Parenting stress of adoptive mothers, mother-child conflict, and behavior problems during adolescence among international adoptees.

International adoptees show more behavior problems than their nonadopted peers do during childhood and adolescence. Although conditions of deprivation experienced prior to adoption have been found to have a long-lasting impact on child psychosocial adjustment, the influence of adoptive families tends to increase over age. The aim of this study was to investigate the impact of parenting stress and parent-child conflict on international adoptees' behavior problems in adolescence.

Neighbourhood Material and Social Deprivation and Exposure to Antidepressant Drug Treatment: A Cohort Study Using Administrative Data.

Objective: To assess whether neighbourhood deprivation is associated with exposure to an antidepressant drug treatment (ADT) and its quality among individuals diagnosed with unipolar depression and insured by the Quebec public drug plan.

Method: We conducted an administrative database cohort study of adults covered by the Quebec public drug plan who were diagnosed with a new episode of unipolar depression. We assessed material and social deprivation using an area-based index.

Assessment of the Psychosocial Predictors of Health-Related Quality of Life in a PTSD Clinical Sample.

Although a wide array of the scientific literature explores the links between posttraumatic stress disorder (PTSD) symptoms, coping strategies, and social support and health-related quality of life (HRQoL) as an outcome variable, their connections remain unclear. It is unknown whether PTSD symptom severity, coping strategies, and social support explain each a unique portion of variance of HRQoL of individuals with PTSD. In the current study, based on pretreatment results of a broader study assessing a specific intervention for PTSD, 94 individuals with PTSD were screened for psychiatric disorders and completed several questionnaires concerning social support, coping strategies, PTSD symptoms, and HRQoL.

The experience of seclusion and restraint in psychiatric settings: perspectives of patients.

Many studies report that the use of seclusion and restraint (SR) is experienced negatively by patients who experience feelings of shame, helplessness, and humiliation, and may relive previous trauma events. Since 2000, in Québec, exceptional measures like SR have been framed by a protocol. This protocol provides health care teams with guidelines for relieving, containing, and reducing the suffering caused by SR.

Dissolving the tenacity of obsessional doubt: implications for treatment outcome.

Background And Objectives: Previous research has found that a high impact of possibility based information during reasoning prevents the resolution of doubt among those with Obsessive-Compulsive Disorder (OCD). It was expected that the ability of those with OCD to resolve obsessional doubt would improve following Inference Based Treatment (IBT).

Methods: The ability to resolve doubt, including the relative impact of reality and possibility based information, was measured before and after treatment with the Inference Processes Task in a group of 35 participants diagnosed with OCD.

Prevalence and correlates of seclusion with or without restraint in a Canadian psychiatric hospital: a 2-year retrospective audit.

Seclusion with or without restraint is a measure used to manage patients with challenging behaviours. Although controversial, the intervention remains poorly documented, especially in Canadian psychiatric hospitals. The purpose of this study is to assess the prevalence of the measure and identify any correlated demographic characteristics and psychiatric disorders.

Schizophrenia and serious violence: a clinical-profile analysis incorporating impulsivity and substance-use disorders.

Objectives: This study is an exploration of the role of SUD and impulsivity in individuals with schizophrenia who are at higher risk of serious violence (SV).

Methods: Multiple correspondence analysis (MCA) and cluster analysis (CA) were performed on a sample of 139 males meeting DSM-IV diagnostic criteria for schizophrenia-spectrum disorders (SSD).

Results: Impulsivity was the main dimension differentiating individuals.

Chronic stress, cognitive functioning and mental health.

This review aims to discuss the evidence supporting the link between chronic stress, cognitive function and mental health. Over the years, the associations between these concepts have been investigated in different populations. This review summarizes the findings that have emerged from older populations as well as from populations suffering from pathological aging, namely Mild Cognitive Impairment and Alzheimer's Disease.

Clinical evolution of substance use disorder patients during treatment with quetiapine: a 12-week, open-label, naturalistic trial.

Objective: Substance use disorders (SUDs) are associated with a variety of psychiatric disorders and mood and behavioral instability. Growing evidence suggests that the atypical antipsychotic quetiapine may be useful in the treatment of SUDs. The primary objective of the current open-label trial was to examine the effects of quetiapine on SUD outcomes in patients entering detoxification.

Imaginative, dissociative, and schizotypal processes in obsessive-compulsive symptoms.

This study investigates imaginative, dissociative, and schizotypal processes that are potentially relevant to obsessive-compulsive (OC) symptoms. Students (n = 377) completed questionnaires that assessed inferential confusion, absorption, schizotypal personality, and other domains. Hierarchical regression revealed that inferential confusion and absorption were the most consistent predictors of OC symptoms; other content predicted variance for specific OC symptoms.

Virtual reality induces dissociation and lowers sense of presence in objective reality.

This study utilizes an innovative experimental paradigm to investigate the effects of virtual reality (VR) on dissociative experience and the sense of presence. A nonclinical sample of 30 people were administered measures of dissociation, sense of presence, and immersion before and after an immersion in a virtual environment. Results indicate an increase in dissociative experience (depersonalization and derealization), including a lessened sense of presence in objective reality as the result of exposure to VR.

Psychometric properties of a pictorial instrument for assessing psychopathology in youth aged 12 to 15 years: the Dominic Interactive for Adolescents.

Objectives: Over the last 15 years, adequate psychometric properties of the different versions of the Dominic led to the development of the Dominic Interactive for Adolescents (DIA). The DIA is a Diagnostic and Statistical Manual of Mental Disorders (DSM), Fourth Edition, Text Revision-based self-administered computerized pictorial instrument for assessing the most frequent mental disorders in adolescents aged 12 to 15 years. Our study aims to verify the internal consistency, the test-retest estimate of reliability, and the criterion-related validity of this instrument.

Inferential confusion, obsessive beliefs and obsessive-compulsive symptoms: a multidimensional investigation of cognitive domains.

Generally, research into the relationship between cognitive domains and obsessive-compulsive symptoms involves the use of scales that are highly intercorrelated with each other. The current study investigates the relationship between cognitive constructs and obsessive-compulsive symptoms using the item set of the Obsessive Beliefs Questionnaire and the Inferential Confusion Questionnaire. In order to create constructs that would not be excessively correlated with each other, factor scores were used to investigate the relationship between cognitive domains and obsessive-compulsive symptoms.

Increased grey matter densities in schizophrenia patients with negative symptoms after treatment with quetiapine: a voxel-based morphometry study.

Among new-generation antipsychotics, quetiapine was found to be associated with a partial 'normalization' of reduced functional activation in prefrontal and temporal areas and studies conducted by our group found a clinical improvement in negative symptoms in addition to restoration of frontal activation in schizophrenia patients with blunted affect after treatment with quetiapine. Here we investigated the parallelism between improved clinical symptoms and grey mater density (GMD) changes in the frontal region after quetiapine treatment in 15 schizophrenia patients. We hypothesize that improvement in clinical symptoms will be associated with change in GMD in prefrontal regions of interest.

Working memory and depressive symptoms in patients with schizophrenia and substance use disorders.

Background: Substance abuse is highly prevalent in schizophrenia and it has been associated with negative consequences on the course of the pathology. Regarding cognition, the prevailing literature has produced mixed results. Some groups have reported greater cognitive impairments in dual diagnosis schizophrenia, while other groups have described the reverse.

Endogenous cannabinoids in patients with schizophrenia and substance use disorder during quetiapine therapy.

Disturbances in the endogenous cannabinoid (ECB) system in schizophrenia may contribute to their enhanced sensitivity to psychoactive substances, and the beneficial effects of second-generation antipsychotics for substance abuse in schizophrenia may involve modulatory effects on ECB. To verify these two assumptions, 29 patients (24 completers) with schizophrenia and substance use disorders (SUD) were treated with quetiapine for 12 weeks, and peripheral ECB levels were measured, using high-performance liquid chromatography/mass spectrometry, in patients (weeks 0, 6 and 12) and 17 healthy volunteers. Baseline anandamide levels were significantly higher in patients, relative to controls.

Anhedonia and social adaptation predict substance abuse evolution in dual diagnosis schizophrenia.

The current study sought to identify the variables, derived from the self-medication hypothesis, which predicted substance abuse evolution during a homogeneous 3-month antipsychotic treatment. Twenty-four patients were diagnosed with schizophrenia and substance abuse (mainly cannabis and alcohol). Substance abuse, psychiatric symptoms, anhedonia, and social adjustment were assessed at baseline and study endpoint.

Benefits and risks of antipsychotic polypharmacy: an evidence-based review of the literature.

Combination antipsychotic prescription is an increasingly common practice in clinical psychiatry. This clinical practice is at odds with clinical guidelines promoting antipsychotic monotherapy. Moreover, there has been increased concern over the safety profile of atypical antipsychotics in the last 10-15 years.

Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review.

Background: Cytokines play an important role in infection and inflammation and are crucial mediators of the cross-talk between the brain and the immune system. Schizophrenia would be associated with an imbalance in inflammatory cytokines, leading to a decrease in Th1 and an increase in Th2 cytokine secretion. However, data published so far have been inconsistent.

Contradictory cognitive capacities among substance-abusing patients with schizophrenia: a meta-analysis.

Although a substance use disorder (SUD) is traditionally associated with psycho-bio-social impairments, recent investigations among persons with schizophrenia (Sz) generated divergent results. Certain persons with Sz+SUD might in fact present better social and cognitive functioning than persons with Sz without SUD. This meta-analysis was conducted to verify this counterintuitive possibility and to determine whether factors such as substance type, severity or nature of psychotic symptoms and age of the patients help discriminate these subgroups.

Selective serotonin reuptake inhibitor (SSRI) add-on therapy for the negative symptoms of schizophrenia: a meta-analysis.

Background: Negative symptoms are among the most chronic symptoms of schizophrenia. Even with the advent of atypical antipsychotic drugs, negative symptoms remain mostly refractory to treatment. It has been proposed that selective serotonin reuptake inhibitor (SSRI) augmentation therapy in schizophrenia could provide a greater relief of these symptoms.

Increased striatal gray matter densities in patients with schizophrenia and substance use disorder: a voxel-based morphometry study.

We sought to investigate the link between substance abuse and increased striatal gray matter densities (GMD) in schizophrenia, using voxel-based morphometry (VBM). Increased striatal GMD were found in patients with schizophrenia and substance use disorder (n=12), but not schizophrenia only patients (n=11), compared to healthy volunteers (n=15).

Correlates of depressive disorders in the Quebec general population 6 to 14 years of age.

There are relatively few community-based epidemiological studies in which correlates of depressive disorders were identified through multivariate analyses in children and adolescents aged 6--14 years. Moreover, several family characteristics (e.g.

Neural correlates of the affect regulation model in schizophrenia patients with substance use history: a functional magnetic resonance imaging study.

Background: The lifetime prevalence of substance use disorders among schizophrenia patients is close to 50%. The negative consequences of substance abuse in schizophrenia are well documented, but the etiology of this comorbid condition remains unknown. According to the affect regulation model, schizophrenia patients abuse drugs in order to cope with their negative affects.