100 results match your criteria: "Ferdowsi University Campus [corrected] Mashhad[Affiliation]"

Protective effect of Auraptene, a novel acetylcholinesterase inhibitor, on hydrogen peroxide-induced cell toxicity in PC12 cells.

Toxicol Res (Camb)

December 2024

Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Khorasan Razavi, Mashhad, Azadi Square, 9177948954, Iran.

Objective: Alzheimer's disease (ad) is a progressive and degenerative disorder of the central nervous system that is associated with cognitive and memory impairment. The main factors which have been implicated in neurodegeneration of ad are oxidative stress and cholinergic neurons dysfunction. Here, we examined the effects of auraptene, a novel acetylcholinesterase (AChE) inhibitor, on hydrogen peroxide (HO)-induced cell death in PC12 cells.

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Micronized versus super-conditioned corn: Effects on starch digestion, performance, and blood metabolites of Holstein dairy calves.

J Dairy Sci

December 2024

Science and Technology Park, Ferdowsi University of Mashhad, Mashhad 9177948974, Iran; Department of Animal Science, Agricultural and Natural Resources Research and Education Center of Razavi Khorasan, Mashhad 91735-488, Iran. Electronic address:

Micronization, a dry-heat process, generates infrared electromagnetic short waves that can affect starch granules and gelatinization. A new method of corn processing, super-conditioned corn, a moisture-heat process, has potential to increase starch digestion and performance in calves. Therefore, incorporating super-conditioned or micronized corn in starter feed may enhance growth performance by improving total-tract starch digestion.

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Although checklists of the Iranian ladybird beetles (Coleoptera: Coccinellidae) have been made twice in recent years, they have a number of shortcomings. Moreover, since these checklist were published, several ladybird species have been added to the Iranian fauna and several previously reported have been excluded. We therefore compiled an updated checklist of Coccinellidae found in Iran and its individual provinces based on available literature and previously unpublished records.

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Self-efficacy in patients with inflammatory bowel disease: the effect of self-care education by two randomized methods-teach-back and a smartphone application.

Health Educ Res

December 2024

Social Determinants of Health Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Shahid Bahonar Boulevard, Qazvin 34197-59811, Iran.

The use of the best teaching method to promote self-care in patients with inflammatory bowel disease (IBD) has not been well defined. Therefore, the current study was conducted to compare the effect of self-care education by two methods of teach-back and a smartphone application. The current clinical trial with a pre- and post-test design was conducted among 78 patients with IBD.

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Background: Due to the diversity of Shiga toxin-producing Escherichia coli (STEC) isolates, detecting highly pathogenic strains in foodstuffs is challenging. Currently, reference protocols for STEC rely on the molecular detection of eae and the stx1 and/or stx2 genes, followed by the detection of serogroup-specific wzx or wzy genes related to the top 7 serogroups. However, these screening methods do not distinguish between samples in which a STEC possessing both determinants are present and those containing two or more organisms, each containing one of these genes.

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Exosomes play a key role in colorectal cancer (CRC) related processes. This review explores the various functions of exosomes in CRC and their potential as diagnostic markers, therapeutic targets, and drug delivery vehicles. Exosomal long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) significantly influence CRC progression.

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Listeria monocytogenes is a notable food-borne pathogen that has the ability to create biofilms on different food processing surfaces, making it more resilient to disinfectants and posing a greater risk to human health. This study assessed melittin peptide's anti-biofilm and anti-pathogenicity effects on L. monocytogenes ATCC 19115.

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Exploring the Nutritional Impact of Sourdough Fermentation: Its Mechanisms and Functional Potential.

Foods

May 2024

Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Davutpasa Campüs, Istanbul 34210, Türkiye.

Sourdough fermentation is one of the oldest traditional methods in food technology and occurs as a result of fermentation of flour prepared from grains. The nutritional role of sourdough is related to the final composition of fermented foods prepared through sourdough fermentation, and recently, sourdough has become an important application to improve nutrition characteristics of bread. Thanks to lactic acid bacteria (LAB) presented in sourdough microflora and metabolites partially produced by yeasts, technological and important nutritional features of the bread improve and an increase in shelf life is achieved.

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Machine learning-based life cycle assessment for environmental sustainability optimization of a food supply chain.

Integr Environ Assess Manag

September 2024

Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.

Effective resource allocation in the agri-food sector is essential in mitigating environmental impacts and moving toward circular food supply chains. The potential of integrating life cycle assessment (LCA) with machine learning has been highlighted in recent studies. This hybrid framework is valuable not only for assessing food supply chains but also for improving them toward a more sustainable system.

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Blast disease caused by the fungus Magnaporthe oryzae is one of the most devastating rice diseases. Disease resistance genes such as Pi-ta or Pi-ta2 are critical in protecting rice production from blast. Published work reports that Pi-ta codes for a nucleotide-binding and leucine-rich repeat domain protein (NLR) that recognizes the fungal protease-like effector AVR-Pita by direct binding.

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In this study, the sequential extraction of the three types of biochemicals from microalgae is employed, which is a more realistic and practical solution for large-scale extraction of bioproducts. The drying, grinding, organic solvent treatment, and ultra-sonication were combined to disrupt cells and sequentially extract bioproducts from three microalgae strains, Chlorella sorokiniana IG-W-96, Chlorella sp. PG-96, and Chlorella vulgaris IG-R-96.

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Hotspots of biogeochemical activity linked to aridity and plant traits across global drylands.

Nat Plants

May 2024

Environmental Sciences and Engineering, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia.

Perennial plants create productive and biodiverse hotspots, known as fertile islands, beneath their canopies. These hotspots largely determine the structure and functioning of drylands worldwide. Despite their ubiquity, the factors controlling fertile islands under conditions of contrasting grazing by livestock, the most prevalent land use in drylands, remain virtually unknown.

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A new cloud-based method for composition of healthcare services using deep reinforcement learning and Kalman filtering.

Comput Biol Med

April 2024

Department of Computer Engineering, Faculty of Engineering and Natural Sciences, Kadir Has University, Istanbul, Turkey; Future Technology Research Center, National Yunlin University of Science and Technology, Douliou, Yunlin, 64002, Taiwan. Electronic address:

Healthcare has significantly contributed to the well-being of individuals around the globe; nevertheless, further benefits could be derived from a more streamlined healthcare system without incurring additional costs. Recently, the main attributes of cloud computing, such as on-demand service, high scalability, and virtualization, have brought many benefits across many areas, especially in medical services. It is considered an important element in healthcare services, enhancing the performance and efficacy of the services.

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Article Synopsis
  • Lithium-sulfur batteries show promise for high-energy storage but need to address issues with sulfur cathodes and lithium metal anodes for commercial use.
  • The study introduces a LiS cathode made from nanosized lithium sulfide on a CoFeP-CN composite, enhancing performance by improving reaction kinetics and reducing activation barriers.
  • The developed Si/LiS full cells with this innovative cathode demonstrate impressive initial capacities over 900 mA h g and maintain good performance with minimal capacity loss over multiple cycles.
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Immune response to COVID-19 vaccines among people living with human T-cell lymphotropic virus type 1 infection: a retrospective cohort study from Iran.

J Neurovirol

October 2023

Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Ferdowsi University Campus, Azadi-Square, Mashhad, 9177949367, Iran.

Article Synopsis
  • The study assessed the humoral immune response to COVID-19 vaccines in individuals infected with HTLV-1 in northeastern Iran over nearly a year.
  • It involved 86 HTLV-1 positive individuals and 90 matched seronegative controls, revealing that those with HTLV-1 had significantly lower antibody responses to the vaccines, even after 2 or 3 doses.
  • The findings suggest that people living with HTLV-1 demonstrate a reduced immune response to COVID-19 vaccination, particularly among those displaying specific symptoms of the disease.
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Article Synopsis
  • Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, prompting research into new biomarkers for early diagnosis and survival prediction using RNA and microRNA sequencing alongside machine learning.
  • Analysis of gene expression from The Cancer Genome Atlas (TCGA) and survival data identified 23 genes and several microRNAs that affect PDAC progression and patient survival.
  • Machine learning techniques, particularly Gradient Boosting Machines, were successful in pinpointing key genes and microRNAs, such as CTSW, which could serve as novel genetic markers for earlier detection of the disease.
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There is an urgent need to find an effective therapy for life-threatening HTLV-1-associated diseases. Bitter melon (Momordica charantia) is considered a traditional herb with antiviral and anticancer properties and was tested in this study on HTLV-1 infectivity. GC-MS analyzed the alcoholic extract.

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Background: The world's population is aging, but life expectancy has risen more than healthy life expectancy (HALE). With respect to brain and cognition, the prevalence of neurodegenerative disorders increases with age, affecting health and quality of life, and imposing significant healthcare costs. Although the effects of physical exercise on cognition in advanced age have been widely explored, in-depth fundamental knowledge of the underlying mechanisms of the exercise-induced cognitive improvements is lacking.

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Co-Producing Phycocyanin and Bioplastic in Using Carbon-Rich Wastewater.

BioTech (Basel)

July 2023

Centre for Water, Energy and Waste, Harry Butler Institute, Murdoch University, Murdoch 6150, Australia.

Microalgae can treat waste streams containing elevated levels of organic carbon and nitrogen. This process can be economically attractive if high value products are created simultaneously from the relatively low-cost waste stream. Co-production of two high value microalgal products, phycocyanin and polyhydroxybutyrate (PHB), was investigated using non-axenic MUR126 and supplemental organic carbon (acetate, oxalate, glycerol and combinations).

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Background: Different dietary protein sources are supposed to have various effects on metabolic responses and arterial stiffness in the postprandial period. This study aims to assess the postprandial effects of dietary protein sources, including animal-based protein (AP) and plant-based protein (PP), as part of a high-protein breakfast on appetite response, energy metabolism, and arterial stiffness in overweight and obese men.

Methods: This acute randomized crossover clinical trial will be conducted at the Persian study research center at Imam Reza Hospital, affiliated with the Mashhad University of Medical Sciences, located in the northeast of Iran.

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Objectives: Recent investigations indicate that canine periodontal ligament-derived stem cells (cPDLSCs) may reveal a reliable strategy for repair of periodontal tissues via cell-based tissue engineering approaches Due to limited research, his study aimed to demonstrate the phenotypic characterization of cPDLSc in comparison with canine bone marrow-derived mesenchymal stem cells (cBMSCs)

Methods: Mesenchymal stem cells (MSCs) were obtained from PDL and BM of five male adult Mongrel dogs. isolation and expansion as well as biologic characterization including colony unit formation (CFU), osteogenic and adipogenic differentiation, flow cytometric analysis of CD34 and CD44, and RT-PCR of alkaline phosphatase (ALP), osteocalcin (OCN), periostin (POSTN) and S100A4 were performed. Furthermore, electron microscopy analysis was done to complement the comparative research.

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Background: Gestational diabetes is the most common medical complication and a common metabolic disorder during pregnancy. Increasing people's self-efficacy is one of the best ways to control this disease. As there is a lag of intervention in this regard, the purpose of this study was to determine the effect of couple supportive counseling on self-efficacy in women with insulin-treated gestational diabetes.

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Among scaffolds used in tissue engineering, natural biomaterials such as plant-based materials show a crucial role in cellular function due to their biocompatibility and chemical indicators. Because of environmentally friendly behavior and safety, green methods are so important in designing scaffolds. A key bioactive flavonoid of the plant, Icariin (ICRN), has a broad range of applications in improving scaffolds as a constant and non-immunogenic material, and in stimulating the cell growth, differentiation of chondrocytes as well as differentiation of embryonic stem cells towards cardiomyocytes.

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Development of a Novel HTLV-1 Protease: Human Fcγ1 Recombinant Fusion Molecule in the CHO Eukaryotic Expression System.

Appl Biochem Biotechnol

March 2023

Inflammation and Inflammatory Diseases Division, Medical Campus, Immunology Research Center, Mashhad University of Medical Sciences, Azadi Square, Mashhad, 9177948564, Iran.

Human T-cell leukaemia virus type 1 (HTLV-1) is the causative agent of two life-threatening diseases, adult T cell leukaemia/lymphoma (ATLL), and HTLV-1-associated myelopathy/tropical spastic (HAM/TSP). HTLV-1 protease (HTLV-1-PR) is an aspartic protease that represents a promising target for therapeutic purposes like human immunodeficiency virus-PR inhibitors (HIV-PR). Therefore, in this study, the human Fc fusion recombinant-PR (HTLV-1-PR:hFcγ1) was designed and expressed for two applications, finding a blocking substrate as a potential therapeutic or a potential subunit peptide vaccine.

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