residents. Moreover, the effect of apparent temperature (AT) on the spectrum of cause-specific CVDs remains unknown.

Outcomes of Canaliculotomy with and without Silicone Tube Intubation in Management of Primary Canaliculitis.

Purpose: To compare the outcomes of canaliculotomy and curettage with and without silicone tube intubation in the treatment of primary canaliculitis.

Methods: A prospective, randomized, interventional case series was performed. Fifty patients diagnosed with unilateral inferior primary canaliculitis underwent canaliculotomy with curettage and were randomly divided into two groups depending on silicone tube intubation.

Development and Application of Medicine-Engineering Integration in the Rehabilitation of Traumatic Brain Injury.

The rapid progress of the combination of medicine and engineering provides better chances for the clinical treatment and healthcare engineering. Traumatic brain injury (TBI) and its related symptoms have become a major global health problem. At present, these techniques has been widely used in the rehabilitation of TBI.

Long-term oncological outcomes of low anterior resection for rectal cancer with and without preservation of the left colic artery: a retrospective cohort study.

Background: There is uncertainty in the literature about preserving the left colic artery (LCA) during low anterior resection for rectal cancer. We analyzed the effect of preserving the LCA on long-term oncological outcomes.

Methods: We retrospectively collected clinicopathological and follow-up details of patients who underwent low anterior resection for rectal cancer in the General Surgery Department of Guangdong Provincial People's Hospital, from January 2014 to December 2015.

Assessing PM-associated risk of hospitalization for COPD: an application of daily excessive concentration hours.

Existing PM-morbidity studies using daily mean concentration as exposure metric may fail to capture intra-day variations of PM concentrations, resulting in underestimated health impacts to some extent. This study introduced a novel indicator, daily excessive concentration hours (DECH), defined as sums of per-hourly excessive concentrations of PM against a specific threshold within a day. PM DECHs were separately calculated as daily concentration-hours >8, 10, 15, 20, and 25 μg/m (abbreviations: DECH-8, DECH-10, DECH-15, DECH-20, and DECH-25).

Ketogenic diet induces autophagy to alleviate bleomycin-induced pulmonary fibrosis in murine models.

Ketogenic diet (KD) has been identified as an effective strategy in treating multiple diseases. KD is capable of inducing autophagy which is an important therapeutic target for pulmonary fibrosis (PF). This study aimed to investigate the effect of KD treatment on PF progression.

Breakfast preferences and consumption location among children at a median age of 7 in Shenzhen: Implications for managing overweight and obesity.

Background: Breakfast is commonly described as the most important meal of the day; however, we have little information regarding its relevance for childhood overweight and obesity in southern mainland China. This study aimed to assess the association between breakfast preferences, consumption location and overweight and obesity for children in Shenzhen.

Methods: Among 6126 children (median age 7.

Anthropometry did not approach adequate predictive accuracies for detecting elevated fasting plasma glucose or hemoglobin A1c levels among Chinese children aged 7-9 years.

Aims/introduction: Elevated concentrations of fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c) are well-established independent risk factors for progression to diabetes, cardiovascular comorbidities and mortality. Most previous studies on the relationships of anthropometric measures with hyperglycemia were carried out among adults and adolescents, but few data are available for the performance predication of the predictors for diagnosing elevated FPG or HbA1c among young children.

Materials And Methods: Involving 5,556 students of aged 7-9 years, a school-based cross-sectional survey was carried out between March and June 2019 in Shenzhen, China.

Synchronous papillary thyroid carcinoma and breast ductal carcinoma.

A 48-year-old woman was admitted to our hospital with a lump in her left breast. She was diagnosed with synchronous papillary thyroid carcinoma and breast ductal carcinoma. The patient underwent four cycles of neoadjuvant chemotherapy with epirubicin and cyclophosphamide, and one cycle of docetaxel.

SNAI1 is a prognostic biomarker and correlated with immune infiltrates in gastrointestinal cancers.

Epithelial-mesenchymal transition (EMT)-related genes play an important role in immunosuppression. However, the correlations of EMT-related genes to prognosis and tumor-infiltrating lymphocytes in different cancers remain unclear. TCGA, GEO databases were used to analyze the expression, prognosis, and immune infiltration of EMT markers in cancer.

Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer cells by inhibiting the expression of FAT‑1.

FAT atypical cadherin 1 (FAT1) regulates complex mechanisms for the promotion of oncogenesis or the suppression of malignancies. Sulforaphane (SFN) has antioxidant and anti‑tumor activities. The present study investigated the roles of SFN and FAT1 in bladder cancer (BC).

Sleep apnea-hypopnea syndrome caused by ankylosing spondylitis: A case report.

Introduction: Sleep apnea-hypopnea syndrome (SAHS) is a multifactorial disease characterized by recurrent hypopnea or respiratory interruption during sleep, which causes intermittent hypoxemia, hypercapnia, and sleep structure disturbances. An association between ankylosing spondylitis (AS) and the type of SAHS has rarely been reported in the literature. Here, we present a case of SAHS in a patient with AS and discuss the possible mechanism underlying the type of SAHS.

Association of body mass index with serum alanine aminotransferase in Chinese adolescents: a school-based cross-sectional study.

Background: Numerous studies have consistently demonstrated that high body mass index (BMI) is related to elevated serum alanine aminotransferase (ALT) among adults, but little is known about the association regarding adolescents, especially in China. In this study, we aimed to investigate the association between BMI and ALT activity among Chinese adolescents.

Methods: A school-based cross-sectional study was performed among nine high schools in Shenzhen, China between February 2017 and June 2018.

Association between excessive smartphone use and cervical disc degeneration in young patients suffering from chronic neck pain.

Background: With the popularity of smartphones, cervical spondylosis is becoming more and more common among young people. The aim of this study was to investigate the association between excessive smartphone use and cervical disc degeneration in young patients suffering from chronic neck pain.

Methods: A total of 2438 young patients suffering from chronic neck pain were included into this study.

Diagnostic performance of individual characteristics and anthropometric measurements in detecting elevated serum alanine aminotransferase among children and adolescents.

Background: Screening for elevated serum alanine aminotransferase (ALAT) can help identifying individuals at the risks of chronic and metabolic diseases, but blood collection is invasive and cannot be widely used for investigations. Considered as simple and inexpensive screening indices, individual characteristics and anthropometric measurements can be measured in a large crowd and may be important surrogate markers for ALAT levels. This study aimed to examine the diagnostic performance of individual characteristics and anthropometric parameters as predictive factors for discerning an elevated ALAT activity among Shenzhen children and adolescents.

Efficacy of antifungal drugs in the treatment of oral candidiasis: A Bayesian network meta-analysis.

Statement Of Problem: The comparative efficacy of antifungal drugs on oral candidiasis remains unclear.

Purpose: The purpose of this Bayesian network meta-analysis was to investigate the efficacy of antifungal drugs on oral candidiasis.

Material And Methods: Databases, including PubMed, The Cochrane Library, and Web of Science, were accessed from the dates of their establishment to October, 2018, to collect randomized controlled trials (RCTs) of different antifungal drugs for oral candidiasis.

Age- and season-specific effects of ambient particles (PM, PM, and PM) on daily emergency department visits among two Chinese metropolitan populations.

Background: Ambient PM has been identified as the top leading cause of risk-attributable deaths worldwide, particularly in China. Evidence suggested that PM contributed the most majority of PM concentrations in Chinese cities. However, epidemiologic knowledge to date is of wide lack regarding PM-associated health effects.

Diagnostic Accuracy of Interleukin-27 in Bronchoalveolar Lavage Fluids for Pulmonary Tuberculosis.

Background: The World Health Organization states that China had 0.9 million cases of tuberculosis in 2017, accounting for 9% of cases globally. Despite a decrease in the incidence and mortality of tuberculosis in China over time, development in choosing the appropriate prevention and control of TB is required.

Short-term effects of ambient PM and PM air pollution on hospital admission for respiratory diseases: Case-crossover evidence from Shenzhen, China.

Background: Ambient PM (particulate matter with aerodynamic diameter ≤1 μm) is an important contribution of PM mass. However, little is known worldwide regarding the PM-associated health effects due to a wide lack of ground-based PM measurements from air monitoring stations.

Methods: We collected daily records of hospital admission for respiratory diseases and station-based measurements of air pollution and weather conditions in Shenzhen, China, 2015-2016.

Dysregulation of miR-195-5p/-218-5p/BIRC5 axis predicts a poor prognosis in patients with gastric cancer.

MicroRNAs (miRNAs) function by negatively regulating their target genes. Aberrant expression of baculoviral IAP repeat containing 5 (BIRC5) is associated with the tumor growth and metastasis, however, the clinical significance of miRNAs/BIRC5 axis in gastric cancer (GC) remains unknown. The association of BIRC5 or miR-195-5p/-218-5p expression levels with the clinicopathological characteristics and prognosis in patients with GC was analysed by using a tissue microarray and TCGA dataset.

Short-term impacts of ambient fine particulate matter on emergency department visits: Comparative analysis of three exposure metrics.

Background: Research argued that daily excessive concentration hours (DECH) could be more informative through accounting for within-day variations, when assessing population-level exposure to ambient fine particle (PM). However, few studies have comparatively investigated PM-associated risks using DECH and two common metrics of daily mean and hourly peak concentration.

Methods: We collected daily records of all-cause emergency department visits (EDVs) and hourly data on air pollutants and meteorological factors from Shenzhen, China, 2015-2018.